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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for IRF7
Z-value: 1.81
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Transcription factors associated with IRF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF7 | hg38_v1_chr11_-_615921_615970, hg38_v1_chr11_-_615570_615728 | 0.84 | 1.7e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 34.5 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.3 | 29.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 2.0 | 24.3 | GO:0018377 | protein myristoylation(GO:0018377) |
| 1.4 | 20.9 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 1.8 | 19.6 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 6.5 | 19.5 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 5.7 | 17.2 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 5.4 | 16.2 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 1.5 | 15.3 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 1.2 | 14.5 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 64.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 33.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 3.5 | 27.7 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 2.8 | 19.7 | GO:0042825 | TAP complex(GO:0042825) |
| 0.2 | 10.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 8.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 7.8 | GO:0018995 | host(GO:0018995) host cell(GO:0043657) |
| 1.9 | 7.7 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.5 | 7.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 5.9 | GO:0015030 | Cajal body(GO:0015030) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 63.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 1.0 | 28.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.6 | 24.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 23.9 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 2.5 | 19.7 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) |
| 3.9 | 19.6 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 16.7 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 2.0 | 14.2 | GO:0015333 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.4 | 10.5 | GO:0070628 | proteasome binding(GO:0070628) |
| 3.0 | 9.0 | GO:0042007 | interleukin-18 binding(GO:0042007) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 19.5 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 8.6 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 7.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 6.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 5.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 4.6 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 4.4 | PID FOXO PATHWAY | FoxO family signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 116.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.5 | 34.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 16.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.7 | 15.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 14.2 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 11.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.5 | 8.2 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 7.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 6.5 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 1.4 | 5.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |