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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for NFKB1
Z-value: 3.40
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Transcription factors associated with NFKB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB1 | hg38_v1_chr4_+_102501298_102501474, hg38_v1_chr4_+_102501885_102501957 | 0.90 | 1.2e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29559724 Show fit | 36.69 |
ENST00000377050.5
|
ubiquitin D |
|
| chr4_-_76023489 Show fit | 34.02 |
ENST00000306602.3
|
C-X-C motif chemokine ligand 10 |
|
| chr6_-_31582415 Show fit | 32.15 |
ENST00000429299.3
ENST00000446745.2 |
lymphotoxin beta |
|
| chr6_+_14117764 Show fit | 30.22 |
ENST00000379153.4
|
CD83 molecule |
|
| chr19_+_45001430 Show fit | 29.72 |
ENST00000625761.2
ENST00000505236.1 ENST00000221452.13 |
RELB proto-oncogene, NF-kB subunit |
|
| chr9_-_120926752 Show fit | 27.83 |
ENST00000373887.8
|
TNF receptor associated factor 1 |
|
| chr10_+_102394488 Show fit | 25.30 |
ENST00000369966.8
|
nuclear factor kappa B subunit 2 |
|
| chr2_+_227813834 Show fit | 24.24 |
ENST00000358813.5
ENST00000409189.7 |
C-C motif chemokine ligand 20 |
|
| chr11_+_102317492 Show fit | 23.47 |
ENST00000673846.1
|
baculoviral IAP repeat containing 3 |
|
| chr4_+_102501298 Show fit | 21.29 |
ENST00000394820.8
ENST00000226574.9 ENST00000511926.5 ENST00000507079.5 |
nuclear factor kappa B subunit 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 58.4 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 5.2 | 57.5 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 6.6 | 46.4 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 9.5 | 38.1 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 4.6 | 36.7 | GO:0070842 | aggresome assembly(GO:0070842) |
| 9.1 | 36.4 | GO:1904141 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 11.7 | 35.2 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 11.6 | 34.8 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 5.3 | 32.1 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 4.6 | 32.1 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 109.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 72.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 68.8 | GO:0045121 | membrane raft(GO:0045121) |
| 4.9 | 43.9 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.6 | 38.1 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.6 | 36.7 | GO:0016235 | aggresome(GO:0016235) |
| 6.1 | 36.4 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 3.6 | 32.1 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 7.5 | 29.9 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 27.2 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 64.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 11.5 | 57.5 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 1.1 | 55.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.8 | 52.0 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 1.6 | 38.4 | GO:0070628 | proteasome binding(GO:0070628) |
| 2.1 | 38.2 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 37.0 | GO:0005125 | cytokine activity(GO:0005125) |
| 5.2 | 36.4 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.1 | 36.3 | GO:0004713 | protein tyrosine kinase activity(GO:0004713) |
| 5.3 | 32.1 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 214.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.3 | 107.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.0 | 67.4 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 1.3 | 49.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.0 | 35.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 1.0 | 34.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.6 | 31.1 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.8 | 28.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.6 | 25.1 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.4 | 17.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 130.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.5 | 100.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 2.9 | 60.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 1.7 | 52.2 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.5 | 42.7 | REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
| 0.9 | 32.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 1.0 | 29.8 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.6 | 27.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.5 | 25.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.0 | 20.8 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |