ISMARA results: IRF3

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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for IRF3

Z-value: 3.29

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Transcription factors associated with IRF3

Gene Symbol	Gene ID	Gene Info
IRF3 Ensembl NCBI GeneCards UniProt	ENSG00000126456.16	IRF3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
IRF3	hg38_v1_chr19_-_49665705_49665806	-0.50	1.1e-02	Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr10_+_89332484 Show fit	31.92	ENST00000371811.4 ENST00000680037.1 ENST00000679583.1 ENST00000679897.1	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein with tetratricopeptide repeats 3
chr10_+_89327989 Show fit	30.91	ENST00000679923.1 ENST00000680085.1 ENST00000371818.9 ENST00000680779.1	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein with tetratricopeptide repeats 3
chr10_+_89327977 Show fit	30.03	ENST00000681277.1	IFIT3 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein with tetratricopeptide repeats 3
chr21_+_41420515 Show fit	29.41	ENST00000398600.6 ENST00000679626.1	MX1 Ensembl NCBI GeneCards UniProt Show fit	MX dynamin like GTPase 1
chr2_-_162318475 Show fit	23.58	ENST00000648433.1	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr6_+_32854179 Show fit	21.69	ENST00000374859.3	PSMB9 Ensembl NCBI GeneCards UniProt Show fit	proteasome 20S subunit beta 9
chr17_-_42112674 Show fit	21.21	ENST00000251642.8 ENST00000591220.5	DHX58 Ensembl NCBI GeneCards UniProt Show fit	DExH-box helicase 58
chr12_+_112978386 Show fit	20.80	ENST00000342315.8	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr15_+_88639009 Show fit	20.48	ENST00000306072.10	ISG20 Ensembl NCBI GeneCards UniProt Show fit	interferon stimulated exonuclease gene 20
chr3_+_122680802 Show fit	19.89	ENST00000474629.7	PARP14 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 14
chr10_-_48493641 Show fit	17.87	ENST00000417247.6	ARHGAP22 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 22
chr6_-_32853618 Show fit	17.74	ENST00000354258.5	TAP1 Ensembl NCBI GeneCards UniProt Show fit	transporter 1, ATP binding cassette subfamily B member
chr6_-_32853813 Show fit	17.53	ENST00000643049.2	TAP1 Ensembl NCBI GeneCards UniProt Show fit	transporter 1, ATP binding cassette subfamily B member
chr12_+_112938523 Show fit	17.41	ENST00000679483.1 ENST00000679493.1	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3
chr12_+_112938284 Show fit	17.07	ENST00000681346.1	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3
chr3_-_122564232 Show fit	16.72	ENST00000471785.5 ENST00000466126.1	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 9
chr17_-_35880350 Show fit	16.58	ENST00000605140.6 ENST00000651122.1 ENST00000603197.6	CCL5 Ensembl NCBI GeneCards UniProt Show fit	C-C motif chemokine ligand 5
chr3_-_122564577 Show fit	16.40	ENST00000477522.6 ENST00000360356.6	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 9
chr2_-_162318129 Show fit	16.31	ENST00000679938.1	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr19_+_18173804 Show fit	16.27	ENST00000407280.4	IFI30 Ensembl NCBI GeneCards UniProt Show fit	IFI30 lysosomal thiol reductase
chr12_+_112978562 Show fit	16.23	ENST00000680122.1	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr11_-_60952559 Show fit	14.48	ENST00000538739.2	SLC15A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 15 member 3
chr11_-_60952134 Show fit	14.14	ENST00000679573.1 ENST00000681882.1 ENST00000681951.1 ENST00000227880.8	SLC15A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 15 member 3
chr3_+_122564327 Show fit	13.91	ENST00000296161.9 ENST00000383661.3	DTX3L Ensembl NCBI GeneCards UniProt Show fit	deltex E3 ubiquitin ligase 3L
chr12_+_112978504 Show fit	13.38	ENST00000392583.7	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr11_-_60952067 Show fit	12.99	ENST00000681275.1	SLC15A3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 15 member 3
chr11_-_4393650 Show fit	12.93	ENST00000254436.8	TRIM21 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 21
chr17_+_6756035 Show fit	12.79	ENST00000361842.8 ENST00000574907.5	XAF1 Ensembl NCBI GeneCards UniProt Show fit	XIAP associated factor 1
chr2_+_126656128 Show fit	12.21	ENST00000259254.9 ENST00000409836.3 ENST00000356887.12	GYPC Ensembl NCBI GeneCards UniProt Show fit	glycophorin C (Gerbich blood group)
chr1_+_78649818 Show fit	12.18	ENST00000370747.9 ENST00000438486.1	IFI44 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein 44
chr7_-_93148345 Show fit	11.69	ENST00000437805.5 ENST00000446959.5 ENST00000439952.5 ENST00000414791.5 ENST00000446033.1 ENST00000411955.5 ENST00000318238.9	SAMD9L Ensembl NCBI GeneCards UniProt Show fit	sterile alpha motif domain containing 9 like
chr6_-_32838727 Show fit	11.44	ENST00000652259.1 ENST00000374897.4 ENST00000620123.4 ENST00000452392.2	TAP2 Ensembl NCBI GeneCards UniProt Show fit ENSG00000250264.1 Ensembl NCBI GeneCards UniProt Show fit	transporter 2, ATP binding cassette subfamily B member novel protein, TAP2-HLA-DOB readthrough
chr6_+_26440472 Show fit	11.23	ENST00000494393.5 ENST00000482451.5 ENST00000471353.5 ENST00000361232.7 ENST00000487627.5 ENST00000496719.1 ENST00000244519.7 ENST00000490254.5 ENST00000487272.1	BTN3A3 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A3
chr12_+_112938422 Show fit	10.91	ENST00000680044.1 ENST00000680966.1 ENST00000548514.2 ENST00000681497.1 ENST00000551007.1 ENST00000228928.12 ENST00000680438.1 ENST00000681147.1 ENST00000679354.1 ENST00000681085.1 ENST00000680161.1	OAS3 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 3
chr1_-_7940825 Show fit	10.36	ENST00000377507.8	TNFRSF9 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 9
chr22_+_35648438 Show fit	10.19	ENST00000409652.5	APOL6 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L6
chr2_-_6865901 Show fit	10.18	ENST00000256722.10	CMPK2 Ensembl NCBI GeneCards UniProt Show fit	cytidine/uridine monophosphate kinase 2
chr3_-_122564253 Show fit	10.12	ENST00000492382.5 ENST00000682323.1 ENST00000462315.5	PARP9 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 9
chr22_+_36253071 Show fit	9.96	ENST00000422706.5 ENST00000426053.5 ENST00000319136.8	APOL1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L1
chr22_+_36253124 Show fit	9.12	ENST00000438034.5 ENST00000427990.5 ENST00000397278.8 ENST00000397279.8 ENST00000433768.5	APOL1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L1
chr11_-_57567617 Show fit	9.07	ENST00000287156.9	UBE2L6 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 L6
chr22_+_18150162 Show fit	8.99	ENST00000215794.8	USP18 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin specific peptidase 18
chr1_-_89198868 Show fit	8.52	ENST00000355754.7	GBP4 Ensembl NCBI GeneCards UniProt Show fit	guanylate binding protein 4
chr17_+_6755834 Show fit	8.24	ENST00000346752.8	XAF1 Ensembl NCBI GeneCards UniProt Show fit	XIAP associated factor 1
chr6_+_26402237 Show fit	7.91	ENST00000476549.6 ENST00000450085.6 ENST00000425234.6 ENST00000427334.5 ENST00000506698.1 ENST00000289361.11	BTN3A1 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A1
chr7_+_101085464 Show fit	7.89	ENST00000306085.11 ENST00000412507.1	TRIM56 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 56
chr19_+_10086305 Show fit	7.12	ENST00000253110.16 ENST00000591813.5	SHFL Ensembl NCBI GeneCards UniProt Show fit	shiftless antiviral inhibitor of ribosomal frameshifting
chr17_+_42289213 Show fit	7.03	ENST00000677301.1	STAT5A Ensembl NCBI GeneCards UniProt Show fit	signal transducer and activator of transcription 5A
chr7_-_140062841 Show fit	6.83	ENST00000263549.8	PARP12 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 12
chr2_-_219387784 Show fit	6.75	ENST00000520694.6	DNPEP Ensembl NCBI GeneCards UniProt Show fit	aspartyl aminopeptidase
chr11_-_615570 Show fit	6.74	ENST00000649187.1 ENST00000647801.1 ENST00000397566.5 ENST00000397570.5	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr7_-_93117956 Show fit	6.61	ENST00000446617.1 ENST00000379958.3 ENST00000620985.4	SAMD9 Ensembl NCBI GeneCards UniProt Show fit	sterile alpha motif domain containing 9
chr19_-_47232649 Show fit	6.41	ENST00000449228.5 ENST00000300880.11 ENST00000341983.8	BBC3 Ensembl NCBI GeneCards UniProt Show fit	BCL2 binding component 3
chr2_-_230219902 Show fit	6.38	ENST00000409815.6	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr6_-_36387736 Show fit	5.95	ENST00000373737.8 ENST00000373738.4 ENST00000538992.3 ENST00000615781.4 ENST00000620358.4	ETV7 Ensembl NCBI GeneCards UniProt Show fit	ETS variant transcription factor 7
chr6_-_36387654 Show fit	5.90	ENST00000340181.9	ETV7 Ensembl NCBI GeneCards UniProt Show fit	ETS variant transcription factor 7
chr2_-_231125032 Show fit	5.76	ENST00000258400.4	HTR2B Ensembl NCBI GeneCards UniProt Show fit	5-hydroxytryptamine receptor 2B
chr7_-_139109702 Show fit	5.61	ENST00000471652.1 ENST00000242351.10	ZC3HAV1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing, antiviral 1
chr4_-_168318770 Show fit	5.49	ENST00000680771.1 ENST00000514995.2	DDX60 Ensembl NCBI GeneCards UniProt Show fit	DExD/H-box helicase 60
chr2_-_219387881 Show fit	5.42	ENST00000322176.11 ENST00000273075.9	DNPEP Ensembl NCBI GeneCards UniProt Show fit	aspartyl aminopeptidase
chr11_-_615921 Show fit	5.32	ENST00000348655.11 ENST00000525445.6 ENST00000330243.9	IRF7 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 7
chr20_-_49278034 Show fit	5.28	ENST00000371744.5 ENST00000396105.6 ENST00000371752.5	ZNFX1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger NFX1-type containing 1
chr2_-_230219944 Show fit	5.22	ENST00000455674.2 ENST00000392048.7 ENST00000258381.11 ENST00000358662.9 ENST00000258382.10	SP110 Ensembl NCBI GeneCards UniProt Show fit	SP110 nuclear body protein
chr22_+_39077264 Show fit	5.05	ENST00000407997.4	APOBEC3G Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein B mRNA editing enzyme catalytic subunit 3G
chr10_+_113679523 Show fit	4.93	ENST00000345633.8 ENST00000614447.4 ENST00000369321.6	CASP7 Ensembl NCBI GeneCards UniProt Show fit	caspase 7
chr4_-_168318743 Show fit	4.91	ENST00000393743.8	DDX60 Ensembl NCBI GeneCards UniProt Show fit	DExD/H-box helicase 60
chr1_+_1013485 Show fit	4.88	ENST00000649529.1	ISG15 Ensembl NCBI GeneCards UniProt Show fit	ISG15 ubiquitin like modifier
chr2_+_112095189 Show fit	4.83	ENST00000649734.1	TMEM87B Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 87B
chr14_-_24146596 Show fit	4.82	ENST00000560410.5 ENST00000216802.10 ENST00000615264.4 ENST00000630027.1	PSME2 Ensembl NCBI GeneCards UniProt Show fit	proteasome activator subunit 2
chr17_-_65056659 Show fit	4.69	ENST00000439174.7	GNA13 Ensembl NCBI GeneCards UniProt Show fit	G protein subunit alpha 13
chr14_-_24146314 Show fit	4.68	ENST00000559056.5	PSME2 Ensembl NCBI GeneCards UniProt Show fit	proteasome activator subunit 2
chr1_+_112674416 Show fit	4.64	ENST00000413052.6 ENST00000369645.5	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10 RISC complex RNA helicase
chr10_+_113679839 Show fit	4.55	ENST00000369318.8 ENST00000369315.5	CASP7 Ensembl NCBI GeneCards UniProt Show fit	caspase 7
chr18_+_24014733 Show fit	4.47	ENST00000317571.8	TTC39C Ensembl NCBI GeneCards UniProt Show fit	tetratricopeptide repeat domain 39C
chr14_+_24136152 Show fit	4.46	ENST00000559123.5 ENST00000206451.11 ENST00000382708.7 ENST00000561435.5	PSME1 Ensembl NCBI GeneCards UniProt Show fit	proteasome activator subunit 1
chr2_-_162318613 Show fit	4.42	ENST00000649979.2 ENST00000421365.2	IFIH1 Ensembl NCBI GeneCards UniProt Show fit	interferon induced with helicase C domain 1
chr11_+_94128834 Show fit	4.40	ENST00000227638.8 ENST00000436171.2	PANX1 Ensembl NCBI GeneCards UniProt Show fit	pannexin 1
chr4_+_99574812 Show fit	4.36	ENST00000422897.6 ENST00000265517.10	MTTP Ensembl NCBI GeneCards UniProt Show fit	microsomal triglyceride transfer protein
chr20_+_408030 Show fit	4.31	ENST00000640614.1 ENST00000475269.5	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RANBP2-type and C3HC4-type zinc finger containing 1
chr4_-_168480477 Show fit	4.29	ENST00000514748.5 ENST00000512371.1 ENST00000505890.5 ENST00000682922.1 ENST00000511577.5	DDX60L Ensembl NCBI GeneCards UniProt Show fit	DExD/H-box 60 like
chr6_+_26365176 Show fit	4.28	ENST00000377708.7	BTN3A2 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A2
chr22_-_36239517 Show fit	4.27	ENST00000358502.10 ENST00000451256.6	APOL2 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein L2
chr6_-_36387566 Show fit	4.26	ENST00000339796.9 ENST00000627426.2	ETV7 Ensembl NCBI GeneCards UniProt Show fit	ETS variant transcription factor 7
chr6_+_26365215 Show fit	4.22	ENST00000527422.5 ENST00000356386.6 ENST00000396948.5	BTN3A2 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A2
chr1_+_112674722 Show fit	4.22	ENST00000357443.2	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10 RISC complex RNA helicase
chr6_+_26365159 Show fit	4.18	ENST00000532865.5 ENST00000396934.7 ENST00000508906.6 ENST00000530653.5 ENST00000527417.5	BTN3A2 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A2
chr1_+_112674649 Show fit	4.09	ENST00000369644.5	MOV10 Ensembl NCBI GeneCards UniProt Show fit	Mov10 RISC complex RNA helicase
chr10_+_89301932 Show fit	4.07	ENST00000371826.4 ENST00000679755.1	IFIT2 Ensembl NCBI GeneCards UniProt Show fit	interferon induced protein with tetratricopeptide repeats 2
chr12_+_112978460 Show fit	4.01	ENST00000449768.2	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr12_+_112978424 Show fit	4.01	ENST00000680685.1 ENST00000620097.2	OAS2 Ensembl NCBI GeneCards UniProt Show fit	2'-5'-oligoadenylate synthetase 2
chr12_-_213656 Show fit	3.91	ENST00000359674.8	SLC6A12 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 member 12
chr12_+_6452024 Show fit	3.84	ENST00000266556.8 ENST00000544021.5	TAPBPL Ensembl NCBI GeneCards UniProt Show fit	TAP binding protein like
chr7_-_139109337 Show fit	3.77	ENST00000464606.5	ZC3HAV1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger CCCH-type containing, antiviral 1
chr12_-_214146 Show fit	3.60	ENST00000684302.1	SLC6A12 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 6 member 12
chr15_+_75201873 Show fit	3.11	ENST00000394987.5	C15orf39 Ensembl NCBI GeneCards UniProt Show fit	chromosome 15 open reading frame 39
chr11_+_124865425 Show fit	3.11	ENST00000397801.6	ROBO3 Ensembl NCBI GeneCards UniProt Show fit	roundabout guidance receptor 3
chr10_-_47384261 Show fit	3.10	ENST00000591025.1 ENST00000585316.3	ZNF488 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 488
chr10_-_22003678 Show fit	3.05	ENST00000376980.8	DNAJC1 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member C1
chr5_-_96808093 Show fit	3.03	ENST00000296754.7	ERAP1 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum aminopeptidase 1
chr13_+_108629605 Show fit	3.01	ENST00000457511.7	MYO16 Ensembl NCBI GeneCards UniProt Show fit	myosin XVI
chr6_+_26402289 Show fit	3.00	ENST00000414912.2	BTN3A1 Ensembl NCBI GeneCards UniProt Show fit	butyrophilin subfamily 3 member A1
chr18_-_6414885 Show fit	3.00	ENST00000317931.12 ENST00000400104.7	L3MBTL4 Ensembl NCBI GeneCards UniProt Show fit	L3MBTL histone methyl-lysine binding protein 4
chr19_+_49928702 Show fit	3.00	ENST00000595125.5	ATF5 Ensembl NCBI GeneCards UniProt Show fit	activating transcription factor 5
chr9_-_32526185 Show fit	2.92	ENST00000379883.3 ENST00000379868.6 ENST00000679859.1	DDX58 Ensembl NCBI GeneCards UniProt Show fit	DExD/H-box helicase 58
chr1_-_161045961 Show fit	2.91	ENST00000368021.7	USF1 Ensembl NCBI GeneCards UniProt Show fit	upstream transcription factor 1
chr2_+_201116793 Show fit	2.82	ENST00000441224.5	CFLAR Ensembl NCBI GeneCards UniProt Show fit	CASP8 and FADD like apoptosis regulator
chr1_-_154608140 Show fit	2.77	ENST00000529168.2 ENST00000368474.9 ENST00000680305.1 ENST00000648231.2	ADAR Ensembl NCBI GeneCards UniProt Show fit	adenosine deaminase RNA specific
chr20_+_408147 Show fit	2.77	ENST00000441733.5 ENST00000353660.7	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RANBP2-type and C3HC4-type zinc finger containing 1
chr5_-_136365476 Show fit	2.58	ENST00000378459.7 ENST00000502753.4 ENST00000513104.6 ENST00000352189.8	TRPC7 Ensembl NCBI GeneCards UniProt Show fit	transient receptor potential cation channel subfamily C member 7
chr6_+_31571957 Show fit	2.21	ENST00000454783.5	LTA Ensembl NCBI GeneCards UniProt Show fit	lymphotoxin alpha
chr5_-_96807899 Show fit	2.13	ENST00000503921.5 ENST00000508227.5 ENST00000507154.1 ENST00000443439.7	ERAP1 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum aminopeptidase 1
chrX_+_147911943 Show fit	2.11	ENST00000621453.4 ENST00000218200.12 ENST00000370471.7 ENST00000440235.6 ENST00000370477.5 ENST00000621987.4	FMR1 Ensembl NCBI GeneCards UniProt Show fit	FMRP translational regulator 1
chr3_-_127591036 Show fit	2.09	ENST00000489960.5 ENST00000490290.5	TPRA1 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein adipocyte associated 1
chr21_-_41926680 Show fit	2.07	ENST00000329623.11	C2CD2 Ensembl NCBI GeneCards UniProt Show fit	C2 calcium dependent domain containing 2
chr2_-_189179754 Show fit	2.00	ENST00000374866.9 ENST00000618828.1	COL5A2 Ensembl NCBI GeneCards UniProt Show fit	collagen type V alpha 2 chain
chr10_-_100286341 Show fit	1.96	ENST00000441611.5 ENST00000614731.4	BLOC1S2 Ensembl NCBI GeneCards UniProt Show fit	biogenesis of lysosomal organelles complex 1 subunit 2
chr12_-_98894830 Show fit	1.95	ENST00000549797.5 ENST00000333732.11 ENST00000341752.11	ANKS1B Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat and sterile alpha motif domain containing 1B
chr2_+_6865557 Show fit	1.94	ENST00000680607.1 ENST00000680320.1 ENST00000442639.6	RSAD2 Ensembl NCBI GeneCards UniProt Show fit	radical S-adenosyl methionine domain containing 2
chr15_-_55319107 Show fit	1.85	ENST00000565225.1 ENST00000436697.3 ENST00000567948.1 ENST00000563262.5	PIGBOS1 Ensembl NCBI GeneCards UniProt Show fit RAB27A Ensembl NCBI GeneCards UniProt Show fit	PIGB opposite strand 1 RAB27A, member RAS oncogene family
chr10_-_100286660 Show fit	1.78	ENST00000370372.7	BLOC1S2 Ensembl NCBI GeneCards UniProt Show fit	biogenesis of lysosomal organelles complex 1 subunit 2
chr18_+_24014390 Show fit	1.75	ENST00000584250.1	TTC39C Ensembl NCBI GeneCards UniProt Show fit	tetratricopeptide repeat domain 39C
chr5_-_157058396 Show fit	1.73	ENST00000518745.1 ENST00000339252.7 ENST00000625904.2	HAVCR1 Ensembl NCBI GeneCards UniProt Show fit	hepatitis A virus cellular receptor 1
chr6_-_30213379 Show fit	1.71	ENST00000418026.1 ENST00000454678.7 ENST00000416596.5 ENST00000453195.5	TRIM26 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 26
chr6_+_31572279 Show fit	1.70	ENST00000418386.3	LTA Ensembl NCBI GeneCards UniProt Show fit	lymphotoxin alpha
chrX_+_147912039 Show fit	1.56	ENST00000334557.10 ENST00000439526.6	FMR1 Ensembl NCBI GeneCards UniProt Show fit	FMRP translational regulator 1
chr19_+_50384323 Show fit	1.54	ENST00000599857.7 ENST00000613923.6 ENST00000601098.6 ENST00000440232.7 ENST00000595904.6 ENST00000593887.1	POLD1 Ensembl NCBI GeneCards UniProt Show fit	DNA polymerase delta 1, catalytic subunit
chr9_+_74497308 Show fit	1.49	ENST00000376896.8	RORB Ensembl NCBI GeneCards UniProt Show fit	RAR related orphan receptor B
chr20_-_35284715 Show fit	1.49	ENST00000374436.7 ENST00000675032.1	EIF6 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 6
chr20_+_62804794 Show fit	1.47	ENST00000290291.10	OGFR Ensembl NCBI GeneCards UniProt Show fit	opioid growth factor receptor
chr19_+_49474208 Show fit	1.44	ENST00000597551.6 ENST00000596435.5 ENST00000204637.6 ENST00000600429.5	FLT3LG Ensembl NCBI GeneCards UniProt Show fit	fms related receptor tyrosine kinase 3 ligand
chr8_-_143986425 Show fit	1.41	ENST00000313059.9 ENST00000524918.5 ENST00000313028.12 ENST00000525773.5	PARP10 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 10
chr5_+_140691591 Show fit	1.39	ENST00000508522.5 ENST00000448069.2	HARS2 Ensembl NCBI GeneCards UniProt Show fit	histidyl-tRNA synthetase 2, mitochondrial
chr1_+_149475045 Show fit	1.34	ENST00000651566.2	NBPF19 Ensembl NCBI GeneCards UniProt Show fit	NBPF member 19
chr20_-_35284745 Show fit	1.32	ENST00000374443.7 ENST00000374450.8	EIF6 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 6
chr1_-_177970213 Show fit	1.30	ENST00000464631.6	SEC16B Ensembl NCBI GeneCards UniProt Show fit	SEC16 homolog B, endoplasmic reticulum export factor
chr1_+_151156627 Show fit	1.30	ENST00000368910.4	TNFAIP8L2 Ensembl NCBI GeneCards UniProt Show fit	TNF alpha induced protein 8 like 2
chrX_+_147911910 Show fit	1.30	ENST00000370475.9	FMR1 Ensembl NCBI GeneCards UniProt Show fit	FMRP translational regulator 1
chr1_+_25272439 Show fit	1.28	ENST00000648012.1	RHD Ensembl NCBI GeneCards UniProt Show fit	Rh blood group D antigen
chr3_+_187368367 Show fit	1.27	ENST00000259030.3	RTP4 Ensembl NCBI GeneCards UniProt Show fit	receptor transporter protein 4
chr4_-_155953851 Show fit	1.26	ENST00000679136.1 ENST00000433477.4 ENST00000679996.1 ENST00000680741.1 ENST00000680553.1 ENST00000679942.1	CTSO Ensembl NCBI GeneCards UniProt Show fit	cathepsin O
chr20_+_45881218 Show fit	1.24	ENST00000372523.1	ZSWIM1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger SWIM-type containing 1
chr1_+_111755892 Show fit	1.19	ENST00000369702.5 ENST00000680627.1 ENST00000680518.1	DDX20 Ensembl NCBI GeneCards UniProt Show fit	DEAD-box helicase 20
chr7_-_106285898 Show fit	1.13	ENST00000424768.2 ENST00000681255.1	NAMPT Ensembl NCBI GeneCards UniProt Show fit	nicotinamide phosphoribosyltransferase
chr1_+_110034607 Show fit	1.11	ENST00000369795.8	STRIP1 Ensembl NCBI GeneCards UniProt Show fit	striatin interacting protein 1
chr22_+_39040857 Show fit	1.07	ENST00000381565.2 ENST00000308521.10	APOBEC3F Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein B mRNA editing enzyme catalytic subunit 3F
chr3_-_195811916 Show fit	0.99	ENST00000463781.8	MUC4 Ensembl NCBI GeneCards UniProt Show fit	mucin 4, cell surface associated
chr19_+_49929196 Show fit	0.98	ENST00000423777.7 ENST00000600336.1 ENST00000597227.5	ATF5 Ensembl NCBI GeneCards UniProt Show fit	activating transcription factor 5
chr20_-_21514046 Show fit	0.95	ENST00000377142.5	NKX2-2 Ensembl NCBI GeneCards UniProt Show fit	NK2 homeobox 2
chr19_+_49474561 Show fit	0.94	ENST00000594009.5 ENST00000595510.1 ENST00000595815.1	FLT3LG Ensembl NCBI GeneCards UniProt Show fit ENSG00000273189.1 Ensembl NCBI GeneCards UniProt Show fit	fms related receptor tyrosine kinase 3 ligand novel transcript
chr2_-_118847638 Show fit	0.93	ENST00000295206.7	EN1 Ensembl NCBI GeneCards UniProt Show fit	engrailed homeobox 1
chr8_-_66613208 Show fit	0.90	ENST00000522677.8	MYBL1 Ensembl NCBI GeneCards UniProt Show fit	MYB proto-oncogene like 1
chr3_+_42149222 Show fit	0.90	ENST00000449246.5 ENST00000613405.4	TRAK1 Ensembl NCBI GeneCards UniProt Show fit	trafficking kinesin protein 1
chr16_+_66934439 Show fit	0.88	ENST00000417689.6 ENST00000561697.5	CES2 Ensembl NCBI GeneCards UniProt Show fit	carboxylesterase 2
chr14_+_73058521 Show fit	0.83	ENST00000527432.5 ENST00000531500.5 ENST00000261973.12 ENST00000525321.5 ENST00000526754.5	RBM25 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 25
chr1_-_147172456 Show fit	0.79	ENST00000254101.4	PRKAB2 Ensembl NCBI GeneCards UniProt Show fit	protein kinase AMP-activated non-catalytic subunit beta 2
chr12_+_4649097 Show fit	0.78	ENST00000648836.1 ENST00000266544.10	ENSG00000255639.3 Ensembl NCBI GeneCards UniProt Show fit NDUFA9 Ensembl NCBI GeneCards UniProt Show fit	novel protein NADH:ubiquinone oxidoreductase subunit A9
chr7_-_127252919 Show fit	0.71	ENST00000339582.7	GRM8 Ensembl NCBI GeneCards UniProt Show fit	glutamate metabotropic receptor 8
chr1_+_25272492 Show fit	0.66	ENST00000454452.6	RHD Ensembl NCBI GeneCards UniProt Show fit	Rh blood group D antigen
chr14_-_91510450 Show fit	0.66	ENST00000555462.5	PPP4R3A Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 4 regulatory subunit 3A
chr8_-_23069012 Show fit	0.65	ENST00000347739.3 ENST00000276431.9	TNFRSF10B Ensembl NCBI GeneCards UniProt Show fit	TNF receptor superfamily member 10b
chr3_+_155870623 Show fit	0.64	ENST00000295920.7 ENST00000496455.7	GMPS Ensembl NCBI GeneCards UniProt Show fit	guanine monophosphate synthase
chr10_-_118595637 Show fit	0.60	ENST00000239032.4	PRLHR Ensembl NCBI GeneCards UniProt Show fit	prolactin releasing hormone receptor
chr1_+_236394268 Show fit	0.59	ENST00000334232.9	EDARADD Ensembl NCBI GeneCards UniProt Show fit	EDAR associated death domain
chr2_-_166494232 Show fit	0.49	ENST00000441411.2 ENST00000643258.1 ENST00000419992.6	SCN7A Ensembl NCBI GeneCards UniProt Show fit	sodium voltage-gated channel alpha subunit 7
chr2_+_99154955 Show fit	0.47	ENST00000393471.2 ENST00000393473.6 ENST00000651691.1 ENST00000449211.1 ENST00000434566.5 ENST00000410042.1	LIPT1 Ensembl NCBI GeneCards UniProt Show fit ENSG00000273155.1 Ensembl NCBI GeneCards UniProt Show fit	lipoyltransferase 1 novel LIPT1-MRPL30 readthrough
chr12_-_4649043 Show fit	0.44	ENST00000545990.6 ENST00000228850.6	AKAP3 Ensembl NCBI GeneCards UniProt Show fit	A-kinase anchoring protein 3
chr6_+_28225257 Show fit	0.39	ENST00000531981.5 ENST00000425468.6 ENST00000252207.10 ENST00000531979.5 ENST00000527436.5	ZSCAN9 Ensembl NCBI GeneCards UniProt Show fit	zinc finger and SCAN domain containing 9
chr2_-_73642413 Show fit	0.39	ENST00000272425.4	NAT8 Ensembl NCBI GeneCards UniProt Show fit	N-acetyltransferase 8 (putative)
chr19_-_39846329 Show fit	0.38	ENST00000599134.1 ENST00000597634.5 ENST00000598417.5 ENST00000601274.5 ENST00000594309.5 ENST00000221801.8	FBL Ensembl NCBI GeneCards UniProt Show fit	fibrillarin
chr1_+_151156659 Show fit	0.36	ENST00000602841.5	SCNM1 Ensembl NCBI GeneCards UniProt Show fit	sodium channel modifier 1
chr2_-_37156942 Show fit	0.28	ENST00000680273.1 ENST00000233057.9 ENST00000679979.1 ENST00000679507.1 ENST00000681463.1 ENST00000395127.6	EIF2AK2 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 2 alpha kinase 2
chr2_+_69013337 Show fit	0.27	ENST00000463335.2	ANTXR1 Ensembl NCBI GeneCards UniProt Show fit	ANTXR cell adhesion molecule 1
chr7_+_143132069 Show fit	0.26	ENST00000291009.4	PIP Ensembl NCBI GeneCards UniProt Show fit	prolactin induced protein
chr20_+_408278 Show fit	0.25	ENST00000356286.10 ENST00000382181.2 ENST00000400247.3	RBCK1 Ensembl NCBI GeneCards UniProt Show fit	RANBP2-type and C3HC4-type zinc finger containing 1
chr19_-_17405554 Show fit	0.23	ENST00000252593.7	BST2 Ensembl NCBI GeneCards UniProt Show fit	bone marrow stromal cell antigen 2
chr9_-_98192614 Show fit	0.23	ENST00000375077.5	CORO2A Ensembl NCBI GeneCards UniProt Show fit	coronin 2A
chr11_+_66241227 Show fit	0.23	ENST00000531597.1	PACS1 Ensembl NCBI GeneCards UniProt Show fit	phosphofurin acidic cluster sorting protein 1
chr8_+_108443601 Show fit	0.21	ENST00000524143.5 ENST00000220853.8	EMC2 Ensembl NCBI GeneCards UniProt Show fit	ER membrane protein complex subunit 2
chr14_-_75051426 Show fit	0.12	ENST00000556257.5 ENST00000355774.7 ENST00000557648.1 ENST00000553263.1 ENST00000380968.6	MLH3 Ensembl NCBI GeneCards UniProt Show fit	mutL homolog 3
chr1_-_177969907 Show fit	0.08	ENST00000308284.10	SEC16B Ensembl NCBI GeneCards UniProt Show fit	SEC16 homolog B, endoplasmic reticulum export factor
chr2_-_37157093 Show fit	0.07	ENST00000681507.1	EIF2AK2 Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 2 alpha kinase 2
chr9_-_92325577 Show fit	0.06	ENST00000358855.8 ENST00000421075.6 ENST00000536624.5	NOL8 Ensembl NCBI GeneCards UniProt Show fit	nucleolar protein 8
chr1_-_161044941 Show fit	0.04	ENST00000368020.5	USF1 Ensembl NCBI GeneCards UniProt Show fit	upstream transcription factor 1
chr12_-_8066331 Show fit	0.00	ENST00000546241.1 ENST00000307637.5	C3AR1 Ensembl NCBI GeneCards UniProt Show fit	complement C3a receptor 1
chr22_+_31496139 Show fit	0.00	ENST00000540643.5	SFI1 Ensembl NCBI GeneCards UniProt Show fit	SFI1 centrin binding protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
15.6	46.7	GO:0046967	cytosol to ER transport(GO:0046967)
9.4	47.2	GO:0034344	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
6.5	96.9	GO:0035457	cellular response to interferon-alpha(GO:0035457)
6.3	31.6	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
5.4	54.0	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
5.1	20.5	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
4.9	58.4	GO:0018377	protein myristoylation(GO:0018377)
4.1	16.6	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
3.8	45.4	GO:0060700	regulation of ribonuclease activity(GO:0060700)
3.4	10.2	GO:0046077	dUDP biosynthetic process(GO:0006227) dTDP biosynthetic process(GO:0006233) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dTDP metabolic process(GO:0046072) dUDP metabolic process(GO:0046077)
3.2	12.9	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
2.0	12.1	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
1.7	10.4	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
1.7	5.0	GO:1901254	modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254)
1.5	18.3	GO:0034058	endosomal vesicle fusion(GO:0034058)
1.5	29.4	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.5	4.4	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
1.3	13.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
1.3	3.9	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
1.2	9.5	GO:0072734	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
1.2	13.0	GO:0098795	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
1.2	5.8	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
1.0	6.1	GO:0070383	DNA cytosine deamination(GO:0070383)
1.0	7.0	GO:0000255	allantoin metabolic process(GO:0000255)
0.9	23.6	GO:0072643	interferon-gamma secretion(GO:0072643)
0.8	7.3	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.7	4.4	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.7	2.0	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.6	2.4	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
0.6	4.7	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.6	2.8	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.5	3.0	GO:0000432	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086)
0.5	2.8	GO:1900369	negative regulation of RNA interference(GO:1900369)
0.5	20.6	GO:0035456	response to interferon-beta(GO:0035456)
0.4	47.1	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.4	7.5	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.3	13.9	GO:0010390	histone monoubiquitination(GO:0010390)
0.3	3.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.3	18.5	GO:0019835	cytolysis(GO:0019835)
0.3	2.0	GO:1900383	regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.3	1.9	GO:2000553	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.3	0.9	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.3	1.8	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.3	4.0	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.3	2.6	GO:0006828	manganese ion transport(GO:0006828)
0.3	1.5	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.2	3.7	GO:0060155	platelet dense granule organization(GO:0060155)
0.2	0.9	GO:0098957	anterograde axonal transport of mitochondrion(GO:0098957)
0.2	39.6	GO:0015992	proton transport(GO:0015992)
0.2	15.7	GO:0034340	response to type I interferon(GO:0034340)
0.2	12.2	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2	0.9	GO:0061743	motor learning(GO:0061743)
0.1	2.1	GO:0040016	embryonic cleavage(GO:0040016)
0.1	1.5	GO:0035881	amacrine cell differentiation(GO:0035881)
0.1	0.6	GO:0006177	GMP biosynthetic process(GO:0006177)
0.1	0.4	GO:0033967	box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.1	3.1	GO:0048714	positive regulation of oligodendrocyte differentiation(GO:0048714)
0.1	3.0	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1	1.4	GO:0070863	positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1	0.3	GO:0035455	response to interferon-alpha(GO:0035455)
0.1	1.5	GO:0038003	opioid receptor signaling pathway(GO:0038003)
0.1	7.3	GO:0002456	T cell mediated immunity(GO:0002456)
0.1	1.2	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1	3.0	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1	1.7	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.1	4.3	GO:0006953	acute-phase response(GO:0006953)
0.1	0.5	GO:0009249	protein lipoylation(GO:0009249)
0.1	1.0	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.7	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0	0.6	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	1.5	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	3.0	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	1.4	GO:0006418	tRNA aminoacylation for protein translation(GO:0006418)
0.0	0.8	GO:0006853	carnitine shuttle(GO:0006853)
0.0	0.8	GO:0006744	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0	1.1	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	3.0	GO:0021549	cerebellum development(GO:0021549)
0.0	10.2	GO:0006869	lipid transport(GO:0006869)
0.0	15.0	GO:0001525	angiogenesis(GO:0001525)
0.0	0.9	GO:0006693	prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0	1.3	GO:0050728	negative regulation of inflammatory response(GO:0050728)
0.0	0.2	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.0	0.5	GO:0055078	sodium ion homeostasis(GO:0055078)
0.0	0.4	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.4	GO:0010738	regulation of protein kinase A signaling(GO:0010738)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.7	46.7	GO:0042825	TAP complex(GO:0042825)
3.5	14.0	GO:0008537	proteasome activator complex(GO:0008537)
2.7	21.7	GO:1990111	spermatoproteasome complex(GO:1990111)
1.7	5.0	GO:1902737	dendritic filopodium(GO:1902737)
1.5	6.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
1.0	7.3	GO:0071797	LUBAC complex(GO:0071797)
0.7	2.0	GO:0005588	collagen type V trimer(GO:0005588)
0.5	19.1	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.4	2.8	GO:0044530	supraspliceosomal complex(GO:0044530)
0.3	1.5	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.3	22.8	GO:0015030	Cajal body(GO:0015030)
0.3	16.3	GO:0043202	lysosomal lumen(GO:0043202)
0.3	4.4	GO:0032059	bleb(GO:0032059)
0.2	1.2	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.2	12.9	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	3.0	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.1	3.7	GO:0031083	gamma-tubulin complex(GO:0000930) BLOC-1 complex(GO:0031083)
0.1	1.8	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	2.8	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.1	210.5	GO:0005739	mitochondrion(GO:0005739)
0.1	12.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.1	4.7	GO:0031526	brush border membrane(GO:0031526)
0.1	2.4	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.1	0.8	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	12.2	GO:0072562	blood microparticle(GO:0072562)
0.0	75.1	GO:0005615	extracellular space(GO:0005615)
0.0	16.7	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0	0.4	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	17.3	GO:0005769	early endosome(GO:0005769)
0.0	8.5	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.0	2.6	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.5	GO:0097386	glial cell projection(GO:0097386)
0.0	17.9	GO:0005925	focal adhesion(GO:0005925)
0.0	3.0	GO:0016459	myosin complex(GO:0016459)
0.0	2.9	GO:0032587	ruffle membrane(GO:0032587)
0.0	0.1	GO:0005712	chiasma(GO:0005712)
0.0	6.1	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
0.0	3.2	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	1.3	GO:0031514	motile cilium(GO:0031514)
0.0	3.0	GO:0031965	nuclear membrane(GO:0031965)
0.0	64.0	GO:0005829	cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.9	103.8	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
6.8	20.5	GO:0008859	exoribonuclease II activity(GO:0008859)
5.9	41.6	GO:0015333	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
5.8	46.7	GO:0015440	peptide-transporting ATPase activity(GO:0015440) MHC class Ib protein binding(GO:0023029)
3.4	10.2	GO:0004798	thymidylate kinase activity(GO:0004798)
3.3	16.6	GO:0030298	receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726)
1.9	52.6	GO:0070403	NAD+ binding(GO:0070403)
1.7	14.0	GO:0061133	endopeptidase activator activity(GO:0061133)
1.3	5.2	GO:0005151	interleukin-1, Type II receptor binding(GO:0005151)
1.2	8.2	GO:0042296	ISG15 transferase activity(GO:0042296)
1.0	5.0	GO:0047844	deoxycytidine deaminase activity(GO:0047844)
0.9	25.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.9	7.5	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.9	4.4	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.8	4.7	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.7	21.7	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.7	5.0	GO:0034046	poly(G) binding(GO:0034046)
0.6	79.2	GO:0003725	double-stranded RNA binding(GO:0003725)
0.5	12.2	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.5	5.8	GO:0051378	amine binding(GO:0043176) serotonin binding(GO:0051378)
0.3	4.9	GO:0031386	protein tag(GO:0031386)
0.3	11.0	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2	4.3	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.2	6.7	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.2	2.6	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.2	1.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.2	1.3	GO:0031849	olfactory receptor binding(GO:0031849)
0.2	0.9	GO:0047374	methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.2	1.0	GO:0030197	extracellular matrix constituent, lubricant activity(GO:0030197)
0.2	0.5	GO:0016979	lipoate-protein ligase activity(GO:0016979)
0.1	12.1	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1	19.1	GO:0005254	chloride channel activity(GO:0005254)
0.1	0.4	GO:0036009	protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.1	1.3	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	1.5	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1	3.0	GO:0001671	ATPase activator activity(GO:0001671)
0.1	1.5	GO:0004985	opioid receptor activity(GO:0004985)
0.1	7.8	GO:0016667	oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.1	39.0	GO:0003924	GTPase activity(GO:0003924)
0.1	3.9	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	3.7	GO:0043015	gamma-tubulin binding(GO:0043015)
0.1	9.0	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1	0.9	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1	0.6	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.1	6.4	GO:0051117	ATPase binding(GO:0051117)
0.1	12.3	GO:0004386	helicase activity(GO:0004386)
0.1	13.9	GO:0042393	histone binding(GO:0042393)
0.1	4.4	GO:0005548	phospholipid transporter activity(GO:0005548)
0.1	0.8	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.4	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.9	GO:0050811	GABA receptor binding(GO:0050811)
0.0	1.4	GO:0004812	aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0	1.9	GO:0051539	4 iron, 4 sulfur cluster binding(GO:0051539)
0.0	0.6	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	2.0	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	23.9	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	10.1	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0	7.0	GO:0004713	protein tyrosine kinase activity(GO:0004713)
0.0	2.0	GO:0046332	SMAD binding(GO:0046332)
0.0	2.4	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.0	11.8	GO:0005096	GTPase activator activity(GO:0005096)
0.0	57.2	GO:0042802	identical protein binding(GO:0042802)
0.0	19.6	GO:0008270	zinc ion binding(GO:0008270)
0.0	4.0	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	0.1	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.7	GO:0008066	glutamate receptor activity(GO:0008066)
0.0	1.3	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.3	GO:0019864	IgG binding(GO:0019864)
0.0	3.0	GO:0003774	motor activity(GO:0003774)
0.0	0.8	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.5	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.2	4.7	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	16.6	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	9.5	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2	21.2	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	41.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	4.0	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	12.1	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	3.0	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	4.1	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	2.0	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.9	PID E2F PATHWAY	E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.8	47.2	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
2.6	295.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
2.0	47.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.6	40.7	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.5	48.6	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.4	5.8	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.4	7.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.4	13.0	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.3	4.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.3	15.9	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.3	25.5	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.3	2.6	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.2	16.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	4.4	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	4.7	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.1	32.4	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	8.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	1.5	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.1	1.4	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.1	1.8	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	3.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	11.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.6	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.8	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.7	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	1.0	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	2.0	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.2	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.2	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	1.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation

Results for IRF3

Z-value: 3.29

Motif logo

Transcription factors associated with IRF3

Activity-expression correlation:

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: