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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for MECP2
Z-value: 1.77
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Transcription factors associated with MECP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECP2 | hg38_v1_chrX_-_154097731_154097746 | -0.28 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECP2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.7 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.3 | 11.0 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 3.4 | 10.3 | GO:1903400 | L-arginine transmembrane transport(GO:1903400) |
| 0.1 | 9.9 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 9.0 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 8.8 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.1 | 8.1 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 1.5 | 7.3 | GO:0003069 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.1 | 7.3 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 0.4 | 6.7 | GO:0042940 | D-amino acid transport(GO:0042940) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.4 | GO:0031965 | nuclear membrane(GO:0031965) |
| 1.4 | 11.3 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.1 | 9.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.4 | 7.6 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 7.2 | GO:0044452 | nucleolar part(GO:0044452) |
| 0.0 | 6.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.5 | 5.9 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.3 | 5.7 | GO:0032059 | bleb(GO:0032059) |
| 0.8 | 5.5 | GO:0042825 | TAP complex(GO:0042825) |
| 0.5 | 5.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.9 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 15.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 13.1 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 3.4 | 10.3 | GO:0005292 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.2 | 8.3 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.5 | 7.7 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.7 | 7.5 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 7.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 7.0 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 7.0 | GO:0031593 | polyubiquitin binding(GO:0031593) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 9.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 8.1 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 7.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 7.7 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 7.6 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 7.1 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 7.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 6.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 5.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 13.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 10.8 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.3 | 10.5 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.2 | 9.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 8.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 8.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 8.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 7.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 6.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |