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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for LHX2

Z-value: 0.79

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Transcription factors associated with LHX2

Gene Symbol Gene ID Gene Info
ENSG00000106689.11 LHX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX2hg38_v1_chr9_+_124011738_124011777,
hg38_v1_chr9_+_124015397_124015421
0.301.4e-01Click!

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_+_102355750 4.58 ENST00000233957.7
interleukin 18 receptor 1
chr7_-_22194709 2.66 ENST00000458533.5
Rap guanine nucleotide exchange factor 5
chr6_+_32844789 2.47 ENST00000414474.5
proteasome 20S subunit beta 9
chr1_-_7940825 2.46 ENST00000377507.8
TNF receptor superfamily member 9
chr5_-_35938572 1.73 ENST00000651391.1
ENST00000397366.5
ENST00000513623.5
ENST00000514524.2
ENST00000397367.6
calcyphosine like
chr2_+_102418642 1.71 ENST00000264260.6
interleukin 18 receptor accessory protein
chr1_-_150765785 1.64 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr11_-_55936400 1.61 ENST00000301532.3
olfactory receptor family 5 subfamily I member 1
chr2_-_174847765 1.50 ENST00000443238.6
chimerin 1
chr13_+_24270681 1.47 ENST00000343003.10
ENST00000399949.6
spermatogenesis associated 13
chr2_+_102337148 1.38 ENST00000311734.6
ENST00000409584.5
interleukin 1 receptor like 1
chr5_-_151093566 1.31 ENST00000521001.1
TNFAIP3 interacting protein 1
chr1_-_89126066 1.29 ENST00000370466.4
guanylate binding protein 2
chr2_-_10447771 1.20 ENST00000405333.5
ENST00000443218.1
ornithine decarboxylase 1
chr2_-_174847525 1.16 ENST00000295497.12
ENST00000652036.1
ENST00000444394.6
ENST00000650731.1
chimerin 1
chr1_+_244352627 1.15 ENST00000366537.5
ENST00000308105.5
chromosome 1 open reading frame 100
chr18_+_58341038 1.08 ENST00000679791.1
NEDD4 like E3 ubiquitin protein ligase
chrX_+_11111291 0.93 ENST00000321143.8
ENST00000380762.5
ENST00000380763.7
holocytochrome c synthase
chr6_-_83193882 0.89 ENST00000506587.5
ENST00000507554.1
phosphoglucomutase 3
chr6_+_29306626 0.84 ENST00000377160.4
olfactory receptor family 14 subfamily J member 1
chr7_-_81770122 0.80 ENST00000423064.7
hepatocyte growth factor
chr5_-_59216826 0.80 ENST00000638939.1
phosphodiesterase 4D
chr3_-_191282383 0.79 ENST00000427544.6
urotensin 2B
chr2_-_201698692 0.77 ENST00000315506.11
ENST00000359962.9
ENST00000620095.4
membrane palmitoylated protein 4
chr3_+_119468952 0.76 ENST00000476573.5
ENST00000295588.9
protein O-glucosyltransferase 1
chr2_-_201698628 0.75 ENST00000602867.1
ENST00000409474.8
membrane palmitoylated protein 4
chr2_+_68974573 0.75 ENST00000673932.3
ENST00000377938.4
gastrokine 1
chrX_-_11265975 0.68 ENST00000303025.10
ENST00000657361.1
Rho GTPase activating protein 6
chr11_+_24496988 0.67 ENST00000336930.11
leucine zipper protein 2
chr15_+_76336755 0.67 ENST00000290759.9
ISL LIM homeobox 2
chr7_+_144000320 0.66 ENST00000641698.1
olfactory receptor family 6 subfamily B member 1
chr2_-_230219902 0.66 ENST00000409815.6
SP110 nuclear body protein
chr12_-_10998304 0.65 ENST00000538986.2
taste 2 receptor member 20
chr10_-_14330879 0.64 ENST00000357447.7
FERM domain containing 4A
chr6_+_125203639 0.64 ENST00000392482.6
TPD52 like 1
chr5_-_24644968 0.62 ENST00000264463.8
cadherin 10
chr19_+_55857437 0.62 ENST00000587891.5
NLR family pyrin domain containing 4
chr1_+_86547070 0.61 ENST00000370563.3
chloride channel accessory 4
chr7_+_20647388 0.60 ENST00000258738.10
ATP binding cassette subfamily B member 5
chr8_+_22567038 0.56 ENST00000523348.1
sorbin and SH3 domain containing 3
chr11_+_55635113 0.56 ENST00000641760.1
olfactory receptor family 4 subfamily P member 4
chr17_-_41168219 0.55 ENST00000391356.4
keratin associated protein 4-3
chr16_-_48610150 0.53 ENST00000262384.4
NEDD4 binding protein 1
chr9_+_105558112 0.53 ENST00000223528.6
ENST00000675668.1
ENST00000357998.10
ENST00000448551.6
fukutin
chr15_-_51243011 0.52 ENST00000405913.7
ENST00000559878.5
cytochrome P450 family 19 subfamily A member 1
chr17_+_46923075 0.50 ENST00000640608.1
ENST00000638634.1
ENST00000623037.2
ENST00000225567.9
ENST00000415811.7
ENST00000576910.7
ENST00000573224.2
ENST00000640621.1
ENST00000638892.1
ENST00000638838.1
ENST00000638216.1
ENST00000575949.6
ENST00000640806.1
ENST00000640269.1
ENST00000640443.1
ENST00000638697.1
ENST00000640051.2
ENST00000640007.1
ENST00000640711.1
ENST00000640495.1
ENST00000638374.1
ENST00000571048.1
ENST00000639287.1
ENST00000640138.1
ENST00000570879.2
ENST00000640068.1
ENST00000393456.7
ENST00000639031.1
golgi SNAP receptor complex member 2
chr10_-_13972355 0.49 ENST00000264546.10
FERM domain containing 4A
chr16_+_56451513 0.47 ENST00000562150.5
ENST00000561646.5
ENST00000566157.6
ENST00000568397.1
2-oxoglutarate and iron dependent oxygenase domain containing 1
chr18_+_68798065 0.47 ENST00000360242.9
coiled-coil domain containing 102B
chrX_+_19355582 0.47 ENST00000379804.1
pyruvate dehydrogenase E1 subunit alpha 1
chr17_+_59331633 0.45 ENST00000312655.9
yippee like 2
chr5_+_141412979 0.45 ENST00000612503.1
ENST00000398610.3
protocadherin gamma subfamily A, 10
chr1_+_54715837 0.45 ENST00000371281.4
tetratricopeptide repeat domain 4
chr11_+_24497155 0.44 ENST00000529015.5
ENST00000533227.5
leucine zipper protein 2
chr11_+_27055215 0.41 ENST00000525090.1
gamma-butyrobetaine hydroxylase 1
chr2_-_230219944 0.41 ENST00000455674.2
ENST00000392048.7
ENST00000258381.11
ENST00000358662.9
ENST00000258382.10
SP110 nuclear body protein
chr6_+_126340107 0.40 ENST00000368328.5
ENST00000368326.5
ENST00000368325.5
centromere protein W
chr3_+_63443306 0.39 ENST00000472899.5
ENST00000479198.5
ENST00000460711.5
ENST00000465156.1
synaptoporin
chr1_-_152360004 0.39 ENST00000388718.5
filaggrin family member 2
chr14_+_22086401 0.38 ENST00000390451.2
T cell receptor alpha variable 23/delta variable 6
chr4_-_159035226 0.37 ENST00000434826.3
chromosome 4 open reading frame 45
chr12_-_21775581 0.37 ENST00000537950.1
ENST00000665145.1
potassium inwardly rectifying channel subfamily J member 8
chr4_+_168497066 0.37 ENST00000261509.10
palladin, cytoskeletal associated protein
chr11_+_121102666 0.37 ENST00000264037.2
tectorin alpha
chr2_-_222656067 0.36 ENST00000281828.8
phenylalanyl-tRNA synthetase subunit beta
chr11_+_124183219 0.35 ENST00000641351.2
olfactory receptor family 10 subfamily D member 3
chr11_+_111245725 0.35 ENST00000280325.7
chromosome 11 open reading frame 53
chr10_-_60141004 0.35 ENST00000355288.6
ankyrin 3
chr7_-_14841267 0.34 ENST00000406247.7
ENST00000399322.7
diacylglycerol kinase beta
chr10_-_88952763 0.33 ENST00000224784.10
actin alpha 2, smooth muscle
chr2_+_233307806 0.32 ENST00000447536.5
ENST00000409110.6
S-antigen visual arrestin
chr5_+_168486462 0.32 ENST00000231572.8
ENST00000626454.1
arginyl-tRNA synthetase 1
chr1_-_27604135 0.32 ENST00000673934.1
ENST00000642245.1
AT-hook DNA binding motif containing 1
chr2_-_88857582 0.32 ENST00000390237.2
immunoglobulin kappa constant
chr6_+_54018992 0.31 ENST00000509997.5
muscular LMNA interacting protein
chr1_-_27604176 0.31 ENST00000642416.1
AT-hook DNA binding motif containing 1
chr12_-_91179517 0.31 ENST00000551354.1
decorin
chr14_+_23376786 0.30 ENST00000359320.7
CKLF like MARVEL transmembrane domain containing 5
chr17_-_41140487 0.30 ENST00000345847.4
keratin associated protein 4-6
chr1_-_147670235 0.30 ENST00000392988.6
acid phosphatase 6, lysophosphatidic
chr11_+_124184244 0.30 ENST00000641546.1
olfactory receptor family 10 subfamily D member 3
chr12_-_91111460 0.29 ENST00000266718.5
lumican
chr3_+_138621225 0.29 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr2_-_178651500 0.27 ENST00000446966.1
ENST00000426232.5
titin
chrX_-_120878924 0.27 ENST00000613352.1
novel protein similar to cancer/testis antigen family 47, member A12 (CT47A12)
chr2_-_208124514 0.27 ENST00000264376.5
crystallin gamma D
chr1_+_160400543 0.26 ENST00000368061.3
VANGL planar cell polarity protein 2
chr2_+_68734773 0.26 ENST00000409202.8
Rho GTPase activating protein 25
chr5_-_157109025 0.26 ENST00000307851.9
hepatitis A virus cellular receptor 2
chr9_-_135499846 0.25 ENST00000429260.7
chromosome 9 open reading frame 116
chr3_+_108822778 0.25 ENST00000295756.11
T cell receptor associated transmembrane adaptor 1
chr13_+_76948500 0.25 ENST00000377462.6
aconitate decarboxylase 1
chr2_-_55049184 0.24 ENST00000357376.7
reticulon 4
chr3_+_35680994 0.24 ENST00000441454.5
cAMP regulated phosphoprotein 21
chr7_-_81770039 0.24 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
hepatocyte growth factor
chr10_-_104232301 0.23 ENST00000369720.6
ENST00000369719.2
ENST00000278064.7
ENST00000357060.8
cilia and flagella associated protein 43
chr10_+_68106109 0.23 ENST00000540630.5
ENST00000354393.6
myopalladin
chr6_-_26199272 0.22 ENST00000650491.1
ENST00000635200.1
ENST00000341023.2
novel protein
H2A clustered histone 7
chr16_+_283157 0.22 ENST00000219406.11
ENST00000404312.5
ENST00000456379.1
protein disulfide isomerase family A member 2
chr6_+_54018910 0.21 ENST00000514921.5
ENST00000274897.9
ENST00000370877.6
muscular LMNA interacting protein
chrX_+_76173010 0.21 ENST00000373357.3
ENST00000373358.8
polysaccharide biosynthesis domain containing 1
chr12_-_25195074 0.20 ENST00000354189.9
ENST00000676236.1
ENST00000545133.5
ENST00000554347.1
ENST00000674567.1
ENST00000395987.8
ENST00000320267.13
ENST00000395990.6
cilia and flagella associated protein 94
chr3_-_131502946 0.20 ENST00000512877.1
ENST00000264995.8
ENST00000511168.5
ENST00000425847.6
mitochondrial ribosomal protein L3
chr4_+_37960397 0.20 ENST00000504686.2
pituitary tumor-transforming 2
chr14_+_56117702 0.20 ENST00000559044.5
pellino E3 ubiquitin protein ligase family member 2
chr17_+_62370218 0.20 ENST00000450662.7
EF-hand calcium binding domain 3
chr3_+_108822759 0.20 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chr1_-_113871665 0.20 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
protein tyrosine phosphatase non-receptor type 22
chr7_+_156640879 0.20 ENST00000311822.12
ring finger protein 32
chr7_-_54759182 0.20 ENST00000450622.1
ENST00000352861.9
ENST00000395535.7
SEC61 translocon subunit gamma
chr16_-_18876305 0.19 ENST00000563235.5
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
chr3_+_138621207 0.19 ENST00000464668.5
Fas apoptotic inhibitory molecule
chr3_+_73061659 0.19 ENST00000533473.1
endogenous Bornavirus like nucleoprotein 2
chr2_+_86907953 0.19 ENST00000409776.6
RANBP2 like and GRIP domain containing 1
chr6_+_26199509 0.18 ENST00000356530.5
H2B clustered histone 7
chr2_+_44941695 0.18 ENST00000260653.5
SIX homeobox 3
chr14_-_50561119 0.18 ENST00000555216.5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_-_205121964 0.18 ENST00000264515.11
RB binding protein 5, histone lysine methyltransferase complex subunit
chrX_-_15314543 0.18 ENST00000344384.8
ankyrin repeat and SOCS box containing 11
chr2_+_161624335 0.18 ENST00000375514.9
ENST00000415876.6
solute carrier family 4 member 10
chr7_+_100733576 0.18 ENST00000613979.5
ENST00000620596.4
zonadhesin
chr14_+_22226711 0.18 ENST00000390463.3
T cell receptor alpha variable 36/delta variable 7
chrX_+_48255390 0.17 ENST00000376919.4
SSX family member 1
chr3_+_4680617 0.17 ENST00000648212.1
inositol 1,4,5-trisphosphate receptor type 1
chr16_+_69311339 0.17 ENST00000254950.13
vacuolar protein sorting 4 homolog A
chr9_-_28670285 0.17 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
leucine rich repeat and Ig domain containing 2
chr15_+_80441229 0.16 ENST00000533983.5
ENST00000527771.5
ENST00000525103.1
aryl hydrocarbon receptor nuclear translocator 2
chr2_-_127526444 0.16 ENST00000295321.9
interacts with SUPT6H, CTD assembly factor 1
chr5_-_157109115 0.16 ENST00000522593.5
hepatitis A virus cellular receptor 2
chrM_+_12329 0.16 ENST00000361567.2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr3_-_12545499 0.16 ENST00000564146.4
MKRN2 opposite strand
chr4_+_69931066 0.16 ENST00000246891.9
casein alpha s1
chr6_+_29111560 0.16 ENST00000377169.2
olfactory receptor family 2 subfamily J member 3
chr10_-_29634964 0.16 ENST00000375398.6
ENST00000355867.8
supervillin
chr7_-_137343688 0.15 ENST00000348225.7
pleiotrophin
chr15_+_22015233 0.15 ENST00000639059.1
ENST00000640156.1
novel protein
novel transcript
chr2_+_119679154 0.15 ENST00000401466.5
ENST00000424086.5
transmembrane protein 177
chr16_+_31259922 0.15 ENST00000648685.1
ENST00000544665.9
integrin subunit alpha M
chr8_-_108248700 0.14 ENST00000220849.10
ENST00000678937.1
ENST00000678901.1
ENST00000678243.1
ENST00000677674.1
ENST00000521297.2
ENST00000677272.1
ENST00000522352.6
ENST00000678042.1
ENST00000519627.2
ENST00000521440.6
ENST00000678773.1
ENST00000676698.1
ENST00000518345.2
ENST00000677447.1
ENST00000676548.1
ENST00000519030.6
ENST00000518442.5
eukaryotic translation initiation factor 3 subunit E
chr18_+_31447732 0.14 ENST00000257189.5
desmoglein 3
chr15_+_21579912 0.14 ENST00000628444.1
long intergenic non-protein coding RNA 2203
chr7_-_140398456 0.14 ENST00000340308.7
ENST00000447932.6
ENST00000326232.14
ENST00000469193.5
solute carrier family 37 member 3
chr2_+_119679184 0.13 ENST00000445518.1
ENST00000272521.7
ENST00000409951.1
transmembrane protein 177
chr7_-_137343752 0.13 ENST00000393083.2
pleiotrophin
chr17_-_40984297 0.13 ENST00000377755.9
keratin 40
chr9_-_4666495 0.13 ENST00000475086.5
spermatogenesis associated 6 like
chr1_-_183590876 0.12 ENST00000367536.5
neutrophil cytosolic factor 2
chr18_+_63702958 0.12 ENST00000544088.6
serpin family B member 11
chr16_+_23641452 0.12 ENST00000300087.7
ENST00000563998.5
dynactin subunit 5
chr15_+_53978201 0.12 ENST00000647821.1
unc-13 homolog C
chr17_-_38853629 0.11 ENST00000378096.3
ENST00000479035.7
ENST00000394332.5
ENST00000394333.5
ENST00000577407.5
ribosomal protein L23
chr4_+_70360751 0.11 ENST00000226460.5
submaxillary gland androgen regulated protein 3A
chr14_-_33951052 0.11 ENST00000250457.9
ENST00000547327.2
egl-9 family hypoxia inducible factor 3
chr7_-_155510158 0.10 ENST00000682997.1
canopy FGF signaling regulator 1
chr21_-_14210884 0.10 ENST00000679868.1
ENST00000400211.3
ENST00000680801.1
ENST00000536861.6
ENST00000614229.5
lipase I
chr20_+_44401397 0.10 ENST00000682427.1
ENST00000681977.1
ENST00000684136.1
ENST00000684046.1
ENST00000684476.1
ENST00000619550.5
ENST00000682169.1
hepatocyte nuclear factor 4 alpha
chr6_+_122717544 0.09 ENST00000354275.2
ENST00000368446.1
cAMP-dependent protein kinase inhibitor beta
chr11_-_62556230 0.09 ENST00000530285.5
AHNAK nucleoprotein
chr5_+_141177790 0.09 ENST00000239444.4
ENST00000623995.1
protocadherin beta 8
novel transcript
chr2_-_73642413 0.08 ENST00000272425.4
N-acetyltransferase 8 (putative)
chr1_-_207032749 0.08 ENST00000359470.6
ENST00000461135.2
chromosome 1 open reading frame 116
chr7_-_38265678 0.08 ENST00000443402.6
T cell receptor gamma constant 1
chr15_+_53978410 0.07 ENST00000260323.16
unc-13 homolog C
chr9_+_121651594 0.07 ENST00000408936.7
DAB2 interacting protein
chr10_+_120851341 0.07 ENST00000263461.11
WD repeat domain 11
chr18_+_34976928 0.07 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
microtubule associated protein RP/EB family member 2
chr9_+_102995308 0.06 ENST00000612124.4
ENST00000374798.8
ENST00000487798.5
cylicin 2
chr11_+_94973640 0.06 ENST00000335080.6
ENST00000536741.1
lysine demethylase 4D
chr17_-_40703744 0.06 ENST00000264651.3
keratin 24
chr16_-_23641270 0.06 ENST00000568219.5
ENST00000261584.9
partner and localizer of BRCA2
chr21_+_33642476 0.06 ENST00000381291.8
ENST00000381285.8
ENST00000399367.7
ENST00000399352.5
ENST00000399355.6
ENST00000399349.5
ENST00000381318.8
intersectin 1
chr14_+_69398683 0.05 ENST00000556605.5
ENST00000031146.8
ENST00000336643.10
solute carrier family 39 member 9
chr12_+_48328980 0.05 ENST00000335017.1
H1.7 linker histone
chr15_+_58138368 0.05 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr13_-_99258366 0.05 ENST00000397470.5
ENST00000397473.7
G protein-coupled receptor 18
chr2_+_68734861 0.05 ENST00000467265.5
Rho GTPase activating protein 25
chr16_-_56451316 0.04 ENST00000300291.10
nudix hydrolase 21
chr2_-_74392025 0.04 ENST00000440727.1
ENST00000409240.5
dynactin subunit 1
chr12_+_12357418 0.04 ENST00000298571.6
BLOC-1 related complex subunit 5
chr6_+_112087576 0.04 ENST00000368656.7
ENST00000604268.1
family with sequence similarity 229 member B
chr22_-_19479160 0.04 ENST00000399523.5
ENST00000421968.6
ENST00000263202.15
ENST00000447868.5
ubiquitin recognition factor in ER associated degradation 1
chr16_+_24729641 0.04 ENST00000395799.8
trinucleotide repeat containing adaptor 6A
chr12_-_118359105 0.03 ENST00000541186.5
ENST00000539872.5
TAO kinase 3
chr1_+_160739265 0.03 ENST00000368042.7
SLAM family member 7
chr18_-_47176297 0.03 ENST00000639845.1
ENST00000256433.6
immediate early response 3 interacting protein 1
chr4_+_48483324 0.03 ENST00000273861.5
solute carrier family 10 member 4
chr8_-_81483226 0.02 ENST00000256104.5
fatty acid binding protein 4
chr3_+_98130721 0.02 ENST00000641874.1
olfactory receptor family 5 subfamily H member 1
chr17_-_31314066 0.02 ENST00000577894.1
ecotropic viral integration site 2B
chr11_-_4608226 0.02 ENST00000300747.10
ENST00000526337.5
tripartite motif containing 68
chr18_+_36544544 0.01 ENST00000591635.5
formin homology 2 domain containing 3
chr7_-_100119840 0.01 ENST00000437822.6
TATA-box binding protein associated factor 6
chr17_+_59940908 0.01 ENST00000591035.1
novel protein
chr1_+_160739239 0.00 ENST00000368043.8
SLAM family member 7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.6 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.5 1.6 GO:0034769 basement membrane disassembly(GO:0034769)
0.4 1.3 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.4 2.5 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.2 1.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.2 1.4 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.2 0.7 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.2 0.6 GO:0048058 compound eye corneal lens development(GO:0048058)
0.2 0.8 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 1.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.9 GO:0006041 glucosamine metabolic process(GO:0006041) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.4 GO:0032712 negative regulation of interleukin-3 production(GO:0032712) negative regulation of granulocyte colony-stimulating factor production(GO:0071656) negative regulation of macrophage colony-stimulating factor production(GO:1901257)
0.1 0.5 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.1 0.2 GO:0070425 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433)
0.1 0.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.2 GO:0009946 proximal/distal axis specification(GO:0009946)
0.1 1.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.4 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.3 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.3 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.4 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.2 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 2.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.3 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.2 GO:0019541 propionate metabolic process(GO:0019541) cellular response to progesterone stimulus(GO:0071393) tolerance induction to lipopolysaccharide(GO:0072573)
0.0 0.5 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.5 GO:0006449 regulation of translational termination(GO:0006449)
0.0 1.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.1 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.3 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 2.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.9 GO:0017004 cytochrome complex assembly(GO:0017004)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 3.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.7 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.0 GO:0002304 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 1.5 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.0 GO:0015855 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 1.6 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 1.6 GO:0036021 endolysosome lumen(GO:0036021)
0.1 0.4 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0097441 basilar dendrite(GO:0097441)
0.0 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0032010 phagolysosome(GO:0032010)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.1 GO:0005771 multivesicular body(GO:0005771)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.7 1.4 GO:0002113 interleukin-33 binding(GO:0002113)
0.3 0.8 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.2 2.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.4 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 0.9 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.5 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.5 GO:0031544 peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.1 2.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.6 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 0.3 GO:0002046 opsin binding(GO:0002046)
0.1 2.3 GO:0005549 odorant binding(GO:0005549)
0.1 0.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 2.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.4 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.1 0.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 2.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.1 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 1.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 1.3 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 1.0 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.7 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 1.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 0.5 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.0 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.2 GO:0001851 complement component C3b binding(GO:0001851)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 4.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 1.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.6 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.9 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 2.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 3.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 1.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.7 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing