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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for MAFK
Z-value: 0.69
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Transcription factors associated with MAFK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFK | hg38_v1_chr7_+_1530684_1530726 | -0.35 | 8.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFK
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_120914549 Show fit | 3.55 |
ENST00000546084.5
|
TNF receptor associated factor 1 |
|
| chr1_-_173050931 Show fit | 2.71 |
ENST00000404377.5
|
TNF superfamily member 18 |
|
| chr3_+_122680802 Show fit | 2.34 |
ENST00000474629.7
|
poly(ADP-ribose) polymerase family member 14 |
|
| chr1_-_169734064 Show fit | 2.06 |
ENST00000333360.12
|
selectin E |
|
| chr4_-_68670648 Show fit | 1.51 |
ENST00000338206.6
|
UDP glucuronosyltransferase family 2 member B15 |
|
| chr5_+_114056017 Show fit | 1.31 |
ENST00000512097.9
|
potassium calcium-activated channel subfamily N member 2 |
|
| chr15_-_79971164 Show fit | 1.29 |
ENST00000335661.6
ENST00000267953.4 ENST00000677151.1 |
BCL2 related protein A1 |
|
| chr1_-_89126066 Show fit | 0.96 |
ENST00000370466.4
|
guanylate binding protein 2 |
|
| chr6_+_32844789 Show fit | 0.92 |
ENST00000414474.5
|
proteasome 20S subunit beta 9 |
|
| chr1_+_86547070 Show fit | 0.84 |
ENST00000370563.3
|
chloride channel accessory 4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.7 | 2.7 | GO:2000329 | negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
| 0.1 | 2.3 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.0 | 1.9 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.3 | 1.8 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.3 | 1.7 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.4 | 1.3 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 0.1 | 1.3 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.1 | 1.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 1.3 | GO:0008053 | mitochondrial fusion(GO:0008053) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 1.8 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.2 | 1.5 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.2 | 1.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 1.2 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 1.2 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.9 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 0.7 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 0.6 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.5 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 3.4 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
| 0.1 | 2.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 2.3 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.1 | 2.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.3 | 1.7 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 1.6 | GO:0043394 | proteoglycan binding(GO:0043394) |
| 0.5 | 1.5 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.0 | 1.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 1.3 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 2.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 1.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 0.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 0.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 2.3 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 1.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 1.5 | REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
| 0.1 | 1.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 1.3 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 1.3 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 1.2 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 1.2 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.9 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |