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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for NFATC2_NFATC3
Z-value: 1.40
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Transcription factors associated with NFATC2_NFATC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC2 | hg38_v1_chr20_-_51562829_51562853 | 0.38 | 6.1e-02 | Click! |
| NFATC3 | hg38_v1_chr16_+_68085861_68085968 | 0.38 | 6.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC2_NFATC3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_91946989 Show fit | 10.35 |
ENST00000556154.5
|
fibulin 5 |
|
| chr4_+_41613476 Show fit | 8.94 |
ENST00000508466.1
|
LIM and calponin homology domains 1 |
|
| chr4_+_41612892 Show fit | 8.67 |
ENST00000509454.5
ENST00000396595.7 ENST00000381753.8 |
LIM and calponin homology domains 1 |
|
| chr14_-_91947383 Show fit | 7.23 |
ENST00000267620.14
|
fibulin 5 |
|
| chr18_+_79395856 Show fit | 6.33 |
ENST00000253506.9
ENST00000591814.5 ENST00000427363.7 |
nuclear factor of activated T cells 1 |
|
| chr1_+_81800906 Show fit | 5.60 |
ENST00000674393.1
ENST00000674208.1 |
adhesion G protein-coupled receptor L2 |
|
| chr10_-_114684612 Show fit | 5.46 |
ENST00000533213.6
ENST00000369252.8 |
actin binding LIM protein 1 |
|
| chrX_-_63785510 Show fit | 5.38 |
ENST00000437457.6
ENST00000374878.5 ENST00000623517.3 |
Cdc42 guanine nucleotide exchange factor 9 |
|
| chr18_+_79395942 Show fit | 5.20 |
ENST00000397790.6
|
nuclear factor of activated T cells 1 |
|
| chr3_-_18438767 Show fit | 4.57 |
ENST00000454909.6
|
SATB homeobox 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 17.6 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.3 | 16.5 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.0 | 13.7 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.1 | 8.9 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 8.8 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.3 | 8.3 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 7.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 6.6 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.2 | 5.3 | GO:0072189 | ureter development(GO:0072189) |
| 0.1 | 5.1 | GO:0010842 | retina layer formation(GO:0010842) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 2.0 | 17.6 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 7.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 6.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 5.1 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 5.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 4.9 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 4.1 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 3.8 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.1 | 3.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.3 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 13.4 | GO:0005178 | integrin binding(GO:0005178) |
| 1.7 | 11.8 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.5 | 11.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 8.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 2.0 | 8.1 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.0 | 8.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 7.5 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 7.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 1.4 | 5.8 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 14.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 11.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 9.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 8.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 4.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 4.2 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.2 | 3.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 3.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 2.9 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 9.7 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 7.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 4.7 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 4.3 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 4.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 3.9 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.1 | 3.4 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 2.9 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 2.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |