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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for LHX3

Z-value: 0.47

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Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
LHX3
ENSG00000107187.17 LHX3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3hg38_v1_chr9_-_136203183_136203194,
hg38_v1_chr9_-_136205122_136205133		-0.349.3e-02Click!

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_72577939 1.26 ENST00000645773.1
TMC1
transmembrane channel like 1
chr3_-_142029108 1.00 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr4_+_41613476 0.81 ENST00000508466.1
LIMCH1
LIM and calponin homology domains 1
chr19_+_14583076 0.72 ENST00000547437.5
ENST00000417570.6
CLEC17A
C-type lectin domain containing 17A
chr2_-_187448244 0.63 ENST00000392370.8
ENST00000410068.5
ENST00000447403.5
ENST00000410102.5
CALCRL
calcitonin receptor like receptor
chr1_-_150235972 0.61 ENST00000534220.1
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr9_+_72577788 0.56 ENST00000645208.2
TMC1
transmembrane channel like 1
chr9_+_72577369 0.54 ENST00000651183.1
TMC1
transmembrane channel like 1
chr9_+_79573162 0.39 ENST00000425506.5
TLE4
TLE family member 4, transcriptional corepressor
chr8_-_30812867 0.37 ENST00000518243.5
PPP2CB
protein phosphatase 2 catalytic subunit beta
chr9_-_72953047 0.36 ENST00000297785.8
ENST00000376939.5
ALDH1A1
aldehyde dehydrogenase 1 family member A1
chr1_-_160954801 0.35 ENST00000368029.4
ITLN2
intelectin 2
chr7_-_86965872 0.33 ENST00000398276.6
ENST00000416314.5
ENST00000425689.1
ELAPOR2
endosome-lysosome associated apoptosis and autophagy regulator family member 2
chr17_-_41467386 0.33 ENST00000225899.4
KRT32
keratin 32
chr17_-_40937641 0.26 ENST00000209718.8
KRT23
keratin 23
chr7_-_105691637 0.24 ENST00000472195.1
ATXN7L1
ataxin 7 like 1
chr17_-_40937445 0.24 ENST00000436344.7
ENST00000485751.1
KRT23
keratin 23
chr18_-_55635948 0.24 ENST00000565124.4
ENST00000398339.5
TCF4
transcription factor 4
chr15_-_19988117 0.23 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr5_-_88823763 0.23 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
MEF2C
myocyte enhancer factor 2C
chr1_+_81306096 0.22 ENST00000370721.5
ENST00000370727.5
ENST00000370725.5
ENST00000370723.5
ENST00000370728.5
ENST00000370730.5
ADGRL2
adhesion G protein-coupled receptor L2
chr20_-_31390580 0.22 ENST00000339144.3
ENST00000376321.4
DEFB119
defensin beta 119
chr15_-_75455767 0.21 ENST00000360439.8
SIN3A
SIN3 transcription regulator family member A
chr9_+_122370523 0.21 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr3_-_20012250 0.20 ENST00000389050.5
PP2D1
protein phosphatase 2C like domain containing 1
chr15_+_65550819 0.20 ENST00000569894.5
HACD3
3-hydroxyacyl-CoA dehydratase 3
chr9_+_96928310 0.20 ENST00000354649.7
NUTM2G
NUT family member 2G
chr1_-_150235943 0.19 ENST00000533654.5
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr2_-_88860605 0.18 ENST00000390238.2
IGKJ5
immunoglobulin kappa joining 5
chr18_-_55423757 0.17 ENST00000675707.1
TCF4
transcription factor 4
chr19_-_51417700 0.16 ENST00000529627.1
ENST00000439889.6
SIGLEC10
sialic acid binding Ig like lectin 10
chr1_+_207325629 0.15 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chr7_-_36724543 0.15 ENST00000612871.4
AOAH
acyloxyacyl hydrolase
chr17_-_10469558 0.15 ENST00000255381.2
MYH4
myosin heavy chain 4
chr1_+_15341744 0.15 ENST00000444385.5
FHAD1
forkhead associated phosphopeptide binding domain 1
chr5_+_148312416 0.15 ENST00000274565.5
SPINK7
serine peptidase inhibitor Kazal type 7
chr1_-_182671853 0.15 ENST00000367556.5
RGS8
regulator of G protein signaling 8
chr1_-_182671902 0.15 ENST00000483095.6
RGS8
regulator of G protein signaling 8
chr3_+_2892199 0.14 ENST00000397459.6
CNTN4
contactin 4
chr11_-_63608542 0.14 ENST00000540943.1
PLAAT3
phospholipase A and acyltransferase 3
chr7_-_4862015 0.14 ENST00000404991.2
PAPOLB
poly(A) polymerase beta
chr7_-_36724457 0.14 ENST00000617537.5
ENST00000435386.1
AOAH
acyloxyacyl hydrolase
chr19_-_51417791 0.14 ENST00000353836.9
SIGLEC10
sialic acid binding Ig like lectin 10
chr20_-_31390483 0.13 ENST00000376315.2
DEFB119
defensin beta 119
chr17_-_5035418 0.12 ENST00000254853.10
ENST00000424747.1
SLC52A1
solute carrier family 52 member 1
chr8_-_18083278 0.12 ENST00000636691.1
ASAH1
N-acylsphingosine amidohydrolase 1
chr9_-_113303271 0.12 ENST00000297894.5
ENST00000489339.2
RNF183
ring finger protein 183
chr17_+_37491464 0.12 ENST00000613659.1
DUSP14
dual specificity phosphatase 14
chr16_+_15395745 0.12 ENST00000287594.7
ENST00000396385.4
ENST00000568766.1
MPV17L
ENSG00000261130.5
MPV17 mitochondrial inner membrane protein like
novel protein
chr10_+_87357720 0.12 ENST00000412718.3
ENST00000381697.7
NUTM2D
NUT family member 2D
chr17_+_70075317 0.12 ENST00000589377.1
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr1_-_158426237 0.12 ENST00000641042.1
OR10K2
olfactory receptor family 10 subfamily K member 2
chr5_-_16916400 0.11 ENST00000513882.5
MYO10
myosin X
chr14_+_88385714 0.11 ENST00000045347.11
SPATA7
spermatogenesis associated 7
chr3_+_141387801 0.11 ENST00000514251.5
ZBTB38
zinc finger and BTB domain containing 38
chr13_-_60013178 0.10 ENST00000498416.2
ENST00000465066.5
DIAPH3
diaphanous related formin 3
chr5_+_55853314 0.10 ENST00000354961.8
ENST00000297015.7
IL31RA
interleukin 31 receptor A
chr3_+_158110052 0.10 ENST00000295930.7
ENST00000471994.5
ENST00000482822.3
ENST00000476899.6
ENST00000683899.1
ENST00000684604.1
ENST00000682164.1
ENST00000464171.5
ENST00000611884.5
ENST00000312179.10
ENST00000475278.6
RSRC1
arginine and serine rich coiled-coil 1
chr8_+_91249307 0.10 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chr17_+_1771688 0.09 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin family F member 1
chr3_+_68006224 0.09 ENST00000496687.1
TAFA1
TAFA chemokine like family member 1
chr5_-_1882902 0.09 ENST00000231357.7
IRX4
iroquois homeobox 4
chr15_-_55408245 0.09 ENST00000563171.5
ENST00000425574.7
ENST00000442196.8
ENST00000564092.1
CCPG1
cell cycle progression 1
chr2_-_98663464 0.09 ENST00000414521.6
MGAT4A
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
chr6_-_49744434 0.09 ENST00000433368.6
ENST00000354620.4
CRISP3
cysteine rich secretory protein 3
chr1_-_93681829 0.09 ENST00000260502.11
BCAR3
BCAR3 adaptor protein, NSP family member
chr6_-_49744378 0.09 ENST00000371159.8
ENST00000263045.9
CRISP3
cysteine rich secretory protein 3
chr18_-_24311495 0.09 ENST00000357041.8
OSBPL1A
oxysterol binding protein like 1A
chr12_+_49346911 0.09 ENST00000395069.3
DNAJC22
DnaJ heat shock protein family (Hsp40) member C22
chr1_-_92486916 0.08 ENST00000294702.6
GFI1
growth factor independent 1 transcriptional repressor
chr8_+_106726115 0.08 ENST00000521592.5
OXR1
oxidation resistance 1
chr1_+_244051275 0.08 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr14_+_21997531 0.08 ENST00000390445.2
TRAV17
T cell receptor alpha variable 17
chr19_+_49513154 0.08 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
FCGRT
Fc fragment of IgG receptor and transporter
chr3_+_46877705 0.08 ENST00000449590.6
PTH1R
parathyroid hormone 1 receptor
chr3_-_142000353 0.08 ENST00000499676.5
TFDP2
transcription factor Dp-2
chr6_+_72216442 0.07 ENST00000425662.6
ENST00000453976.6
RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_152697888 0.07 ENST00000367245.5
ENST00000529453.1
MYCT1
MYC target 1
chr5_-_39274515 0.07 ENST00000510188.1
FYB1
FYN binding protein 1
chr11_-_790062 0.07 ENST00000330106.5
CEND1
cell cycle exit and neuronal differentiation 1
chr6_+_122996227 0.07 ENST00000275162.10
CLVS2
clavesin 2
chr4_+_53377630 0.07 ENST00000337488.11
ENST00000358575.9
ENST00000507922.5
ENST00000306932.10
FIP1L1
factor interacting with PAPOLA and CPSF1
chr6_+_106360668 0.06 ENST00000633556.3
CRYBG1
crystallin beta-gamma domain containing 1
chr6_-_31120437 0.06 ENST00000376288.3
CDSN
corneodesmosin
chr17_-_44066595 0.06 ENST00000585388.2
ENST00000293406.8
LSM12
LSM12 homolog
chr8_-_109974688 0.06 ENST00000297404.1
KCNV1
potassium voltage-gated channel modifier subfamily V member 1
chr3_+_101724602 0.06 ENST00000341893.8
CEP97
centrosomal protein 97
chr13_-_83882456 0.06 ENST00000674365.1
SLITRK1
SLIT and NTRK like family member 1
chr19_+_49513353 0.06 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr13_+_53028806 0.05 ENST00000219022.3
OLFM4
olfactomedin 4
chr6_+_130018565 0.05 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr16_+_67570741 0.05 ENST00000644753.1
ENST00000642819.1
ENST00000645306.1
CTCF
CCCTC-binding factor
chr19_+_48695952 0.05 ENST00000522966.2
ENST00000425340.3
ENST00000391876.5
FUT2
fucosyltransferase 2
chr3_-_64019334 0.05 ENST00000480205.5
PSMD6
proteasome 26S subunit, non-ATPase 6
chr19_+_11346499 0.05 ENST00000458408.6
ENST00000586451.5
ENST00000588592.5
CCDC159
coiled-coil domain containing 159
chr12_-_86256299 0.04 ENST00000552808.6
ENST00000547225.5
MGAT4C
MGAT4 family member C
chr8_-_18083184 0.04 ENST00000636269.1
ASAH1
N-acylsphingosine amidohydrolase 1
chr6_+_26103922 0.04 ENST00000377803.4
H4C3
H4 clustered histone 3
chr9_+_35042213 0.04 ENST00000378745.3
ENST00000312292.6
C9orf131
chromosome 9 open reading frame 131
chr4_+_112647059 0.04 ENST00000511529.1
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr5_+_141177790 0.04 ENST00000239444.4
ENST00000623995.1
PCDHB8
ENSG00000279472.1
protocadherin beta 8
novel transcript
chr2_+_233917371 0.04 ENST00000324695.9
ENST00000433712.6
TRPM8
transient receptor potential cation channel subfamily M member 8
chr18_-_24272179 0.04 ENST00000399443.7
OSBPL1A
oxysterol binding protein like 1A
chr2_-_99255107 0.04 ENST00000333017.6
ENST00000626374.2
ENST00000409679.5
ENST00000423306.1
LYG2
lysozyme g2
chr1_-_45522870 0.04 ENST00000424390.2
PRDX1
peroxiredoxin 1
chr4_+_154563003 0.04 ENST00000302068.9
ENST00000509493.1
FGB
fibrinogen beta chain
chrX_+_85003863 0.04 ENST00000373173.7
APOOL
apolipoprotein O like
chr16_-_28623330 0.04 ENST00000677940.1
ENSG00000288656.1
novel protein
chr4_+_168631597 0.04 ENST00000504519.5
ENST00000512127.5
PALLD
palladin, cytoskeletal associated protein
chr10_-_27240505 0.04 ENST00000375888.5
ENST00000676732.1
ACBD5
acyl-CoA binding domain containing 5
chr7_+_134986483 0.04 ENST00000436302.6
ENST00000435976.6
ENST00000455283.2
AGBL3
ATP/GTP binding protein like 3
chr12_-_86256267 0.04 ENST00000620241.4
MGAT4C
MGAT4 family member C
chr13_+_30422487 0.04 ENST00000638137.1
ENST00000635918.2
UBE2L5
ubiquitin conjugating enzyme E2 L5
chr2_-_178108339 0.04 ENST00000358450.8
PDE11A
phosphodiesterase 11A
chr12_-_10130143 0.03 ENST00000298523.9
ENST00000396484.6
ENST00000310002.4
ENST00000304084.13
CLEC7A
C-type lectin domain containing 7A
chr19_-_11346486 0.03 ENST00000590482.5
TMEM205
transmembrane protein 205
chr13_-_83882390 0.03 ENST00000377084.3
SLITRK1
SLIT and NTRK like family member 1
chr18_+_616711 0.03 ENST00000579494.1
CLUL1
clusterin like 1
chr13_-_70108441 0.03 ENST00000377844.9
ENST00000545028.2
KLHL1
kelch like family member 1
chr3_+_41194741 0.03 ENST00000643541.1
ENST00000426215.5
ENST00000645210.1
ENST00000646381.1
ENST00000405570.6
ENST00000642248.1
ENST00000433400.6
CTNNB1
catenin beta 1
chr7_+_97732046 0.03 ENST00000350485.8
ENST00000346867.4
ENST00000319273.10
TAC1
tachykinin precursor 1
chr12_-_10130082 0.02 ENST00000533022.5
CLEC7A
C-type lectin domain containing 7A
chr6_+_152697934 0.02 ENST00000532295.1
MYCT1
MYC target 1
chr18_+_616672 0.02 ENST00000338387.11
CLUL1
clusterin like 1
chr7_+_92057602 0.02 ENST00000491695.2
AKAP9
A-kinase anchoring protein 9
chr17_+_46511511 0.02 ENST00000576629.5
LRRC37A2
leucine rich repeat containing 37 member A2
chr12_-_10130241 0.02 ENST00000353231.9
ENST00000525605.1
CLEC7A
C-type lectin domain containing 7A
chr4_-_86357722 0.02 ENST00000641341.1
ENST00000642038.1
ENST00000641116.1
ENST00000641767.1
ENST00000639242.1
ENST00000638313.1
MAPK10
mitogen-activated protein kinase 10
chr1_+_196888014 0.02 ENST00000367416.6
ENST00000608469.6
ENST00000251424.8
ENST00000367418.2
CFHR4
complement factor H related 4
chr5_+_127649018 0.02 ENST00000379445.7
CTXN3
cortexin 3
chr1_-_56819365 0.02 ENST00000343433.7
FYB2
FYN binding protein 2
chr19_-_6279921 0.02 ENST00000252674.9
MLLT1
MLLT1 super elongation complex subunit
chr4_-_103019634 0.02 ENST00000510559.1
ENST00000296422.12
ENST00000394789.7
SLC9B1
solute carrier family 9 member B1
chr10_+_92591733 0.02 ENST00000676647.1
KIF11
kinesin family member 11
chr7_-_123199960 0.02 ENST00000194130.7
SLC13A1
solute carrier family 13 member 1
chr17_+_7407838 0.02 ENST00000302926.7
NLGN2
neuroligin 2
chrM_+_10055 0.02 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
chr1_-_150235995 0.02 ENST00000436748.6
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr7_+_30145789 0.01 ENST00000324489.5
MTURN
maturin, neural progenitor differentiation regulator homolog
chr7_+_107583919 0.01 ENST00000491150.5
BCAP29
B cell receptor associated protein 29
chr9_+_122371014 0.01 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr18_-_5197241 0.01 ENST00000434239.4
AKAIN1
A-kinase anchor inhibitor 1
chr9_-_21482313 0.00 ENST00000448696.4
IFNE
interferon epsilon
chr3_-_47475811 0.00 ENST00000265565.10
ENST00000428413.5
SCAP
SREBF chaperone
chr3_-_191282383 0.00 ENST00000427544.6
UTS2B
urotensin 2B
chr1_-_23799533 0.00 ENST00000429356.5
GALE
UDP-galactose-4-epimerase
chr17_-_66229380 0.00 ENST00000205948.11
APOH
apolipoprotein H
chr2_+_54558348 0.00 ENST00000333896.5
SPTBN1
spectrin beta, non-erythrocytic 1
chr8_-_25424260 0.00 ENST00000421054.7
GNRH1
gonadotropin releasing hormone 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.6 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.4 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0 0.1 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.0 0.1 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.1 GO:0048560 establishment of anatomical structure orientation(GO:0048560)
0.0 0.2 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.2 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 0.2 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 1.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0021590 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279)
0.0 0.8 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:1902572 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.1 GO:0040030 nucleosome positioning(GO:0016584) regulation of molecular function, epigenetic(GO:0040030)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.8 GO:0000812 Swr1 complex(GO:0000812)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 0.6 GO:0004948 calcitonin receptor activity(GO:0004948)
0.1 0.7 GO:0042806 fucose binding(GO:0042806)
0.1 0.3 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.1 0.4 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.2 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.2 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.1 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.8 GO:0019212 phosphatase inhibitor activity(GO:0019212)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1