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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for HOXD1

Z-value: 0.39

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
ENSG00000128645.15 HOXD1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg38_v1_chr2_+_176188658_1761886740.377.1e-02Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr9_+_72577939 1.01 ENST00000645773.1
transmembrane channel like 1
chr4_+_143433491 0.77 ENST00000512843.1
GRB2 associated binding protein 1
chrX_+_54920796 0.57 ENST00000442098.5
ENST00000430420.5
ENST00000453081.5
ENST00000319167.12
ENST00000622017.4
ENST00000375022.8
ENST00000399736.5
ENST00000440072.5
ENST00000173898.12
ENST00000431115.5
ENST00000440759.5
ENST00000375041.6
trophinin
chr20_-_51802433 0.55 ENST00000395997.3
spalt like transcription factor 4
chr12_-_9869345 0.52 ENST00000228438.3
C-type lectin domain family 2 member B
chr13_+_35476740 0.44 ENST00000537702.5
neurobeachin
chr6_+_130421086 0.42 ENST00000545622.5
transmembrane protein 200A
chr6_-_110179995 0.35 ENST00000392586.5
ENST00000419252.1
ENST00000359451.6
ENST00000392588.5
WASP family member 1
chr9_+_72577788 0.34 ENST00000645208.2
transmembrane channel like 1
chr9_+_72577369 0.33 ENST00000651183.1
transmembrane channel like 1
chr4_-_137532452 0.32 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
protocadherin 18
chr4_-_25863537 0.32 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L family member 3
chr7_+_100119607 0.30 ENST00000262932.5
canopy FGF signaling regulator 4
chrX_+_77910656 0.28 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr20_-_51802509 0.27 ENST00000371539.7
ENST00000217086.9
spalt like transcription factor 4
chr1_-_201171545 0.25 ENST00000367333.6
transmembrane protein 9
chr19_+_49513353 0.24 ENST00000596975.5
Fc fragment of IgG receptor and transporter
chr3_+_158801926 0.23 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
major facilitator superfamily domain containing 1
chr1_+_117001744 0.23 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101 molecule
chr6_+_130018565 0.23 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL histone methyl-lysine binding protein 3
chr5_+_149357999 0.20 ENST00000274569.9
prenylcysteine oxidase 1 like
chr4_-_149815826 0.20 ENST00000636793.2
ENST00000636414.1
IQ motif containing M
chr12_+_29223730 0.19 ENST00000547116.5
fatty acyl-CoA reductase 2
chr7_+_134127299 0.19 ENST00000645682.1
ENST00000285928.2
leucine rich repeats and guanylate kinase domain containing
chr6_-_111606260 0.19 ENST00000340026.10
TRAF3 interacting protein 2
chr1_-_99766620 0.18 ENST00000646001.2
ferric chelate reductase 1
chr12_+_29223659 0.18 ENST00000182377.8
fatty acyl-CoA reductase 2
chrX_+_77899440 0.17 ENST00000373335.4
ENST00000475465.1
ENST00000650309.2
ENST00000647835.1
cytochrome c oxidase subunit 7B
chr15_+_58410543 0.16 ENST00000356113.10
ENST00000414170.7
lipase C, hepatic type
chr5_+_67004618 0.15 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chr6_-_111605859 0.15 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3 interacting protein 2
chr3_-_151316795 0.14 ENST00000260843.5
G protein-coupled receptor 87
chr15_-_37101205 0.14 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
Meis homeobox 2
chr4_+_85827745 0.14 ENST00000509300.5
Rho GTPase activating protein 24
chr1_-_248277976 0.13 ENST00000641220.1
olfactory receptor family 2 subfamily T member 33
chr12_+_28257195 0.13 ENST00000381259.5
coiled-coil domain containing 91
chr9_-_5304713 0.13 ENST00000381627.4
relaxin 2
chr6_+_121437378 0.12 ENST00000650427.1
ENST00000647564.1
gap junction protein alpha 1
chr12_+_15546344 0.11 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
protein tyrosine phosphatase receptor type O
chr2_+_54123179 0.11 ENST00000606865.1
acylphosphatase 2
chr4_+_85827891 0.09 ENST00000514229.5
Rho GTPase activating protein 24
chr7_-_100119323 0.07 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TATA-box binding protein associated factor 6
chr11_+_118527463 0.07 ENST00000302783.10
tetratricopeptide repeat domain 36
chrX_+_43656289 0.07 ENST00000338702.4
monoamine oxidase A
chr11_+_72189659 0.07 ENST00000393681.6
folate receptor alpha
chr11_+_72189528 0.07 ENST00000312293.9
folate receptor alpha
chr7_-_100119840 0.06 ENST00000437822.6
TATA-box binding protein associated factor 6
chr7_+_8433602 0.06 ENST00000405863.6
neurexophilin 1
chr2_+_218260991 0.06 ENST00000522678.5
ENST00000519574.2
ENST00000521462.1
G protein-coupled bile acid receptor 1
chr2_+_11542662 0.06 ENST00000389825.7
ENST00000381483.6
growth regulating estrogen receptor binding 1
chr8_+_54616078 0.06 ENST00000220676.2
RP1 axonemal microtubule associated
chr3_+_2892199 0.06 ENST00000397459.6
contactin 4
chr22_+_24555981 0.05 ENST00000215829.8
ENST00000402849.5
small nuclear ribonucleoprotein D3 polypeptide
chr5_+_36606355 0.05 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
solute carrier family 1 member 3
chr11_+_65787056 0.05 ENST00000335987.8
ovo like transcriptional repressor 1
chr5_+_177384430 0.05 ENST00000512593.5
ENST00000324417.6
solute carrier family 34 member 1
chr6_+_110180418 0.05 ENST00000368930.5
ENST00000307731.2
cell division cycle 40
chr14_+_32329341 0.05 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
A-kinase anchoring protein 6
chr5_-_140346596 0.04 ENST00000230990.7
heparin binding EGF like growth factor
chrX_-_31178220 0.04 ENST00000681026.1
dystrophin
chr19_-_14848922 0.04 ENST00000641129.1
olfactory receptor family 7 subfamily A member 10
chr11_-_72112068 0.03 ENST00000537644.5
ENST00000538919.5
ENST00000539395.1
ENST00000542531.5
anaphase promoting complex subunit 15
chr1_-_151459471 0.03 ENST00000271715.7
pogo transposable element derived with ZNF domain
chr13_+_77741160 0.03 ENST00000314070.9
ENST00000351546.7
SLAIN motif family member 1
chr1_-_151459169 0.03 ENST00000368863.6
ENST00000409503.5
ENST00000491586.5
ENST00000533351.5
pogo transposable element derived with ZNF domain
chr7_+_6615576 0.03 ENST00000457543.4
zinc finger protein 853
chr3_-_99850976 0.03 ENST00000487087.5
filamin A interacting protein 1 like
chr7_-_73842508 0.03 ENST00000297873.9
methyltransferase like 27
chr5_+_132873660 0.03 ENST00000296877.3
liver enriched antimicrobial peptide 2
chr11_-_62754141 0.02 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
zinc finger and BTB domain containing 3
chr11_-_72112669 0.02 ENST00000545944.5
ENST00000502597.2
anaphase promoting complex subunit 15
chr12_-_118359639 0.02 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr15_+_21579912 0.02 ENST00000628444.1
long intergenic non-protein coding RNA 2203
chr2_+_134838610 0.02 ENST00000356140.10
ENST00000392928.5
aminocarboxymuconate semialdehyde decarboxylase
chr11_-_94973541 0.02 ENST00000279839.8
CWC15 spliceosome associated protein homolog
chr1_+_207325629 0.02 ENST00000618707.2
CD55 molecule (Cromer blood group)
chrX_+_115593570 0.01 ENST00000539310.5
plastin 3
chr3_-_165078480 0.01 ENST00000264382.8
sucrase-isomaltase
chr6_+_110180116 0.01 ENST00000368932.5
cell division cycle 40
chr4_-_68245683 0.01 ENST00000332644.6
transmembrane serine protease 11B
chr7_-_81770122 0.01 ENST00000423064.7
hepatocyte growth factor
chr5_-_22853320 0.01 ENST00000504376.6
ENST00000382254.6
cadherin 12
chr7_+_148590760 0.01 ENST00000307003.3
chromosome 7 open reading frame 33
chr5_+_157731400 0.00 ENST00000231198.12
tRNA-histidine guanylyltransferase 1 like
chr17_-_59151794 0.00 ENST00000584089.1
spindle and kinetochore associated complex subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.3 GO:0060003 copper ion export(GO:0060003) cellular response to lead ion(GO:0071284)
0.1 0.2 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.2 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 0.4 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.0 0.4 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.1 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.0 0.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.7 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.1 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.0 GO:2000118 dentinogenesis(GO:0097187) regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.3 GO:0004008 copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682)
0.1 0.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.1 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.2 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.8 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism