Project
Inflammatory response time course, HUVEC (Wada, 2009)
Navigation
Downloads
Results for NFKB2
Z-value: 1.65
Motif logo
Transcription factors associated with NFKB2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NFKB2
|
ENSG00000077150.20 | NFKB2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB2 | hg38_v1_chr10_+_102395693_102395777 | 0.76 | 9.8e-06 | Click! |
Activity profile of NFKB2 motif
Sorted Z-values of NFKB2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 15.6 | GO:2000753 | regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755) |
| 2.9 | 11.5 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 2.6 | 10.3 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 2.1 | 6.4 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 1.6 | 6.5 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 1.5 | 5.9 | GO:0046035 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 1.2 | 3.6 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 1.0 | 4.1 | GO:0042488 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 1.0 | 3.9 | GO:0033091 | positive regulation of immature T cell proliferation(GO:0033091) |
| 1.0 | 2.9 | GO:0090222 | centrosome-templated microtubule nucleation(GO:0090222) |
| 0.9 | 5.5 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 0.8 | 5.5 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.7 | 5.1 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.7 | 2.8 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
| 0.7 | 24.3 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.6 | 7.0 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.6 | 4.6 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
| 0.5 | 2.1 | GO:0050822 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 0.5 | 2.0 | GO:1905224 | clathrin-coated pit assembly(GO:1905224) |
| 0.5 | 3.9 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.5 | 1.5 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.5 | 2.8 | GO:1901857 | positive regulation of cellular respiration(GO:1901857) |
| 0.5 | 7.5 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.4 | 1.2 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.4 | 1.9 | GO:0046167 | glycerol-3-phosphate biosynthetic process(GO:0046167) |
| 0.4 | 6.0 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.3 | 9.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 5.3 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
| 0.3 | 1.0 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.3 | 1.0 | GO:1904529 | regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616) |
| 0.3 | 1.2 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.3 | 6.8 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.3 | 1.5 | GO:0071034 | CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) |
| 0.3 | 2.8 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.3 | 1.9 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.3 | 3.9 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.3 | 0.8 | GO:0002876 | positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876) |
| 0.3 | 3.3 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.3 | 1.0 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.2 | 1.2 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
| 0.2 | 1.6 | GO:0097052 | L-kynurenine metabolic process(GO:0097052) |
| 0.2 | 1.7 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.2 | 0.6 | GO:1903216 | regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217) |
| 0.2 | 2.0 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.2 | 0.8 | GO:0061055 | myotome development(GO:0061055) |
| 0.2 | 0.6 | GO:0060309 | elastin catabolic process(GO:0060309) |
| 0.2 | 1.4 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
| 0.2 | 0.8 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.2 | 0.8 | GO:1901594 | detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594) |
| 0.2 | 0.8 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.2 | 0.8 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
| 0.2 | 0.9 | GO:0002351 | serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554) |
| 0.2 | 1.2 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.2 | 1.5 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.2 | 1.0 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.2 | 0.5 | GO:0098904 | regulation of AV node cell action potential(GO:0098904) |
| 0.2 | 2.2 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.2 | 0.9 | GO:0090070 | positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234) |
| 0.1 | 1.9 | GO:0021840 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.1 | 0.4 | GO:0001560 | regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724) |
| 0.1 | 0.5 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.1 | 1.2 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.1 | 0.5 | GO:0086021 | SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) |
| 0.1 | 0.6 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.1 | 2.0 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.1 | 1.0 | GO:0036072 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.1 | 0.6 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 0.8 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.1 | 1.1 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.1 | 1.3 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 0.6 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.1 | 0.4 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.1 | 11.1 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.1 | 1.2 | GO:0045657 | positive regulation of monocyte differentiation(GO:0045657) |
| 0.1 | 2.7 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 3.8 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.1 | 0.9 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.1 | 1.5 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.1 | 0.6 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.1 | 0.4 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 0.1 | 1.1 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.1 | 2.6 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 0.3 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.1 | 1.0 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.1 | 0.9 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.1 | 0.5 | GO:0002483 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.1 | 0.3 | GO:0009386 | translational attenuation(GO:0009386) |
| 0.1 | 1.6 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) |
| 0.1 | 3.2 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 1.1 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.1 | 0.5 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
| 0.1 | 1.3 | GO:0051660 | establishment of centrosome localization(GO:0051660) |
| 0.1 | 2.4 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.1 | 0.7 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.1 | 0.6 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.1 | 0.6 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.1 | 0.4 | GO:0044571 | [2Fe-2S] cluster assembly(GO:0044571) |
| 0.1 | 0.2 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.1 | 0.2 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 0.1 | 2.5 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.1 | 0.7 | GO:0017182 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.1 | 0.4 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
| 0.1 | 4.3 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) |
| 0.1 | 0.8 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.1 | 0.5 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.1 | 2.3 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.1 | 0.4 | GO:0071306 | cellular response to vitamin E(GO:0071306) pancreatic stellate cell proliferation(GO:0072343) response to metformin(GO:1901558) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.1 | 0.9 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 0.8 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.1 | 1.5 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 0.5 | GO:0019732 | antifungal humoral response(GO:0019732) |
| 0.1 | 0.2 | GO:0061589 | calcium activated phosphatidylserine scrambling(GO:0061589) |
| 0.1 | 0.9 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.1 | 0.2 | GO:0019072 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.1 | 1.1 | GO:0098780 | response to mitochondrial depolarisation(GO:0098780) |
| 0.1 | 2.9 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 0.2 | GO:1903659 | regulation of complement-dependent cytotoxicity(GO:1903659) |
| 0.0 | 0.5 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.0 | 0.2 | GO:0001971 | negative regulation of activation of membrane attack complex(GO:0001971) |
| 0.0 | 0.6 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.8 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 1.7 | GO:1903846 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.0 | 1.0 | GO:0007100 | mitotic centrosome separation(GO:0007100) |
| 0.0 | 0.3 | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.0 | 0.8 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.0 | 1.6 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 1.3 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.0 | 0.8 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 1.9 | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230) |
| 0.0 | 3.5 | GO:0042102 | positive regulation of T cell proliferation(GO:0042102) |
| 0.0 | 2.9 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.8 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 2.0 | GO:0010259 | multicellular organism aging(GO:0010259) |
| 0.0 | 0.4 | GO:0046322 | negative regulation of fatty acid oxidation(GO:0046322) |
| 0.0 | 1.2 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 0.5 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.0 | 0.2 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.0 | 0.7 | GO:0007351 | tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595) |
| 0.0 | 0.5 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.0 | 0.5 | GO:0042407 | cristae formation(GO:0042407) |
| 0.0 | 1.7 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.0 | 0.2 | GO:0060174 | limb bud formation(GO:0060174) |
| 0.0 | 0.1 | GO:0044725 | chromatin reprogramming in the zygote(GO:0044725) |
| 0.0 | 3.1 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.0 | 0.1 | GO:0044209 | AMP salvage(GO:0044209) |
| 0.0 | 1.5 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
| 0.0 | 0.6 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 0.6 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.0 | 0.6 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
| 0.0 | 0.9 | GO:0009081 | branched-chain amino acid metabolic process(GO:0009081) |
| 0.0 | 0.8 | GO:0045880 | positive regulation of smoothened signaling pathway(GO:0045880) |
| 0.0 | 1.0 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.0 | 0.2 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.0 | 1.0 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 1.6 | GO:0032922 | circadian regulation of gene expression(GO:0032922) |
| 0.0 | 0.1 | GO:0009137 | purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181) |
| 0.0 | 1.8 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 0.4 | GO:0007614 | short-term memory(GO:0007614) |
| 0.0 | 0.2 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.0 | 0.5 | GO:0051481 | negative regulation of cytosolic calcium ion concentration(GO:0051481) |
| 0.0 | 2.7 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 0.2 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.0 | 0.9 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 0.0 | 0.7 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.0 | 1.1 | GO:0043486 | histone exchange(GO:0043486) |
| 0.0 | 1.7 | GO:0045921 | positive regulation of exocytosis(GO:0045921) |
| 0.0 | 1.8 | GO:0007004 | telomere maintenance via telomerase(GO:0007004) |
| 0.0 | 1.0 | GO:0050710 | negative regulation of cytokine secretion(GO:0050710) |
| 0.0 | 1.8 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 0.2 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.0 | 0.5 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 0.0 | 0.0 | GO:1904862 | inhibitory synapse assembly(GO:1904862) |
| 0.0 | 0.4 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
| 0.0 | 0.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.0 | 0.1 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
| 0.0 | 0.3 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 0.2 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 0.1 | GO:0033313 | meiotic cell cycle checkpoint(GO:0033313) |
| 0.0 | 0.2 | GO:0000717 | nucleotide-excision repair, DNA duplex unwinding(GO:0000717) |
| 0.0 | 1.1 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.0 | 0.4 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.0 | 0.2 | GO:0015732 | prostaglandin transport(GO:0015732) |
| 0.0 | 0.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.4 | GO:0060441 | epithelial tube branching involved in lung morphogenesis(GO:0060441) |
| 0.0 | 0.2 | GO:1904152 | regulation of retrograde protein transport, ER to cytosol(GO:1904152) |
| 0.0 | 1.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.3 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.0 | 0.0 | GO:0043449 | cellular alkene metabolic process(GO:0043449) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 9.8 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 1.6 | 6.5 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 1.4 | 9.5 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.8 | 3.9 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.8 | 6.0 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.7 | 4.1 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.3 | 1.9 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.3 | 0.9 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.3 | 2.1 | GO:0042825 | TAP complex(GO:0042825) |
| 0.3 | 2.6 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.2 | 2.9 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.2 | 0.6 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.2 | 11.4 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.2 | 2.0 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.2 | 1.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.2 | 1.1 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.2 | 0.6 | GO:1990879 | CST complex(GO:1990879) |
| 0.2 | 0.6 | GO:1990742 | microvesicle(GO:1990742) |
| 0.1 | 3.3 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 1.3 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 1.5 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.1 | 0.9 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 0.9 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 16.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 1.4 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 0.6 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 0.8 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.1 | 1.5 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.1 | 2.0 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 1.2 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.1 | 0.8 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.1 | 6.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 0.9 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 1.1 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 2.4 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.1 | 0.5 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.1 | 2.0 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 1.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 0.5 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.1 | 0.8 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 1.9 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 1.6 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.1 | 0.6 | GO:0016589 | NURF complex(GO:0016589) |
| 0.1 | 0.6 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 0.3 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.1 | 0.5 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.3 | GO:0030934 | anchoring collagen complex(GO:0030934) |
| 0.1 | 1.0 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 0.2 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 1.5 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 1.8 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 0.6 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.0 | 0.7 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 2.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 2.4 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 5.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.2 | GO:0031523 | Myb complex(GO:0031523) |
| 0.0 | 1.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 1.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.9 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 1.8 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.9 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.4 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 9.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.6 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.1 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.0 | 0.5 | GO:0035748 | myelin sheath abaxonal region(GO:0035748) |
| 0.0 | 0.3 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 5.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 3.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 2.2 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 1.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.4 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.0 | 1.0 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.2 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 45.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.6 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 3.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.8 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.5 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.6 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 2.9 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 3.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 0.9 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 0.7 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 1.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.1 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.0 | 0.1 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.0 | 1.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 15.6 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 2.1 | 10.3 | GO:0030298 | receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726) |
| 1.8 | 5.3 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 1.4 | 20.3 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 1.2 | 9.8 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.7 | 5.2 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.7 | 2.1 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.6 | 11.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.5 | 1.6 | GO:0047315 | kynurenine-glyoxylate transaminase activity(GO:0047315) |
| 0.5 | 3.3 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
| 0.5 | 7.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.4 | 4.7 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.4 | 2.1 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 0.4 | 2.9 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.4 | 3.9 | GO:0089720 | caspase binding(GO:0089720) |
| 0.4 | 2.0 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.4 | 1.2 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.4 | 1.9 | GO:0004370 | glycerol kinase activity(GO:0004370) |
| 0.4 | 1.1 | GO:0060001 | minus-end directed microfilament motor activity(GO:0060001) |
| 0.4 | 3.7 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.3 | 1.6 | GO:0003870 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 0.3 | 1.2 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.2 | 1.7 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.2 | 1.0 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.2 | 0.9 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.2 | 1.0 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.2 | 0.6 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.2 | 2.0 | GO:0001727 | lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.2 | 0.8 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.2 | 1.0 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.2 | 1.5 | GO:0070728 | leucine binding(GO:0070728) |
| 0.2 | 1.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.2 | 12.2 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.2 | 1.6 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.2 | 3.9 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.2 | 0.6 | GO:0047708 | biotinidase activity(GO:0047708) |
| 0.1 | 1.5 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.1 | 0.6 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.1 | 0.5 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) |
| 0.1 | 1.5 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.5 | GO:0086020 | gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) |
| 0.1 | 0.8 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.1 | 0.5 | GO:0048763 | calcium-induced calcium release activity(GO:0048763) |
| 0.1 | 9.5 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 2.0 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 1.4 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.1 | 0.8 | GO:0097603 | temperature-gated ion channel activity(GO:0097603) |
| 0.1 | 0.7 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 1.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 1.3 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 1.9 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.1 | 0.8 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.1 | 2.1 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 0.8 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 9.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.6 | GO:0008309 | double-stranded DNA exodeoxyribonuclease activity(GO:0008309) |
| 0.1 | 3.2 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 0.3 | GO:0098640 | integrin binding involved in cell-matrix adhesion(GO:0098640) |
| 0.1 | 0.9 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 0.7 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.1 | 0.4 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.1 | 0.5 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 0.1 | 0.7 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.1 | 1.4 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 3.3 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 0.6 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.1 | 0.4 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.1 | 0.4 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 1.0 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 1.5 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.1 | 0.2 | GO:0035663 | Toll-like receptor 2 binding(GO:0035663) |
| 0.1 | 0.4 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 1.7 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 1.8 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 2.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 1.3 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.6 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 0.5 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 1.0 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 5.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 1.5 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.0 | 6.8 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 1.0 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.2 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.0 | 0.6 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.0 | 1.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 0.4 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 1.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.1 | GO:0002060 | purine nucleobase binding(GO:0002060) |
| 0.0 | 1.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.4 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.0 | 0.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 1.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 0.6 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 0.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 1.1 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 1.5 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 0.9 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 2.0 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.4 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.0 | 0.1 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.0 | 0.6 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.4 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.0 | 6.7 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 8.4 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 0.1 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.0 | 2.8 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.2 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 3.2 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.6 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.1 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
| 0.0 | 0.5 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 0.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 0.8 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 1.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.2 | GO:0004075 | biotin carboxylase activity(GO:0004075) |
| 0.0 | 0.2 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.1 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.0 | 0.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.2 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.0 | 0.4 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.1 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.0 | 3.3 | GO:0004713 | protein tyrosine kinase activity(GO:0004713) |
| 0.0 | 0.4 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.0 | 2.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 2.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.1 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.0 | 0.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 1.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.1 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 0.4 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 0.5 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.4 | 1.7 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.3 | 23.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 15.4 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.3 | 10.9 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.2 | 18.4 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.2 | 2.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 8.9 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 2.7 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 8.9 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 3.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 6.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 4.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 1.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 1.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 1.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 1.2 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 0.8 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 2.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.0 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 1.0 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 18.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 3.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 3.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.1 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.1 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.6 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 0.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.1 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.1 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.5 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.3 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.6 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.6 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 0.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.0 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 30.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 15.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 7.2 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.3 | 15.2 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.3 | 0.9 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.3 | 5.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 1.1 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.2 | 2.0 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 3.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 9.8 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 18.9 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 4.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 1.5 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 7.4 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 2.3 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 1.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.7 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 3.6 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 3.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.6 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 1.7 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 2.0 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 0.8 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 2.1 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 1.1 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 1.6 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 1.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 1.0 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 1.0 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.1 | 2.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.5 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 1.3 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 5.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 6.5 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 1.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.8 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.6 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 1.1 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 1.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.0 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.0 | 0.7 | REACTOME SIGNALING BY ERBB2 | Genes involved in Signaling by ERBB2 |
| 0.0 | 1.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.5 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.6 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 0.5 | REACTOME GAP JUNCTION TRAFFICKING | Genes involved in Gap junction trafficking |
| 0.0 | 0.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.6 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.6 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.4 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 1.3 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.1 | REACTOME ADP SIGNALLING THROUGH P2RY1 | Genes involved in ADP signalling through P2Y purinoceptor 1 |
| 0.0 | 0.5 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.3 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.2 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 1.0 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.0 | 1.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 2.7 | REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | Genes involved in Class I MHC mediated antigen processing & presentation |
| 0.0 | 0.5 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.0 | 0.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.0 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.7 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |