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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for LEF1

Z-value: 1.10

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Transcription factors associated with LEF1

Gene Symbol Gene ID Gene Info
ENSG00000138795.10 LEF1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LEF1hg38_v1_chr4_-_108168950_108168969,
hg38_v1_chr4_-_108168919_108168939
-0.321.2e-01Click!

Activity profile of LEF1 motif

Sorted Z-values of LEF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LEF1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr13_-_71867192 9.73 ENST00000611519.4
ENST00000620444.4
ENST00000613252.5
dachshund family transcription factor 1
chr13_-_71866769 6.82 ENST00000619232.1
dachshund family transcription factor 1
chr1_+_84181630 5.51 ENST00000610457.1
protein kinase cAMP-activated catalytic subunit beta
chr4_-_185956348 4.94 ENST00000431902.5
ENST00000284776.11
ENST00000415274.5
sorbin and SH3 domain containing 2
chr1_+_99646025 4.83 ENST00000263174.9
ENST00000605497.5
ENST00000615664.1
palmdelphin
chr15_+_96325935 3.11 ENST00000421109.6
nuclear receptor subfamily 2 group F member 2
chr3_-_66038537 3.04 ENST00000483466.5
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr13_+_32031300 2.94 ENST00000642040.1
FRY microtubule binding protein
chr3_-_18424533 2.85 ENST00000417717.6
SATB homeobox 1
chr7_-_27180230 2.78 ENST00000396344.4
homeobox A10
chr1_+_81800368 2.67 ENST00000674489.1
ENST00000674442.1
ENST00000674419.1
ENST00000674407.1
ENST00000674168.1
ENST00000674307.1
ENST00000674209.1
ENST00000370715.5
ENST00000370713.5
ENST00000319517.10
ENST00000627151.2
ENST00000370717.6
adhesion G protein-coupled receptor L2
chr1_+_60865259 2.57 ENST00000371191.5
nuclear factor I A
chr1_+_77918128 2.50 ENST00000342754.5
nexilin F-actin binding protein
chr13_+_31945826 2.23 ENST00000647500.1
FRY microtubule binding protein
chr1_+_61082702 2.20 ENST00000485903.6
ENST00000371185.6
ENST00000371184.6
nuclear factor I A
chr1_+_61082553 2.13 ENST00000403491.8
ENST00000371187.7
nuclear factor I A
chr3_-_149086488 2.13 ENST00000392912.6
ENST00000465259.5
ENST00000310053.10
ENST00000494055.5
helicase like transcription factor
chr18_+_23135452 2.13 ENST00000580153.5
ENST00000256925.12
Cdk5 and Abl enzyme substrate 1
chrX_+_72069659 2.12 ENST00000631375.1
NHS like 2
chr4_-_16898561 2.03 ENST00000515064.5
ENST00000441778.6
LIM domain binding 2
chr4_-_16898619 2.00 ENST00000502640.5
ENST00000304523.10
ENST00000506732.1
LIM domain binding 2
chr8_-_80080816 2.00 ENST00000520527.5
ENST00000517427.5
ENST00000379097.7
ENST00000448733.3
tumor protein D52
chr18_+_75210789 1.96 ENST00000580243.3
teashirt zinc finger homeobox 1
chr18_+_75210755 1.95 ENST00000322038.5
teashirt zinc finger homeobox 1
chr3_+_107525378 1.89 ENST00000456419.5
ENST00000402163.6
BBX high mobility group box domain containing
chr15_-_52652031 1.89 ENST00000546305.6
family with sequence similarity 214 member A
chr13_+_32031706 1.88 ENST00000542859.6
FRY microtubule binding protein
chr18_+_44697118 1.84 ENST00000677077.1
SET binding protein 1
chr7_-_27174253 1.69 ENST00000613671.1
homeobox A10
chr3_-_15797930 1.69 ENST00000683139.1
ankyrin repeat domain 28
chr7_-_27174274 1.68 ENST00000283921.5
homeobox A10
chr2_+_176129680 1.68 ENST00000429017.2
ENST00000313173.6
homeobox D8
chr3_-_65622073 1.68 ENST00000621418.4
ENST00000611645.4
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr8_-_92095215 1.62 ENST00000360348.6
ENST00000520428.5
ENST00000518992.5
ENST00000520556.5
ENST00000518317.5
ENST00000521319.5
ENST00000521375.5
ENST00000518449.5
ENST00000613886.4
RUNX1 partner transcriptional co-repressor 1
chr1_+_84164370 1.56 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
protein kinase cAMP-activated catalytic subunit beta
chr3_-_169663704 1.55 ENST00000651503.2
ENST00000494292.6
ENST00000486748.2
MDS1 and EVI1 complex locus
chr13_+_102656933 1.55 ENST00000650757.1
tripeptidyl peptidase 2
chr8_-_92095627 1.54 ENST00000517919.5
ENST00000617740.4
ENST00000613302.4
ENST00000436581.6
ENST00000614812.4
ENST00000519847.5
RUNX1 partner transcriptional co-repressor 1
chr11_-_95232514 1.51 ENST00000634898.1
ENST00000542176.1
ENST00000278499.6
sestrin 3
chr20_+_32010429 1.48 ENST00000452892.3
ENST00000262659.12
CCM2 like scaffold protein
chr2_-_182522703 1.47 ENST00000410103.1
phosphodiesterase 1A
chr4_+_30720348 1.39 ENST00000361762.3
protocadherin 7
chr9_-_81689536 1.33 ENST00000376499.8
TLE family member 1, transcriptional corepressor
chr7_+_116672187 1.29 ENST00000318493.11
ENST00000397752.8
MET proto-oncogene, receptor tyrosine kinase
chr10_+_52314272 1.29 ENST00000373970.4
dickkopf WNT signaling pathway inhibitor 1
chr3_-_142028597 1.27 ENST00000467667.5
transcription factor Dp-2
chr8_-_123541197 1.25 ENST00000517956.5
ENST00000443022.2
F-box protein 32
chr5_-_91383310 1.19 ENST00000265138.4
arrestin domain containing 3
chr13_+_39038292 1.18 ENST00000470258.5
NHL repeat containing 3
chr13_+_39038347 1.17 ENST00000379599.6
ENST00000379600.8
NHL repeat containing 3
chr8_-_17722217 1.16 ENST00000381861.7
microtubule associated scaffold protein 1
chrX_+_81202066 1.16 ENST00000373212.6
SH3 domain binding glutamate rich protein like
chr2_+_205683109 1.15 ENST00000357118.8
ENST00000272849.7
ENST00000412873.2
neuropilin 2
chr18_-_48950960 1.12 ENST00000262158.8
SMAD family member 7
chrX_-_120560884 1.09 ENST00000404115.8
cullin 4B
chr15_-_101252040 1.09 ENST00000254190.4
chondroitin sulfate synthase 1
chr3_-_142028617 1.07 ENST00000477292.5
ENST00000478006.5
ENST00000495310.5
ENST00000486111.5
transcription factor Dp-2
chr5_-_88883147 1.06 ENST00000513252.5
ENST00000506554.5
ENST00000508569.5
ENST00000637732.1
ENST00000504921.7
ENST00000637481.1
ENST00000510942.5
myocyte enhancer factor 2C
chr9_+_131096476 1.02 ENST00000372309.7
ENST00000247291.8
ENST00000372302.5
ENST00000372300.5
ENST00000372298.1
allograft inflammatory factor 1 like
chr17_-_65561640 1.01 ENST00000618960.4
ENST00000307078.10
axin 2
chr1_+_6785518 1.00 ENST00000467404.6
calmodulin binding transcription activator 1
chrX_-_120560947 0.99 ENST00000674137.11
ENST00000371322.11
ENST00000681090.1
cullin 4B
chr15_-_68820861 0.99 ENST00000560303.1
ENST00000465139.6
acidic nuclear phosphoprotein 32 family member A
chrX_-_81201886 0.99 ENST00000451455.1
ENST00000358130.7
ENST00000436386.5
high mobility group nucleosome binding domain 5
chr18_+_44680093 0.99 ENST00000426838.8
ENST00000677068.1
SET binding protein 1
chr9_+_125748175 0.99 ENST00000491787.7
ENST00000447726.6
PBX homeobox 3
chr8_-_92095598 0.98 ENST00000520724.5
ENST00000518844.5
RUNX1 partner transcriptional co-repressor 1
chr9_+_36036899 0.97 ENST00000377966.4
reversion inducing cysteine rich protein with kazal motifs
chr2_-_75560893 0.96 ENST00000410113.5
ENST00000393913.8
eva-1 homolog A, regulator of programmed cell death
chr17_+_67825664 0.96 ENST00000321892.8
bromodomain PHD finger transcription factor
chr2_-_136116165 0.95 ENST00000409817.1
C-X-C motif chemokine receptor 4
chr3_-_149657996 0.95 ENST00000360632.8
ENST00000467467.5
ENST00000460517.1
WW domain containing transcription regulator 1
chr7_-_20786879 0.95 ENST00000418710.3
ENST00000617581.4
ENST00000361443.4
Sp8 transcription factor
chr12_+_101666203 0.93 ENST00000549608.1
myosin binding protein C1
chr6_+_143608170 0.93 ENST00000427704.6
ENST00000305766.10
phosphatase and actin regulator 2
chr2_+_69013170 0.93 ENST00000303714.9
ANTXR cell adhesion molecule 1
chr8_+_30095400 0.92 ENST00000321250.13
ENST00000518001.1
ENST00000520682.5
ENST00000442880.6
ENST00000523116.5
leptin receptor overlapping transcript like 1
chr6_-_31714062 0.92 ENST00000409239.5
lymphocyte antigen 6 family member G6E
chr1_+_84164684 0.92 ENST00000370680.5
protein kinase cAMP-activated catalytic subunit beta
chr15_-_82045998 0.91 ENST00000329713.5
mex-3 RNA binding family member B
chr7_-_27185223 0.91 ENST00000517402.1
ENST00000006015.4
homeobox A11
chr13_-_51974775 0.91 ENST00000674147.1
ATPase copper transporting beta
chr15_-_82046119 0.87 ENST00000558133.1
mex-3 RNA binding family member B
chr1_+_93448155 0.87 ENST00000370253.6
formin binding protein 1 like
chrX_-_63754664 0.86 ENST00000677315.1
ENST00000636392.1
ENST00000637040.1
ENST00000637178.1
ENST00000637557.1
ENST00000636048.1
ENST00000638021.1
ENST00000672513.1
novel protein
Cdc42 guanine nucleotide exchange factor 9
chr15_+_57219411 0.86 ENST00000543579.5
ENST00000537840.5
ENST00000343827.7
transcription factor 12
chr4_+_169660062 0.86 ENST00000507875.5
ENST00000613795.4
chloride voltage-gated channel 3
chr7_+_30852273 0.85 ENST00000509504.2
novel protein, MINDY4 and AQP1 readthrough
chr15_+_96330691 0.85 ENST00000394166.8
nuclear receptor subfamily 2 group F member 2
chr20_+_11917859 0.85 ENST00000618296.4
ENST00000378226.7
BTB domain containing 3
chr12_+_32107151 0.84 ENST00000548411.5
BICD cargo adaptor 1
chr18_-_55422306 0.84 ENST00000566777.5
ENST00000626584.2
transcription factor 4
chr12_-_6663083 0.84 ENST00000467678.5
ENST00000493873.1
ENST00000412586.6
ENST00000423703.6
ENST00000444704.5
ENST00000341550.9
inhibitor of growth family member 4
chrX_-_32155462 0.84 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
dystrophin
chr12_-_6663136 0.83 ENST00000396807.8
ENST00000619641.4
ENST00000446105.6
inhibitor of growth family member 4
chr5_-_88877967 0.83 ENST00000508610.5
ENST00000636294.1
myocyte enhancer factor 2C
chrX_+_87517784 0.83 ENST00000373119.9
ENST00000373114.4
kelch like family member 4
chr17_-_48613468 0.83 ENST00000498634.2
homeobox B8
chr3_+_156674579 0.81 ENST00000295924.12
TCDD inducible poly(ADP-ribose) polymerase
chr18_-_55351977 0.81 ENST00000643689.1
transcription factor 4
chr11_-_66677748 0.81 ENST00000525754.5
ENST00000531969.5
ENST00000524637.1
ENST00000531036.2
ENST00000310046.9
RNA binding motif protein 4B
chr16_-_15643024 0.80 ENST00000540441.6
meiosis regulator and mRNA stability factor 1
chr12_+_7061206 0.80 ENST00000423384.5
ENST00000413211.5
complement C1s
chr11_+_5389377 0.79 ENST00000328611.5
olfactory receptor family 51 subfamily M member 1
chr16_+_53208438 0.79 ENST00000565442.1
chromodomain helicase DNA binding protein 9
chr11_-_119364166 0.78 ENST00000525735.1
ubiquitin specific peptidase 2
chr11_+_123590939 0.78 ENST00000646146.1
GRAM domain containing 1B
chr10_-_86957582 0.78 ENST00000372027.10
multimerin 2
chr18_-_55321640 0.78 ENST00000637169.2
transcription factor 4
chr9_+_88388356 0.77 ENST00000375859.4
spindlin 1
chr7_+_80646305 0.77 ENST00000426978.5
ENST00000432207.5
CD36 molecule
chr5_-_88785493 0.77 ENST00000503554.4
myocyte enhancer factor 2C
chr1_+_87331668 0.77 ENST00000370542.1
LIM domain only 4
chr7_+_116210501 0.77 ENST00000455989.1
ENST00000358204.9
testin LIM domain protein
chr3_-_65597886 0.77 ENST00000460329.6
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr10_-_114684612 0.76 ENST00000533213.6
ENST00000369252.8
actin binding LIM protein 1
chr17_+_32486975 0.75 ENST00000313401.4
cyclin dependent kinase 5 regulatory subunit 1
chr3_+_42856021 0.73 ENST00000493193.1
atypical chemokine receptor 2
chr11_+_114059702 0.73 ENST00000335953.9
ENST00000684612.1
ENST00000682810.1
ENST00000544220.1
zinc finger and BTB domain containing 16
chr18_+_6729698 0.73 ENST00000383472.9
Rho GTPase activating protein 28
chr11_-_47185840 0.72 ENST00000539589.5
ENST00000528462.5
protein kinase C and casein kinase substrate in neurons 3
chr14_-_20802836 0.72 ENST00000397967.5
ENST00000555698.5
ENST00000397970.4
ENST00000340900.3
ribonuclease A family member 1, pancreatic
chr5_-_88883420 0.72 ENST00000437473.6
myocyte enhancer factor 2C
chr5_-_39425187 0.72 ENST00000545653.5
DAB adaptor protein 2
chr14_-_34713759 0.70 ENST00000673315.1
cofilin 2
chr7_+_16753731 0.70 ENST00000262067.5
tetraspanin 13
chr2_+_66439294 0.69 ENST00000495021.6
Meis homeobox 1
chr8_+_30095649 0.69 ENST00000518192.5
leptin receptor overlapping transcript like 1
chr12_+_8914525 0.68 ENST00000543824.5
polyhomeotic homolog 1
chr11_-_130314858 0.68 ENST00000527478.6
ENST00000357899.9
zinc finger and BTB domain containing 44
chr8_+_39913881 0.68 ENST00000518237.6
indoleamine 2,3-dioxygenase 1
chr8_+_62248591 0.67 ENST00000519049.6
sodium/potassium transporting ATPase interacting 3
chr2_+_178320228 0.67 ENST00000315022.2
oxysterol binding protein like 6
chr1_+_185734362 0.65 ENST00000271588.9
hemicentin 1
chr18_-_55422492 0.65 ENST00000561992.5
ENST00000630712.2
transcription factor 4
chr14_+_74763308 0.64 ENST00000325680.12
ENST00000552421.5
YLP motif containing 1
chr2_-_182522556 0.64 ENST00000435564.5
phosphodiesterase 1A
chrX_-_50814095 0.63 ENST00000376020.8
shroom family member 4
chr9_+_87498491 0.61 ENST00000622514.4
death associated protein kinase 1
chr1_-_26354080 0.61 ENST00000308182.10
crystallin beta-gamma domain containing 2
chr7_+_107583919 0.60 ENST00000491150.5
B cell receptor associated protein 29
chr17_+_59220446 0.59 ENST00000284116.9
ENST00000581140.5
ENST00000581276.5
glycerophosphodiester phosphodiesterase domain containing 1
chr7_-_27102669 0.59 ENST00000222718.7
homeobox A2
chrX_-_10620534 0.59 ENST00000317552.9
midline 1
chrX_-_10620419 0.58 ENST00000380782.6
midline 1
chr16_+_30378312 0.58 ENST00000528032.5
ENST00000622647.3
zinc finger protein 48
chr3_+_183635605 0.58 ENST00000493074.1
ENST00000437402.5
ENST00000454495.6
ENST00000473045.5
ENST00000468101.5
ENST00000427201.2
ENST00000482138.1
ENST00000454652.6
ENST00000242810.11
kelch like family member 24
chr5_-_88883199 0.57 ENST00000514015.5
ENST00000503075.1
myocyte enhancer factor 2C
chr3_+_152300135 0.57 ENST00000465907.6
ENST00000492948.5
ENST00000485509.5
ENST00000464596.5
muscleblind like splicing regulator 1
chr15_+_51751587 0.56 ENST00000539962.6
ENST00000249700.9
tropomodulin 2
chr6_-_159045010 0.56 ENST00000338313.5
T cell activation RhoGTPase activating protein
chrX_-_136880715 0.56 ENST00000431446.7
ENST00000320676.11
ENST00000562646.5
RNA binding motif protein X-linked
chr3_-_142029108 0.56 ENST00000497579.5
transcription factor Dp-2
chr3_+_52779916 0.56 ENST00000537050.5
inter-alpha-trypsin inhibitor heavy chain 1
chr15_-_51751525 0.55 ENST00000454181.6
LysM domain containing 2
chr2_+_176151543 0.55 ENST00000306324.4
homeobox D4
chr5_+_175861628 0.55 ENST00000509837.5
complexin 2
chr12_+_8914464 0.54 ENST00000544916.6
polyhomeotic homolog 1
chr17_-_41315706 0.54 ENST00000334202.5
keratin associated protein 17-1
chr8_-_17002327 0.54 ENST00000180166.6
fibroblast growth factor 20
chr5_-_138178599 0.54 ENST00000454473.5
ENST00000418329.5
ENST00000254900.10
ENST00000230901.9
ENST00000402931.5
ENST00000411594.6
ENST00000430331.1
bromodomain containing 8
chr12_-_117968972 0.54 ENST00000339824.7
kinase suppressor of ras 2
chr11_-_130314686 0.53 ENST00000525842.5
zinc finger and BTB domain containing 44
chr7_+_80646436 0.53 ENST00000419819.2
CD36 molecule
chr6_-_166167832 0.52 ENST00000366876.7
T-box transcription factor T
chr3_+_124094663 0.52 ENST00000460856.5
ENST00000240874.7
kalirin RhoGEF kinase
chr4_+_85778681 0.52 ENST00000395183.6
Rho GTPase activating protein 24
chr18_-_55585773 0.52 ENST00000563824.5
ENST00000626425.2
ENST00000566514.5
ENST00000568673.5
ENST00000562847.5
ENST00000568147.5
transcription factor 4
chr22_-_32464440 0.52 ENST00000397450.2
ENST00000397452.5
ENST00000300399.8
BPI fold containing family C
chr21_+_39452077 0.51 ENST00000452550.5
SH3 domain binding glutamate rich protein
chr14_-_104978360 0.51 ENST00000333244.6
AHNAK nucleoprotein 2
chr1_+_66533575 0.51 ENST00000684751.1
ENST00000683291.1
ENST00000682054.1
ENST00000435165.3
ENST00000684539.1
ENST00000681971.1
ENST00000682476.1
ENST00000684168.1
ENST00000371039.5
SH3GL interacting endocytic adaptor 1
chr8_-_42377227 0.51 ENST00000220812.3
dickkopf WNT signaling pathway inhibitor 4
chr15_-_74202742 0.50 ENST00000395105.9
signaling receptor and transporter of retinol STRA6
chr21_+_39451963 0.49 ENST00000333634.10
SH3 domain binding glutamate rich protein
chr11_-_63768762 0.49 ENST00000433688.2
chromosome 11 open reading frame 95
chr18_-_55402187 0.49 ENST00000630268.2
ENST00000570177.6
transcription factor 4
chr6_+_118894144 0.48 ENST00000229595.6
anti-silencing function 1A histone chaperone
chr1_+_196819731 0.48 ENST00000320493.10
ENST00000367424.4
complement factor H related 1
chrX_-_50814302 0.48 ENST00000289292.11
shroom family member 4
chr1_+_231528541 0.48 ENST00000413309.3
ENST00000366639.9
translin associated factor X
chr7_-_148884266 0.48 ENST00000483967.5
ENST00000320356.7
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr2_-_210476687 0.48 ENST00000233714.8
ENST00000443314.5
ENST00000441020.7
ENST00000450366.7
ENST00000431941.6
LanC like 1
chr11_-_102452758 0.48 ENST00000398136.7
ENST00000361236.7
transmembrane protein 123
chr6_+_83067655 0.48 ENST00000237163.9
ENST00000349129.7
DOP1 leucine zipper like protein A
chr11_-_130314575 0.47 ENST00000397753.5
zinc finger and BTB domain containing 44
chr9_+_18474206 0.47 ENST00000276935.6
ADAMTS like 1
chr11_+_114060204 0.47 ENST00000683318.1
zinc finger and BTB domain containing 16
chr3_+_44584953 0.47 ENST00000441021.5
ENST00000322734.2
zinc finger protein 660
chr1_+_66332004 0.46 ENST00000371045.9
ENST00000531025.5
ENST00000526197.5
phosphodiesterase 4B
chr2_+_197804583 0.46 ENST00000428675.6
phospholipase C like 1 (inactive)
chr1_+_27342014 0.46 ENST00000618673.4
ENST00000318074.9
ENST00000616558.5
synaptotagmin like 1
chr6_+_154995258 0.46 ENST00000682666.1
TIAM Rac1 associated GEF 2
chr4_+_112231748 0.46 ENST00000274000.10
ENST00000309703.10
adaptor related protein complex 1 associated regulatory protein
chr2_+_200440649 0.46 ENST00000366118.2
spermatogenesis associated serine rich 2 like
chr10_+_22316445 0.45 ENST00000448361.5
COMM domain containing 3
chr18_+_3450036 0.45 ENST00000546979.5
ENST00000343820.10
ENST00000551402.1
ENST00000577543.5
TGFB induced factor homeobox 1
chr12_-_48570046 0.45 ENST00000301046.6
ENST00000549817.1
lactalbumin alpha
chr10_+_22316375 0.45 ENST00000376836.8
ENST00000456711.5
ENST00000444869.5
ENST00000475460.6
ENST00000602390.5
ENST00000489125.2
COMM domain containing 3
COMMD3-BMI1 readthrough
chr5_-_149551381 0.45 ENST00000670598.1
ENST00000657001.1
ENST00000515768.6
ENST00000261798.10
ENST00000377843.8
casein kinase 1 alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 16.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.8 7.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
1.1 8.0 GO:0097338 response to clozapine(GO:0097338)
1.0 4.0 GO:0009956 radial pattern formation(GO:0009956)
0.7 3.9 GO:0060023 soft palate development(GO:0060023)
0.5 4.0 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.5 1.5 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.4 1.3 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.3 0.3 GO:0007418 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.3 0.9 GO:0060003 copper ion export(GO:0060003)
0.3 0.9 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.2 0.7 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.2 0.7 GO:0035026 leading edge cell differentiation(GO:0035026)
0.2 1.2 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.2 1.4 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.2 0.7 GO:0051230 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.2 2.0 GO:2000334 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2 6.9 GO:0072189 ureter development(GO:0072189)
0.2 1.0 GO:0007386 compartment pattern specification(GO:0007386)
0.2 0.6 GO:0021658 rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658)
0.2 0.6 GO:2000174 pro-T cell differentiation(GO:0002572) regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.2 0.9 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.2 8.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 1.6 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.2 0.9 GO:0048388 endosomal lumen acidification(GO:0048388)
0.2 0.7 GO:0036269 swimming behavior(GO:0036269)
0.2 1.5 GO:0097491 sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.2 0.5 GO:1903217 negative regulation of late endosome to lysosome transport(GO:1902823) regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.2 2.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 1.1 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.2 0.6 GO:1900276 regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737)
0.2 0.5 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 0.6 GO:1903633 regulation of calcium-dependent ATPase activity(GO:1903610) negative regulation of calcium-dependent ATPase activity(GO:1903611) regulation of dUTP diphosphatase activity(GO:1903627) positive regulation of dUTP diphosphatase activity(GO:1903629) negative regulation of aminoacyl-tRNA ligase activity(GO:1903631) regulation of leucine-tRNA ligase activity(GO:1903633) negative regulation of leucine-tRNA ligase activity(GO:1903634)
0.1 0.4 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.1 2.3 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 4.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.6 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 1.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 1.6 GO:0070494 endothelial cell morphogenesis(GO:0001886) regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 4.0 GO:0010669 epithelial structure maintenance(GO:0010669)
0.1 0.4 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 1.7 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.5 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1 0.6 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.1 0.3 GO:1903028 positive regulation of opsonization(GO:1903028)
0.1 0.2 GO:0003129 heart induction(GO:0003129) negative regulation of mesodermal cell fate specification(GO:0042662)
0.1 1.2 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.3 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1 1.0 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.1 2.6 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 0.3 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.1 0.9 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 1.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.4 GO:0072011 diapedesis(GO:0050904) glomerular endothelium development(GO:0072011)
0.1 1.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 0.4 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.9 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1 2.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.4 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1 1.4 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.9 GO:0046959 habituation(GO:0046959) negative regulation of growth hormone secretion(GO:0060125)
0.1 0.2 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 0.3 GO:1904908 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.1 0.3 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 1.7 GO:0007351 blastoderm segmentation(GO:0007350) tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.1 0.5 GO:0061143 alveolar primary septum development(GO:0061143) paramesonephric duct development(GO:0061205)
0.1 0.1 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.1 0.2 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.1 1.0 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 0.6 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.1 1.0 GO:0042659 regulation of cell fate specification(GO:0042659)
0.1 4.3 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 0.9 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 2.9 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.1 GO:2001202 negative regulation of transforming growth factor-beta secretion(GO:2001202)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 1.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.5 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 1.6 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.3 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.2 GO:1990637 response to prolactin(GO:1990637)
0.1 0.2 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.8 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.5 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.3 GO:0033080 immature T cell proliferation in thymus(GO:0033080) regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.1 0.3 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.1 0.5 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 0.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.2 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.7 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.2 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.6 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.0 GO:0007440 foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617)
0.0 1.5 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.1 GO:2000195 primary sex determination(GO:0007538) negative regulation of female gonad development(GO:2000195)
0.0 0.5 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.4 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.7 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.4 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.3 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.1 GO:1903596 regulation of gap junction assembly(GO:1903596) positive regulation of gap junction assembly(GO:1903598)
0.0 0.2 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.5 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.3 GO:0031133 regulation of axon diameter(GO:0031133)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 1.3 GO:2000811 negative regulation of anoikis(GO:2000811)
0.0 0.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 1.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0030576 Cajal body organization(GO:0030576)
0.0 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0003290 atrial septum secundum morphogenesis(GO:0003290)
0.0 0.1 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.4 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.8 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 0.8 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 1.2 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.2 GO:0048570 notochord morphogenesis(GO:0048570)
0.0 0.5 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.5 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.3 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.6 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.7 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.7 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.1 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 2.2 GO:0006301 postreplication repair(GO:0006301)
0.0 0.1 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.0 0.4 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 1.0 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.5 GO:0001780 neutrophil homeostasis(GO:0001780)
0.0 0.2 GO:0070162 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
0.0 0.3 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.0 0.2 GO:0030903 notochord development(GO:0030903)
0.0 1.0 GO:0007625 grooming behavior(GO:0007625)
0.0 0.5 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 5.4 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.5 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.1 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 0.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.1 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.1 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.1 GO:0033058 directional locomotion(GO:0033058)
0.0 0.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0007567 parturition(GO:0007567)
0.0 0.2 GO:0009597 detection of virus(GO:0009597)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 1.7 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 1.0 GO:1901998 toxin transport(GO:1901998)
0.0 0.7 GO:0007143 female meiotic division(GO:0007143)
0.0 4.3 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.2 GO:0060973 cell migration involved in heart development(GO:0060973)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.9 GO:0007492 endoderm development(GO:0007492)
0.0 0.0 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.4 GO:0006900 membrane budding(GO:0006900)
0.0 0.1 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.0 0.1 GO:0009629 response to gravity(GO:0009629)
0.0 0.1 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 1.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:0006183 GTP biosynthetic process(GO:0006183)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 2.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 0.5 GO:0044753 amphisome(GO:0044753)
0.2 0.6 GO:0039713 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.1 0.7 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 1.8 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 1.0 GO:0016589 NURF complex(GO:0016589)
0.1 4.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.7 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 1.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.8 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.5 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.5 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.6 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.5 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.3 GO:0035102 PRC1 complex(GO:0035102)
0.1 3.1 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.3 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 0.9 GO:0045120 pronucleus(GO:0045120)
0.1 31.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 2.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 12.2 GO:0030018 Z disc(GO:0030018)
0.0 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.7 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.7 GO:0070938 contractile ring(GO:0070938)
0.0 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.0 7.9 GO:0000922 spindle pole(GO:0000922)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0044609 DBIRD complex(GO:0044609)
0.0 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0005915 zonula adherens(GO:0005915)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 3.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.8 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.1 GO:0097169 IPAF inflammasome complex(GO:0072557) AIM2 inflammasome complex(GO:0097169)
0.0 2.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 1.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 2.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.9 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 1.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 16.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.7 2.7 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.5 8.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 1.9 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 4.0 GO:0030274 LIM domain binding(GO:0030274)
0.3 1.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.3 0.9 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.3 0.9 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.3 1.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.3 2.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 0.7 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.2 0.7 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.2 0.7 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.2 0.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 4.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 4.0 GO:0003680 AT DNA binding(GO:0003680)
0.2 5.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.6 GO:0004341 gluconolactonase activity(GO:0004341)
0.1 0.6 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 1.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.7 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.5 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 1.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 4.1 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.3 GO:0019150 D-ribulokinase activity(GO:0019150)
0.1 6.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.1 1.0 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.3 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.5 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 0.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0070905 serine binding(GO:0070905)
0.1 1.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.1 0.9 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 1.8 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.2 GO:0035500 MH2 domain binding(GO:0035500)
0.1 0.3 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.5 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.7 GO:0004679 AMP-activated protein kinase activity(GO:0004679) phosphorylase kinase regulator activity(GO:0008607)
0.1 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.5 GO:0005113 patched binding(GO:0005113)
0.0 1.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.4 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.2 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 2.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.2 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 1.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.5 GO:0043295 glutathione binding(GO:0043295)
0.0 0.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0019534 toxin transporter activity(GO:0019534)
0.0 11.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 1.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.9 GO:0030332 cyclin binding(GO:0030332)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.7 GO:0015248 sterol transporter activity(GO:0015248)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.3 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.2 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 1.4 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.1 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 3.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 6.1 GO:0003682 chromatin binding(GO:0003682)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.0 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.8 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.0 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 10.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 8.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 5.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 0.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.2 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 3.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.4 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 2.7 PID E2F PATHWAY E2F transcription factor network
0.0 0.9 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 1.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.1 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.1 PID REELIN PATHWAY Reelin signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 0.9 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 8.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.9 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.1 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.1 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 0.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 2.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 5.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.0 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 2.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.6 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 4.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.1 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.0 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.4 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.0 0.3 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 1.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.2 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.1 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade