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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for MYF6
Z-value: 2.03
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Transcription factors associated with MYF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYF6 | hg38_v1_chr12_+_80707625_80707642 | -0.08 | 7.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYF6
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_71866769 Show fit | 24.06 |
ENST00000619232.1
|
dachshund family transcription factor 1 |
|
| chr2_+_148021404 Show fit | 11.43 |
ENST00000638043.2
|
methyl-CpG binding domain protein 5 |
|
| chr17_+_41237998 Show fit | 10.75 |
ENST00000254072.7
|
keratin associated protein 9-8 |
|
| chr7_-_11832190 Show fit | 9.61 |
ENST00000423059.9
ENST00000617773.1 |
thrombospondin type 1 domain containing 7A |
|
| chr6_+_136038195 Show fit | 9.37 |
ENST00000615259.4
|
phosphodiesterase 7B |
|
| chr11_+_71527267 Show fit | 9.24 |
ENST00000398536.6
|
keratin associated protein 5-7 |
|
| chr12_+_20368495 Show fit | 8.65 |
ENST00000359062.4
|
phosphodiesterase 3A |
|
| chr2_+_190880809 Show fit | 7.63 |
ENST00000320717.8
|
glutaminase |
|
| chr18_-_55585773 Show fit | 7.60 |
ENST00000563824.5
ENST00000626425.2 ENST00000566514.5 ENST00000568673.5 ENST00000562847.5 ENST00000568147.5 |
transcription factor 4 |
|
| chr1_+_25616780 Show fit | 7.36 |
ENST00000374332.9
|
mannosidase alpha class 1C member 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 24.4 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 3.9 | 23.7 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.2 | 11.6 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 3.7 | 11.0 | GO:2000007 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.5 | 11.0 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.1 | 9.9 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 9.8 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 1.6 | 9.6 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 1.4 | 9.6 | GO:0090210 | regulation of establishment of blood-brain barrier(GO:0090210) |
| 3.1 | 9.4 | GO:0021593 | rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.9 | 24.2 | GO:0010369 | chromocenter(GO:0010369) |
| 0.4 | 15.6 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.2 | 12.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 11.4 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 9.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 8.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.7 | 8.1 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 1.0 | 6.0 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.0 | 5.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 24.1 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 1.1 | 14.4 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.2 | 13.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.6 | 12.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 11.6 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.3 | 11.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 1.6 | 9.6 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 9.6 | GO:0003682 | chromatin binding(GO:0003682) |
| 1.0 | 8.8 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 2.9 | 8.6 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 14.2 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 12.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 12.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 11.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 8.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.5 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 4.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.9 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 13.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 11.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.7 | 10.1 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.3 | 9.6 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 5.8 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 5.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 4.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 4.1 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 4.1 | REACTOME SIGNALING BY NOTCH1 | Genes involved in Signaling by NOTCH1 |