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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for IKZF1
Z-value: 2.66
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Transcription factors associated with IKZF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF1 | hg38_v1_chr7_+_50304693_50304782 | 0.67 | 2.9e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IKZF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_41426031 Show fit | 10.28 |
ENST00000455164.6
ENST00000681849.1 ENST00000679705.1 ENST00000424365.6 |
MX dynamin like GTPase 1 |
|
| chr17_+_79022908 Show fit | 9.94 |
ENST00000354124.7
ENST00000580454.5 |
C1q and TNF related 1 |
|
| chr6_-_31582415 Show fit | 9.88 |
ENST00000429299.3
ENST00000446745.2 |
lymphotoxin beta |
|
| chr17_+_43006740 Show fit | 9.11 |
ENST00000438323.2
ENST00000415816.7 |
interferon induced protein 35 |
|
| chr6_-_159693262 Show fit | 8.77 |
ENST00000337404.8
|
superoxide dismutase 2 |
|
| chr19_+_4229502 Show fit | 8.39 |
ENST00000221847.6
|
Epstein-Barr virus induced 3 |
|
| chr9_-_120914549 Show fit | 8.07 |
ENST00000546084.5
|
TNF receptor associated factor 1 |
|
| chr2_+_149330506 Show fit | 7.98 |
ENST00000334166.9
|
LY6/PLAUR domain containing 6 |
|
| chr1_-_153549120 Show fit | 7.97 |
ENST00000368712.1
|
S100 calcium binding protein A3 |
|
| chr6_+_31587002 Show fit | 7.39 |
ENST00000376090.6
|
leukocyte specific transcript 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 50.3 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.4 | 37.1 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 3.6 | 25.1 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 2.4 | 21.6 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.2 | 20.2 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 3.9 | 19.4 | GO:0001315 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.2 | 18.0 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 2.0 | 17.8 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.6 | 17.6 | GO:2001223 | negative regulation of neuron migration(GO:2001223) |
| 0.5 | 17.3 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 56.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 36.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 34.3 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.3 | 31.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 22.6 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 22.1 | GO:0044431 | Golgi apparatus part(GO:0044431) |
| 2.4 | 18.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.3 | 17.3 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 16.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 2.3 | 16.2 | GO:0042825 | TAP complex(GO:0042825) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 54.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 48.6 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 38.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.8 | 27.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 23.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.1 | 21.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 2.3 | 21.0 | GO:0046978 | TAP binding(GO:0046977) TAP1 binding(GO:0046978) |
| 0.7 | 20.7 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.5 | 20.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 1.9 | 19.4 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 84.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.7 | 37.2 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.5 | 32.9 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.3 | 23.4 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 22.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 19.3 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 18.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 18.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.5 | 17.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 17.3 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 111.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.6 | 41.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.4 | 40.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.4 | 27.9 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.7 | 26.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 24.3 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.4 | 18.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 1.0 | 18.5 | REACTOME P75NTR SIGNALS VIA NFKB | Genes involved in p75NTR signals via NF-kB |
| 0.3 | 17.3 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.5 | 16.9 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |