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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for IRF3
Z-value: 3.29
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Transcription factors associated with IRF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg38_v1_chr19_-_49665705_49665806 | -0.50 | 1.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_89332484 Show fit | 31.92 |
ENST00000371811.4
ENST00000680037.1 ENST00000679583.1 ENST00000679897.1 |
interferon induced protein with tetratricopeptide repeats 3 |
|
| chr10_+_89327989 Show fit | 30.91 |
ENST00000679923.1
ENST00000680085.1 ENST00000371818.9 ENST00000680779.1 |
interferon induced protein with tetratricopeptide repeats 3 |
|
| chr10_+_89327977 Show fit | 30.03 |
ENST00000681277.1
|
interferon induced protein with tetratricopeptide repeats 3 |
|
| chr21_+_41420515 Show fit | 29.41 |
ENST00000398600.6
ENST00000679626.1 |
MX dynamin like GTPase 1 |
|
| chr2_-_162318475 Show fit | 23.58 |
ENST00000648433.1
|
interferon induced with helicase C domain 1 |
|
| chr6_+_32854179 Show fit | 21.69 |
ENST00000374859.3
|
proteasome 20S subunit beta 9 |
|
| chr17_-_42112674 Show fit | 21.21 |
ENST00000251642.8
ENST00000591220.5 |
DExH-box helicase 58 |
|
| chr12_+_112978386 Show fit | 20.80 |
ENST00000342315.8
|
2'-5'-oligoadenylate synthetase 2 |
|
| chr15_+_88639009 Show fit | 20.48 |
ENST00000306072.10
|
interferon stimulated exonuclease gene 20 |
|
| chr3_+_122680802 Show fit | 19.89 |
ENST00000474629.7
|
poly(ADP-ribose) polymerase family member 14 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 96.9 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 4.9 | 58.4 | GO:0018377 | protein myristoylation(GO:0018377) |
| 5.4 | 54.0 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 9.4 | 47.2 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.4 | 47.1 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 15.6 | 46.7 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 3.8 | 45.4 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.2 | 39.6 | GO:0015992 | proton transport(GO:0015992) |
| 6.3 | 31.6 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 1.5 | 29.4 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 210.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 75.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 64.0 | GO:0005829 | cytosol(GO:0005829) |
| 6.7 | 46.7 | GO:0042825 | TAP complex(GO:0042825) |
| 0.3 | 22.8 | GO:0015030 | Cajal body(GO:0015030) |
| 2.7 | 21.7 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.5 | 19.1 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.0 | 17.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 17.3 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 16.7 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.9 | 103.8 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.6 | 79.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 57.2 | GO:0042802 | identical protein binding(GO:0042802) |
| 1.9 | 52.6 | GO:0070403 | NAD+ binding(GO:0070403) |
| 5.8 | 46.7 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) MHC class Ib protein binding(GO:0023029) |
| 5.9 | 41.6 | GO:0015333 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.1 | 39.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.9 | 25.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 23.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.7 | 21.7 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 41.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 21.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 16.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 12.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 9.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.3 | 7.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.2 | 4.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 4.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 4.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 3.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 295.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 48.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 2.8 | 47.2 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 2.0 | 47.0 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.6 | 40.7 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.1 | 32.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 25.5 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.2 | 16.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 15.9 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.4 | 13.0 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |