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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for IRF7
Z-value: 1.81
Motif logo
Transcription factors associated with IRF7
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
IRF7
|
ENSG00000185507.21 | IRF7 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF7 | hg38_v1_chr11_-_615921_615970, hg38_v1_chr11_-_615570_615728 | 0.84 | 1.7e-07 | Click! |
Activity profile of IRF7 motif
Sorted Z-values of IRF7 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 19.5 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 5.7 | 17.2 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 5.4 | 16.2 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 2.0 | 24.3 | GO:0018377 | protein myristoylation(GO:0018377) |
| 1.9 | 5.7 | GO:0046072 | dUDP biosynthetic process(GO:0006227) dTDP biosynthetic process(GO:0006233) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dTDP metabolic process(GO:0046072) dUDP metabolic process(GO:0046077) |
| 1.9 | 5.7 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 1.8 | 19.6 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 1.8 | 8.9 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 1.6 | 8.0 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 1.5 | 15.3 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 1.5 | 6.0 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.4 | 20.9 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 1.4 | 4.1 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 1.3 | 10.5 | GO:0070842 | aggresome assembly(GO:0070842) |
| 1.2 | 6.2 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 1.2 | 14.5 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 1.1 | 1.1 | GO:1905154 | negative regulation of membrane invagination(GO:1905154) |
| 1.1 | 5.5 | GO:0003068 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 1.1 | 4.3 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 1.0 | 3.8 | GO:0042488 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.9 | 1.9 | GO:0031393 | negative regulation of prostaglandin biosynthetic process(GO:0031393) |
| 0.9 | 5.3 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.9 | 3.5 | GO:0050822 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 0.8 | 4.8 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.8 | 4.7 | GO:0034165 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) |
| 0.8 | 4.7 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.8 | 2.3 | GO:1902530 | regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530) |
| 0.8 | 7.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.7 | 2.1 | GO:0044830 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 0.7 | 3.3 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.6 | 2.3 | GO:0006238 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.5 | 1.6 | GO:1902524 | positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.5 | 1.6 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.5 | 2.6 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.5 | 3.0 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564) |
| 0.5 | 2.4 | GO:0021824 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) sensory system development(GO:0048880) facioacoustic ganglion development(GO:1903375) |
| 0.5 | 6.1 | GO:0046449 | creatinine metabolic process(GO:0046449) |
| 0.5 | 3.2 | GO:0071898 | regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 0.4 | 5.2 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.4 | 2.1 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.4 | 1.2 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.4 | 2.1 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.4 | 3.3 | GO:0035655 | interleukin-18-mediated signaling pathway(GO:0035655) |
| 0.4 | 3.2 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.4 | 10.6 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.4 | 3.7 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.4 | 1.4 | GO:0090290 | positive regulation of osteoclast proliferation(GO:0090290) |
| 0.4 | 6.1 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.3 | 34.5 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.3 | 4.4 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.3 | 9.0 | GO:1900115 | extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116) |
| 0.3 | 1.9 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.3 | 29.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.3 | 0.9 | GO:0002728 | negative regulation of natural killer cell cytokine production(GO:0002728) |
| 0.3 | 2.3 | GO:1902748 | melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.3 | 1.5 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.3 | 3.5 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.3 | 1.7 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.3 | 2.3 | GO:0072734 | response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) |
| 0.3 | 3.0 | GO:2000645 | positive regulation of early endosome to late endosome transport(GO:2000643) negative regulation of receptor catabolic process(GO:2000645) |
| 0.3 | 1.1 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.3 | 2.9 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.3 | 1.3 | GO:0019401 | alditol biosynthetic process(GO:0019401) |
| 0.3 | 0.8 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
| 0.3 | 0.8 | GO:1900186 | negative regulation of clathrin-mediated endocytosis(GO:1900186) |
| 0.2 | 0.7 | GO:0021503 | neural fold bending(GO:0021503) |
| 0.2 | 1.1 | GO:0071034 | CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) |
| 0.2 | 0.7 | GO:1990654 | regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654) |
| 0.2 | 0.7 | GO:0071288 | cellular response to mercury ion(GO:0071288) |
| 0.2 | 2.4 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.2 | 0.4 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.2 | 1.5 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.2 | 0.6 | GO:0006045 | N-acetylglucosamine biosynthetic process(GO:0006045) glucosamine-containing compound biosynthetic process(GO:1901073) |
| 0.2 | 3.2 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.2 | 0.6 | GO:0035915 | pore formation in membrane of other organism(GO:0035915) |
| 0.2 | 0.6 | GO:1904582 | regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582) |
| 0.2 | 0.8 | GO:0097325 | melanocyte proliferation(GO:0097325) |
| 0.2 | 0.4 | GO:0009946 | proximal/distal axis specification(GO:0009946) |
| 0.2 | 1.3 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.2 | 0.4 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 0.2 | 0.7 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 0.2 | 1.6 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.2 | 0.9 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 0.2 | 1.2 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.2 | 0.3 | GO:1901253 | negative regulation of intracellular transport of viral material(GO:1901253) |
| 0.2 | 0.7 | GO:0045875 | negative regulation of sister chromatid cohesion(GO:0045875) |
| 0.2 | 3.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 0.2 | GO:0061056 | sclerotome development(GO:0061056) |
| 0.2 | 1.1 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.2 | 0.5 | GO:0006147 | guanine catabolic process(GO:0006147) |
| 0.2 | 0.5 | GO:0007518 | myoblast fate determination(GO:0007518) |
| 0.2 | 0.8 | GO:0001757 | somite specification(GO:0001757) |
| 0.2 | 0.5 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.1 | 0.4 | GO:0030505 | inorganic diphosphate transport(GO:0030505) |
| 0.1 | 1.9 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.1 | 0.8 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.1 | 1.4 | GO:0051177 | meiotic sister chromatid cohesion(GO:0051177) |
| 0.1 | 0.4 | GO:0070340 | detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) |
| 0.1 | 0.8 | GO:0071105 | response to interleukin-11(GO:0071105) |
| 0.1 | 2.9 | GO:0008228 | opsonization(GO:0008228) |
| 0.1 | 0.4 | GO:0070858 | negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252) |
| 0.1 | 0.6 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.1 | 0.5 | GO:0006235 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) |
| 0.1 | 0.4 | GO:0021893 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
| 0.1 | 5.4 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
| 0.1 | 0.7 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.1 | 1.1 | GO:0045359 | positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.1 | 0.4 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
| 0.1 | 1.1 | GO:0051122 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.1 | 0.5 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.1 | 1.3 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.1 | 5.0 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 0.4 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.1 | 0.4 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 2.4 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.1 | 1.6 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 1.6 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.1 | 2.4 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.1 | 4.0 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.1 | 3.0 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.1 | 0.6 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 1.4 | GO:0031953 | negative regulation of protein autophosphorylation(GO:0031953) |
| 0.1 | 0.7 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 0.4 | GO:1903781 | endoplasmic reticulum membrane organization(GO:0090158) positive regulation of cardiac conduction(GO:1903781) |
| 0.1 | 0.4 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.1 | 0.6 | GO:0071287 | cellular response to manganese ion(GO:0071287) |
| 0.1 | 0.8 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.1 | 0.9 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.1 | 0.2 | GO:1904158 | axonemal central apparatus assembly(GO:1904158) |
| 0.1 | 1.0 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.1 | 0.8 | GO:0070170 | regulation of tooth mineralization(GO:0070170) |
| 0.1 | 0.6 | GO:0003402 | planar cell polarity pathway involved in axis elongation(GO:0003402) |
| 0.1 | 0.4 | GO:0030241 | skeletal muscle myosin thick filament assembly(GO:0030241) |
| 0.1 | 1.8 | GO:0010944 | negative regulation of transcription by competitive promoter binding(GO:0010944) |
| 0.1 | 4.0 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
| 0.1 | 0.2 | GO:0033326 | cerebrospinal fluid secretion(GO:0033326) |
| 0.1 | 1.0 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.1 | 0.8 | GO:0002024 | diet induced thermogenesis(GO:0002024) |
| 0.1 | 0.2 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) |
| 0.1 | 0.2 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.1 | 0.2 | GO:0051659 | regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) maintenance of mitochondrion location(GO:0051659) |
| 0.1 | 4.5 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 0.5 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.1 | 4.1 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.1 | 0.3 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.1 | 2.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 0.9 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.1 | 1.1 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 0.9 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.1 | 0.8 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.1 | 1.9 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.1 | 1.0 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 0.3 | GO:0030037 | actin filament reorganization involved in cell cycle(GO:0030037) |
| 0.1 | 1.3 | GO:0042481 | regulation of odontogenesis(GO:0042481) |
| 0.1 | 0.5 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 2.0 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.1 | 11.2 | GO:0015992 | proton transport(GO:0015992) |
| 0.1 | 0.8 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.1 | 0.2 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.1 | 0.6 | GO:0048671 | negative regulation of collateral sprouting(GO:0048671) nephric duct morphogenesis(GO:0072178) |
| 0.1 | 0.3 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) regulation of skeletal muscle tissue growth(GO:0048631) negative regulation of satellite cell differentiation(GO:1902725) |
| 0.1 | 0.2 | GO:0048867 | stem cell fate determination(GO:0048867) |
| 0.1 | 0.3 | GO:0071934 | thiamine transmembrane transport(GO:0071934) |
| 0.1 | 0.2 | GO:0050992 | dimethylallyl diphosphate biosynthetic process(GO:0050992) dimethylallyl diphosphate metabolic process(GO:0050993) |
| 0.1 | 0.1 | GO:0010520 | regulation of reciprocal meiotic recombination(GO:0010520) |
| 0.1 | 0.2 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.1 | 0.7 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.1 | 0.4 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.1 | 0.7 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 0.1 | 1.0 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.1 | 0.3 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
| 0.1 | 0.6 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 0.8 | GO:0032096 | negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) |
| 0.1 | 1.1 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.1 | 0.7 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.1 | 1.8 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.1 | 1.5 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation(GO:0033137) |
| 0.0 | 0.3 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
| 0.0 | 0.2 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.0 | 0.5 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 0.2 | GO:0033058 | directional locomotion(GO:0033058) |
| 0.0 | 0.4 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.0 | 1.0 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 1.1 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.0 | 0.3 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.0 | 0.8 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.0 | 0.2 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 0.0 | 0.7 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.0 | 0.4 | GO:2000169 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) regulation of peptidyl-cysteine S-nitrosylation(GO:2000169) |
| 0.0 | 0.2 | GO:0000023 | maltose metabolic process(GO:0000023) |
| 0.0 | 0.3 | GO:0060648 | mammary gland bud morphogenesis(GO:0060648) |
| 0.0 | 0.2 | GO:0001969 | activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969) negative regulation of activation of membrane attack complex(GO:0001971) |
| 0.0 | 0.2 | GO:0070836 | plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836) |
| 0.0 | 0.2 | GO:0042904 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.0 | 0.7 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 1.4 | GO:0010390 | histone monoubiquitination(GO:0010390) |
| 0.0 | 1.4 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 2.9 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 7.3 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 0.9 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.0 | 0.9 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.0 | 0.5 | GO:0046149 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.0 | 0.8 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.0 | 0.1 | GO:0032252 | secretory granule localization(GO:0032252) |
| 0.0 | 1.5 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.0 | 0.7 | GO:1904261 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
| 0.0 | 0.2 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.0 | 0.7 | GO:0060856 | establishment of blood-brain barrier(GO:0060856) |
| 0.0 | 0.3 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.4 | GO:0018342 | protein prenylation(GO:0018342) prenylation(GO:0097354) |
| 0.0 | 0.2 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.0 | 0.4 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.0 | 1.4 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 2.4 | GO:0055008 | cardiac muscle tissue morphogenesis(GO:0055008) |
| 0.0 | 0.2 | GO:1903588 | regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.0 | 0.4 | GO:0071361 | cellular response to ethanol(GO:0071361) |
| 0.0 | 0.5 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.0 | 0.1 | GO:1903936 | cellular response to sodium arsenite(GO:1903936) |
| 0.0 | 0.5 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.0 | 0.1 | GO:0033313 | meiotic cell cycle checkpoint(GO:0033313) |
| 0.0 | 0.6 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.2 | GO:1903975 | regulation of glial cell migration(GO:1903975) |
| 0.0 | 0.2 | GO:1900242 | regulation of synaptic vesicle endocytosis(GO:1900242) |
| 0.0 | 0.5 | GO:0042136 | neurotransmitter biosynthetic process(GO:0042136) |
| 0.0 | 0.9 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.2 | GO:0035771 | interleukin-4-mediated signaling pathway(GO:0035771) |
| 0.0 | 0.8 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.2 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.0 | 0.6 | GO:1902603 | carnitine transmembrane transport(GO:1902603) |
| 0.0 | 0.4 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.1 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.0 | 1.6 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 1.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.4 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 0.7 | GO:0035428 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.0 | 0.2 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.7 | GO:0048147 | negative regulation of fibroblast proliferation(GO:0048147) |
| 0.0 | 0.1 | GO:1904073 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.0 | 0.3 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 0.1 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.0 | 0.4 | GO:0030517 | negative regulation of axon extension(GO:0030517) |
| 0.0 | 0.4 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.0 | 0.2 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.0 | 0.7 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 1.0 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 0.0 | 0.1 | GO:0014734 | skeletal muscle hypertrophy(GO:0014734) regulation of skeletal muscle hypertrophy(GO:1904204) |
| 0.0 | 0.5 | GO:0045577 | regulation of B cell differentiation(GO:0045577) |
| 0.0 | 0.1 | GO:2000662 | interleukin-5 secretion(GO:0072603) regulation of interleukin-5 secretion(GO:2000662) |
| 0.0 | 0.3 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 4.2 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.0 | 0.1 | GO:0046167 | glycerol-3-phosphate biosynthetic process(GO:0046167) |
| 0.0 | 0.1 | GO:0006154 | adenosine catabolic process(GO:0006154) hypoxanthine salvage(GO:0043103) inosine biosynthetic process(GO:0046103) |
| 0.0 | 0.2 | GO:0002155 | regulation of thyroid hormone mediated signaling pathway(GO:0002155) |
| 0.0 | 0.2 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 2.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 0.2 | GO:0038003 | opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 1.1 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
| 0.0 | 0.1 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.0 | 0.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 2.1 | GO:0031333 | negative regulation of protein complex assembly(GO:0031333) |
| 0.0 | 0.1 | GO:0008298 | intracellular mRNA localization(GO:0008298) |
| 0.0 | 0.3 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 0.1 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
| 0.0 | 0.1 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.0 | 0.5 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.4 | GO:0033046 | negative regulation of sister chromatid segregation(GO:0033046) negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 0.0 | 0.3 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.0 | 0.3 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.0 | 0.1 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.1 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 0.0 | 0.0 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216) |
| 0.0 | 1.7 | GO:0001763 | morphogenesis of a branching structure(GO:0001763) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 27.7 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 2.8 | 19.7 | GO:0042825 | TAP complex(GO:0042825) |
| 1.9 | 7.7 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.8 | 5.7 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.8 | 2.3 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.7 | 2.9 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.7 | 2.1 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 0.6 | 3.8 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.5 | 7.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.4 | 4.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.4 | 1.1 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.4 | 5.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.4 | 1.4 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.3 | 2.1 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.3 | 1.5 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.3 | 2.1 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.2 | 1.1 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.2 | 2.7 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 1.0 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.2 | 0.8 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.2 | 0.5 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.2 | 10.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 3.2 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 1.6 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 1.3 | GO:0072487 | MSL complex(GO:0072487) |
| 0.1 | 0.7 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.1 | 0.4 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.1 | 5.4 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 0.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 0.9 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 4.9 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.1 | 1.6 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.1 | 1.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.1 | 0.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 0.9 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.1 | 0.3 | GO:0008623 | CHRAC(GO:0008623) |
| 0.1 | 0.8 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 1.1 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 1.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 1.3 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 0.8 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.1 | 0.4 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.1 | 1.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 1.1 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.1 | 5.9 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 2.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 1.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 4.4 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 1.2 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 7.8 | GO:0018995 | host(GO:0018995) host cell(GO:0043657) |
| 0.1 | 33.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 0.7 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.1 | 2.5 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 0.5 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.1 | 2.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 1.4 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.1 | 0.9 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 1.9 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.7 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 1.6 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 0.6 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.9 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 1.0 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 3.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.3 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.0 | 8.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.7 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 4.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.2 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 0.8 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 1.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 1.1 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.3 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.0 | 0.5 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.0 | 0.8 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.0 | 0.4 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.0 | 0.3 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.0 | 1.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.0 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.9 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 1.0 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 1.0 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 64.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 4.5 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.0 | 1.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.4 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 1.4 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 5.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 0.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 1.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 0.1 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.0 | 0.1 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.0 | 0.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 0.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 0.1 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
| 0.0 | 0.1 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.0 | 0.2 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.1 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.0 | 0.3 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.7 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 5.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.0 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 0.1 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 1.2 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 0.1 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.0 | 0.8 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 63.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 3.9 | 19.6 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 3.0 | 9.0 | GO:0042007 | interleukin-18 binding(GO:0042007) |
| 2.5 | 19.7 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) |
| 2.0 | 14.2 | GO:0015333 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 2.0 | 6.1 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 2.0 | 6.0 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 1.9 | 5.7 | GO:0004798 | thymidylate kinase activity(GO:0004798) |
| 1.1 | 7.7 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 1.0 | 3.0 | GO:0042008 | interleukin-18 receptor activity(GO:0042008) |
| 1.0 | 28.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.0 | 7.7 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.8 | 6.2 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.6 | 3.2 | GO:0015119 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.6 | 2.5 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.6 | 5.5 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.6 | 24.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.5 | 3.8 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.5 | 2.1 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) |
| 0.4 | 10.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.4 | 1.3 | GO:0052739 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) |
| 0.4 | 1.6 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.3 | 1.7 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.3 | 1.6 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.3 | 2.1 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.3 | 3.6 | GO:0051378 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.3 | 1.5 | GO:0015094 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.3 | 1.2 | GO:0004307 | ethanolaminephosphotransferase activity(GO:0004307) |
| 0.3 | 6.9 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.3 | 0.8 | GO:0004980 | melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 0.2 | 4.6 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.2 | 1.1 | GO:0051120 | hepoxilin A3 synthase activity(GO:0051120) |
| 0.2 | 2.3 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.2 | 1.1 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.2 | 1.6 | GO:0043140 | ATP-dependent 3'-5' DNA helicase activity(GO:0043140) |
| 0.2 | 1.1 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) |
| 0.2 | 2.9 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.2 | 1.6 | GO:0043426 | MRF binding(GO:0043426) |
| 0.2 | 2.6 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.2 | 0.4 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.2 | 0.5 | GO:0004611 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.2 | 3.8 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.2 | 5.3 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.2 | 0.8 | GO:0004082 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.2 | 1.2 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.2 | 1.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.2 | 0.5 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 0.2 | 2.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 16.7 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.1 | 1.9 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 23.9 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.1 | 0.7 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 0.1 | 1.0 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.1 | 0.7 | GO:0005502 | 11-cis retinal binding(GO:0005502) |
| 0.1 | 0.4 | GO:0035663 | Toll-like receptor 2 binding(GO:0035663) |
| 0.1 | 2.2 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 0.9 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.1 | 0.8 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.1 | 0.5 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.1 | 0.3 | GO:0086020 | gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) |
| 0.1 | 1.6 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 1.2 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.1 | 5.7 | GO:0043394 | proteoglycan binding(GO:0043394) |
| 0.1 | 0.5 | GO:0004102 | choline O-acetyltransferase activity(GO:0004102) |
| 0.1 | 1.0 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.1 | 0.5 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 0.2 | GO:0098808 | mRNA cap binding(GO:0098808) |
| 0.1 | 1.6 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 0.3 | GO:0015403 | thiamine uptake transmembrane transporter activity(GO:0015403) |
| 0.1 | 4.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 1.2 | GO:0005221 | intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855) |
| 0.1 | 0.7 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 0.6 | GO:0016433 | rRNA (adenine) methyltransferase activity(GO:0016433) |
| 0.1 | 0.6 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.1 | 3.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 1.9 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.1 | 0.4 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.1 | 0.5 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 4.8 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.1 | 4.8 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.1 | 0.6 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 0.8 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.1 | 3.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.5 | GO:0015180 | L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) |
| 0.1 | 3.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 1.7 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.4 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.1 | 1.3 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 0.7 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.1 | 2.1 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 1.2 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 0.7 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.1 | 0.5 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.1 | 0.2 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 0.3 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 0.1 | 0.2 | GO:0004452 | isopentenyl-diphosphate delta-isomerase activity(GO:0004452) |
| 0.1 | 0.8 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.1 | 1.0 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 1.3 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 0.5 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.1 | 0.6 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 1.6 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.1 | 0.7 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.1 | 1.4 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.1 | 0.2 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 0.8 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.1 | 0.2 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
| 0.0 | 0.2 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 0.5 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.0 | 1.4 | GO:0005549 | odorant binding(GO:0005549) |
| 0.0 | 0.4 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.0 | 0.2 | GO:0031531 | thyrotropin-releasing hormone receptor binding(GO:0031531) |
| 0.0 | 0.4 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 0.3 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 0.2 | GO:0032450 | maltose alpha-glucosidase activity(GO:0032450) |
| 0.0 | 0.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.6 | GO:1901611 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 0.0 | 0.4 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.0 | 1.6 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.0 | 1.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 6.7 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.0 | 0.7 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.4 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.0 | 0.4 | GO:0008318 | protein prenyltransferase activity(GO:0008318) |
| 0.0 | 2.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 4.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.3 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.0 | 0.7 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 0.8 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.4 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 1.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 2.0 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 0.3 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.0 | 0.7 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.9 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 1.2 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 0.2 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.0 | 0.6 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.0 | 5.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 4.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 2.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.2 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.9 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.4 | GO:0070679 | store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.0 | 0.1 | GO:0001601 | peptide YY receptor activity(GO:0001601) |
| 0.0 | 2.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 3.4 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 0.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.2 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.0 | 0.2 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.0 | 0.5 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.2 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.0 | 2.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.2 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.2 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.0 | 0.2 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 3.2 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.0 | 0.7 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 0.2 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.7 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.6 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 1.4 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 0.2 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.0 | 2.0 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.1 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.0 | 0.1 | GO:0047322 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405) |
| 0.0 | 0.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 1.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.1 | GO:0004370 | glycerol kinase activity(GO:0004370) |
| 0.0 | 2.9 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.3 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.0 | 0.3 | GO:0031702 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 0.2 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.0 | 0.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.1 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 0.2 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.0 | 0.6 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 1.1 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.4 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 0.3 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.3 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.0 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 0.0 | 0.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.0 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.0 | 0.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.6 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.2 | GO:0000150 | recombinase activity(GO:0000150) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.5 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.2 | 6.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 3.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 8.6 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 1.3 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 4.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 2.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 22.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 7.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 1.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 4.6 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 2.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 4.1 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 4.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 3.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 4.4 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 1.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 0.8 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 1.0 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.2 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 2.1 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 1.6 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 0.5 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.2 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.3 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 0.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 6.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 5.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.2 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 0.6 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 5.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 1.0 | 116.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.7 | 15.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.5 | 34.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.5 | 8.2 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.3 | 3.6 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.2 | 16.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 4.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 3.0 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.2 | 3.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 2.9 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 1.8 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 14.2 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 7.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 4.8 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.1 | 1.0 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.1 | 2.4 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 6.5 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 1.4 | REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
| 0.1 | 4.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 2.9 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 2.4 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 11.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 1.7 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.1 | 2.9 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 0.4 | REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
| 0.1 | 2.1 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 1.0 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.5 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 2.0 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 2.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 1.0 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.2 | REACTOME DNA STRAND ELONGATION | Genes involved in DNA strand elongation |
| 0.0 | 0.6 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 2.4 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.8 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 1.6 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.0 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.2 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 0.4 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 4.2 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 0.9 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.4 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.8 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.3 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.4 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 1.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.3 | REACTOME SIGNALING BY ILS | Genes involved in Signaling by Interleukins |
| 0.0 | 1.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 2.6 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.5 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.5 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.0 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.0 | 0.2 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.4 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.3 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.7 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.2 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 2.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.3 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 1.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.1 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.0 | 0.2 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 1.3 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.0 | 0.2 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 0.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |