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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for KLF6

Z-value: 0.90

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Transcription factors associated with KLF6

Gene Symbol Gene ID Gene Info
KLF6
ENSG00000067082.15 KLF6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF6hg38_v1_chr10_-_3785225_37852810.519.5e-03Click!

Activity profile of KLF6 motif

Sorted Z-values of KLF6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_+_123135938 4.91 ENST00000357878.7
HMX3
H6 family homeobox 3
chr11_+_71527267 2.24 ENST00000398536.6
KRTAP5-7
keratin associated protein 5-7
chr10_-_73874461 1.94 ENST00000305762.11
CAMK2G
calcium/calmodulin dependent protein kinase II gamma
chr10_-_129964240 1.79 ENST00000440978.2
ENST00000355311.10
EBF3
EBF transcription factor 3
chr10_-_73874568 1.65 ENST00000322635.7
ENST00000322680.7
ENST00000394762.7
ENST00000680035.1
CAMK2G
calcium/calmodulin dependent protein kinase II gamma
chr4_+_4859658 1.52 ENST00000382723.5
MSX1
msh homeobox 1
chr13_+_31846713 1.42 ENST00000645780.1
FRY
FRY microtubule binding protein
chr17_-_49764123 1.39 ENST00000240364.7
ENST00000506156.1
FAM117A
family with sequence similarity 117 member A
chr1_+_37474572 1.32 ENST00000373087.7
ZC3H12A
zinc finger CCCH-type containing 12A
chr20_+_43914801 1.31 ENST00000341197.9
TOX2
TOX high mobility group box family member 2
chr4_+_41360759 1.23 ENST00000508501.5
ENST00000512946.5
ENST00000313860.11
ENST00000512632.5
ENST00000512820.5
LIMCH1
LIM and calponin homology domains 1
chr1_+_113979460 1.14 ENST00000320334.5
OLFML3
olfactomedin like 3
chr1_+_113979391 1.14 ENST00000393300.6
ENST00000369551.5
OLFML3
olfactomedin like 3
chrX_+_151694967 1.14 ENST00000448726.5
ENST00000538575.5
PRRG3
proline rich and Gla domain 3
chr2_-_85888958 1.12 ENST00000377332.8
ENST00000639119.1
ENST00000638572.2
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr2_-_43226594 1.06 ENST00000282388.4
ZFP36L2
ZFP36 ring finger protein like 2
chr2_-_85888685 1.05 ENST00000638178.1
ENST00000640982.1
ENST00000640992.1
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr10_+_110871789 1.03 ENST00000393104.6
PDCD4
programmed cell death 4
chr17_+_63477052 0.96 ENST00000290866.10
ENST00000428043.5
ACE
angiotensin I converting enzyme
chr5_-_108381109 0.93 ENST00000619412.4
FBXL17
F-box and leucine rich repeat protein 17
chr16_+_29806519 0.92 ENST00000322945.11
ENST00000562337.5
ENST00000566906.6
ENST00000563402.1
ENST00000219782.10
MAZ
MYC associated zinc finger protein
chr7_-_27174274 0.91 ENST00000283921.5
HOXA10
homeobox A10
chr7_-_27174253 0.90 ENST00000613671.1
HOXA10
homeobox A10
chr17_+_7834200 0.89 ENST00000448097.7
KDM6B
lysine demethylase 6B
chr16_+_30395400 0.89 ENST00000320159.2
ENST00000613509.2
ZNF48
zinc finger protein 48
chr2_-_85888897 0.89 ENST00000639305.1
ENST00000638986.1
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr22_-_37519528 0.85 ENST00000403299.5
CARD10
caspase recruitment domain family member 10
chr1_-_221742074 0.84 ENST00000366899.4
DUSP10
dual specificity phosphatase 10
chr1_+_33256479 0.84 ENST00000539719.6
ENST00000483388.5
ZNF362
zinc finger protein 362
chr22_-_37519349 0.81 ENST00000251973.10
CARD10
caspase recruitment domain family member 10
chr1_-_114153863 0.80 ENST00000610222.3
ENST00000369547.6
ENST00000641643.2
SYT6
synaptotagmin 6
chr19_+_42284020 0.77 ENST00000160740.7
CIC
capicua transcriptional repressor
chr8_-_79767843 0.77 ENST00000337919.9
HEY1
hes related family bHLH transcription factor with YRPW motif 1
chr19_-_17245889 0.77 ENST00000291442.4
NR2F6
nuclear receptor subfamily 2 group F member 6
chr10_-_73874502 0.77 ENST00000372765.5
ENST00000351293.7
ENST00000441192.2
ENST00000423381.6
CAMK2G
calcium/calmodulin dependent protein kinase II gamma
chr1_-_211579064 0.77 ENST00000367001.5
SLC30A1
solute carrier family 30 member 1
chr12_+_57089094 0.76 ENST00000342556.6
ENST00000300131.8
NAB2
NGFI-A binding protein 2
chr17_+_67825494 0.74 ENST00000306378.11
ENST00000544778.6
BPTF
bromodomain PHD finger transcription factor
chr5_+_138465472 0.73 ENST00000239938.5
EGR1
early growth response 1
chr14_-_29927473 0.73 ENST00000616995.4
PRKD1
protein kinase D1
chr14_-_29927801 0.73 ENST00000331968.11
PRKD1
protein kinase D1
chr6_+_11537738 0.72 ENST00000379426.2
TMEM170B
transmembrane protein 170B
chr1_-_94541746 0.72 ENST00000334047.12
F3
coagulation factor III, tissue factor
chr12_-_49828394 0.72 ENST00000335999.7
NCKAP5L
NCK associated protein 5 like
chr11_+_44726811 0.71 ENST00000533202.5
ENST00000520358.7
ENST00000533080.5
ENST00000520999.6
TSPAN18
tetraspanin 18
chr11_-_2885728 0.71 ENST00000647251.1
ENST00000380725.2
ENST00000430149.3
ENST00000414822.8
ENST00000440480.8
CDKN1C
cyclin dependent kinase inhibitor 1C
chr6_-_31897200 0.70 ENST00000395728.7
ENST00000375528.8
EHMT2
euchromatic histone lysine methyltransferase 2
chr17_+_67825664 0.69 ENST00000321892.8
BPTF
bromodomain PHD finger transcription factor
chr14_-_29927596 0.69 ENST00000415220.6
PRKD1
protein kinase D1
chr8_-_79767462 0.68 ENST00000674295.1
ENST00000518733.1
ENST00000674418.1
ENST00000674358.1
ENST00000354724.8
HEY1
hes related family bHLH transcription factor with YRPW motif 1
chr14_-_105168753 0.67 ENST00000331782.8
ENST00000347004.2
JAG2
jagged canonical Notch ligand 2
chr7_-_140478975 0.67 ENST00000474576.5
ENST00000473444.1
ENST00000471104.5
MKRN1
makorin ring finger protein 1
chr16_+_31459950 0.64 ENST00000564900.1
ARMC5
armadillo repeat containing 5
chr21_-_26845402 0.64 ENST00000284984.8
ENST00000676955.1
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif 1
chr2_+_45651650 0.62 ENST00000306156.8
PRKCE
protein kinase C epsilon
chr12_+_19129779 0.61 ENST00000539256.5
ENST00000299275.10
ENST00000538714.5
PLEKHA5
pleckstrin homology domain containing A5
chr6_-_110179995 0.61 ENST00000392586.5
ENST00000419252.1
ENST00000359451.6
ENST00000392588.5
WASF1
WASP family member 1
chr17_-_42121330 0.61 ENST00000225916.10
KAT2A
lysine acetyltransferase 2A
chr12_-_94650506 0.61 ENST00000261226.9
TMCC3
transmembrane and coiled-coil domain family 3
chr15_+_96330691 0.60 ENST00000394166.8
NR2F2
nuclear receptor subfamily 2 group F member 2
chr16_+_68085344 0.59 ENST00000575270.5
ENST00000346183.8
NFATC3
nuclear factor of activated T cells 3
chr11_-_63768762 0.59 ENST00000433688.2
C11orf95
chromosome 11 open reading frame 95
chr10_+_110871903 0.58 ENST00000280154.12
PDCD4
programmed cell death 4
chr10_-_102114935 0.58 ENST00000361198.9
LDB1
LIM domain binding 1
chr4_-_13484313 0.58 ENST00000330852.10
ENST00000288723.9
ENST00000338176.8
ENST00000630951.1
RAB28
RAB28, member RAS oncogene family
chr1_+_87331668 0.58 ENST00000370542.1
LMO4
LIM domain only 4
chr6_-_110179702 0.58 ENST00000392587.6
WASF1
WASP family member 1
chr1_-_21937300 0.56 ENST00000374695.8
HSPG2
heparan sulfate proteoglycan 2
chr3_-_125055987 0.56 ENST00000311127.9
HEG1
heart development protein with EGF like domains 1
chr11_-_119364166 0.56 ENST00000525735.1
USP2
ubiquitin specific peptidase 2
chr2_-_219543793 0.56 ENST00000243776.11
CHPF
chondroitin polymerizing factor
chr2_+_20667136 0.55 ENST00000272224.5
GDF7
growth differentiation factor 7
chr3_+_124584625 0.55 ENST00000291478.9
ENST00000682363.1
ENST00000454902.1
KALRN
kalirin RhoGEF kinase
chr16_+_68085420 0.55 ENST00000349223.9
NFATC3
nuclear factor of activated T cells 3
chr19_+_34254543 0.55 ENST00000588470.5
ENST00000299505.8
ENST00000589583.5
GARRE1
granule associated Rac and RHOG effector 1
chr9_+_112750722 0.55 ENST00000374232.8
SNX30
sorting nexin family member 30
chr15_-_55743086 0.54 ENST00000561292.1
ENST00000389286.9
PRTG
protogenin
chr3_+_50155305 0.53 ENST00000002829.8
ENST00000426511.5
SEMA3F
semaphorin 3F
chr5_-_81751022 0.53 ENST00000509013.2
ENST00000505980.5
ENST00000509053.5
SSBP2
single stranded DNA binding protein 2
chr3_-_15859771 0.52 ENST00000399451.6
ANKRD28
ankyrin repeat domain 28
chr11_+_64234569 0.52 ENST00000309422.7
ENST00000426086.3
VEGFB
vascular endothelial growth factor B
chr9_+_127611760 0.52 ENST00000625363.2
ENST00000626539.3
STXBP1
syntaxin binding protein 1
chr6_-_110179623 0.52 ENST00000265601.7
ENST00000447287.5
ENST00000392589.6
ENST00000444391.5
WASF1
WASP family member 1
chr16_+_68085552 0.52 ENST00000329524.8
NFATC3
nuclear factor of activated T cells 3
chr4_-_25862979 0.52 ENST00000399878.8
SEL1L3
SEL1L family member 3
chr17_-_21253398 0.51 ENST00000611551.1
NATD1
N-acetyltransferase domain containing 1
chr19_+_1249870 0.51 ENST00000591446.6
MIDN
midnolin
chr16_+_31459479 0.51 ENST00000268314.9
ARMC5
armadillo repeat containing 5
chr1_+_86914616 0.51 ENST00000370550.10
ENST00000370551.8
HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr6_+_34889228 0.51 ENST00000360359.5
ENST00000649117.1
ENST00000650178.1
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr1_-_35557378 0.50 ENST00000325722.8
ENST00000469892.5
KIAA0319L
KIAA0319 like
chr9_+_2017383 0.50 ENST00000382194.6
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_+_50155024 0.50 ENST00000414301.5
ENST00000450338.5
ENST00000413852.5
SEMA3F
semaphorin 3F
chr10_+_74825445 0.49 ENST00000649006.1
ENST00000649463.1
ENST00000372725.6
KAT6B
lysine acetyltransferase 6B
chr6_+_107490103 0.49 ENST00000317357.10
SOBP
sine oculis binding protein homolog
chr18_+_62523002 0.48 ENST00000269499.10
ZCCHC2
zinc finger CCHC-type containing 2
chr12_-_57430956 0.47 ENST00000347140.7
ENST00000402412.5
R3HDM2
R3H domain containing 2
chr15_-_64775574 0.47 ENST00000300069.5
RBPMS2
RNA binding protein, mRNA processing factor 2
chr7_-_28958321 0.47 ENST00000539664.3
TRIL
TLR4 interactor with leucine rich repeats
chr2_-_73233206 0.47 ENST00000258083.3
PRADC1
protease associated domain containing 1
chrX_-_129654946 0.46 ENST00000429967.3
APLN
apelin
chr3_+_111071773 0.46 ENST00000485303.6
NECTIN3
nectin cell adhesion molecule 3
chr12_-_57430778 0.46 ENST00000448732.1
ENST00000634871.1
R3HDM2
R3H domain containing 2
chr20_+_34876603 0.46 ENST00000360596.7
ENST00000253382.5
ACSS2
acyl-CoA synthetase short chain family member 2
chr6_-_31897675 0.46 ENST00000375530.8
ENST00000375537.8
EHMT2
euchromatic histone lysine methyltransferase 2
chr11_+_68312542 0.45 ENST00000294304.12
LRP5
LDL receptor related protein 5
chr13_-_36920227 0.45 ENST00000379826.5
ENST00000350148.10
SMAD9
SMAD family member 9
chr7_-_87059639 0.45 ENST00000450689.7
ELAPOR2
endosome-lysosome associated apoptosis and autophagy regulator family member 2
chr1_+_26696348 0.45 ENST00000457599.6
ARID1A
AT-rich interaction domain 1A
chr4_-_101347492 0.45 ENST00000394854.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr9_-_107489754 0.44 ENST00000610832.1
ENST00000374672.5
KLF4
Kruppel like factor 4
chr20_-_31870216 0.44 ENST00000486996.5
ENST00000398084.6
DUSP15
dual specificity phosphatase 15
chr17_+_28744034 0.43 ENST00000444415.7
ENST00000262396.10
TRAF4
TNF receptor associated factor 4
chr9_+_126326809 0.43 ENST00000361171.8
ENST00000489637.3
MVB12B
multivesicular body subunit 12B
chr1_+_32072919 0.43 ENST00000438825.5
ENST00000336294.10
TMEM39B
transmembrane protein 39B
chr4_-_101347471 0.43 ENST00000323055.10
ENST00000512215.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr3_-_171460368 0.43 ENST00000436636.7
ENST00000465393.1
ENST00000341852.10
TNIK
TRAF2 and NCK interacting kinase
chr10_+_74826406 0.43 ENST00000648892.1
ENST00000647890.1
ENST00000372724.6
KAT6B
lysine acetyltransferase 6B
chr12_+_121626493 0.43 ENST00000617316.2
ORAI1
ORAI calcium release-activated calcium modulator 1
chr17_+_83079595 0.42 ENST00000320095.12
METRNL
meteorin like, glial cell differentiation regulator
chr13_-_44436801 0.42 ENST00000261489.6
TSC22D1
TSC22 domain family member 1
chr19_+_42284483 0.42 ENST00000575354.6
CIC
capicua transcriptional repressor
chr13_-_44437214 0.42 ENST00000622051.1
TSC22D1
TSC22 domain family member 1
chr22_-_20437785 0.42 ENST00000622235.5
ENST00000623402.1
SCARF2
scavenger receptor class F member 2
chr7_-_87059624 0.42 ENST00000444627.5
ELAPOR2
endosome-lysosome associated apoptosis and autophagy regulator family member 2
chr10_+_97498881 0.41 ENST00000370664.4
UBTD1
ubiquitin domain containing 1
chr11_-_66677748 0.41 ENST00000525754.5
ENST00000531969.5
ENST00000524637.1
ENST00000531036.2
ENST00000310046.9
RBM4B
RNA binding motif protein 4B
chr21_+_46324081 0.41 ENST00000359568.10
PCNT
pericentrin
chr16_+_53130921 0.41 ENST00000564845.5
CHD9
chromodomain helicase DNA binding protein 9
chr12_+_8914525 0.41 ENST00000543824.5
PHC1
polyhomeotic homolog 1
chr5_+_93584916 0.41 ENST00000647447.1
ENST00000615873.1
NR2F1
nuclear receptor subfamily 2 group F member 1
chr7_-_122886706 0.41 ENST00000313070.11
ENST00000334010.11
ENST00000615869.4
CADPS2
calcium dependent secretion activator 2
chr19_-_36032799 0.41 ENST00000592017.5
ENST00000360535.9
CLIP3
CAP-Gly domain containing linker protein 3
chr16_-_49856105 0.40 ENST00000563137.7
ZNF423
zinc finger protein 423
chr19_+_12938598 0.40 ENST00000586760.2
ENST00000316448.10
ENST00000588454.6
CALR
calreticulin
chr13_+_34942263 0.40 ENST00000379939.7
ENST00000400445.7
NBEA
neurobeachin
chr3_+_112562059 0.40 ENST00000261034.6
SLC35A5
solute carrier family 35 member A5
chr2_-_96116565 0.39 ENST00000620793.2
ADRA2B
adrenoceptor alpha 2B
chr16_+_29812230 0.39 ENST00000300797.7
ENST00000637403.1
ENST00000572820.2
ENST00000637064.1
ENST00000636246.1
PRRT2
proline rich transmembrane protein 2
chr6_+_71886900 0.39 ENST00000517960.5
ENST00000518273.5
ENST00000522291.5
ENST00000521978.5
ENST00000520567.5
ENST00000264839.11
RIMS1
regulating synaptic membrane exocytosis 1
chr16_-_28211476 0.39 ENST00000569951.1
ENST00000565698.5
XPO6
exportin 6
chr1_-_45206594 0.39 ENST00000359600.6
ZSWIM5
zinc finger SWIM-type containing 5
chr2_+_219442023 0.39 ENST00000431523.5
ENST00000396698.5
SPEG
striated muscle enriched protein kinase
chr1_-_205680486 0.38 ENST00000367145.4
SLC45A3
solute carrier family 45 member 3
chr3_+_9933805 0.38 ENST00000684493.1
ENST00000673935.2
ENST00000684181.1
ENST00000683189.1
ENST00000383811.8
ENST00000452070.6
ENST00000682642.1
ENST00000684659.1
ENST00000491527.2
ENST00000326434.9
ENST00000682783.1
ENST00000683835.1
ENST00000682570.1
CRELD1
cysteine rich with EGF like domains 1
chr8_-_8386429 0.38 ENST00000615670.5
PRAG1
PEAK1 related, kinase-activating pseudokinase 1
chr3_+_112562030 0.38 ENST00000468642.5
ENST00000492406.6
SLC35A5
solute carrier family 35 member A5
chrX_-_120561424 0.37 ENST00000681206.1
ENST00000679927.1
ENST00000336592.11
CUL4B
cullin 4B
chr14_+_74763308 0.37 ENST00000325680.12
ENST00000552421.5
YLPM1
YLP motif containing 1
chr5_+_79236092 0.37 ENST00000396137.5
JMY
junction mediating and regulatory protein, p53 cofactor
chr16_-_28211908 0.37 ENST00000566073.1
ENST00000304658.10
XPO6
exportin 6
chr12_-_57006476 0.37 ENST00000300101.3
ZBTB39
zinc finger and BTB domain containing 39
chr18_+_48539017 0.37 ENST00000256413.8
CTIF
cap binding complex dependent translation initiation factor
chr11_-_64810678 0.37 ENST00000312049.11
MEN1
menin 1
chr1_-_114152915 0.36 ENST00000609117.5
ENST00000608879.1
ENST00000608203.1
ENST00000609577.1
SYT6
synaptotagmin 6
chr19_+_35000426 0.36 ENST00000411896.6
ENST00000424536.2
GRAMD1A
GRAM domain containing 1A
chr1_+_156728442 0.36 ENST00000368218.8
ENST00000368216.9
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr11_-_6655788 0.36 ENST00000299441.5
DCHS1
dachsous cadherin-related 1
chr9_+_128276222 0.36 ENST00000608796.6
ENST00000419867.7
ENST00000418976.2
SWI5
SWI5 homologous recombination repair protein
chr7_-_29990113 0.36 ENST00000426154.5
ENST00000421434.5
ENST00000434476.6
SCRN1
secernin 1
chr20_-_31870510 0.36 ENST00000339738.10
DUSP15
dual specificity phosphatase 15
chr5_-_81751085 0.35 ENST00000515395.5
SSBP2
single stranded DNA binding protein 2
chr12_+_6766353 0.35 ENST00000309083.8
ENST00000389462.8
PTMS
parathymosin
chr1_+_32741779 0.35 ENST00000401073.7
KIAA1522
KIAA1522
chr19_-_31349408 0.35 ENST00000240587.5
TSHZ3
teashirt zinc finger homeobox 3
chr7_-_29989774 0.35 ENST00000242059.10
SCRN1
secernin 1
chr1_-_165355746 0.35 ENST00000367893.4
LMX1A
LIM homeobox transcription factor 1 alpha
chr9_-_34589716 0.35 ENST00000378980.8
CNTFR
ciliary neurotrophic factor receptor
chr5_+_141637398 0.35 ENST00000518856.1
RELL2
RELT like 2
chr2_-_219229309 0.35 ENST00000443140.5
ENST00000432520.5
ENST00000409618.5
ATG9A
autophagy related 9A
chr1_+_210232776 0.35 ENST00000367012.4
SERTAD4
SERTA domain containing 4
chr9_+_36036899 0.34 ENST00000377966.4
RECK
reversion inducing cysteine rich protein with kazal motifs
chr2_-_219229571 0.34 ENST00000436856.5
ENST00000428226.5
ENST00000409422.5
ENST00000361242.9
ENST00000431715.5
ENST00000457841.5
ENST00000439812.5
ENST00000396761.6
ATG9A
autophagy related 9A
chr9_-_127755243 0.34 ENST00000629203.2
ENST00000420366.5
SH2D3C
SH2 domain containing 3C
chr2_+_181891904 0.34 ENST00000320370.11
ITPRID2
ITPR interacting domain containing 2
chr11_+_62613236 0.34 ENST00000278833.4
ROM1
retinal outer segment membrane protein 1
chr19_-_6279921 0.34 ENST00000252674.9
MLLT1
MLLT1 super elongation complex subunit
chr9_-_34589701 0.34 ENST00000351266.8
CNTFR
ciliary neurotrophic factor receptor
chr9_+_35605277 0.33 ENST00000620767.4
TESK1
testis associated actin remodelling kinase 1
chr12_-_124863902 0.33 ENST00000339570.9
ENST00000680556.1
SCARB1
scavenger receptor class B member 1
chr9_+_128275343 0.33 ENST00000495313.5
ENST00000372898.6
SWI5
SWI5 homologous recombination repair protein
chr19_-_14090695 0.33 ENST00000533683.7
SAMD1
sterile alpha motif domain containing 1
chr2_+_181891697 0.33 ENST00000431877.7
ITPRID2
ITPR interacting domain containing 2
chr9_+_125747345 0.33 ENST00000342287.9
ENST00000373489.10
ENST00000373487.8
PBX3
PBX homeobox 3
chr9_+_35605234 0.33 ENST00000336395.6
TESK1
testis associated actin remodelling kinase 1
chr12_-_79934920 0.33 ENST00000550107.5
PPP1R12A
protein phosphatase 1 regulatory subunit 12A
chr16_+_788614 0.32 ENST00000262315.14
ENST00000455171.6
ENST00000317063.10
CHTF18
chromosome transmission fidelity factor 18
chr17_-_3964291 0.31 ENST00000359983.7
ENST00000352011.7
ATP2A3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr1_+_155323911 0.31 ENST00000368347.8
RUSC1
RUN and SH3 domain containing 1
chr4_-_2262082 0.31 ENST00000337190.7
MXD4
MAX dimerization protein 4
chr3_-_184361594 0.31 ENST00000344937.11
ENST00000434054.6
ENST00000457512.1
ENST00000265593.9
CLCN2
chloride voltage-gated channel 2
chr11_-_19240936 0.31 ENST00000250024.9
E2F8
E2F transcription factor 8
chr11_-_62612725 0.31 ENST00000419857.1
ENST00000394773.7
EML3
EMAP like 3
chr4_+_112145445 0.30 ENST00000309733.6
FAM241A
family with sequence similarity 241 member A
chr19_-_55180242 0.30 ENST00000592470.1
ENST00000354308.8
SYT5
synaptotagmin 5
chr19_+_33796846 0.30 ENST00000590771.5
ENST00000589786.5
ENST00000284006.10
ENST00000683859.1
ENST00000588881.5
KCTD15
potassium channel tetramerization domain containing 15
chr12_-_7018465 0.30 ENST00000261407.9
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr5_-_180291967 0.30 ENST00000425491.6
ENST00000523583.1
ENST00000393360.7
ENST00000455781.5
ENST00000452135.7
ENST00000347470.8
ENST00000343111.10
MAPK9
mitogen-activated protein kinase 9
chr15_-_82647960 0.30 ENST00000615198.4
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr17_-_63842663 0.30 ENST00000613943.4
ENST00000448276.7
SMARCD2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1904761 negative regulation of myofibroblast differentiation(GO:1904761)
0.5 0.5 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.4 1.3 GO:0061027 umbilical cord morphogenesis(GO:0036304) umbilical cord development(GO:0061027)
0.4 1.5 GO:0090427 embryonic nail plate morphogenesis(GO:0035880) activation of meiosis(GO:0090427)
0.4 1.4 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.3 0.8 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.3 2.4 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.3 0.3 GO:1902958 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.2 0.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182)
0.2 1.0 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.2 2.0 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 0.9 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.2 0.6 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 0.6 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.2 1.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 0.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 3.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 0.7 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.2 4.2 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.2 0.7 GO:0044805 late nucleophagy(GO:0044805)
0.2 1.2 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 0.5 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.2 0.5 GO:0019542 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542)
0.2 0.8 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.1 0.6 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.4 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.1 1.0 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.1 0.5 GO:1903294 regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
0.1 0.8 GO:0061687 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.2 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.6 GO:0006344 optic cup formation involved in camera-type eye development(GO:0003408) maintenance of chromatin silencing(GO:0006344)
0.1 0.2 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.1 0.6 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 0.3 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.1 0.3 GO:0003192 mitral valve formation(GO:0003192)
0.1 0.5 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.3 GO:0060689 cell differentiation involved in salivary gland development(GO:0060689)
0.1 0.4 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.1 2.5 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.4 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 0.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 0.7 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.4 GO:0035625 negative regulation of epinephrine secretion(GO:0032811) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.1 0.5 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 0.8 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 0.2 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.1 1.0 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.5 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 0.4 GO:0019075 virus maturation(GO:0019075)
0.1 1.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.3 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.1 0.2 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.5 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.2 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.5 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.2 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1 5.2 GO:0007566 embryo implantation(GO:0007566)
0.1 2.7 GO:0060065 uterus development(GO:0060065)
0.1 0.7 GO:0003360 brainstem development(GO:0003360)
0.1 2.1 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.1 0.3 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.7 GO:0060120 auditory receptor cell fate commitment(GO:0009912) gamma-delta T cell differentiation(GO:0042492) inner ear receptor cell fate commitment(GO:0060120)
0.1 0.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.5 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.1 0.3 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.1 0.5 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.2 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.1 0.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.2 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340) regulation of embryonic cell shape(GO:0016476)
0.1 0.5 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 0.2 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.2 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.4 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.1 0.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.3 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 1.3 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.1 0.2 GO:0003420 regulation of growth plate cartilage chondrocyte proliferation(GO:0003420) histone H3-R2 methylation(GO:0034970)
0.0 0.1 GO:1902824 positive regulation of late endosome to lysosome transport(GO:1902824)
0.0 0.1 GO:0070846 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.1 GO:2000777 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.0 0.2 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.2 GO:1902559 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.0 0.7 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.4 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.1 GO:0060979 vasculogenesis involved in coronary vascular morphogenesis(GO:0060979)
0.0 0.2 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.6 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.3 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.5 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.6 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0051228 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.0 0.4 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:1990737 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.5 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.2 GO:0042426 choline catabolic process(GO:0042426)
0.0 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.2 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.1 GO:0042040 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.0 0.2 GO:1902075 cellular response to salt(GO:1902075)
0.0 0.5 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.3 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.4 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.1 GO:1903984 rhythmic synaptic transmission(GO:0060024) negative regulation of ribosome biogenesis(GO:0090071) regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.6 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
0.0 0.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.2 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
0.0 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.6 GO:0050884 neuromuscular process controlling posture(GO:0050884)
0.0 0.4 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.0 0.1 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.0 0.2 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.2 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.3 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.2 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121) respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.2 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.1 GO:1901078 mastication(GO:0071626) learned vocalization behavior(GO:0098583) negative regulation of relaxation of muscle(GO:1901078)
0.0 0.1 GO:2000691 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 0.3 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.2 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.4 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.1 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.2 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.0 0.1 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.0 0.1 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609)
0.0 0.2 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.2 GO:2000580 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:0043418 homocysteine catabolic process(GO:0043418)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0080154 regulation of fertilization(GO:0080154)
0.0 1.1 GO:1990090 cellular response to nerve growth factor stimulus(GO:1990090)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.4 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.6 GO:0051084 'de novo' posttranslational protein folding(GO:0051084)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:0060068 vagina development(GO:0060068)
0.0 0.0 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0030421 defecation(GO:0030421)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.7 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.1 GO:0051586 glial cell-derived neurotrophic factor secretion(GO:0044467) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.0 GO:0034729 histone H3-K79 methylation(GO:0034729) regulation of genetic imprinting(GO:2000653)
0.0 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0060539 diaphragm development(GO:0060539)
0.0 0.2 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.4 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.6 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.3 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.0 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.2 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.0 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.0 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.3 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.5 GO:0090102 cochlea development(GO:0090102)
0.0 0.1 GO:1901908 diadenosine polyphosphate metabolic process(GO:0015959) diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0032449 CBM complex(GO:0032449)
0.2 0.7 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.2 0.7 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 1.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.2 GO:0016589 NURF complex(GO:0016589)
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 1.7 GO:0031209 SCAR complex(GO:0031209)
0.1 0.5 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.1 0.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.4 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.1 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 3.1 GO:0000421 autophagosome membrane(GO:0000421)
0.1 0.8 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 0.8 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 4.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.0 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.1 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.1 GO:0000805 X chromosome(GO:0000805) autosome(GO:0030849)
0.0 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 1.5 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.6 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)
0.0 0.5 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.2 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.3 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.1 GO:0060987 lipid tube(GO:0060987)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.3 GO:0097449 astrocyte projection(GO:0097449)
0.0 1.6 GO:0045095 keratin filament(GO:0045095)
0.0 0.5 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.0 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.1 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.4 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0004513 neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.4 5.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.3 1.3 GO:0035939 microsatellite binding(GO:0035939)
0.2 1.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.2 0.7 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.2 0.5 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
0.1 0.6 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 2.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.6 GO:0035276 ethanol binding(GO:0035276)
0.1 0.7 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.4 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.1 0.5 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 0.3 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 0.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.3 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.3 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.4 GO:0015154 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 0.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.4 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.6 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 0.5 GO:0097001 glycosphingolipid binding(GO:0043208) ceramide binding(GO:0097001)
0.1 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.3 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.3 GO:0033142 progesterone receptor binding(GO:0033142)
0.1 0.5 GO:0010465 neurotrophin p75 receptor binding(GO:0005166) nerve growth factor receptor activity(GO:0010465)
0.1 0.2 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.1 0.5 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.4 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.7 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 0.3 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 1.7 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.3 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.1 0.2 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 0.8 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 0.3 GO:0050436 microfibril binding(GO:0050436)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.2 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.2 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.8 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.6 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.4 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.1 GO:0061598 nitrate reductase activity(GO:0008940) molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.0 0.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.5 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.5 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.4 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.5 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.7 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.1 GO:0051766 inositol trisphosphate kinase activity(GO:0051766)
0.0 0.4 GO:0010857 calcium-dependent protein kinase activity(GO:0010857)
0.0 0.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.2 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 1.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.2 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.6 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 1.9 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.3 GO:0019215 intermediate filament binding(GO:0019215)
0.0 2.9 GO:0035326 enhancer binding(GO:0035326)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.0 0.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 0.2 PID EPO PATHWAY EPO signaling pathway
0.1 2.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 4.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.9 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.3 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.9 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 1.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.3 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.1 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.1 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.4 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.6 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.0 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.8 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.2 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 1.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.1 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets