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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for HOXD9

Z-value: 0.88

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Transcription factors associated with HOXD9

Gene Symbol Gene ID Gene Info
ENSG00000128709.13 HOXD9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD9hg38_v1_chr2_+_176122712_176122727-0.519.0e-03Click!

Activity profile of HOXD9 motif

Sorted Z-values of HOXD9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD9

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_-_76023489 7.30 ENST00000306602.3
C-X-C motif chemokine ligand 10
chr6_+_32844789 5.16 ENST00000414474.5
proteasome 20S subunit beta 9
chr1_-_173050931 3.46 ENST00000404377.5
TNF superfamily member 18
chr18_+_63887698 2.91 ENST00000457692.5
ENST00000299502.9
ENST00000413956.5
serpin family B member 2
chr1_+_100719734 2.79 ENST00000370119.8
ENST00000294728.7
ENST00000347652.6
ENST00000370115.1
vascular cell adhesion molecule 1
chr2_-_201697993 2.37 ENST00000428900.6
membrane palmitoylated protein 4
chr4_+_73740541 2.29 ENST00000401931.1
ENST00000307407.8
C-X-C motif chemokine ligand 8
chr2_-_201698040 2.27 ENST00000396886.7
ENST00000409143.5
membrane palmitoylated protein 4
chr2_-_231125032 2.07 ENST00000258400.4
5-hydroxytryptamine receptor 2B
chr22_-_41286168 1.63 ENST00000356244.8
Ran GTPase activating protein 1
chr3_-_108058361 1.62 ENST00000398258.7
CD47 molecule
chr3_-_116444983 1.53 ENST00000333617.8
limbic system associated membrane protein
chr19_-_49896868 1.49 ENST00000593956.5
ENST00000391826.7
interleukin 4 induced 1
chr11_-_105035113 1.27 ENST00000526568.5
ENST00000531166.5
ENST00000534497.5
ENST00000527979.5
ENST00000533400.6
ENST00000528974.1
ENST00000525825.5
ENST00000353247.9
ENST00000446369.5
ENST00000436863.7
caspase 1
chr18_-_5396265 1.27 ENST00000579951.2
erythrocyte membrane protein band 4.1 like 3
chr17_-_42112674 1.23 ENST00000251642.8
ENST00000591220.5
DExH-box helicase 58
chr11_-_128587551 1.16 ENST00000392668.8
ETS proto-oncogene 1, transcription factor
chr12_-_57078784 1.15 ENST00000300128.9
nuclear envelope integral membrane protein 1
chr2_+_142877653 1.11 ENST00000375773.6
ENST00000409512.5
ENST00000264170.9
ENST00000410015.6
kynureninase
chr12_-_88580459 1.06 ENST00000552044.1
ENST00000644744.1
ENST00000357116.4
KIT ligand
chr4_-_68670648 1.05 ENST00000338206.6
UDP glucuronosyltransferase family 2 member B15
chr22_-_30246739 1.05 ENST00000403987.3
ENST00000249075.4
LIF interleukin 6 family cytokine
chr7_-_122699108 1.01 ENST00000340112.3
ring finger protein 133
chr12_+_55681711 1.01 ENST00000394252.4
methyltransferase like 7B
chr2_+_143129379 1.00 ENST00000295095.11
Rho GTPase activating protein 15
chr3_-_27456743 0.97 ENST00000295736.9
ENST00000428386.5
ENST00000428179.1
solute carrier family 4 member 7
chr16_-_18876305 0.96 ENST00000563235.5
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
chr7_-_108240049 0.94 ENST00000379022.8
neuronal cell adhesion molecule
chr4_-_76007501 0.94 ENST00000264888.6
C-X-C motif chemokine ligand 9
chr15_-_55270383 0.93 ENST00000396307.6
RAB27A, member RAS oncogene family
chr2_-_174847765 0.93 ENST00000443238.6
chimerin 1
chr20_+_59835853 0.88 ENST00000492611.5
phosphatase and actin regulator 3
chr2_-_174847525 0.80 ENST00000295497.12
ENST00000652036.1
ENST00000444394.6
ENST00000650731.1
chimerin 1
chr17_-_10549694 0.80 ENST00000622564.4
myosin heavy chain 2
chrX_-_111270474 0.76 ENST00000324068.2
calpain 6
chr3_-_167474026 0.75 ENST00000466903.1
ENST00000264677.8
serpin family I member 2
chr11_+_62190212 0.73 ENST00000306238.3
secretoglobin family 1D member 1
chr1_-_94925759 0.72 ENST00000415017.1
ENST00000545882.5
calponin 3
chr4_+_186069144 0.71 ENST00000513189.1
ENST00000296795.8
toll like receptor 3
chr4_-_67883987 0.70 ENST00000283916.11
transmembrane serine protease 11D
chr18_+_58196736 0.70 ENST00000675221.1
NEDD4 like E3 ubiquitin protein ligase
chr9_-_92482350 0.69 ENST00000375543.2
asporin
chr6_+_45422485 0.69 ENST00000359524.7
RUNX family transcription factor 2
chr6_+_122996227 0.64 ENST00000275162.10
clavesin 2
chr6_+_45422564 0.63 ENST00000625924.1
RUNX family transcription factor 2
chr6_+_29306626 0.62 ENST00000377160.4
olfactory receptor family 14 subfamily J member 1
chr3_-_157503574 0.61 ENST00000494677.5
ENST00000468233.5
ventricular zone expressed PH domain containing 1
chr17_-_10549652 0.60 ENST00000245503.10
myosin heavy chain 2
chr17_-_10549612 0.60 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
myosin heavy chain 2
chr9_+_94084458 0.59 ENST00000620992.5
ENST00000288976.3
protein tyrosine phosphatase domain containing 1
chr1_-_100178215 0.59 ENST00000370138.1
ENST00000370137.6
ENST00000342895.7
ENST00000620882.4
leucine rich repeat containing 39
chr3_+_156120572 0.57 ENST00000389636.9
ENST00000490337.6
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr1_-_165445220 0.57 ENST00000619224.1
retinoid X receptor gamma
chr4_+_174918400 0.57 ENST00000404450.8
ENST00000514159.1
ADAM metallopeptidase domain 29
chr17_+_21126947 0.56 ENST00000579303.5
dehydrogenase/reductase 7B
chr15_+_66504959 0.55 ENST00000535141.6
ENST00000613446.4
ENST00000446801.6
zwilch kinetochore protein
chr1_-_165445088 0.54 ENST00000359842.10
retinoid X receptor gamma
chr3_-_197260369 0.53 ENST00000658155.1
ENST00000453607.5
discs large MAGUK scaffold protein 1
chr10_-_113854368 0.53 ENST00000369305.1
DNA cross-link repair 1A
chr15_+_66505289 0.49 ENST00000565627.5
ENST00000564179.5
ENST00000307897.10
zwilch kinetochore protein
chr8_+_103880412 0.47 ENST00000436393.6
regulating synaptic membrane exocytosis 2
chrX_-_15314543 0.46 ENST00000344384.8
ankyrin repeat and SOCS box containing 11
chr2_-_165203870 0.46 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
sodium voltage-gated channel alpha subunit 3
chr7_+_144000320 0.45 ENST00000641698.1
olfactory receptor family 6 subfamily B member 1
chr4_-_167234552 0.45 ENST00000512648.5
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr10_+_27532521 0.45 ENST00000683924.1
RAB18, member RAS oncogene family
chr8_-_20183090 0.43 ENST00000265808.11
ENST00000522513.5
solute carrier family 18 member A1
chr6_+_13272709 0.43 ENST00000379335.8
phosphatase and actin regulator 1
chr10_+_84424919 0.43 ENST00000543283.2
ENST00000494586.5
coiled-coil serine rich protein 2
chr1_+_171557845 0.42 ENST00000644916.1
proline rich coiled-coil 2C
chr8_+_12104389 0.42 ENST00000400085.7
zinc finger protein 705D
chr2_+_161136901 0.41 ENST00000259075.6
ENST00000432002.5
TRAF family member associated NFKB activator
chr12_-_84892120 0.40 ENST00000680379.1
solute carrier family 6 member 15
chr21_+_34364003 0.40 ENST00000290310.4
potassium voltage-gated channel subfamily E regulatory subunit 2
chr5_+_141364231 0.40 ENST00000611914.1
protocadherin gamma subfamily A, 5
chr8_-_20183127 0.39 ENST00000276373.10
ENST00000519026.5
ENST00000440926.3
ENST00000437980.3
solute carrier family 18 member A1
chr6_-_31665185 0.39 ENST00000456540.1
ENST00000445768.5
G-patch domain and ankyrin repeats 1
chr15_-_66386668 0.38 ENST00000568216.5
ENST00000562124.5
ENST00000570251.1
TIMELESS interacting protein
chr20_+_6007245 0.38 ENST00000378868.4
cardiolipin synthase 1
chr8_-_85341705 0.38 ENST00000517618.5
carbonic anhydrase 1
chr1_+_86547070 0.37 ENST00000370563.3
chloride channel accessory 4
chr3_-_112845950 0.36 ENST00000398214.5
CD200 receptor 1 like
chr5_+_95391361 0.36 ENST00000283357.10
family with sequence similarity 81 member B
chr3_-_146528750 0.36 ENST00000483300.5
phospholipid scramblase 1
chr22_-_32255344 0.35 ENST00000266086.6
solute carrier family 5 member 4
chrX_-_131289412 0.35 ENST00000652189.1
ENST00000651556.1
immunoglobulin superfamily member 1
chr2_-_227379297 0.35 ENST00000304568.4
transmembrane 4 L six family member 20
chr6_+_131637296 0.34 ENST00000358229.6
ENST00000357639.8
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr12_-_9999176 0.34 ENST00000298527.10
ENST00000348658.4
C-type lectin domain family 1 member B
chr1_+_50105666 0.34 ENST00000651347.1
ELAV like RNA binding protein 4
chr6_+_10528326 0.33 ENST00000379597.7
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr19_-_56314788 0.33 ENST00000592509.5
ENST00000592679.5
ENST00000683990.1
ENST00000588442.5
ENST00000593106.5
ENST00000587492.5
zinc finger and SCAN domain containing 5A
chr2_+_100974849 0.32 ENST00000450763.1
neuronal PAS domain protein 2
chr11_+_117203135 0.32 ENST00000529622.1
transgelin
chr20_+_13221257 0.32 ENST00000262487.5
isthmin 1
chr9_-_121050264 0.32 ENST00000223642.3
complement C5
chr6_-_17706852 0.32 ENST00000262077.3
nucleoporin 153
chr11_-_95910748 0.31 ENST00000675933.1
myotubularin related protein 2
chr22_-_35840218 0.31 ENST00000414461.6
ENST00000416721.6
ENST00000449924.6
ENST00000262829.11
ENST00000397305.3
RNA binding fox-1 homolog 2
chr14_-_60724300 0.31 ENST00000556952.3
ENST00000216513.5
SIX homeobox 4
chr1_+_44405164 0.31 ENST00000355387.6
ring finger protein 220
chr3_+_109136707 0.30 ENST00000622536.6
chromosome 3 open reading frame 85
chr4_-_167234579 0.30 ENST00000502330.5
ENST00000357154.7
ENST00000421836.6
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr11_-_95910824 0.30 ENST00000674528.1
ENST00000675477.1
ENST00000675636.1
myotubularin related protein 2
chr21_-_18403754 0.30 ENST00000284885.8
transmembrane serine protease 15
chr3_-_132684685 0.30 ENST00000512094.5
ENST00000632629.1
nephrocystin 3
NPHP3-ACAD11 readthrough (NMD candidate)
chr10_+_5364955 0.30 ENST00000380433.5
urocortin 3
chr2_+_89947508 0.30 ENST00000491977.1
immunoglobulin kappa variable 2D-29
chr12_+_11649666 0.30 ENST00000396373.9
ETS variant transcription factor 6
chr11_-_95910665 0.29 ENST00000674610.1
ENST00000675660.1
myotubularin related protein 2
chr2_-_135837170 0.29 ENST00000264162.7
lactase
chr2_-_174597728 0.29 ENST00000409891.5
ENST00000410117.5
WAS/WASL interacting protein family member 1
chr12_-_124567464 0.29 ENST00000458234.5
nuclear receptor corepressor 2
chr17_-_41168219 0.29 ENST00000391356.4
keratin associated protein 4-3
chr17_+_62370218 0.29 ENST00000450662.7
EF-hand calcium binding domain 3
chr10_+_17752185 0.28 ENST00000377495.2
transmembrane protein 236
chr14_+_23185316 0.28 ENST00000399910.5
ENST00000492621.5
ring finger protein 212B
chr10_-_50885656 0.28 ENST00000374001.6
ENST00000395489.6
ENST00000282641.6
ENST00000395495.5
ENST00000373995.7
ENST00000414883.1
APOBEC1 complementation factor
chr8_+_54616078 0.28 ENST00000220676.2
RP1 axonemal microtubule associated
chr4_+_87799546 0.27 ENST00000226284.7
integrin binding sialoprotein
chr7_+_93906557 0.27 ENST00000248572.10
ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
G protein subunit gamma transducin 1
chrX_+_136305988 0.27 ENST00000394141.1
adhesion G protein-coupled receptor G4
chr9_+_12693327 0.27 ENST00000388918.10
tyrosinase related protein 1
chr4_-_167234426 0.27 ENST00000541354.5
ENST00000509854.5
ENST00000512681.5
ENST00000357545.9
ENST00000510741.5
ENST00000510403.5
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr2_-_162838728 0.27 ENST00000328032.8
ENST00000332142.10
potassium voltage-gated channel subfamily H member 7
chr12_+_14973020 0.26 ENST00000266395.3
phosphodiesterase 6H
chr4_+_70383123 0.26 ENST00000304915.8
submaxillary gland androgen regulated protein 3B
chrX_+_48761743 0.26 ENST00000303227.11
glyoxalase domain containing 5
chr8_+_24294107 0.26 ENST00000437154.6
ADAM metallopeptidase domain 28
chr2_-_95484731 0.26 ENST00000639673.2
tripartite motif containing 43B
chr12_+_75334675 0.26 ENST00000312442.2
GLIPR1 like 1
chr3_+_63443076 0.26 ENST00000295894.9
synaptoporin
chr7_+_114416286 0.26 ENST00000635534.1
forkhead box P2
chr5_+_141364153 0.25 ENST00000518069.2
protocadherin gamma subfamily A, 5
chr15_+_58138368 0.25 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr22_+_50170720 0.25 ENST00000159647.9
ENST00000395842.3
pannexin 2
chr14_-_67533720 0.25 ENST00000554278.6
transmembrane protein 229B
chr10_-_88851809 0.25 ENST00000371930.5
ankyrin repeat domain 22
chr11_+_112175526 0.24 ENST00000532612.5
ENST00000438022.5
beta-carotene oxygenase 2
chr1_+_197268222 0.24 ENST00000367400.8
ENST00000638467.1
ENST00000367399.6
crumbs cell polarity complex component 1
chr1_+_181088692 0.24 ENST00000367577.7
immediate early response 5
chr10_-_50885619 0.24 ENST00000373997.8
APOBEC1 complementation factor
chr12_+_53954870 0.24 ENST00000243103.4
homeobox C12
chr5_+_141412979 0.23 ENST00000612503.1
ENST00000398610.3
protocadherin gamma subfamily A, 10
chr2_-_178702479 0.23 ENST00000414766.5
titin
chr2_+_36696686 0.23 ENST00000379242.7
ENST00000389975.7
vitrin
chr9_-_28670285 0.23 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
leucine rich repeat and Ig domain containing 2
chr10_-_104085847 0.23 ENST00000648076.2
collagen type XVII alpha 1 chain
chr8_+_106726115 0.22 ENST00000521592.5
oxidation resistance 1
chr3_-_167653916 0.22 ENST00000488012.5
ENST00000682715.1
ENST00000647816.1
WD repeat domain 49
chr11_-_16408853 0.22 ENST00000528252.5
SRY-box transcription factor 6
chr1_-_86383078 0.22 ENST00000460698.6
outer dense fiber of sperm tails 2 like
chr11_-_84720876 0.21 ENST00000648622.1
discs large MAGUK scaffold protein 2
chr7_+_90383672 0.21 ENST00000416322.5
claudin 12
chr8_-_58500158 0.20 ENST00000301645.4
cytochrome P450 family 7 subfamily A member 1
chr19_+_15082211 0.20 ENST00000641398.1
olfactory receptor family 1 subfamily I member 1
chr1_+_197268204 0.20 ENST00000535699.5
ENST00000538660.5
crumbs cell polarity complex component 1
chr5_-_79512794 0.20 ENST00000282260.10
ENST00000508576.5
ENST00000535690.1
homer scaffold protein 1
chr17_+_43483949 0.20 ENST00000540306.5
ENST00000262415.8
DEAH-box helicase 8
chr17_+_59155726 0.19 ENST00000578777.5
ENST00000577457.1
ENST00000582995.5
ENST00000262293.9
ENST00000614081.1
proline rich 11
chr16_-_66730216 0.19 ENST00000569320.5
dynein cytoplasmic 1 light intermediate chain 2
chr1_+_192158448 0.19 ENST00000367460.4
regulator of G protein signaling 18
chr3_-_167653952 0.19 ENST00000466760.5
ENST00000479765.5
WD repeat domain 49
chr17_+_58169401 0.19 ENST00000641866.1
olfactory receptor family 4 subfamily D member 2
chr6_-_49866453 0.19 ENST00000507853.5
cysteine rich secretory protein 1
chr2_+_24793098 0.19 ENST00000473706.5
centromere protein O
chr18_+_616672 0.19 ENST00000338387.11
clusterin like 1
chr3_+_178558700 0.19 ENST00000432997.5
ENST00000455865.5
potassium calcium-activated channel subfamily M regulatory beta subunit 2
chr11_-_13496018 0.19 ENST00000529816.1
parathyroid hormone
chr1_-_148152272 0.19 ENST00000682118.1
ENST00000615281.4
NBPF member 11
chr9_+_133376334 0.18 ENST00000371957.4
serine/threonine kinase like domain containing 1
chr1_+_240014319 0.18 ENST00000447095.5
formin 2
chr18_-_77017042 0.18 ENST00000359645.7
ENST00000397875.7
ENST00000397869.7
ENST00000578193.5
ENST00000578873.5
ENST00000397866.8
ENST00000528160.1
ENST00000527041.1
ENST00000526111.5
ENST00000397865.9
ENST00000382582.7
myelin basic protein
chr1_+_160400543 0.17 ENST00000368061.3
VANGL planar cell polarity protein 2
chr9_-_21482313 0.17 ENST00000448696.4
interferon epsilon
chr2_+_127701490 0.17 ENST00000310981.6
SFT2 domain containing 3
chr7_+_45027634 0.17 ENST00000381112.7
ENST00000474617.1
CCM2 scaffold protein
chr4_-_82844418 0.17 ENST00000503937.5
SEC31 homolog A, COPII coat complex component
chr8_-_673547 0.17 ENST00000522893.1
glutamate rich 1
chr3_-_197226351 0.17 ENST00000656428.1
discs large MAGUK scaffold protein 1
chr9_-_21351378 0.17 ENST00000380210.1
interferon alpha 6
chr6_+_151809105 0.17 ENST00000427531.6
estrogen receptor 1
chr18_-_72865680 0.16 ENST00000397929.5
neuropilin and tolloid like 1
chr17_-_41489907 0.16 ENST00000328119.11
keratin 36
chr8_+_36784324 0.16 ENST00000523973.5
ENST00000399881.8
potassium calcium-activated channel subfamily U member 1
chr5_-_177780633 0.16 ENST00000513554.5
ENST00000440605.7
family with sequence similarity 153 member A
chr22_+_31754862 0.16 ENST00000382111.6
ENST00000645407.1
ENST00000646701.1
DEP domain containing 5, GATOR1 subcomplex subunit
novel protein, DEPDC5-YWHAH readthrough
chr1_-_197067234 0.16 ENST00000367412.2
coagulation factor XIII B chain
chr4_+_48483324 0.15 ENST00000273861.5
solute carrier family 10 member 4
chr18_+_616711 0.15 ENST00000579494.1
clusterin like 1
chr6_+_29111560 0.15 ENST00000377169.2
olfactory receptor family 2 subfamily J member 3
chr1_+_197413827 0.15 ENST00000367397.1
ENST00000681519.1
crumbs cell polarity complex component 1
chr6_-_49866527 0.15 ENST00000335847.9
cysteine rich secretory protein 1
chr6_-_106975616 0.14 ENST00000610952.1
CD24 molecule
chr5_+_136160986 0.14 ENST00000507637.1
SMAD family member 5
chr2_-_208146150 0.14 ENST00000260988.5
crystallin gamma B
chr7_-_28180735 0.14 ENST00000283928.10
JAZF zinc finger 1
chr4_-_99321362 0.14 ENST00000625860.2
ENST00000305046.13
ENST00000506651.5
alcohol dehydrogenase 1B (class I), beta polypeptide
chr6_+_132538290 0.14 ENST00000434551.2
trace amine associated receptor 9
chr3_-_139678011 0.14 ENST00000646611.1
ENST00000645290.1
ENST00000647257.1
nicotinamide nucleotide adenylyltransferase 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:2000329 negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.7 8.2 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.4 1.3 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.4 2.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.4 1.6 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.4 2.8 GO:0022614 membrane to membrane docking(GO:0022614)
0.4 1.1 GO:0033023 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) mast cell proliferation(GO:0070662)
0.3 1.2 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.3 1.0 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.2 1.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.2 2.3 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.2 0.4 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.2 0.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 1.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.7 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.1 1.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 1.2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.1 0.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.3 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.7 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 0.3 GO:1902594 viral penetration into host nucleus(GO:0075732) multi-organism nuclear import(GO:1902594)
0.1 0.3 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.1 0.3 GO:0016116 tetraterpenoid metabolic process(GO:0016108) carotenoid metabolic process(GO:0016116) carotene catabolic process(GO:0016121) xanthophyll metabolic process(GO:0016122) terpene catabolic process(GO:0046247)
0.1 1.5 GO:1902221 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1 0.3 GO:0021757 caudate nucleus development(GO:0021757) putamen development(GO:0021758)
0.1 2.9 GO:0042730 fibrinolysis(GO:0042730)
0.1 0.9 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.1 0.3 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.1 0.3 GO:0061055 myotome development(GO:0061055)
0.1 1.6 GO:0008228 opsonization(GO:0008228)
0.1 0.5 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.3 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.9 GO:0045162 neuronal action potential propagation(GO:0019227) clustering of voltage-gated sodium channels(GO:0045162) action potential propagation(GO:0098870)
0.1 0.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 0.3 GO:1904823 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.1 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.1 0.2 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.7 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.2 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 1.5 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 0.5 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.8 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.2 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0 0.3 GO:0007296 vitellogenesis(GO:0007296)
0.0 5.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.2 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.2 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.5 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.2 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.4 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.4 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 1.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0032597 B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
0.0 0.6 GO:1903817 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.7 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:1904207 maintenance of blood-brain barrier(GO:0035633) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.0 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.0 0.2 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.0 0.2 GO:0048478 replication fork protection(GO:0048478)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 0.1 GO:1905225 thyroid-stimulating hormone signaling pathway(GO:0038194) cellular response to glycoprotein(GO:1904588) response to thyrotropin-releasing hormone(GO:1905225) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.0 0.3 GO:0034214 protein hexamerization(GO:0034214)
0.0 1.5 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.2 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857)
0.0 0.1 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:0048021 regulation of melanin biosynthetic process(GO:0048021) positive regulation of melanin biosynthetic process(GO:0048023) regulation of secondary metabolite biosynthetic process(GO:1900376) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 0.4 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.3 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.1 GO:0035989 tendon development(GO:0035989)
0.0 0.0 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.0 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.2 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.3 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.5 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.8 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.6 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.6 5.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.5 1.6 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.3 1.3 GO:0097179 protease inhibitor complex(GO:0097179)
0.3 2.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.3 1.0 GO:1990423 RZZ complex(GO:1990423)
0.1 0.5 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.8 GO:0070083 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.1 0.6 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.4 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.8 GO:0043219 lateral loop(GO:0043219)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.9 GO:0043194 axon initial segment(GO:0043194)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.7 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0005592 collagen type XI trimer(GO:0005592)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 6.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.0 1.6 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.3 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.0 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.6 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 8.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.5 1.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.3 2.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.3 1.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 1.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 2.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 1.1 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.2 0.8 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.2 5.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 2.1 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 1.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 1.3 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.3 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 0.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.4 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.1 0.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.2 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.1 0.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.3 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.3 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.4 GO:0034711 inhibin binding(GO:0034711)
0.0 2.0 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.8 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.9 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 3.2 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.4 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 1.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.4 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.2 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 3.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:1902271 D3 vitamins binding(GO:1902271)
0.0 0.6 GO:0070402 NADPH binding(GO:0070402)
0.0 0.4 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.6 GO:0005549 odorant binding(GO:0005549)
0.0 1.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 8.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 1.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 2.0 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.9 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.3 PID FGF PATHWAY FGF signaling pathway
0.0 1.2 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 7.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 3.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 8.2 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 5.2 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.1 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 0.9 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 1.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 1.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.9 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 2.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors