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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for IRF9
Z-value: 3.76
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Transcription factors associated with IRF9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF9 | hg38_v1_chr14_+_24161257_24161322 | 0.96 | 1.0e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF9
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.0 | 240.4 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 1.5 | 196.5 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 5.4 | 54.0 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 14.9 | 44.7 | GO:0006233 | dUDP biosynthetic process(GO:0006227) dTDP biosynthetic process(GO:0006233) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dTDP metabolic process(GO:0046072) dUDP metabolic process(GO:0046077) |
| 3.7 | 44.1 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.2 | 40.6 | GO:0015992 | proton transport(GO:0015992) |
| 3.5 | 38.0 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 10.6 | 31.9 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 5.0 | 25.2 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 4.0 | 23.9 | GO:0034165 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 250.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 229.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 36.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 4.6 | 31.9 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.0 | 30.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 27.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.2 | 23.9 | GO:0005811 | lipid particle(GO:0005811) |
| 2.6 | 23.1 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 3.0 | 21.0 | GO:0042825 | TAP complex(GO:0042825) |
| 0.2 | 15.7 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 240.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 8.8 | 132.6 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 61.3 | GO:0008270 | zinc ion binding(GO:0008270) |
| 2.1 | 58.4 | GO:0070403 | NAD+ binding(GO:0070403) |
| 14.9 | 44.7 | GO:0004798 | thymidylate kinase activity(GO:0004798) |
| 0.4 | 43.8 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 5.8 | 40.6 | GO:0015333 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 7.9 | 39.6 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.8 | 31.9 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.4 | 23.9 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 39.6 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 31.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 21.9 | PID MYC PATHWAY | C-MYC pathway |
| 1.1 | 16.9 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 15.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 15.0 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 8.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 6.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 5.4 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 4.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 495.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.4 | 40.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.6 | 39.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 5.4 | 26.9 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.4 | 23.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 20.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.6 | 14.3 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.6 | 13.3 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.3 | 12.6 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.7 | 12.1 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |