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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for MLX_USF2_USF1_PAX2
Z-value: 2.34
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Transcription factors associated with MLX_USF2_USF1_PAX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX2 | hg38_v1_chr10_+_100746197_100746220 | 0.61 | 1.2e-03 | Click! |
| USF1 | hg38_v1_chr1_-_161044941_161044998, hg38_v1_chr1_-_161045961_161045988 | -0.52 | 7.2e-03 | Click! |
| MLX | hg38_v1_chr17_+_42567084_42567125 | -0.48 | 1.6e-02 | Click! |
| USF2 | hg38_v1_chr19_+_35269065_35269140 | 0.48 | 1.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_67391948 Show fit | 17.51 |
ENST00000544620.5
|
RAD9 checkpoint clamp component A |
|
| chr14_-_53953415 Show fit | 15.62 |
ENST00000559501.1
ENST00000558984.1 |
bone morphogenetic protein 4 |
|
| chr8_+_119208322 Show fit | 14.40 |
ENST00000614891.5
|
mal, T cell differentiation protein 2 |
|
| chr1_-_11805949 Show fit | 13.08 |
ENST00000376590.9
|
methylenetetrahydrofolate reductase |
|
| chr17_-_48610971 Show fit | 12.90 |
ENST00000239165.9
|
homeobox B7 |
|
| chr7_+_1044542 Show fit | 12.46 |
ENST00000444847.2
|
G protein-coupled receptor 146 |
|
| chr3_-_122793772 Show fit | 12.37 |
ENST00000306103.3
|
HSPB1 associated protein 1 |
|
| chr11_+_67391975 Show fit | 11.01 |
ENST00000307980.7
|
RAD9 checkpoint clamp component A |
|
| chr14_-_54488940 Show fit | 9.19 |
ENST00000628554.2
ENST00000358056.8 |
glia maturation factor beta |
|
| chr14_-_54489003 Show fit | 9.17 |
ENST00000554908.5
ENST00000616146.4 |
glia maturation factor beta |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 28.2 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 4.0 | 24.3 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.6 | 21.4 | GO:0006293 | nucleotide-excision repair, preincision complex stabilization(GO:0006293) |
| 2.3 | 18.4 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 1.4 | 16.3 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 1.2 | 15.8 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 5.2 | 15.6 | GO:0061155 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.2 | 15.2 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.3 | 14.2 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 1.3 | 13.5 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 35.7 | GO:0016604 | nuclear body(GO:0016604) |
| 0.1 | 30.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 28.6 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 3.6 | 28.5 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.1 | 13.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 2.7 | 13.5 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 4.1 | 12.3 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.1 | 11.9 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 1.0 | 11.4 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.1 | 11.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 50.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 4.1 | 28.5 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 4.0 | 24.3 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 1.5 | 19.8 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 1.5 | 19.5 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.3 | 17.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.8 | 16.3 | GO:0005402 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) |
| 1.0 | 15.2 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.6 | 15.1 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.8 | 13.5 | GO:0050544 | arachidonic acid binding(GO:0050544) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 19.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.3 | 18.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 11.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 11.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 9.5 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 8.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 7.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 7.9 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 6.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 33.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.5 | 27.5 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.4 | 16.2 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.5 | 13.5 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 12.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 10.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 9.8 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.2 | 9.6 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.3 | 8.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 8.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |