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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for NFATC4
Z-value: 2.00
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Transcription factors associated with NFATC4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC4 | hg38_v1_chr14_+_24368020_24368341 | 0.32 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_155666963 Show fit | 19.71 |
ENST00000455639.6
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155666718 Show fit | 18.76 |
ENST00000621234.4
ENST00000511108.5 |
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155667096 Show fit | 18.53 |
ENST00000393832.7
|
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr4_+_155666827 Show fit | 14.35 |
ENST00000511507.5
ENST00000506455.6 |
guanylate cyclase 1 soluble subunit alpha 1 |
|
| chr1_+_99646025 Show fit | 13.75 |
ENST00000263174.9
ENST00000605497.5 ENST00000615664.1 |
palmdelphin |
|
| chr10_-_114684612 Show fit | 11.79 |
ENST00000533213.6
ENST00000369252.8 |
actin binding LIM protein 1 |
|
| chr14_-_91946989 Show fit | 11.07 |
ENST00000556154.5
|
fibulin 5 |
|
| chr4_+_41538143 Show fit | 9.10 |
ENST00000503057.6
ENST00000511496.5 |
LIM and calponin homology domains 1 |
|
| chr1_+_164559173 Show fit | 8.59 |
ENST00000420696.7
|
PBX homeobox 1 |
|
| chr4_+_155667198 Show fit | 8.28 |
ENST00000296518.11
|
guanylate cyclase 1 soluble subunit alpha 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 1.4 | 16.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.5 | 11.6 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
| 0.4 | 11.5 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 10.4 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 10.3 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 1.2 | 9.9 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.3 | 8.6 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 7.2 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.5 | 6.6 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 19.4 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 17.6 | GO:0016604 | nuclear body(GO:0016604) |
| 0.0 | 11.2 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 10.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 10.0 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 7.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.3 | 6.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 1.1 | 5.7 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.3 | 5.6 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 5.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.4 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 18.3 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 13.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.6 | 11.6 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 2.7 | 10.7 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.4 | 10.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.5 | 9.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.2 | 6.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.4 | 6.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.4 | 5.7 | GO:0050544 | arachidonic acid binding(GO:0050544) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 12.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 11.5 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 8.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 7.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 7.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 5.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 4.1 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 2.9 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 2.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.4 | 11.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.2 | 10.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 7.4 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 6.4 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.2 | 6.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 6.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.3 | 5.1 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 4.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 4.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |