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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for MNT_HEY1_HEY2
Z-value: 1.19
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Transcription factors associated with MNT_HEY1_HEY2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HEY1 | hg38_v1_chr8_-_79767843_79767867, hg38_v1_chr8_-_79767462_79767776 | 0.41 | 3.9e-02 | Click! |
| MNT | hg38_v1_chr17_-_2401038_2401104 | -0.26 | 2.1e-01 | Click! |
| HEY2 | hg38_v1_chr6_+_125749623_125749655 | 0.24 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MNT_HEY1_HEY2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 14.5 | GO:1903400 | L-arginine transmembrane transport(GO:1903400) |
| 3.1 | 12.4 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.1 | 10.0 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.3 | 9.0 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 1.2 | 8.2 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.7 | 7.2 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 1.4 | 6.9 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.7 | 6.4 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.1 | 5.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 5.2 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 12.8 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 12.7 | GO:0030529 | intracellular ribonucleoprotein complex(GO:0030529) |
| 0.0 | 9.4 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.2 | 8.7 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.9 | 7.2 | GO:1905202 | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202) |
| 0.0 | 5.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.4 | 5.7 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.3 | 5.3 | GO:0032059 | bleb(GO:0032059) |
| 0.4 | 5.1 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.9 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 4.8 | 14.5 | GO:0005292 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 4.1 | 12.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.5 | 10.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.2 | 8.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.1 | 7.5 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.9 | 7.2 | GO:0004485 | methylcrotonoyl-CoA carboxylase activity(GO:0004485) |
| 0.1 | 6.5 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.1 | 6.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 5.8 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 7.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.2 | 7.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 6.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 6.2 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 5.8 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.2 | 5.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 4.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 4.2 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 3.9 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 12.9 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 10.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.4 | 8.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.4 | 7.5 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 6.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 6.0 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 5.6 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 5.2 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 5.1 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |