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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for ISL2

Z-value: 0.52

Motif logo

Transcription factors associated with ISL2

Gene Symbol Gene ID Gene Info
ENSG00000159556.10 ISL2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL2hg38_v1_chr15_+_76336755_76336779-0.125.7e-01Click!

Activity profile of ISL2 motif

Sorted Z-values of ISL2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr19_+_14583076 2.12 ENST00000547437.5
ENST00000417570.6
C-type lectin domain containing 17A
chr12_-_57818704 1.09 ENST00000549994.1
advillin
chr9_+_72577939 1.01 ENST00000645773.1
transmembrane channel like 1
chr21_-_30487436 0.61 ENST00000334055.5
keratin associated protein 19-2
chr9_+_72577369 0.60 ENST00000651183.1
transmembrane channel like 1
chr9_+_72577788 0.56 ENST00000645208.2
transmembrane channel like 1
chr17_-_3592877 0.50 ENST00000399756.8
transient receptor potential cation channel subfamily V member 1
chr11_+_28108248 0.47 ENST00000406787.7
ENST00000403099.5
ENST00000407364.8
methyltransferase like 15
chr4_+_127781815 0.45 ENST00000508776.5
heat shock protein family A (Hsp70) member 4 like
chr7_-_120858066 0.42 ENST00000222747.8
tetraspanin 12
chr14_+_38207893 0.40 ENST00000267377.3
somatostatin receptor 1
chr3_+_42979281 0.40 ENST00000488863.5
ENST00000430121.3
golgi associated kinase 1A
chr4_+_94207596 0.39 ENST00000359052.8
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr3_-_142029108 0.39 ENST00000497579.5
transcription factor Dp-2
chr1_+_14929734 0.36 ENST00000376028.8
ENST00000400798.6
kazrin, periplakin interacting protein
chr11_+_5389377 0.33 ENST00000328611.5
olfactory receptor family 51 subfamily M member 1
chr1_+_149899561 0.32 ENST00000369152.6
bolA family member 1
chr6_-_111483700 0.32 ENST00000435970.5
ENST00000358835.7
REV3 like, DNA directed polymerase zeta catalytic subunit
chr2_-_197675578 0.32 ENST00000295049.9
raftlin family member 2
chr4_-_137532452 0.32 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
protocadherin 18
chr7_-_116030750 0.31 ENST00000265440.12
ENST00000320239.11
transcription factor EC
chrX_-_31266925 0.31 ENST00000680557.1
ENST00000378680.6
ENST00000378723.7
ENST00000680768.2
ENST00000681870.1
ENST00000680355.1
ENST00000682322.1
ENST00000682600.1
ENST00000680162.2
ENST00000681153.1
ENST00000681334.1
dystrophin
chr15_+_48191648 0.29 ENST00000646012.1
ENST00000561127.5
ENST00000647546.1
ENST00000559641.5
ENST00000417307.3
solute carrier family 12 member 1
cortexin 2
chrX_-_32155462 0.28 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
dystrophin
chr9_+_12693327 0.28 ENST00000388918.10
tyrosinase related protein 1
chr14_-_67412112 0.27 ENST00000216446.9
pleckstrin 2
chr13_+_77741160 0.26 ENST00000314070.9
ENST00000351546.7
SLAIN motif family member 1
chr7_-_116030735 0.25 ENST00000393485.5
transcription factor EC
chr10_+_94762673 0.24 ENST00000480405.2
ENST00000371321.9
cytochrome P450 family 2 subfamily C member 19
chr2_+_167135901 0.24 ENST00000628543.2
xin actin binding repeat containing 2
chr10_-_27240505 0.24 ENST00000375888.5
ENST00000676732.1
acyl-CoA binding domain containing 5
chr1_-_223665685 0.23 ENST00000366872.10
calpain 8
chr12_-_95116967 0.22 ENST00000551521.5
FYVE, RhoGEF and PH domain containing 6
chr14_+_101809795 0.22 ENST00000350249.7
ENST00000557621.5
ENST00000556946.1
protein phosphatase 2 regulatory subunit B'gamma
chr7_-_24757926 0.22 ENST00000342947.9
ENST00000419307.6
gasdermin E
chr5_+_132873660 0.22 ENST00000296877.3
liver enriched antimicrobial peptide 2
chr7_-_120857124 0.21 ENST00000441017.5
ENST00000424710.5
ENST00000433758.5
tetraspanin 12
chr6_+_151239951 0.21 ENST00000402676.7
A-kinase anchoring protein 12
chr12_+_130953898 0.20 ENST00000261654.10
adhesion G protein-coupled receptor D1
chr11_+_86374736 0.20 ENST00000354755.5
ENST00000531271.5
ENST00000445632.7
coiled-coil domain containing 81
chr6_+_130018565 0.19 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL histone methyl-lysine binding protein 3
chr11_-_28108109 0.19 ENST00000263181.7
kinesin family member 18A
chr12_-_56741535 0.19 ENST00000647707.1
novel protein
chr13_+_48976597 0.19 ENST00000541916.5
fibronectin type III domain containing 3A
chr16_+_86566821 0.18 ENST00000649859.1
forkhead box C2
chr4_+_94207845 0.17 ENST00000457823.6
ENST00000354268.9
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr12_+_64404338 0.17 ENST00000332707.10
exportin for tRNA
chr9_-_96778053 0.16 ENST00000375231.5
ENST00000223428.9
zinc finger protein 510
chr7_-_42152396 0.16 ENST00000642432.1
ENST00000647255.1
ENST00000677288.1
GLI family zinc finger 3
chrY_+_18546691 0.15 ENST00000309834.8
ENST00000307393.3
ENST00000382856.2
heat shock transcription factor Y-linked 1
chr2_+_87748087 0.14 ENST00000359481.9
plasminogen like B2
chr1_-_228425350 0.14 ENST00000366696.2
H3.4 histone
chr2_-_87021844 0.14 ENST00000355705.4
ENST00000409310.6
plasminogen like B1
chr7_-_138679045 0.14 ENST00000419765.4
SVOP like
chrX_-_31266857 0.13 ENST00000378702.8
ENST00000361471.8
dystrophin
chr1_-_225428813 0.13 ENST00000338179.6
ENST00000425080.1
lamin B receptor
chr6_-_155455830 0.13 ENST00000159060.3
NADPH oxidase 3
chr17_-_7404039 0.13 ENST00000576017.1
ENST00000302422.4
transmembrane protein 256
chr17_-_10469558 0.13 ENST00000255381.2
myosin heavy chain 4
chr10_+_61662921 0.12 ENST00000648843.3
ENST00000330194.2
ENST00000389639.3
ciliary associated calcium binding coiled-coil 1
chr12_-_95551417 0.12 ENST00000258499.8
ubiquitin specific peptidase 44
chr17_+_4807119 0.12 ENST00000263088.11
ENST00000572940.5
phospholipase D2
chr9_-_14300231 0.12 ENST00000636735.1
nuclear factor I B
chrX_-_77634229 0.11 ENST00000675732.1
ATRX chromatin remodeler
chr17_-_8119047 0.11 ENST00000318227.4
arachidonate lipoxygenase 3
chr3_-_191282383 0.11 ENST00000427544.6
urotensin 2B
chr5_-_140346596 0.11 ENST00000230990.7
heparin binding EGF like growth factor
chr21_+_38272410 0.10 ENST00000398934.5
ENST00000398930.5
potassium inwardly rectifying channel subfamily J member 15
chrM_+_9207 0.10 ENST00000362079.2
mitochondrially encoded cytochrome c oxidase III
chr11_-_124320197 0.09 ENST00000624618.2
olfactory receptor family 8 subfamily D member 2
chr9_-_92404559 0.09 ENST00000262551.8
ENST00000375561.10
osteoglycin
chr15_+_78873723 0.09 ENST00000559690.5
ENST00000559158.5
mortality factor 4 like 1
chrX_+_109535775 0.09 ENST00000218004.5
nuclear transport factor 2 like export factor 2
chr3_+_169911566 0.08 ENST00000428432.6
ENST00000335556.7
sterile alpha motif domain containing 7
chr19_+_4402615 0.08 ENST00000301280.10
chromatin assembly factor 1 subunit A
chr2_+_32277883 0.08 ENST00000238831.9
Yip1 domain family member 4
chr12_-_118190510 0.08 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chr2_+_233760265 0.08 ENST00000305208.10
ENST00000360418.4
UDP glucuronosyltransferase family 1 member A1
chr5_+_90640718 0.07 ENST00000640403.1
adhesion G protein-coupled receptor V1
chr11_+_35186820 0.07 ENST00000531110.6
ENST00000525685.6
CD44 molecule (Indian blood group)
chrX_-_15314543 0.07 ENST00000344384.8
ankyrin repeat and SOCS box containing 11
chr5_+_154755272 0.07 ENST00000518297.6
La ribonucleoprotein 1, translational regulator
chr2_-_84881238 0.07 ENST00000335459.9
TraB domain containing 2A
chr15_+_58410543 0.06 ENST00000356113.10
ENST00000414170.7
lipase C, hepatic type
chr10_-_49188380 0.06 ENST00000374153.7
ENST00000374148.1
ENST00000374151.7
transmembrane protein 273
chr10_-_93482326 0.06 ENST00000359263.9
myoferlin
chr6_+_31137646 0.06 ENST00000547221.1
psoriasis susceptibility 1 candidate 1
chr1_+_117001744 0.06 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101 molecule
chr7_-_45111673 0.06 ENST00000461363.1
ENST00000258770.8
ENST00000495078.1
ENST00000494076.5
ENST00000478532.5
ENST00000361278.7
transforming growth factor beta regulator 4
chr10_-_5003850 0.06 ENST00000421196.7
ENST00000455190.2
ENST00000380753.8
aldo-keto reductase family 1 member C2
chr16_+_53099100 0.05 ENST00000565832.5
chromodomain helicase DNA binding protein 9
chr3_-_20186127 0.05 ENST00000425061.5
ENST00000443724.5
ENST00000421451.5
ENST00000452020.5
ENST00000417364.1
ENST00000306698.6
ENST00000419233.6
ENST00000263753.8
ENST00000437051.5
ENST00000442720.5
ENST00000412997.6
shugoshin 1
chr1_+_98661666 0.05 ENST00000529992.5
sorting nexin 7
chr6_+_63635792 0.05 ENST00000262043.8
ENST00000506783.5
ENST00000481385.6
ENST00000515594.5
ENST00000494284.6
PHD finger protein 3
chr11_-_95923763 0.05 ENST00000497683.6
ENST00000470293.6
ENST00000674968.1
ENST00000484818.6
ENST00000675454.1
ENST00000675981.1
ENST00000674924.1
ENST00000676166.1
ENST00000676440.1
ENST00000675807.1
ENST00000495134.6
ENST00000675196.1
myotubularin related protein 2
chr3_-_20012250 0.05 ENST00000389050.5
protein phosphatase 2C like domain containing 1
chr5_-_131165231 0.05 ENST00000675100.1
ENST00000304043.10
ENST00000513012.2
histidine triad nucleotide binding protein 1
chr14_+_92323154 0.04 ENST00000532405.6
ENST00000676001.1
ENST00000531433.5
solute carrier family 24 member 4
chr3_+_160225409 0.04 ENST00000326474.5
chromosome 3 open reading frame 80
chr8_-_124565699 0.04 ENST00000519168.5
MTSS I-BAR domain containing 1
chr10_-_93482194 0.04 ENST00000358334.9
ENST00000371488.3
myoferlin
chr1_+_149899618 0.04 ENST00000369150.1
bolA family member 1
chr17_-_5035418 0.04 ENST00000254853.10
ENST00000424747.1
solute carrier family 52 member 1
chr17_+_10697576 0.04 ENST00000379774.5
ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
chr4_+_15469865 0.04 ENST00000515124.6
ENST00000512702.6
ENST00000503292.6
ENST00000424120.6
ENST00000507954.5
ENST00000514450.3
ENST00000503658.2
coiled-coil and C2 domain containing 2A
chr17_-_66229380 0.04 ENST00000205948.11
apolipoprotein H
chr12_-_54295748 0.04 ENST00000540264.2
ENST00000312156.8
nuclear factor, erythroid 2
chr11_-_5301946 0.04 ENST00000380224.2
olfactory receptor family 51 subfamily B member 4
chr5_-_131165272 0.04 ENST00000675491.1
ENST00000506908.2
histidine triad nucleotide binding protein 1
chrX_+_66164340 0.04 ENST00000441993.7
ENST00000419594.6
ENST00000425114.2
hephaestin
chr12_+_26011713 0.04 ENST00000542004.5
Ras association domain family member 8
chr8_+_106726115 0.04 ENST00000521592.5
oxidation resistance 1
chr2_+_233671879 0.04 ENST00000354728.5
UDP glucuronosyltransferase family 1 member A9
chr6_+_26402289 0.03 ENST00000414912.2
butyrophilin subfamily 3 member A1
chr1_+_62597510 0.03 ENST00000371129.4
angiopoietin like 3
chr11_-_95924067 0.03 ENST00000676027.1
ENST00000675489.1
ENST00000409459.5
ENST00000676261.1
ENST00000352297.11
ENST00000346299.10
ENST00000676272.1
ENST00000393223.8
ENST00000675022.1
ENST00000675362.1
ENST00000675174.1
ENST00000674989.1
ENST00000675848.1
ENST00000675652.1
ENST00000481642.6
myotubularin related protein 2
chr21_+_14216145 0.03 ENST00000400577.4
RNA binding motif protein 11
chr5_+_40841308 0.03 ENST00000381677.4
ENST00000254691.10
caspase recruitment domain family member 6
chr1_-_247760556 0.02 ENST00000641256.1
olfactory receptor family 1 subfamily C member 1
chrX_+_55452119 0.02 ENST00000342972.3
MAGE family member H1
chr9_-_21368962 0.02 ENST00000610660.1
interferon alpha 13
chr12_+_75391078 0.02 ENST00000550916.6
ENST00000378692.7
ENST00000320460.8
ENST00000547164.1
GLIPR1 like 2
chr5_+_40909490 0.02 ENST00000313164.10
complement C7
chr1_-_178871022 0.02 ENST00000367629.1
angiopoietin like 1
chr14_+_21997531 0.02 ENST00000390445.2
T cell receptor alpha variable 17
chr17_+_1771688 0.02 ENST00000572048.1
ENST00000573763.1
serpin family F member 1
chr5_+_140875299 0.02 ENST00000613593.1
ENST00000398631.3
protocadherin alpha 12
chr20_-_52105644 0.02 ENST00000371523.8
ZFP64 zinc finger protein
chr14_-_90331904 0.02 ENST00000628832.1
ENST00000354366.8
NRDE-2, necessary for RNA interference, domain containing
chr17_-_40999903 0.02 ENST00000391587.3
keratin associated protein 3-2
chr4_-_174263080 0.02 ENST00000615392.4
F-box protein 8
chr1_-_13056575 0.02 ENST00000436041.6
PRAME family member 27
chrX_-_49073989 0.01 ENST00000376386.3
ENST00000553851.3
PRA1 domain family member 2
chr2_+_113067970 0.01 ENST00000341010.6
interleukin 1 family member 10
chr2_+_233917371 0.01 ENST00000324695.9
ENST00000433712.6
transient receptor potential cation channel subfamily M member 8
chr21_-_30492008 0.01 ENST00000334063.6
keratin associated protein 19-3
chr12_-_10130241 0.01 ENST00000353231.9
ENST00000525605.1
C-type lectin domain containing 7A
chr12_-_10130143 0.01 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
C-type lectin domain containing 7A
chr2_-_158380960 0.01 ENST00000409187.5
coiled-coil domain containing 148
chr2_-_135876382 0.01 ENST00000264156.3
minichromosome maintenance complex component 6
chr18_-_36798482 0.00 ENST00000590258.2
tubulin polyglutamylase complex subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.5 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.1 0.4 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 0.2 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.1 0.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.5 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.2 GO:0022018 subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875)
0.0 0.1 GO:0099404 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.0 0.2 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.6 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.3 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:1901355 response to rapamycin(GO:1901355)
0.0 0.1 GO:1904808 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.0 0.3 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 1.1 GO:0051693 actin filament capping(GO:0051693)
0.0 0.6 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.1 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.7 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0042806 fucose binding(GO:0042806)
0.2 2.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.5 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.1 0.3 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 0.5 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 0.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166) nitric-oxide synthase binding(GO:0050998)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction