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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for IRX5
Z-value: 0.55
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Transcription factors associated with IRX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX5 | hg38_v1_chr16_+_54930827_54930898 | 0.05 | 8.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_41359599 Show fit | 2.10 |
ENST00000513024.5
|
LIM and calponin homology domains 1 |
|
| chr9_-_41908681 Show fit | 1.68 |
ENST00000476961.5
|
contactin associated protein family member 3B |
|
| chr1_+_61203496 Show fit | 1.60 |
ENST00000663597.1
|
nuclear factor I A |
|
| chr15_+_66293217 Show fit | 1.41 |
ENST00000319194.9
ENST00000525134.6 |
DIS3 like exosome 3'-5' exoribonuclease |
|
| chr1_-_145910031 Show fit | 1.30 |
ENST00000369304.8
|
integrin subunit alpha 10 |
|
| chr1_+_61081728 Show fit | 1.23 |
ENST00000371189.8
|
nuclear factor I A |
|
| chr1_+_61082398 Show fit | 1.23 |
ENST00000664149.1
|
nuclear factor I A |
|
| chr9_-_90642855 Show fit | 1.18 |
ENST00000637905.1
|
DIRAS family GTPase 2 |
|
| chr1_-_145910066 Show fit | 1.14 |
ENST00000539363.2
|
integrin subunit alpha 10 |
|
| chr2_-_182242031 Show fit | 1.00 |
ENST00000358139.6
|
phosphodiesterase 1A |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 2.4 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.1 | 1.9 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.0 | 1.4 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.1 | 1.0 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.0 | 1.0 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.8 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 0.7 | GO:1901187 | regulation of ephrin receptor signaling pathway(GO:1901187) |
| 0.1 | 0.7 | GO:0060054 | positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054) |
| 0.0 | 0.7 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.4 | GO:0034680 | integrin alpha10-beta1 complex(GO:0034680) |
| 0.1 | 1.9 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 1.5 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 0.6 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 0.5 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.1 | 0.4 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.1 | 0.4 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 0.4 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.0 | 0.4 | GO:0035748 | myelin sheath abaxonal region(GO:0035748) |
| 0.0 | 0.4 | GO:0000421 | autophagosome membrane(GO:0000421) dendrite membrane(GO:0032590) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.4 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.1 | 1.4 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.2 | 1.0 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 0.8 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.2 | 0.7 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
| 0.0 | 0.7 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 0.6 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.2 | 0.5 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.0 | 0.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.4 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 0.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.0 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.7 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.5 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 0.4 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.3 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.3 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.2 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |