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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for MSX1

Z-value: 0.46

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Transcription factors associated with MSX1

Gene Symbol Gene ID Gene Info
ENSG00000163132.8 MSX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX1hg38_v1_chr4_+_4859658_4859672-0.367.9e-02Click!

Activity profile of MSX1 motif

Sorted Z-values of MSX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr3_-_123620496 1.27 ENST00000578202.1
myosin light chain kinase
chr3_-_123620571 1.24 ENST00000583087.5
myosin light chain kinase
chr10_-_99620401 1.00 ENST00000370495.6
solute carrier family 25 member 28
chr12_-_52517929 0.97 ENST00000548409.5
keratin 5
chr1_-_149936324 0.88 ENST00000369140.7
myotubularin related protein 11
chr1_-_150765785 0.87 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr2_+_167135901 0.85 ENST00000628543.2
xin actin binding repeat containing 2
chr21_+_42199686 0.85 ENST00000398457.6
ATP binding cassette subfamily G member 1
chr22_+_41301514 0.73 ENST00000352645.5
zinc finger CCCH-type containing 7B
chr1_+_206635521 0.64 ENST00000367109.8
dual specificity tyrosine phosphorylation regulated kinase 3
chr3_-_15440560 0.49 ENST00000595627.5
ENST00000597949.1
ENST00000494875.3
ENST00000595975.1
ENST00000598878.1
EAF1 antisense RNA 1
methyltransferase like 6
chr8_+_30387064 0.46 ENST00000523115.5
ENST00000519647.5
RNA binding protein, mRNA processing factor
chr17_-_39778213 0.45 ENST00000583368.1
IKAROS family zinc finger 3
chr14_+_77116562 0.43 ENST00000557408.5
transmembrane protein 63C
chr11_+_45804038 0.40 ENST00000442528.2
ENST00000526817.1
solute carrier family 35 member C1
chr11_-_104968533 0.40 ENST00000444739.7
caspase 4
chr22_+_50738198 0.39 ENST00000216139.10
ENST00000529621.1
acrosin
chr13_-_37598750 0.38 ENST00000379743.8
ENST00000379742.4
ENST00000379749.8
ENST00000379747.9
ENST00000541179.5
ENST00000541481.5
periostin
chr11_-_55936400 0.37 ENST00000301532.3
olfactory receptor family 5 subfamily I member 1
chr14_-_74923234 0.35 ENST00000556776.1
ENST00000557413.6
ENST00000555647.5
ribosomal protein S6 kinase like 1
chr1_-_158426237 0.34 ENST00000641042.1
olfactory receptor family 10 subfamily K member 2
chr11_-_102625332 0.32 ENST00000260228.3
matrix metallopeptidase 20
chr3_+_171843337 0.30 ENST00000334567.9
ENST00000619900.4
ENST00000450693.1
transmembrane protein 212
chr12_-_12684490 0.28 ENST00000540510.1
G protein-coupled receptor 19
chr18_+_63970029 0.28 ENST00000353706.6
ENST00000542677.5
ENST00000397985.7
ENST00000636430.1
ENST00000397988.7
ENST00000448851.5
serpin family B member 8
chr2_+_147845020 0.28 ENST00000241416.12
activin A receptor type 2A
chr11_+_55635113 0.28 ENST00000641760.1
olfactory receptor family 4 subfamily P member 4
chr16_+_56935371 0.27 ENST00000568358.1
homocysteine inducible ER protein with ubiquitin like domain 1
chr7_-_32299287 0.26 ENST00000396193.5
phosphodiesterase 1C
chr18_-_5396265 0.25 ENST00000579951.2
erythrocyte membrane protein band 4.1 like 3
chr17_-_31901658 0.24 ENST00000261708.9
UTP6 small subunit processome component
chr18_-_50195138 0.24 ENST00000285039.12
myosin VB
chr17_+_57085092 0.23 ENST00000575322.1
ENST00000337714.8
A-kinase anchoring protein 1
chr19_-_53254688 0.22 ENST00000594517.5
ENST00000601413.5
ENST00000594681.5
zinc finger protein 677
chr2_-_208163588 0.22 ENST00000304502.5
crystallin gamma A
chr20_+_6007245 0.22 ENST00000378868.4
cardiolipin synthase 1
chr8_+_116950951 0.21 ENST00000427715.2
solute carrier family 30 member 8
chr1_-_167518583 0.21 ENST00000392122.3
CD247 molecule
chr19_-_53254841 0.20 ENST00000601828.5
ENST00000599012.5
ENST00000598513.6
ENST00000598806.5
zinc finger protein 677
chr5_-_147782518 0.19 ENST00000507386.5
janus kinase and microtubule interacting protein 2
chr4_+_118888918 0.19 ENST00000434046.6
synaptopodin 2
chr5_+_83471736 0.19 ENST00000265077.8
versican
chr9_+_113150991 0.18 ENST00000259392.8
solute carrier family 31 member 2
chr1_+_110873135 0.18 ENST00000271324.6
CD53 molecule
chr1_-_167518521 0.18 ENST00000362089.10
CD247 molecule
chr11_-_93197932 0.18 ENST00000326402.9
solute carrier family 36 member 4
chr12_+_104986292 0.18 ENST00000552951.7
ENST00000637147.1
ENST00000622317.5
ENST00000280749.5
chromosome 12 open reading frame 45
chr12_+_9827472 0.18 ENST00000617793.4
ENST00000617889.5
ENST00000354855.7
ENST00000279545.7
killer cell lectin like receptor F1
chr5_+_83471764 0.18 ENST00000512590.6
ENST00000513960.5
ENST00000513984.5
versican
chr6_+_96563117 0.18 ENST00000450218.6
four and a half LIM domains 5
chrX_-_11265975 0.17 ENST00000303025.10
ENST00000657361.1
Rho GTPase activating protein 6
chr12_+_106357729 0.17 ENST00000228347.9
RNA polymerase III subunit B
chr1_+_224183197 0.17 ENST00000323699.9
delta 4-desaturase, sphingolipid 1
chr2_+_95165784 0.16 ENST00000622059.4
ENST00000614034.5
ENST00000611147.1
zinc finger protein 2
chr9_+_127264740 0.16 ENST00000373387.9
GTPase activating Rap/RanGAP domain like 3
chr1_-_72100930 0.16 ENST00000306821.3
neuronal growth regulator 1
chr7_+_148590760 0.16 ENST00000307003.3
chromosome 7 open reading frame 33
chr16_+_69311339 0.16 ENST00000254950.13
vacuolar protein sorting 4 homolog A
chr15_+_51377247 0.15 ENST00000396399.6
gliomedin
chr5_+_83471668 0.15 ENST00000342785.8
ENST00000343200.9
versican
chr16_+_21678514 0.15 ENST00000286149.8
ENST00000388958.8
otoancorin
chr17_-_50707855 0.14 ENST00000285243.7
ankyrin repeat domain 40
chr17_-_8210203 0.14 ENST00000578549.5
ENST00000582368.5
aurora kinase B
chr15_-_76012390 0.13 ENST00000394907.8
neuregulin 4
chr1_+_158845798 0.13 ENST00000438394.1
myeloid cell nuclear differentiation antigen
chr21_+_32298849 0.13 ENST00000303645.10
melanocortin 2 receptor accessory protein
chr7_-_20217342 0.13 ENST00000400331.10
ENST00000332878.8
MET transcriptional regulator MACC1
chr17_-_40994159 0.12 ENST00000391586.3
keratin associated protein 3-3
chr4_+_112647059 0.12 ENST00000511529.1
La ribonucleoprotein 7, transcriptional regulator
chr21_+_32298945 0.12 ENST00000339944.4
melanocortin 2 receptor accessory protein
chr9_-_128656649 0.12 ENST00000372715.7
dynein 2 intermediate chain 2
chr18_-_3874247 0.12 ENST00000581699.5
DLG associated protein 1
chr1_+_244835616 0.12 ENST00000366528.3
ENST00000411948.7
cytochrome c oxidase assembly factor COX20
chr5_+_122129597 0.12 ENST00000514925.1
novel zinc finger protein
chr5_+_122129533 0.11 ENST00000296600.5
ENST00000504912.1
ENST00000505843.1
zinc finger protein 474
chr10_-_32378720 0.11 ENST00000375110.6
enhancer of polycomb homolog 1
chr15_-_77420135 0.11 ENST00000560626.6
pseudopodium enriched atypical kinase 1
chr6_+_29170907 0.11 ENST00000641417.1
olfactory receptor family 2 subfamily J member 2
chr1_+_74235377 0.10 ENST00000326637.8
TNNI3 interacting kinase
chr2_+_157257687 0.10 ENST00000259056.5
polypeptide N-acetylgalactosaminyltransferase 5
chr16_-_29923237 0.10 ENST00000568995.1
ENST00000566413.1
potassium channel tetramerization domain containing 13
chr15_-_42208153 0.10 ENST00000348544.4
ENST00000318006.10
VPS39 subunit of HOPS complex
chr18_-_3874270 0.10 ENST00000400149.7
ENST00000400155.5
ENST00000400150.7
DLG associated protein 1
chr11_-_129024157 0.09 ENST00000392657.7
Rho GTPase activating protein 32
chr10_+_27532521 0.09 ENST00000683924.1
RAB18, member RAS oncogene family
chr8_-_25424260 0.09 ENST00000421054.7
gonadotropin releasing hormone 1
chr3_-_21751189 0.09 ENST00000281523.8
zinc finger protein 385D
chr15_-_77420087 0.09 ENST00000564328.5
ENST00000682557.1
ENST00000558305.5
pseudopodium enriched atypical kinase 1
chr7_+_139133744 0.09 ENST00000430935.5
ENST00000495038.5
ENST00000474035.6
ENST00000478836.6
ENST00000464848.5
ENST00000343187.8
tetratricopeptide repeat domain 26
chr9_-_92482350 0.09 ENST00000375543.2
asporin
chr2_+_32277883 0.08 ENST00000238831.9
Yip1 domain family member 4
chr12_-_42144823 0.08 ENST00000398675.8
glucoside xylosyltransferase 1
chr5_-_139404050 0.08 ENST00000514983.5
ENST00000507779.2
ENST00000451821.6
ENST00000509959.5
ENST00000302091.9
ENST00000450845.7
spermatogenesis associated 24
chr10_+_96304425 0.08 ENST00000371174.5
DNA nucleotidylexotransferase
chr12_+_7711418 0.08 ENST00000345088.3
developmental pluripotency associated 3
chr19_-_7747559 0.08 ENST00000394173.8
CD209 molecule
chr14_-_51096029 0.08 ENST00000298355.7
tripartite motif containing 9
chr20_+_54208072 0.07 ENST00000371419.7
prefoldin subunit 4
chr5_+_173889337 0.07 ENST00000520867.5
ENST00000334035.9
cytoplasmic polyadenylation element binding protein 4
chr10_+_112283399 0.07 ENST00000643850.1
ENST00000646139.2
ENST00000645243.1
tectorin beta
chr1_-_160523204 0.07 ENST00000368055.1
ENST00000368057.8
ENST00000368059.7
SLAM family member 6
chr21_+_29130630 0.07 ENST00000399926.5
ENST00000399928.6
MAP3K7 C-terminal like
chr11_-_124320197 0.06 ENST00000624618.2
olfactory receptor family 8 subfamily D member 2
chr6_+_29173303 0.06 ENST00000377167.3
olfactory receptor family 2 subfamily J member 2
chr1_+_202122910 0.06 ENST00000682545.1
ENST00000367282.6
ENST00000682887.1
G protein-coupled receptor 37 like 1
chr1_-_205994439 0.06 ENST00000617991.4
RAB7B, member RAS oncogene family
chr3_+_108589667 0.06 ENST00000361582.8
ENST00000486815.5
DAZ interacting zinc finger protein 3
chr6_+_29100609 0.06 ENST00000377171.3
olfactory receptor family 2 subfamily J member 1
chr10_-_29634964 0.06 ENST00000375398.6
ENST00000355867.8
supervillin
chr14_-_106791226 0.06 ENST00000433072.2
immunoglobulin heavy variable 3-72
chr3_+_114294020 0.05 ENST00000383671.8
T cell immunoreceptor with Ig and ITIM domains
chrX_-_123623155 0.05 ENST00000618150.4
THO complex 2
chr4_+_158521714 0.05 ENST00000613319.4
ENST00000423548.5
ENST00000448688.6
relaxin family peptide receptor 1
chr6_+_26240385 0.05 ENST00000244537.6
H4 clustered histone 6
chr6_-_32816910 0.05 ENST00000447394.1
ENST00000438763.7
major histocompatibility complex, class II, DO beta
chr4_+_158521872 0.05 ENST00000307765.10
relaxin family peptide receptor 1
chr15_+_36579782 0.04 ENST00000437989.6
CDAN1 interacting nuclease 1
chr4_+_118888829 0.04 ENST00000448416.6
ENST00000307142.9
ENST00000429713.7
synaptopodin 2
chr18_-_72865680 0.04 ENST00000397929.5
neuropilin and tolloid like 1
chr20_+_58389197 0.04 ENST00000475243.6
ENST00000395802.7
VAMP associated protein B and C
chr8_-_71361860 0.04 ENST00000303824.11
ENST00000645451.1
EYA transcriptional coactivator and phosphatase 1
chrX_-_123622809 0.04 ENST00000441692.5
THO complex 2
chr19_-_53159004 0.04 ENST00000599096.1
ENST00000597183.5
ENST00000601804.5
ENST00000334197.12
ENST00000601469.2
ENST00000452676.6
zinc finger protein 347
chrX_-_14873027 0.03 ENST00000452869.1
ENST00000398334.5
ENST00000650831.1
ENST00000324138.7
FA complementation group B
chr2_-_168890368 0.03 ENST00000282074.7
SPC25 component of NDC80 kinetochore complex
chr16_-_71484543 0.03 ENST00000565100.6
zinc finger protein 19
chr14_+_55027200 0.03 ENST00000395472.2
ENST00000555846.2
suppressor of cytokine signaling 4
chr6_+_28281555 0.03 ENST00000259883.3
ENST00000682144.1
piggyBac transposable element derived 1
chr14_+_55027576 0.03 ENST00000339298.2
suppressor of cytokine signaling 4
chr2_-_77522347 0.03 ENST00000409093.1
ENST00000409884.6
ENST00000409088.3
leucine rich repeat transmembrane neuronal 4
chr1_-_247536440 0.02 ENST00000366487.4
ENST00000641802.1
olfactory receptor family 2 subfamily C member 3
chr11_+_126327863 0.02 ENST00000648516.1
decapping enzyme, scavenger
chr14_+_93185304 0.02 ENST00000415050.3
transmembrane protein 251
chr10_+_88586762 0.02 ENST00000371939.7
lipase family member J
chr6_-_109483208 0.02 ENST00000230122.4
zinc finger and BTB domain containing 24
chr14_-_73558945 0.02 ENST00000563329.1
ENST00000553558.6
ENST00000334988.2
HEAT repeat containing 4
chr17_+_76732978 0.01 ENST00000587459.1
novel protein
chr13_-_85799400 0.01 ENST00000647374.2
SLIT and NTRK like family member 6
chr9_-_83978429 0.01 ENST00000351839.7
heterogeneous nuclear ribonucleoprotein K
chr7_+_99828010 0.01 ENST00000631161.2
ENST00000354829.7
ENST00000342499.8
ENST00000417625.5
ENST00000415413.5
ENST00000444905.5
ENST00000222382.5
ENST00000312017.9
cytochrome P450 family 3 subfamily A member 43
chr6_+_118548289 0.01 ENST00000357525.6
phospholamban
chr6_+_6588082 0.01 ENST00000379953.6
lymphocyte antigen 86
chr4_-_99219230 0.01 ENST00000394897.5
ENST00000508558.1
ENST00000394899.6
alcohol dehydrogenase 6 (class V)
chr4_-_163613505 0.01 ENST00000339875.9
membrane associated ring-CH-type finger 1
chr19_-_9107475 0.00 ENST00000641081.1
olfactory receptor family 7 subfamily G member 2
chr14_+_51860632 0.00 ENST00000555472.5
ENST00000556766.5
G protein subunit gamma 2
chrX_+_11293411 0.00 ENST00000348912.4
ENST00000380714.7
ENST00000380712.7
amelogenin X-linked

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 1.0 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.3 0.9 GO:0034769 basement membrane disassembly(GO:0034769)
0.3 0.8 GO:0009720 detection of hormone stimulus(GO:0009720)
0.1 0.6 GO:0035617 stress granule disassembly(GO:0035617)
0.1 0.4 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 0.4 GO:1990523 bone regeneration(GO:1990523)
0.1 0.4 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.2 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 1.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0032439 endosome localization(GO:0032439)
0.0 0.4 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.1 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.1 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.2 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.5 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.1 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.0 0.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.0 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.3 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.1 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.4 GO:0045577 regulation of B cell differentiation(GO:0045577)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043159 acrosomal matrix(GO:0043159)
0.1 0.9 GO:0036021 endolysosome lumen(GO:0036021)
0.1 0.4 GO:0097169 IPAF inflammasome complex(GO:0072557) AIM2 inflammasome complex(GO:0097169)
0.0 0.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.3 GO:1990037 Lewy body core(GO:1990037)
0.0 0.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 3.6 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.5 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0033270 paranode region of axon(GO:0033270)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 0.8 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 0.4 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 0.4 GO:0004040 amidase activity(GO:0004040)
0.1 0.5 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.3 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 1.0 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.2 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.0 0.3 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.9 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.6 PID AURORA B PATHWAY Aurora B signaling
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 2.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease