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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for MYB
Z-value: 1.39
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Transcription factors associated with MYB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYB | hg38_v1_chr6_+_135181323_135181328, hg38_v1_chr6_+_135181268_135181322 | -0.26 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 9.5 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.3 | 6.0 | GO:0010666 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
| 0.9 | 5.7 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.0 | 5.6 | GO:0032508 | DNA duplex unwinding(GO:0032508) |
| 0.3 | 5.1 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.4 | 3.6 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.3 | 3.0 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.1 | 3.0 | GO:2000810 | regulation of bicellular tight junction assembly(GO:2000810) |
| 0.0 | 2.8 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 0.7 | 2.7 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.7 | 12.1 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 7.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 3.1 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 3.1 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 2.5 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.3 | 2.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.2 | 2.4 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 2.2 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 2.1 | GO:0030673 | axolemma(GO:0030673) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.8 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.3 | 6.0 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 5.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 5.4 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 1.3 | 5.1 | GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) |
| 0.1 | 3.6 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.5 | 2.7 | GO:0030298 | receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726) |
| 0.4 | 2.7 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.2 | 2.7 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 2.5 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 5.9 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 4.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 3.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 3.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 2.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 2.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 2.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.2 | 6.6 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 4.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 3.9 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 3.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 3.1 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 2.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.6 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 2.5 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 2.3 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |