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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for LEF1
Z-value: 1.10
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Transcription factors associated with LEF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LEF1 | hg38_v1_chr4_-_108168950_108168969, hg38_v1_chr4_-_108168919_108168939 | -0.32 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of LEF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_71867192 Show fit | 9.73 |
ENST00000611519.4
ENST00000620444.4 ENST00000613252.5 |
dachshund family transcription factor 1 |
|
| chr13_-_71866769 Show fit | 6.82 |
ENST00000619232.1
|
dachshund family transcription factor 1 |
|
| chr1_+_84181630 Show fit | 5.51 |
ENST00000610457.1
|
protein kinase cAMP-activated catalytic subunit beta |
|
| chr4_-_185956348 Show fit | 4.94 |
ENST00000431902.5
ENST00000284776.11 ENST00000415274.5 |
sorbin and SH3 domain containing 2 |
|
| chr1_+_99646025 Show fit | 4.83 |
ENST00000263174.9
ENST00000605497.5 ENST00000615664.1 |
palmdelphin |
|
| chr15_+_96325935 Show fit | 3.11 |
ENST00000421109.6
|
nuclear receptor subfamily 2 group F member 2 |
|
| chr3_-_66038537 Show fit | 3.04 |
ENST00000483466.5
|
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
|
| chr13_+_32031300 Show fit | 2.94 |
ENST00000642040.1
|
FRY microtubule binding protein |
|
| chr3_-_18424533 Show fit | 2.85 |
ENST00000417717.6
|
SATB homeobox 1 |
|
| chr7_-_27180230 Show fit | 2.78 |
ENST00000396344.4
|
homeobox A10 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 16.5 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.2 | 8.3 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 1.1 | 8.0 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.8 | 7.1 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.2 | 6.9 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 5.4 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.1 | 4.9 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 4.3 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 4.3 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 1.0 | 4.0 | GO:0009956 | radial pattern formation(GO:0009956) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 12.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.4 | 8.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 7.9 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 4.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 3.5 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 3.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 2.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 2.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 2.5 | GO:0031901 | early endosome membrane(GO:0031901) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 16.4 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 11.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.5 | 8.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 6.1 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.1 | 6.0 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.2 | 5.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.2 | 4.4 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 4.1 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.3 | 4.0 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 4.0 | GO:0003680 | AT DNA binding(GO:0003680) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 8.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 5.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 5.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 3.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.5 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 8.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 5.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 4.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.6 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 2.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.1 | REACTOME DAG AND IP3 SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.0 | 2.0 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 1.9 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 1.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |