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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for IRF2_STAT2_IRF8_IRF1
Z-value: 10.71
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Transcription factors associated with IRF2_STAT2_IRF8_IRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF2 | hg38_v1_chr4_-_184474518_184474556 | 0.59 | 1.9e-03 | Click! |
| IRF8 | hg38_v1_chr16_+_85908988_85909033 | 0.56 | 3.6e-03 | Click! |
| IRF1 | hg38_v1_chr5_-_132490750_132490840 | 0.46 | 2.0e-02 | Click! |
| STAT2 | hg38_v1_chr12_-_56360084_56360146 | 0.37 | 7.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_6865901 Show fit | 172.41 |
ENST00000256722.10
|
cytidine/uridine monophosphate kinase 2 |
|
| chr4_-_76023489 Show fit | 155.23 |
ENST00000306602.3
|
C-X-C motif chemokine ligand 10 |
|
| chr13_-_42992165 Show fit | 139.33 |
ENST00000398762.7
ENST00000313640.11 ENST00000313624.12 |
epithelial stromal interaction 1 |
|
| chr6_+_32854179 Show fit | 138.92 |
ENST00000374859.3
|
proteasome 20S subunit beta 9 |
|
| chr1_+_78620722 Show fit | 138.55 |
ENST00000679848.1
|
interferon induced protein 44 like |
|
| chr10_+_89327989 Show fit | 124.28 |
ENST00000679923.1
ENST00000680085.1 ENST00000371818.9 ENST00000680779.1 |
interferon induced protein with tetratricopeptide repeats 3 |
|
| chr10_+_89327977 Show fit | 123.93 |
ENST00000681277.1
|
interferon induced protein with tetratricopeptide repeats 3 |
|
| chr10_+_89332484 Show fit | 123.71 |
ENST00000371811.4
ENST00000680037.1 ENST00000679583.1 ENST00000679897.1 |
interferon induced protein with tetratricopeptide repeats 3 |
|
| chr12_+_112978386 Show fit | 121.99 |
ENST00000342315.8
|
2'-5'-oligoadenylate synthetase 2 |
|
| chr10_+_89392546 Show fit | 118.58 |
ENST00000546318.2
ENST00000371804.4 |
interferon induced protein with tetratricopeptide repeats 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 500.4 | GO:0034340 | response to type I interferon(GO:0034340) |
| 23.7 | 474.2 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 26.4 | 396.7 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 29.2 | 350.3 | GO:0018377 | protein myristoylation(GO:0018377) |
| 1.2 | 325.5 | GO:0051607 | defense response to virus(GO:0051607) |
| 1.7 | 323.4 | GO:0015992 | proton transport(GO:0015992) |
| 3.1 | 299.3 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 21.0 | 252.3 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 23.5 | 234.9 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 78.0 | 234.0 | GO:0046967 | cytosol to ER transport(GO:0046967) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1262.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.4 | 789.8 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.4 | 755.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 375.6 | GO:0005829 | cytosol(GO:0005829) |
| 46.1 | 322.7 | GO:0042825 | TAP complex(GO:0042825) |
| 35.8 | 286.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.5 | 222.3 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 2.0 | 165.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 142.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.0 | 106.8 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 47.7 | 716.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 1.2 | 677.7 | GO:0005525 | GTP binding(GO:0005525) |
| 3.2 | 461.7 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 8.1 | 357.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 40.3 | 322.7 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) |
| 46.0 | 322.3 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.3 | 299.6 | GO:0008270 | zinc ion binding(GO:0008270) |
| 10.2 | 295.9 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 224.6 | GO:0042802 | identical protein binding(GO:0042802) |
| 1.0 | 176.6 | GO:0004896 | cytokine receptor activity(GO:0004896) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 196.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.9 | 193.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.8 | 146.5 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 1.6 | 103.1 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.8 | 101.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.1 | 98.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 1.8 | 88.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.3 | 81.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.5 | 78.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 1.7 | 63.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.2 | 2287.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 5.1 | 349.8 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 3.4 | 322.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 11.0 | 253.0 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 2.7 | 183.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 2.5 | 172.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 10.2 | 172.7 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.6 | 134.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.8 | 132.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 1.7 | 75.1 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |