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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for IRF6_IRF4_IRF5
Z-value: 2.01
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Transcription factors associated with IRF6_IRF4_IRF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF6 | hg38_v1_chr1_-_209806124_209806175 | -0.80 | 1.7e-06 | Click! |
| IRF5 | hg38_v1_chr7_+_128937917_128937994 | 0.71 | 7.1e-05 | Click! |
| IRF4 | hg38_v1_chr6_+_391743_391759 | 0.22 | 2.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF6_IRF4_IRF5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 98.7 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 3.0 | 35.8 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 1.6 | 16.1 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 4.9 | 14.7 | GO:0046072 | dUDP biosynthetic process(GO:0006227) dTDP biosynthetic process(GO:0006233) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dTDP metabolic process(GO:0046072) dUDP metabolic process(GO:0046077) |
| 2.4 | 14.5 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.3 | 9.9 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 1.5 | 9.2 | GO:0034165 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) |
| 1.7 | 8.7 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.8 | 8.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.8 | 7.7 | GO:0045345 | positive regulation of MHC class I biosynthetic process(GO:0045345) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 94.7 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 36.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 18.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 9.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.9 | 8.3 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 7.9 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 6.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 5.2 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 4.4 | GO:0015030 | Cajal body(GO:0015030) |
| 0.3 | 4.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 97.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 2.4 | 35.8 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 27.9 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 22.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.6 | 17.3 | GO:0070403 | NAD+ binding(GO:0070403) |
| 4.9 | 14.7 | GO:0004798 | thymidylate kinase activity(GO:0004798) |
| 0.1 | 11.8 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.2 | 9.3 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.4 | 8.3 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.1 | 8.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 9.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 7.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 6.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 6.0 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 3.4 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 1.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.5 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 1.3 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 1.3 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 163.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 8.0 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 7.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 7.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 3.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 3.2 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.0 | 2.7 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 2.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.8 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 1.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |