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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for IRF9

Z-value: 3.76

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
IRF9
ENSG00000213928.9 IRF9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg38_v1_chr14_+_24161257_241613220.961.0e-14Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr21_+_41426590 60.76 ENST00000679543.1
ENST00000680364.1
MX1
MX dynamin like GTPase 1
chr2_-_6865901 44.74 ENST00000256722.10
CMPK2
cytidine/uridine monophosphate kinase 2
chr4_-_76023489 39.63 ENST00000306602.3
CXCL10
C-X-C motif chemokine ligand 10
chr21_+_41426197 36.39 ENST00000680942.1
ENST00000288383.11
ENST00000679386.1
MX1
MX dynamin like GTPase 1
chr21_+_41426031 34.95 ENST00000455164.6
ENST00000681849.1
ENST00000679705.1
ENST00000424365.6
MX1
MX dynamin like GTPase 1
chr17_+_6756035 32.78 ENST00000361842.8
ENST00000574907.5
XAF1
XIAP associated factor 1
chr21_+_41426168 32.06 ENST00000681266.1
ENST00000417963.6
MX1
MX dynamin like GTPase 1
chr21_+_41426232 30.36 ENST00000398598.8
ENST00000681896.1
ENST00000680629.1
ENST00000680760.1
ENST00000680176.1
ENST00000680776.1
ENST00000681607.1
ENST00000680536.1
MX1
MX dynamin like GTPase 1
chr21_+_41426289 30.13 ENST00000679408.1
ENST00000681039.1
ENST00000681671.1
MX1
MX dynamin like GTPase 1
chr12_+_112906949 23.56 ENST00000679971.1
ENST00000675868.2
ENST00000550883.2
ENST00000553152.2
ENST00000202917.10
ENST00000679467.1
ENST00000680659.1
ENST00000540589.3
ENST00000552526.2
ENST00000681228.1
ENST00000680934.1
ENST00000681700.1
ENST00000679987.1
OAS1
2'-5'-oligoadenylate synthetase 1
chr12_+_112906777 23.51 ENST00000452357.7
ENST00000445409.7
OAS1
2'-5'-oligoadenylate synthetase 1
chr13_-_42992165 23.37 ENST00000398762.7
ENST00000313640.11
ENST00000313624.12
EPSTI1
epithelial stromal interaction 1
chr12_+_112907006 23.33 ENST00000680455.1
ENST00000551241.6
ENST00000550689.2
ENST00000679841.1
ENST00000679494.1
ENST00000553185.2
OAS1
2'-5'-oligoadenylate synthetase 1
chr17_+_6755834 22.74 ENST00000346752.8
XAF1
XIAP associated factor 1
chr3_-_122564232 19.93 ENST00000471785.5
ENST00000466126.1
PARP9
poly(ADP-ribose) polymerase family member 9
chr3_-_122564577 19.48 ENST00000477522.6
ENST00000360356.6
PARP9
poly(ADP-ribose) polymerase family member 9
chr1_+_78649818 17.97 ENST00000370747.9
ENST00000438486.1
IFI44
interferon induced protein 44
chr14_+_24161257 17.41 ENST00000396864.8
ENST00000557894.5
ENST00000559284.5
ENST00000560275.5
IRF9
interferon regulatory factor 9
chr12_+_112938523 17.12 ENST00000679483.1
ENST00000679493.1
OAS3
2'-5'-oligoadenylate synthetase 3
chr12_+_112938284 16.87 ENST00000681346.1
OAS3
2'-5'-oligoadenylate synthetase 3
chr1_-_150765785 16.34 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
CTSS
cathepsin S
chr6_-_81752671 16.20 ENST00000320172.11
ENST00000369754.7
ENST00000369756.3
TENT5A
terminal nucleotidyltransferase 5A
chr11_-_60952067 15.91 ENST00000681275.1
SLC15A3
solute carrier family 15 member 3
chr21_+_41361999 15.75 ENST00000436410.5
ENST00000435611.6
ENST00000330714.8
MX2
MX dynamin like GTPase 2
chr1_-_150765735 15.58 ENST00000679898.1
ENST00000448301.7
ENST00000680664.1
ENST00000679512.1
ENST00000368985.8
ENST00000679582.1
CTSS
cathepsin S
chr2_+_6865557 15.30 ENST00000680607.1
ENST00000680320.1
ENST00000442639.6
RSAD2
radical S-adenosyl methionine domain containing 2
chr3_+_122564327 14.60 ENST00000296161.9
ENST00000383661.3
DTX3L
deltex E3 ubiquitin ligase 3L
chr9_+_5510492 14.34 ENST00000397747.5
PDCD1LG2
programmed cell death 1 ligand 2
chr10_+_89332484 13.86 ENST00000371811.4
ENST00000680037.1
ENST00000679583.1
ENST00000679897.1
IFIT3
interferon induced protein with tetratricopeptide repeats 3
chr6_-_32838727 13.32 ENST00000652259.1
ENST00000374897.4
ENST00000620123.4
ENST00000452392.2
TAP2
ENSG00000250264.1
transporter 2, ATP binding cassette subfamily B member
novel protein, TAP2-HLA-DOB readthrough
chr3_+_122680802 13.18 ENST00000474629.7
PARP14
poly(ADP-ribose) polymerase family member 14
chr11_-_60952134 13.05 ENST00000679573.1
ENST00000681882.1
ENST00000681951.1
ENST00000227880.8
SLC15A3
solute carrier family 15 member 3
chr3_-_122564253 12.62 ENST00000492382.5
ENST00000682323.1
ENST00000462315.5
PARP9
poly(ADP-ribose) polymerase family member 9
chr2_-_162318475 12.02 ENST00000648433.1
IFIH1
interferon induced with helicase C domain 1
chr17_-_42112674 11.69 ENST00000251642.8
ENST00000591220.5
DHX58
DExH-box helicase 58
chr11_-_60952559 11.65 ENST00000538739.2
SLC15A3
solute carrier family 15 member 3
chr10_-_5978022 11.30 ENST00000525219.6
IL15RA
interleukin 15 receptor subunit alpha
chr22_+_18150162 10.89 ENST00000215794.8
USP18
ubiquitin specific peptidase 18
chr10_+_89414555 10.19 ENST00000371795.5
ENST00000681422.1
IFIT5
interferon induced protein with tetratricopeptide repeats 5
chr12_+_112938422 10.15 ENST00000680044.1
ENST00000680966.1
ENST00000548514.2
ENST00000681497.1
ENST00000551007.1
ENST00000228928.12
ENST00000680438.1
ENST00000681147.1
ENST00000679354.1
ENST00000681085.1
ENST00000680161.1
OAS3
2'-5'-oligoadenylate synthetase 3
chr11_-_615570 10.07 ENST00000649187.1
ENST00000647801.1
ENST00000397566.5
ENST00000397570.5
IRF7
interferon regulatory factor 7
chr11_-_4393650 9.15 ENST00000254436.8
TRIM21
tripartite motif containing 21
chr2_+_6877768 8.62 ENST00000382040.4
RSAD2
radical S-adenosyl methionine domain containing 2
chr15_+_73994667 8.47 ENST00000395135.7
PML
PML nuclear body scaffold
chr15_+_73994694 8.30 ENST00000268058.8
ENST00000395132.6
ENST00000268059.10
ENST00000354026.10
ENST00000565898.5
ENST00000569477.5
ENST00000569965.5
ENST00000567543.5
ENST00000436891.7
ENST00000435786.6
ENST00000564428.5
ENST00000359928.8
PML
PML nuclear body scaffold
chr11_-_615921 7.81 ENST00000348655.11
ENST00000525445.6
ENST00000330243.9
IRF7
interferon regulatory factor 7
chr13_+_49496355 7.57 ENST00000496612.5
ENST00000357596.7
ENST00000485919.5
ENST00000442195.5
PHF11
PHD finger protein 11
chr11_-_57567617 7.44 ENST00000287156.9
UBE2L6
ubiquitin conjugating enzyme E2 L6
chr7_-_140062841 7.41 ENST00000263549.8
PARP12
poly(ADP-ribose) polymerase family member 12
chr13_+_49495941 7.39 ENST00000378319.8
ENST00000496623.5
ENST00000426879.5
PHF11
PHD finger protein 11
chr4_-_168318770 7.04 ENST00000680771.1
ENST00000514995.2
DDX60
DExD/H-box helicase 60
chr2_-_219387784 6.81 ENST00000520694.6
DNPEP
aspartyl aminopeptidase
chr4_-_168318743 6.44 ENST00000393743.8
DDX60
DExD/H-box helicase 60
chr2_-_106194286 6.40 ENST00000409501.7
ENST00000441952.5
ENST00000457835.5
ENST00000483426.5
ENST00000283148.12
UXS1
UDP-glucuronate decarboxylase 1
chr15_+_73994777 6.34 ENST00000563500.5
PML
PML nuclear body scaffold
chr7_+_101085464 6.29 ENST00000306085.11
ENST00000412507.1
TRIM56
tripartite motif containing 56
chr17_+_27631148 6.16 ENST00000313648.10
ENST00000395473.7
ENST00000577392.5
ENST00000584661.5
LGALS9
galectin 9
chr5_-_95961830 6.02 ENST00000513343.1
ENST00000237853.9
ELL2
elongation factor for RNA polymerase II 2
chr6_-_33314386 5.97 ENST00000456592.3
TAPBP
TAP binding protein
chr1_+_1013485 5.65 ENST00000649529.1
ISG15
ISG15 ubiquitin like modifier
chr1_+_112674416 5.48 ENST00000413052.6
ENST00000369645.5
MOV10
Mov10 RISC complex RNA helicase
chr12_-_121039204 5.46 ENST00000620239.5
OASL
2'-5'-oligoadenylate synthetase like
chr12_-_121039236 5.25 ENST00000257570.9
OASL
2'-5'-oligoadenylate synthetase like
chr2_-_219387881 5.20 ENST00000322176.11
ENST00000273075.9
DNPEP
aspartyl aminopeptidase
chr1_+_112674722 5.04 ENST00000357443.2
MOV10
Mov10 RISC complex RNA helicase
chr12_-_121039156 4.94 ENST00000339275.10
OASL
2'-5'-oligoadenylate synthetase like
chr1_+_112674649 4.91 ENST00000369644.5
MOV10
Mov10 RISC complex RNA helicase
chr16_-_74700786 4.68 ENST00000306247.11
ENST00000575686.1
MLKL
mixed lineage kinase domain like pseudokinase
chr4_-_168480477 4.29 ENST00000514748.5
ENST00000512371.1
ENST00000505890.5
ENST00000682922.1
ENST00000511577.5
DDX60L
DExD/H-box 60 like
chr3_-_142448060 4.22 ENST00000264951.8
XRN1
5'-3' exoribonuclease 1
chr3_-_142448028 4.14 ENST00000392981.7
XRN1
5'-3' exoribonuclease 1
chr17_+_43211835 4.08 ENST00000588693.5
ENST00000588659.5
ENST00000541594.5
ENST00000536052.5
ENST00000612339.4
TMEM106A
transmembrane protein 106A
chr9_+_99906646 4.02 ENST00000259400.11
ENST00000531035.5
ENST00000525640.5
ENST00000534052.1
ENST00000526607.1
STX17
syntaxin 17
chr2_-_151289613 3.85 ENST00000243346.10
NMI
N-myc and STAT interactor
chr1_-_154608140 3.80 ENST00000529168.2
ENST00000368474.9
ENST00000680305.1
ENST00000648231.2
ADAR
adenosine deaminase RNA specific
chr20_-_49278034 3.79 ENST00000371744.5
ENST00000396105.6
ENST00000371752.5
ZNFX1
zinc finger NFX1-type containing 1
chr11_-_86672419 3.64 ENST00000524826.7
ENST00000532471.1
ME3
malic enzyme 3
chr4_+_186069144 3.55 ENST00000513189.1
ENST00000296795.8
TLR3
toll like receptor 3
chr11_-_86672114 3.22 ENST00000393324.7
ME3
malic enzyme 3
chr11_-_86672630 3.15 ENST00000543262.5
ME3
malic enzyme 3
chr6_-_33314055 3.12 ENST00000434618.7
TAPBP
TAP binding protein
chr6_+_125919210 3.07 ENST00000438495.6
NCOA7
nuclear receptor coactivator 7
chr6_+_125919296 3.05 ENST00000444128.2
NCOA7
nuclear receptor coactivator 7
chr3_-_121660892 3.02 ENST00000428394.6
ENST00000314583.8
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_+_6772512 2.98 ENST00000441671.6
ENST00000203629.3
LAG3
lymphocyte activating 3
chr10_+_113679523 2.71 ENST00000345633.8
ENST00000614447.4
ENST00000369321.6
CASP7
caspase 7
chr17_-_4263847 2.68 ENST00000570535.5
ENST00000574367.5
ENST00000341657.9
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr10_+_113679839 2.67 ENST00000369318.8
ENST00000369315.5
CASP7
caspase 7
chr17_+_80260826 2.59 ENST00000508628.6
ENST00000582970.5
ENST00000319921.4
RNF213
ring finger protein 213
chr18_-_28036585 2.55 ENST00000399380.7
CDH2
cadherin 2
chr1_+_156082563 2.47 ENST00000368301.6
LMNA
lamin A/C
chr12_-_121038967 2.38 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
OASL
2'-5'-oligoadenylate synthetase like
chr2_-_55693817 2.29 ENST00000625249.1
ENST00000447944.7
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr9_-_32526185 2.25 ENST00000379883.3
ENST00000379868.6
ENST00000679859.1
DDX58
DExD/H-box helicase 58
chr7_+_134866831 2.24 ENST00000435928.1
CALD1
caldesmon 1
chr3_-_142448004 2.04 ENST00000463916.5
XRN1
5'-3' exoribonuclease 1
chr8_-_143986425 1.97 ENST00000313059.9
ENST00000524918.5
ENST00000313028.12
ENST00000525773.5
PARP10
poly(ADP-ribose) polymerase family member 10
chr3_+_187368367 1.78 ENST00000259030.3
RTP4
receptor transporter protein 4
chr10_+_89301932 1.72 ENST00000371826.4
ENST00000679755.1
IFIT2
interferon induced protein with tetratricopeptide repeats 2
chr9_+_72149424 1.63 ENST00000358399.8
ENST00000376986.5
GDA
guanine deaminase
chr4_+_37891060 1.55 ENST00000261439.9
ENST00000508802.5
ENST00000402522.1
TBC1D1
TBC1 domain family member 1
chr16_+_28950807 1.54 ENST00000564978.5
ENST00000320805.8
NFATC2IP
nuclear factor of activated T cells 2 interacting protein
chr6_+_37433197 1.38 ENST00000455891.5
ENST00000373451.9
CMTR1
cap methyltransferase 1
chr2_-_37156942 1.37 ENST00000680273.1
ENST00000233057.9
ENST00000679979.1
ENST00000679507.1
ENST00000681463.1
ENST00000395127.6
EIF2AK2
eukaryotic translation initiation factor 2 alpha kinase 2
chr3_-_71581540 1.27 ENST00000650068.1
FOXP1
forkhead box P1
chr9_+_72149351 1.26 ENST00000238018.8
GDA
guanine deaminase
chr3_-_45995807 1.21 ENST00000535325.5
ENST00000296137.7
FYCO1
FYVE and coiled-coil domain autophagy adaptor 1
chr9_-_83978429 1.17 ENST00000351839.7
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr18_-_69956924 1.16 ENST00000581982.5
ENST00000280200.8
CD226
CD226 molecule
chr6_+_106098933 1.06 ENST00000369089.3
PRDM1
PR/SET domain 1
chr2_-_37157093 1.05 ENST00000681507.1
EIF2AK2
eukaryotic translation initiation factor 2 alpha kinase 2
chr3_-_146544538 0.95 ENST00000462666.5
PLSCR1
phospholipid scramblase 1
chr14_-_56810448 0.90 ENST00000339475.10
ENST00000555006.5
ENST00000672264.2
ENST00000554559.5
ENST00000555804.1
OTX2
orthodenticle homeobox 2
chr2_-_162318613 0.78 ENST00000649979.2
ENST00000421365.2
IFIH1
interferon induced with helicase C domain 1
chr3_-_146544850 0.75 ENST00000472349.1
PLSCR1
phospholipid scramblase 1
chr19_-_17405554 0.60 ENST00000252593.7
BST2
bone marrow stromal cell antigen 2
chr20_+_62804794 0.56 ENST00000290291.10
OGFR
opioid growth factor receptor
chr17_+_40140500 0.54 ENST00000264645.12
CASC3
CASC3 exon junction complex subunit
chr14_-_56810380 0.44 ENST00000672125.1
ENST00000673481.1
OTX2
orthodenticle homeobox 2
chr3_-_167734510 0.41 ENST00000475915.6
ENST00000462725.6
ENST00000461494.5
PDCD10
programmed cell death 10
chr9_-_21995301 0.34 ENST00000498628.6
CDKN2A
cyclin dependent kinase inhibitor 2A
chr3_-_146544701 0.26 ENST00000487389.5
PLSCR1
phospholipid scramblase 1
chr4_+_88457110 0.22 ENST00000264350.8
HERC5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr6_-_33314247 0.16 ENST00000475304.5
ENST00000489157.5
TAPBP
TAP binding protein
chr3_-_146544636 0.11 ENST00000486631.5
PLSCR1
phospholipid scramblase 1
chrX_-_49002197 0.10 ENST00000622231.1
ENST00000617369.4
ENST00000593475.5
ENST00000622599.4
GRIPAP1
GRIP1 associated protein 1
chr1_-_161631032 0.10 ENST00000534776.1
ENST00000613418.4
ENST00000614870.4
FCGR3B
Fc fragment of IgG receptor IIIb
chr19_-_12696581 0.09 ENST00000587955.1
ENST00000393261.8
FBXW9
F-box and WD repeat domain containing 9

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.9 44.7 GO:0006233 dUDP biosynthetic process(GO:0006227) dTDP biosynthetic process(GO:0006233) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dTDP metabolic process(GO:0046072) dUDP metabolic process(GO:0046077)
12.0 240.4 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
10.6 31.9 GO:0034769 basement membrane disassembly(GO:0034769)
5.4 54.0 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
5.0 25.2 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
4.4 13.3 GO:0046967 cytosol to ER transport(GO:0046967)
4.0 23.9 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
3.7 18.6 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
3.7 44.1 GO:0060700 regulation of ribonuclease activity(GO:0060700)
3.5 38.0 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
3.1 6.2 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
3.0 17.9 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
2.3 23.1 GO:0045345 positive regulation of MHC class I biosynthetic process(GO:0045345)
2.3 9.2 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
2.1 10.4 GO:0071409 cellular response to cycloheximide(GO:0071409)
1.9 7.7 GO:0050822 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
1.5 196.5 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
1.4 15.4 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
1.3 3.8 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
1.0 6.3 GO:0034340 response to type I interferon(GO:0034340)
1.0 10.0 GO:0072592 oxygen metabolic process(GO:0072592)
1.0 3.0 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
1.0 2.9 GO:0006147 guanine catabolic process(GO:0006147)
1.0 7.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.9 14.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.8 4.0 GO:0016240 autophagosome docking(GO:0016240)
0.8 5.4 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.8 2.3 GO:0035928 mitochondrial RNA 5'-end processing(GO:0000964) rRNA import into mitochondrion(GO:0035928)
0.6 1.2 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.5 2.6 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.5 1.4 GO:0036451 cap mRNA methylation(GO:0036451)
0.4 2.5 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.4 2.7 GO:0032439 endosome localization(GO:0032439) positive regulation of pinocytosis(GO:0048549)
0.4 1.1 GO:1990654 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
0.3 2.4 GO:0052572 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.3 13.5 GO:0010390 histone monoubiquitination(GO:0010390)
0.3 1.2 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.3 6.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.3 2.5 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.2 40.6 GO:0015992 proton transport(GO:0015992)
0.2 3.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 6.4 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
0.2 1.8 GO:2000373 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.1 1.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.1 4.7 GO:0070207 protein homotrimerization(GO:0070207)
0.1 5.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 1.3 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.1 0.4 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 6.0 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.6 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.5 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 1.5 GO:1902017 regulation of cilium assembly(GO:1902017)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 31.9 GO:0036021 endolysosome lumen(GO:0036021)
3.0 21.0 GO:0042825 TAP complex(GO:0042825)
2.6 23.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.7 10.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.5 3.8 GO:0044530 supraspliceosomal complex(GO:0044530)
0.5 4.0 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.4 250.0 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.7 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.2 15.7 GO:0005643 nuclear pore(GO:0005643)
0.2 23.9 GO:0005811 lipid particle(GO:0005811)
0.2 2.3 GO:0042788 polysomal ribosome(GO:0042788)
0.2 27.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.2 GO:0030478 actin cap(GO:0030478)
0.1 3.5 GO:0036020 endolysosome membrane(GO:0036020)
0.1 2.5 GO:0016342 catenin complex(GO:0016342)
0.1 229.9 GO:0005739 mitochondrion(GO:0005739)
0.1 36.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 11.8 GO:0072562 blood microparticle(GO:0072562)
0.1 1.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 13.5 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.0 30.5 GO:0005615 extracellular space(GO:0005615)
0.0 2.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.6 GO:0005771 multivesicular body(GO:0005771)
0.0 2.4 GO:0005840 ribosome(GO:0005840)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.9 44.7 GO:0004798 thymidylate kinase activity(GO:0004798)
8.8 132.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
7.9 39.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
5.8 40.6 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
4.2 21.0 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
2.1 58.4 GO:0070403 NAD+ binding(GO:0070403)
2.0 10.0 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
1.7 10.4 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
1.1 7.7 GO:0042296 ISG15 transferase activity(GO:0042296)
1.0 6.2 GO:0048030 disaccharide binding(GO:0048030)
1.0 23.1 GO:0032183 SUMO binding(GO:0032183)
1.0 2.9 GO:0008892 guanine deaminase activity(GO:0008892)
0.8 22.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.8 31.9 GO:0001968 fibronectin binding(GO:0001968)
0.6 240.4 GO:0008017 microtubule binding(GO:0008017)
0.6 2.3 GO:0034046 poly(G) binding(GO:0034046)
0.5 7.2 GO:0031386 protein tag(GO:0031386)
0.5 1.4 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.4 12.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 1.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.4 3.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.4 23.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.4 2.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.4 10.2 GO:0000339 RNA cap binding(GO:0000339)
0.4 43.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 5.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 14.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 2.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 19.7 GO:0004386 helicase activity(GO:0004386)
0.1 1.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 10.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 2.2 GO:0005523 tropomyosin binding(GO:0005523)
0.1 6.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 4.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 14.6 GO:0042393 histone binding(GO:0042393)
0.1 9.6 GO:0001047 core promoter binding(GO:0001047)
0.1 61.3 GO:0008270 zinc ion binding(GO:0008270)
0.1 9.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0004985 opioid receptor activity(GO:0004985)
0.0 1.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.7 GO:1901981 phosphatidylinositol phosphate binding(GO:1901981)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 16.9 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.5 39.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.4 21.9 PID MYC PATHWAY C-MYC pathway
0.2 15.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 5.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 15.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 8.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 3.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 31.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.4 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 3.0 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 3.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 4.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 26.9 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
4.4 495.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.7 12.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.6 13.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.6 39.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.6 14.3 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.5 10.4 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.4 40.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.4 23.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.3 12.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 3.5 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.2 5.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 7.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 6.8 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2 2.9 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 20.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.4 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.0 1.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell