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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for KLF16_SP2
Z-value: 1.12
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF16 | hg38_v1_chr19_-_1863497_1863587 | -0.32 | 1.2e-01 | Click! |
| SP2 | hg38_v1_chr17_+_47896150_47896262 | -0.08 | 6.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_11197516 Show fit | 5.30 |
ENST00000592903.5
ENST00000586659.6 ENST00000589359.5 ENST00000588724.5 |
KN motif and ankyrin repeat domains 2 |
|
| chr2_+_11155498 Show fit | 4.21 |
ENST00000402361.5
ENST00000428481.1 |
solute carrier family 66 member 3 |
|
| chr3_+_37861926 Show fit | 3.96 |
ENST00000443503.6
|
CTD small phosphatase like |
|
| chr6_+_35452314 Show fit | 3.57 |
ENST00000229769.3
|
FA complementation group E |
|
| chr8_-_144465343 Show fit | 3.10 |
ENST00000526887.5
ENST00000533764.5 ENST00000403000.6 ENST00000306145.10 |
cysteine and histidine rich 1 |
|
| chr1_+_25616780 Show fit | 3.10 |
ENST00000374332.9
|
mannosidase alpha class 1C member 1 |
|
| chr7_-_27174253 Show fit | 2.94 |
ENST00000613671.1
|
homeobox A10 |
|
| chr20_+_59933761 Show fit | 2.91 |
ENST00000358293.7
|
family with sequence similarity 217 member B |
|
| chr11_+_7513966 Show fit | 2.87 |
ENST00000299492.9
|
PPFIA binding protein 2 |
|
| chr19_+_45497221 Show fit | 2.85 |
ENST00000456399.6
|
protein phosphatase, Mg2+/Mn2+ dependent 1N (putative) |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.4 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 0.2 | 8.9 | GO:0060065 | uterus development(GO:0060065) |
| 0.0 | 8.2 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 7.8 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.5 | 6.6 | GO:0021853 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.3 | 6.1 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.1 | 5.9 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.1 | 5.8 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 1.8 | 5.3 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
| 1.1 | 5.3 | GO:2000690 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.2 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 8.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 8.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 7.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 7.7 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 7.7 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 7.6 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 7.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 6.7 | GO:0045095 | keratin filament(GO:0045095) |
| 1.2 | 5.9 | GO:0032449 | CBM complex(GO:0032449) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.4 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 7.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 6.6 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.5 | 6.5 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.1 | 5.9 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 4.9 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.6 | 4.7 | GO:0052832 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.4 | 4.5 | GO:0034485 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) |
| 0.3 | 4.2 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 4.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 9.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 8.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 4.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 3.8 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 3.6 | PID EPO PATHWAY | EPO signaling pathway |
| 0.1 | 2.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 2.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 6.5 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 6.1 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.1 | 6.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 5.0 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.1 | 4.7 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.0 | 4.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 4.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.2 | 4.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |