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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for NFIA
Z-value: 0.67
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Transcription factors associated with NFIA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIA | hg38_v1_chr1_+_60865259_60865345 | 0.31 | 1.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_30906263 Show fit | 1.20 |
ENST00000380482.9
|
mesenteric estrogen dependent adipogenesis |
|
| chr7_-_27143672 Show fit | 1.04 |
ENST00000222726.4
|
homeobox A5 |
|
| chr7_+_1055285 Show fit | 1.04 |
ENST00000397095.2
|
G protein-coupled receptor 146 |
|
| chr7_-_41703062 Show fit | 1.04 |
ENST00000242208.5
|
inhibin subunit beta A |
|
| chr9_-_90642855 Show fit | 0.87 |
ENST00000637905.1
|
DIRAS family GTPase 2 |
|
| chr4_-_156970903 Show fit | 0.80 |
ENST00000422544.2
|
platelet derived growth factor C |
|
| chr7_+_80134794 Show fit | 0.75 |
ENST00000649796.2
|
G protein subunit alpha i1 |
|
| chr3_-_15797930 Show fit | 0.74 |
ENST00000683139.1
|
ankyrin repeat domain 28 |
|
| chr4_+_41360759 Show fit | 0.69 |
ENST00000508501.5
ENST00000512946.5 ENST00000313860.11 ENST00000512632.5 ENST00000512820.5 |
LIM and calponin homology domains 1 |
|
| chr12_+_82686889 Show fit | 0.68 |
ENST00000321196.8
|
transmembrane O-mannosyltransferase targeting cadherins 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.1 | 1.4 | GO:0061370 | testosterone biosynthetic process(GO:0061370) |
| 0.0 | 1.1 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.3 | 1.0 | GO:0060279 | positive regulation of ovulation(GO:0060279) |
| 0.1 | 1.0 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 1.0 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.2 | 0.9 | GO:1903758 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.1 | 0.9 | GO:0046092 | deoxycytidine metabolic process(GO:0046092) |
| 0.0 | 0.9 | GO:0030888 | regulation of B cell proliferation(GO:0030888) |
| 0.0 | 0.9 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 1.2 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 1.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.3 | 1.0 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 0.9 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.8 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.1 | 0.5 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.0 | 0.5 | GO:0016342 | catenin complex(GO:0016342) |
| 0.1 | 0.4 | GO:0034753 | nuclear aryl hydrocarbon receptor complex(GO:0034753) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.2 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.2 | 1.5 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.2 | 1.4 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.0 | 1.2 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 0.9 | GO:0004797 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.2 | 0.8 | GO:0019976 | interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976) |
| 0.2 | 0.8 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.0 | 0.8 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.0 | 0.8 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.0 | 0.7 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.8 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.6 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.2 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.1 | 1.1 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.1 | 1.0 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 1.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 1.0 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.8 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.0 | 0.8 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.8 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 0.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |