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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for MAZ_ZNF281_GTF2F1
Z-value: 2.06
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Transcription factors associated with MAZ_ZNF281_GTF2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2F1 | hg38_v1_chr19_-_6393131_6393172 | -0.69 | 1.4e-04 | Click! |
| ZNF281 | hg38_v1_chr1_-_200410052_200410063, hg38_v1_chr1_-_200410001_200410049 | -0.56 | 3.5e-03 | Click! |
| MAZ | hg38_v1_chr16_+_29806519_29806596 | 0.55 | 4.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ_ZNF281_GTF2F1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_71867192 Show fit | 15.52 |
ENST00000611519.4
ENST00000620444.4 ENST00000613252.5 |
dachshund family transcription factor 1 |
|
| chr4_-_16898561 Show fit | 13.17 |
ENST00000515064.5
ENST00000441778.6 |
LIM domain binding 2 |
|
| chr4_-_16898619 Show fit | 12.46 |
ENST00000502640.5
ENST00000304523.10 ENST00000506732.1 |
LIM domain binding 2 |
|
| chr3_-_18424533 Show fit | 11.97 |
ENST00000417717.6
|
SATB homeobox 1 |
|
| chr2_+_48530132 Show fit | 10.44 |
ENST00000404752.6
ENST00000406226.1 |
stonin 1 |
|
| chr8_-_22693469 Show fit | 8.70 |
ENST00000317216.3
|
early growth response 3 |
|
| chr14_+_24398986 Show fit | 8.27 |
ENST00000382554.4
|
NYN domain and retroviral integrase containing |
|
| chr3_+_37861849 Show fit | 7.86 |
ENST00000273179.10
|
CTD small phosphatase like |
|
| chr13_-_71866769 Show fit | 7.82 |
ENST00000619232.1
|
dachshund family transcription factor 1 |
|
| chr12_+_27244222 Show fit | 7.69 |
ENST00000545470.5
ENST00000389032.8 ENST00000540996.5 |
serine/threonine kinase 38 like |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 31.3 | GO:0072189 | ureter development(GO:0072189) |
| 0.9 | 27.0 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 2.3 | 20.9 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.8 | 17.3 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 1.1 | 17.1 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 1.4 | 15.8 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.7 | 15.2 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.3 | 14.5 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.3 | 14.4 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 2.3 | 14.1 | GO:0051621 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 69.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.6 | 24.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.4 | 18.6 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.1 | 17.2 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 1.4 | 15.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.3 | 13.2 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.4 | 12.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.5 | 12.5 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 11.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 11.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 59.1 | GO:0003682 | chromatin binding(GO:0003682) |
| 2.1 | 26.8 | GO:0030274 | LIM domain binding(GO:0030274) |
| 1.6 | 25.0 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 2.2 | 17.3 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 17.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.8 | 15.6 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 14.3 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 2.3 | 14.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.1 | 13.2 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.4 | 12.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 60.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.4 | 22.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 20.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.2 | 14.8 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 13.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 12.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.3 | 10.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 10.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.3 | 10.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 9.8 | PID SHP2 PATHWAY | SHP2 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.8 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.2 | 18.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 17.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 16.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.3 | 13.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.4 | 13.2 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.3 | 12.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 9.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.4 | 8.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 8.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |