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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for IRX6_IRX4

Z-value: 0.20

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
ENSG00000159387.8 IRX6
ENSG00000113430.10 IRX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg38_v1_chr5_-_1882902_1882932,
hg38_v1_chr5_-_1886938_1886984
-0.301.4e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_+_41359599 0.44 ENST00000513024.5
LIM and calponin homology domains 1
chr1_+_61082398 0.31 ENST00000664149.1
nuclear factor I A
chr1_+_61081728 0.25 ENST00000371189.8
nuclear factor I A
chr12_+_32502114 0.24 ENST00000682739.1
ENST00000427716.7
ENST00000583694.2
FYVE, RhoGEF and PH domain containing 4
chr3_-_169147734 0.20 ENST00000464456.5
MDS1 and EVI1 complex locus
chr15_+_66293217 0.17 ENST00000319194.9
ENST00000525134.6
DIS3 like exosome 3'-5' exoribonuclease
chr15_+_66293541 0.16 ENST00000319212.9
ENST00000525109.1
DIS3 like exosome 3'-5' exoribonuclease
chr8_-_17697654 0.15 ENST00000297488.10
microtubule associated scaffold protein 1
chr14_-_23154369 0.14 ENST00000453702.5
solute carrier family 7 member 8
chr20_+_10218808 0.14 ENST00000254976.7
ENST00000304886.6
synaptosome associated protein 25
chr14_-_23155302 0.14 ENST00000529705.6
solute carrier family 7 member 8
chr17_-_49646581 0.12 ENST00000510476.5
ENST00000503676.5
speckle type BTB/POZ protein
chr2_-_182242031 0.11 ENST00000358139.6
phosphodiesterase 1A
chr4_+_140343443 0.11 ENST00000338517.8
ENST00000394203.7
ENST00000506322.5
short coiled-coil protein
chr1_+_63523490 0.11 ENST00000371088.5
EF-hand calcium binding domain 7
chr19_+_50188180 0.09 ENST00000598205.5
myosin heavy chain 14
chr6_+_116369837 0.08 ENST00000645988.1
dermatan sulfate epimerase
chr3_-_9952337 0.08 ENST00000411976.2
ENST00000412055.6
proline rich transmembrane protein 3
chr20_+_56358938 0.07 ENST00000371384.4
ENST00000437418.1
family with sequence similarity 210 member B
chr1_+_220094086 0.07 ENST00000366922.3
isoleucyl-tRNA synthetase 2, mitochondrial
chrX_+_100644183 0.06 ENST00000640889.1
ENST00000373004.5
sushi repeat containing protein X-linked 2
chr15_-_63156774 0.06 ENST00000462430.5
ribosomal protein S27 like
chr4_+_40193642 0.06 ENST00000617441.4
ENST00000503941.5
ras homolog family member H
chr14_-_23154422 0.05 ENST00000422941.6
solute carrier family 7 member 8
chr4_-_103198331 0.05 ENST00000265148.9
ENST00000514974.1
centromere protein E
chr4_-_103198371 0.05 ENST00000611174.4
ENST00000380026.8
centromere protein E
chr6_-_52840843 0.05 ENST00000370989.6
glutathione S-transferase alpha 5
chr11_-_35526024 0.05 ENST00000615849.4
peptidase domain containing associated with muscle regeneration 1
chr14_+_55661272 0.04 ENST00000555573.5
kinectin 1
chr1_+_67207614 0.04 ENST00000425614.3
interleukin 23 receptor
chr9_-_41189310 0.04 ENST00000456520.5
ENST00000377391.8
ENST00000613716.4
ENST00000617933.1
COBW domain containing 6
chr2_+_159733958 0.04 ENST00000409591.5
membrane associated ring-CH-type finger 7
chr2_+_113072318 0.04 ENST00000393197.3
interleukin 1 family member 10
chr6_-_33711684 0.04 ENST00000374231.8
ENST00000607484.6
ubiquinol-cytochrome c reductase complex assembly factor 2
chr9_+_68241854 0.03 ENST00000616550.4
ENST00000618217.4
ENST00000377342.9
ENST00000478048.5
ENST00000360171.11
COBW domain containing 3
chr9_+_65675834 0.03 ENST00000377392.9
ENST00000377384.5
ENST00000430059.6
ENST00000429800.6
ENST00000382405.8
ENST00000377395.8
COBW domain containing 5
chr17_-_31314066 0.03 ENST00000577894.1
ecotropic viral integration site 2B
chr3_+_111911604 0.03 ENST00000495180.1
pleckstrin homology like domain family B member 2
chr4_+_129096144 0.03 ENST00000425929.6
ENST00000508622.1
chromosome 4 open reading frame 33
chr1_-_38881587 0.03 ENST00000357771.5
ENST00000621281.1
gap junction protein alpha 9
novel protein
chrY_-_6874027 0.02 ENST00000215479.10
amelogenin Y-linked
chr13_+_111186773 0.02 ENST00000426073.6
Rho guanine nucleotide exchange factor 7
chr5_-_177780633 0.02 ENST00000513554.5
ENST00000440605.7
family with sequence similarity 153 member A
chr12_-_123633604 0.02 ENST00000534960.5
ENST00000424014.7
eukaryotic translation initiation factor 2B subunit alpha
chr7_-_93226449 0.02 ENST00000394468.7
ENST00000453812.2
HEPACAM family member 2
chrX_+_22136552 0.02 ENST00000682888.1
ENST00000684356.1
phosphate regulating endopeptidase homolog X-linked
chr8_+_67064316 0.02 ENST00000675306.2
ENST00000678017.1
ENST00000262210.11
ENST00000675869.1
ENST00000677009.1
ENST00000676847.1
ENST00000676471.1
ENST00000678542.1
ENST00000677619.1
ENST00000676605.1
ENST00000678553.1
ENST00000674993.1
ENST00000678318.1
ENST00000676573.1
ENST00000676317.1
ENST00000677592.1
ENST00000679226.1
ENST00000675955.1
ENST00000676882.1
ENST00000678616.1
ENST00000678645.1
ENST00000678747.1
centrosome and spindle pole associated protein 1
chrX_-_15315615 0.02 ENST00000380470.7
ENST00000480796.6
ankyrin repeat and SOCS box containing 11
chr12_+_5432101 0.02 ENST00000423158.4
neurotrophin 3
chr4_-_176269213 0.01 ENST00000296525.7
ankyrin repeat and SOCS box containing 5
chr12_-_10130143 0.01 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
C-type lectin domain containing 7A
chr5_+_36608146 0.01 ENST00000381918.4
ENST00000513646.1
solute carrier family 1 member 3
chr20_+_45361936 0.01 ENST00000372727.5
ENST00000414310.5
SYS1 golgi trafficking protein
chr16_+_727246 0.01 ENST00000561546.5
ENST00000564545.1
ENST00000567414.5
ENST00000568141.5
hydroxyacylglutathione hydrolase like
chr12_-_10130241 0.01 ENST00000353231.9
ENST00000525605.1
C-type lectin domain containing 7A
chr2_-_55917699 0.01 ENST00000634374.1
EGF containing fibulin extracellular matrix protein 1
chr3_+_68004231 0.01 ENST00000478136.6
TAFA chemokine like family member 1
chr12_-_10130082 0.01 ENST00000533022.5
C-type lectin domain containing 7A
chr6_-_49866527 0.01 ENST00000335847.9
cysteine rich secretory protein 1
chr12_-_76068933 0.01 ENST00000552056.5
nucleosome assembly protein 1 like 1
chr16_+_726936 0.00 ENST00000549114.5
ENST00000341413.8
ENST00000562187.1
ENST00000564537.5
ENST00000389703.8
hydroxyacylglutathione hydrolase like
chr2_+_225399684 0.00 ENST00000636099.1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr6_-_49866453 0.00 ENST00000507853.5
cysteine rich secretory protein 1
chr12_+_53454764 0.00 ENST00000439930.7
ENST00000548933.5
poly(rC) binding protein 2
chr6_+_149566356 0.00 ENST00000367419.10
glycoprotein integral membrane 1
chr12_-_31792290 0.00 ENST00000340398.5
H3.5 histone
chr4_+_40192989 0.00 ENST00000508513.5
ras homolog family member H

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.1 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.5 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.0 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.0 GO:0072536 interleukin-23 receptor complex(GO:0072536)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.0 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)