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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for MSX2

Z-value: 0.40

Motif logo

Transcription factors associated with MSX2

Gene Symbol Gene ID Gene Info
ENSG00000120149.9 MSX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX2hg38_v1_chr5_+_174724549_1747246070.232.8e-01Click!

Activity profile of MSX2 motif

Sorted Z-values of MSX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_-_137532452 0.83 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
protocadherin 18
chr12_-_9869345 0.79 ENST00000228438.3
C-type lectin domain family 2 member B
chr6_-_111606260 0.59 ENST00000340026.10
TRAF3 interacting protein 2
chrX_+_54920796 0.59 ENST00000442098.5
ENST00000430420.5
ENST00000453081.5
ENST00000319167.12
ENST00000622017.4
ENST00000375022.8
ENST00000399736.5
ENST00000440072.5
ENST00000173898.12
ENST00000431115.5
ENST00000440759.5
ENST00000375041.6
trophinin
chr1_+_220879434 0.57 ENST00000366903.8
H2.0 like homeobox
chr5_-_31532039 0.53 ENST00000511367.6
ENST00000344624.8
ENST00000513349.5
drosha ribonuclease III
chr11_-_125111708 0.49 ENST00000531909.5
ENST00000529530.1
transmembrane protein 218
chr6_-_111605859 0.48 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3 interacting protein 2
chr6_+_130018565 0.48 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL histone methyl-lysine binding protein 3
chr14_+_58298497 0.43 ENST00000348476.7
ENST00000355431.8
ENST00000395168.7
AT-rich interaction domain 4A
chr11_-_69819410 0.35 ENST00000334134.4
fibroblast growth factor 3
chr10_-_103351074 0.34 ENST00000337211.8
polycomb group ring finger 6
chr10_-_103351133 0.33 ENST00000369847.4
polycomb group ring finger 6
chr12_+_52301833 0.31 ENST00000293525.5
keratin 86
chr1_+_158461574 0.30 ENST00000641432.1
ENST00000641460.1
ENST00000641535.1
ENST00000641971.1
olfactory receptor family 10 subfamily K member 1
chr20_-_51802433 0.30 ENST00000395997.3
spalt like transcription factor 4
chr20_+_56392607 0.29 ENST00000217109.9
ENST00000452950.1
cleavage stimulation factor subunit 1
chr2_-_73233206 0.28 ENST00000258083.3
protease associated domain containing 1
chr1_-_151790475 0.27 ENST00000368825.7
ENST00000368823.5
ENST00000368824.8
ENST00000458431.6
ENST00000368827.10
ENST00000440583.6
tudor and KH domain containing
chr4_+_70721953 0.27 ENST00000381006.8
ENST00000226328.8
RUN and FYVE domain containing 3
chr3_-_48635426 0.27 ENST00000455886.6
ENST00000431739.5
ENST00000426599.1
ENST00000383733.7
ENST00000395550.7
ENST00000420764.6
ENST00000337000.12
solute carrier family 26 member 6
chr7_+_100119607 0.26 ENST00000262932.5
canopy FGF signaling regulator 4
chr1_-_93585071 0.26 ENST00000539242.5
BCAR3 adaptor protein, NSP family member
chr19_+_41363989 0.25 ENST00000413014.6
transmembrane protein 91
chr8_+_2045037 0.25 ENST00000262113.9
myomesin 2
chr19_-_46634685 0.25 ENST00000300873.4
G protein subunit gamma 8
chr6_-_31862809 0.24 ENST00000375631.5
neuraminidase 1
chr8_+_2045058 0.23 ENST00000523438.1
myomesin 2
chr6_+_25652272 0.23 ENST00000334979.6
secretagogin, EF-hand calcium binding protein
chr19_+_50203607 0.23 ENST00000642316.2
ENST00000425460.6
ENST00000440075.6
ENST00000376970.6
ENST00000599920.5
myosin heavy chain 14
chr1_+_248508073 0.21 ENST00000641804.1
olfactory receptor family 2 subfamily G member 6
chr7_+_91940851 0.21 ENST00000679821.1
ENST00000681722.1
ENST00000680181.1
ENST00000356239.8
ENST00000679521.1
ENST00000680952.1
ENST00000681412.1
ENST00000680766.1
A-kinase anchoring protein 9
chr3_-_151316795 0.20 ENST00000260843.5
G protein-coupled receptor 87
chr12_+_8950036 0.20 ENST00000539240.5
killer cell lectin like receptor G1
chr3_-_115147237 0.20 ENST00000357258.8
zinc finger and BTB domain containing 20
chr7_+_91940836 0.20 ENST00000680534.1
ENST00000680513.1
ENST00000680072.1
A-kinase anchoring protein 9
chr11_+_17276708 0.19 ENST00000531172.5
ENST00000529010.6
ENST00000533738.6
ENST00000323688.10
nucleobindin 2
chr14_+_32329341 0.19 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
A-kinase anchoring protein 6
chr17_+_12665882 0.19 ENST00000425538.6
myocardin
chr17_+_81035122 0.19 ENST00000321280.11
ENST00000575989.5
ENST00000428708.7
ENST00000575712.5
ENST00000575245.5
ENST00000435091.7
ENST00000321300.10
BAR/IMD domain containing adaptor protein 2
chr3_-_142029108 0.19 ENST00000497579.5
transcription factor Dp-2
chr3_-_115147277 0.19 ENST00000675478.1
zinc finger and BTB domain containing 20
chr6_+_159761991 0.18 ENST00000367048.5
acetyl-CoA acetyltransferase 2
chr1_-_151459471 0.17 ENST00000271715.7
pogo transposable element derived with ZNF domain
chr4_+_76435216 0.17 ENST00000296043.7
shroom family member 3
chr18_+_41955186 0.17 ENST00000639914.1
ENST00000262039.9
ENST00000398870.7
ENST00000586545.5
ENST00000585528.5
phosphatidylinositol 3-kinase catalytic subunit type 3
chr2_-_55419821 0.16 ENST00000644630.1
ENST00000471947.2
ENST00000436346.7
ENST00000642200.1
ENST00000413716.7
ENST00000263630.13
ENST00000645072.1
coiled-coil domain containing 88A
chr11_-_125111579 0.16 ENST00000532156.5
ENST00000532407.5
ENST00000279968.8
ENST00000527766.5
ENST00000529583.5
ENST00000524373.5
ENST00000527271.5
ENST00000526175.5
ENST00000529609.5
ENST00000682305.1
ENST00000533273.1
transmembrane protein 218
chr8_+_38974212 0.16 ENST00000302495.5
HtrA serine peptidase 4
chr15_-_37101205 0.16 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
Meis homeobox 2
chr7_+_100612372 0.16 ENST00000493970.5
motile sperm domain containing 3
chr6_+_31739948 0.15 ENST00000375755.8
ENST00000425703.5
ENST00000375750.9
ENST00000375703.7
ENST00000375740.7
mutS homolog 5
chr1_+_43650118 0.15 ENST00000372396.4
lysine demethylase 4A
chr1_-_151459169 0.15 ENST00000368863.6
ENST00000409503.5
ENST00000491586.5
ENST00000533351.5
pogo transposable element derived with ZNF domain
chr14_+_39267377 0.15 ENST00000556148.5
ENST00000348007.7
MIA SH3 domain ER export factor 2
chr5_+_31532277 0.14 ENST00000507818.6
ENST00000325366.14
chromosome 5 open reading frame 22
chr16_+_53099100 0.14 ENST00000565832.5
chromodomain helicase DNA binding protein 9
chr1_+_151762899 0.14 ENST00000635322.1
ENST00000321531.10
ornithine decarboxylase antizyme 3
chr2_-_55419565 0.14 ENST00000647341.1
ENST00000647401.1
ENST00000336838.10
ENST00000621814.4
ENST00000644033.1
ENST00000645477.1
ENST00000647517.1
coiled-coil domain containing 88A
chr1_-_21050952 0.14 ENST00000264211.12
eukaryotic translation initiation factor 4 gamma 3
chr17_+_44187210 0.14 ENST00000589785.1
ENST00000592825.1
ENST00000589184.5
transmembrane and ubiquitin like domain containing 2
chr17_+_44187190 0.14 ENST00000319511.6
transmembrane and ubiquitin like domain containing 2
chr12_+_28257195 0.14 ENST00000381259.5
coiled-coil domain containing 91
chr2_-_55296361 0.13 ENST00000647547.1
coiled-coil domain containing 88A
chr12_+_107318395 0.13 ENST00000420571.6
ENST00000280758.10
BTB domain containing 11
chr1_-_151992571 0.12 ENST00000368809.1
S100 calcium binding protein A10
chr1_-_8817633 0.12 ENST00000400908.7
arginine-glutamic acid dipeptide repeats
chr8_+_9555900 0.12 ENST00000310430.11
ENST00000520408.5
ENST00000522110.1
tankyrase
chr1_-_68232514 0.12 ENST00000262348.9
ENST00000370973.2
ENST00000370971.1
Wnt ligand secretion mediator
chr8_-_42768602 0.11 ENST00000534622.5
cholinergic receptor nicotinic alpha 6 subunit
chr7_+_100612102 0.10 ENST00000223054.8
motile sperm domain containing 3
chr1_-_68232539 0.10 ENST00000370976.7
ENST00000354777.6
Wnt ligand secretion mediator
chr9_-_134068012 0.10 ENST00000303407.12
bromodomain containing 3
chr7_+_100612430 0.10 ENST00000379527.6
motile sperm domain containing 3
chr19_+_11374658 0.10 ENST00000674460.1
ENST00000312423.4
SWIM-type zinc finger 7 associated protein 1
chr7_+_100612522 0.10 ENST00000393950.7
ENST00000424091.2
motile sperm domain containing 3
chr7_+_131110087 0.10 ENST00000421797.6
muskelin 1
chr1_-_145996567 0.10 ENST00000582401.6
thioredoxin interacting protein
chr12_+_55549602 0.09 ENST00000641569.1
ENST00000641851.1
olfactory receptor family 6 subfamily C member 4
chr1_-_153922901 0.09 ENST00000634401.1
ENST00000368655.5
GATA zinc finger domain containing 2B
chr19_+_17267469 0.09 ENST00000596335.5
ENST00000601436.5
ENST00000595632.5
BRISC and BRCA1 A complex member 1
chrX_+_77899440 0.09 ENST00000373335.4
ENST00000475465.1
ENST00000650309.2
ENST00000647835.1
cytochrome c oxidase subunit 7B
chr19_-_19138442 0.09 ENST00000587583.6
ENST00000450333.6
ENST00000587096.5
ENST00000162044.14
ENST00000592369.1
ENST00000587915.1
transmembrane protein 161A
chr1_+_174700413 0.08 ENST00000529145.6
ENST00000325589.9
RAB GTPase activating protein 1 like
chr19_+_17267376 0.07 ENST00000447614.6
ENST00000359435.8
ENST00000599474.5
ENST00000599057.5
ENST00000598188.6
ENST00000601043.5
BRISC and BRCA1 A complex member 1
chr11_+_67483019 0.07 ENST00000279146.8
ENST00000528641.7
ENST00000682324.1
ENST00000684006.1
ENST00000683237.1
ENST00000684657.1
aryl hydrocarbon receptor interacting protein
chr11_+_108665045 0.07 ENST00000322536.8
DEAD-box helicase 10
chr7_+_48171451 0.07 ENST00000435803.6
ATP binding cassette subfamily A member 13
chr7_-_100119323 0.07 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TATA-box binding protein associated factor 6
chr14_+_64914361 0.06 ENST00000607599.6
ENST00000548752.7
ENST00000551947.6
ENST00000549115.7
ENST00000552002.7
ENST00000551093.6
ENST00000549987.1
churchill domain containing 1
CHURC1-FNTB readthrough
chr19_+_15082211 0.06 ENST00000641398.1
olfactory receptor family 1 subfamily I member 1
chr12_-_8949628 0.06 ENST00000000412.8
ENST00000543845.1
ENST00000544245.1
ENST00000536844.5
mannose-6-phosphate receptor, cation dependent
chr10_-_97687191 0.06 ENST00000370626.4
arginine vasopressin induced 1
chr17_-_10026265 0.06 ENST00000437099.6
ENST00000396115.6
growth arrest specific 7
chr10_-_54801221 0.05 ENST00000644397.2
ENST00000395445.6
ENST00000613657.5
ENST00000320301.11
protocadherin related 15
chr4_-_108762964 0.05 ENST00000512646.5
ENST00000411864.6
ENST00000296486.8
ENST00000510706.5
ethanolamine-phosphate phospho-lyase
chr19_-_45782388 0.05 ENST00000458663.6
DM1 protein kinase
chr1_+_11654857 0.05 ENST00000425796.5
ENST00000376770.5
ENST00000251547.10
ENST00000376768.5
ENST00000376760.5
ENST00000376762.8
F-box protein 44
chr16_-_46621345 0.05 ENST00000303383.8
SHC binding and spindle associated 1
chr10_-_54801262 0.05 ENST00000373965.6
ENST00000616114.4
ENST00000621708.4
ENST00000495484.5
ENST00000395440.5
ENST00000395442.5
ENST00000617271.4
ENST00000395446.5
ENST00000409834.5
ENST00000361849.7
ENST00000373957.7
ENST00000395430.5
ENST00000395433.5
ENST00000437009.5
protocadherin related 15
chr11_+_67483119 0.05 ENST00000682659.1
ENST00000525341.2
aryl hydrocarbon receptor interacting protein
chr7_+_8433602 0.05 ENST00000405863.6
neurexophilin 1
chrX_-_8801337 0.05 ENST00000543214.1
ENST00000381003.7
family with sequence similarity 9 member A
chr20_-_51802509 0.04 ENST00000371539.7
ENST00000217086.9
spalt like transcription factor 4
chr5_+_66958870 0.04 ENST00000405643.5
ENST00000407621.1
ENST00000432426.5
microtubule associated serine/threonine kinase family member 4
chr1_-_228425350 0.04 ENST00000366696.2
H3.4 histone
chr12_+_119668109 0.03 ENST00000229328.10
ENST00000630317.1
protein kinase AMP-activated non-catalytic subunit beta 1
chr14_+_22202561 0.03 ENST00000390460.1
T cell receptor alpha variable 26-2
chr3_-_165078480 0.03 ENST00000264382.8
sucrase-isomaltase
chr17_-_10469558 0.03 ENST00000255381.2
myosin heavy chain 4
chr19_-_45584810 0.03 ENST00000323060.3
outer mitochondrial membrane lipid metabolism regulator OPA3
chr3_+_113532508 0.03 ENST00000264852.9
SID1 transmembrane family member 1
chr1_+_152970646 0.03 ENST00000328051.3
small proline rich protein 4
chr1_-_197146688 0.03 ENST00000294732.11
assembly factor for spindle microtubules
chrX_+_89921903 0.03 ENST00000283891.6
ENST00000561129.2
TGFB induced factor homeobox 2 like X-linked
chr10_+_84194527 0.02 ENST00000623527.4
cadherin related family member 1
chr7_-_88795732 0.02 ENST00000297203.3
testis expressed 47
chr2_+_89913982 0.02 ENST00000390265.2
immunoglobulin kappa variable 1D-33
chr6_+_132538290 0.02 ENST00000434551.2
trace amine associated receptor 9
chrX_+_115593570 0.02 ENST00000539310.5
plastin 3
chr12_-_95003666 0.02 ENST00000327772.7
ENST00000547157.1
ENST00000684171.1
ENST00000547986.5
NADH:ubiquinone oxidoreductase subunit A12
chr2_-_89268506 0.02 ENST00000473726.1
immunoglobulin kappa variable 1-33
chr6_-_116545658 0.02 ENST00000368602.4
trafficking protein particle complex 3 like
chr1_+_15236509 0.01 ENST00000683790.1
forkhead associated phosphopeptide binding domain 1
chr3_+_140678041 0.01 ENST00000286349.4
tripartite motif containing 42
chr19_+_4007714 0.01 ENST00000262971.3
protein inhibitor of activated STAT 4
chr17_-_40417873 0.01 ENST00000423485.6
DNA topoisomerase II alpha
chr11_+_108665122 0.01 ENST00000526794.1
DEAD-box helicase 10
chr10_+_97446194 0.00 ENST00000370846.8
ENST00000352634.8
ENST00000353979.7
ENST00000370842.6
ENST00000345745.9
zinc finger DHHC-type palmitoyltransferase 16
chr10_-_28282086 0.00 ENST00000375719.7
ENST00000375732.5
membrane palmitoylated protein 7
chr2_-_27380715 0.00 ENST00000323703.11
ENST00000436006.1
zinc finger protein 513

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.4 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.4 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.2 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.1 0.5 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.1 GO:0015847 putrescine transport(GO:0015847)
0.0 0.5 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.1 GO:0099404 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.0 1.1 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 0.2 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.3 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.3 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.1 GO:0090160 Golgi to lysosome transport(GO:0090160)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044307 dendritic branch(GO:0044307)
0.1 0.2 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.3 GO:0071547 piP-body(GO:0071547)
0.0 0.2 GO:0097513 myosin II filament(GO:0097513)
0.0 0.7 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:1902555 endoribonuclease complex(GO:1902555)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 0.3 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
0.0 0.2 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0015489 polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
0.0 0.2 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.1 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 0.4 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.5 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.4 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation