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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for NFIX_NFIB
Z-value: 2.71
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Transcription factors associated with NFIX_NFIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIB | hg38_v1_chr9_-_14300231_14300269 | 0.92 | 1.0e-10 | Click! |
| NFIX | hg38_v1_chr19_+_12995467_12995500 | -0.69 | 1.2e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIX_NFIB
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_41612702 Show fit | 22.92 |
ENST00000509277.5
|
LIM and calponin homology domains 1 |
|
| chr4_+_41612892 Show fit | 17.20 |
ENST00000509454.5
ENST00000396595.7 ENST00000381753.8 |
LIM and calponin homology domains 1 |
|
| chr4_+_41613476 Show fit | 9.59 |
ENST00000508466.1
|
LIM and calponin homology domains 1 |
|
| chr1_+_99646025 Show fit | 9.44 |
ENST00000263174.9
ENST00000605497.5 ENST00000615664.1 |
palmdelphin |
|
| chr20_+_43916142 Show fit | 9.42 |
ENST00000423191.6
ENST00000372999.5 |
TOX high mobility group box family member 2 |
|
| chr7_+_94394886 Show fit | 8.98 |
ENST00000297268.11
ENST00000620463.1 |
collagen type I alpha 2 chain |
|
| chr13_+_57631735 Show fit | 7.81 |
ENST00000377918.8
|
protocadherin 17 |
|
| chr6_-_129710145 Show fit | 7.67 |
ENST00000368149.3
|
Rho GTPase activating protein 18 |
|
| chr6_-_32224060 Show fit | 7.44 |
ENST00000375023.3
|
notch receptor 4 |
|
| chr11_+_59713403 Show fit | 7.40 |
ENST00000641815.1
|
syntaxin 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.9 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.1 | 16.5 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.1 | 14.4 | GO:0031424 | keratinization(GO:0031424) |
| 0.4 | 12.4 | GO:0072189 | ureter development(GO:0072189) |
| 0.8 | 11.7 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.5 | 10.6 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.1 | 10.0 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.5 | 9.9 | GO:0060347 | heart trabecula formation(GO:0060347) |
| 2.3 | 9.3 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.8 | 9.1 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.8 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 19.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 17.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.2 | 15.5 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 15.2 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.4 | 15.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 14.4 | GO:0099738 | cell cortex region(GO:0099738) |
| 0.2 | 12.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 12.2 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 11.9 | GO:0035579 | specific granule membrane(GO:0035579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 29.7 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 21.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.4 | 13.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.6 | 12.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 11.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 1.3 | 10.7 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.7 | 10.6 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.5 | 10.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.7 | 10.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 38.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 18.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 15.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 10.5 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.2 | 10.3 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.2 | 10.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 10.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 9.4 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 8.5 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 8.3 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 19.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 14.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 13.8 | REACTOME BOTULINUM NEUROTOXICITY | Genes involved in Botulinum neurotoxicity |
| 0.3 | 13.8 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.8 | 13.1 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.4 | 11.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.3 | 10.9 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 10.7 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 9.9 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |