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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for NKX1-1

Z-value: 0.39

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
ENSG00000235608.2 NKX1-1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_63699730 0.43 ENST00000578061.5
LIM domain containing 2
chr19_+_45001430 0.37 ENST00000625761.2
ENST00000505236.1
ENST00000221452.13
RELB proto-oncogene, NF-kB subunit
chr2_+_149330506 0.34 ENST00000334166.9
LY6/PLAUR domain containing 6
chr1_+_100352451 0.32 ENST00000361544.11
ENST00000370124.8
ENST00000336454.5
cell division cycle 14A
chr5_+_67004618 0.32 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chr18_+_58221535 0.32 ENST00000431212.6
ENST00000586268.5
ENST00000587190.5
NEDD4 like E3 ubiquitin protein ligase
chr11_+_19712823 0.32 ENST00000396085.6
ENST00000349880.9
neuron navigator 2
chr1_+_155308748 0.31 ENST00000611010.4
ENST00000447866.5
ENST00000368356.9
ENST00000467076.5
ENST00000491013.5
ENST00000356657.10
farnesyl diphosphate synthase
chr1_+_155308930 0.30 ENST00000465559.5
ENST00000612683.1
farnesyl diphosphate synthase
chr11_+_134331874 0.30 ENST00000339772.9
ENST00000535456.7
galactosidase beta 1 like 2
chr12_+_6904962 0.27 ENST00000415834.5
ENST00000436789.5
leucine rich repeat containing 23
chr6_+_106360668 0.27 ENST00000633556.3
crystallin beta-gamma domain containing 1
chr7_+_100119607 0.26 ENST00000262932.5
canopy FGF signaling regulator 4
chr16_-_10942443 0.24 ENST00000570440.2
ENST00000331808.5
Dexi homolog
chr13_-_110242694 0.23 ENST00000648989.1
ENST00000647797.1
ENST00000648966.1
ENST00000649484.1
ENST00000648695.1
ENST00000650115.1
ENST00000650566.1
collagen type IV alpha 1 chain
chr7_+_100049765 0.22 ENST00000456748.6
ENST00000292450.9
ENST00000438937.1
ENST00000543588.2
zinc finger and SCAN domain containing 21
chrX_+_152831054 0.21 ENST00000370274.8
NAD(P) dependent steroid dehydrogenase-like
chr6_-_73395133 0.21 ENST00000441145.1
oocyte expressed protein
chr11_-_106022209 0.21 ENST00000301919.9
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr9_+_113463697 0.18 ENST00000317613.10
regulator of G protein signaling 3
chr16_-_57536543 0.18 ENST00000258214.3
coiled-coil domain containing 102A
chr7_-_73842508 0.18 ENST00000297873.9
methyltransferase like 27
chr1_-_51330553 0.17 ENST00000680483.1
ENST00000371747.7
tetratricopeptide repeat domain 39A
chr21_-_36542600 0.17 ENST00000399136.5
claudin 14
chr11_-_2139382 0.16 ENST00000416167.7
insulin like growth factor 2
chr2_+_216659600 0.16 ENST00000456764.1
insulin like growth factor binding protein 2
chr2_-_238203611 0.15 ENST00000612675.4
ENST00000622223.4
ENST00000254654.8
ENST00000457149.1
ILK associated serine/threonine phosphatase
chr6_-_73395093 0.15 ENST00000370363.5
oocyte expressed protein
chr10_-_1049110 0.15 ENST00000381344.8
isopentenyl-diphosphate delta isomerase 1
chr10_-_1048879 0.14 ENST00000429642.2
isopentenyl-diphosphate delta isomerase 1
chrX_-_23743201 0.14 ENST00000492081.1
ENST00000379303.10
ENST00000336430.11
acyl-CoA thioesterase 9
chr17_+_47209338 0.13 ENST00000393450.5
myosin light chain 4
chr17_+_47209035 0.13 ENST00000572316.5
ENST00000354968.5
ENST00000576874.5
ENST00000536623.6
myosin light chain 4
chr4_-_145180496 0.13 ENST00000447906.8
OTU deubiquitinase 4
chr11_-_62754141 0.12 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
zinc finger and BTB domain containing 3
chr19_+_10252206 0.12 ENST00000253099.11
ENST00000393733.6
ENST00000588502.5
mitochondrial ribosomal protein L4
chr7_+_6009222 0.12 ENST00000400479.6
ENST00000223029.8
ENST00000395236.2
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
chr9_+_34646589 0.12 ENST00000450095.6
galactose-1-phosphate uridylyltransferase
chr11_-_72112750 0.12 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
anaphase promoting complex subunit 15
chr9_+_34646654 0.12 ENST00000378842.8
galactose-1-phosphate uridylyltransferase
chr19_-_45782479 0.11 ENST00000447742.6
ENST00000354227.9
ENST00000291270.9
ENST00000683086.1
ENST00000343373.10
DM1 protein kinase
chr11_-_72112669 0.11 ENST00000545944.5
ENST00000502597.2
anaphase promoting complex subunit 15
chr14_-_24242320 0.11 ENST00000557921.2
TERF1 interacting nuclear factor 2
chr12_+_28257195 0.10 ENST00000381259.5
coiled-coil domain containing 91
chr11_-_111871530 0.10 ENST00000614444.4
ENST00000616540.5
ALG9 alpha-1,2-mannosyltransferase
chr13_+_35476740 0.10 ENST00000537702.5
neurobeachin
chr19_-_45782388 0.10 ENST00000458663.6
DM1 protein kinase
chrX_+_44844015 0.10 ENST00000339042.6
dual specificity phosphatase 21
chr3_+_186570663 0.10 ENST00000265028.8
DnaJ heat shock protein family (Hsp40) member B11
chr7_-_87220567 0.10 ENST00000433078.5
transmembrane protein 243
chr1_-_51330527 0.09 ENST00000439482.6
tetratricopeptide repeat domain 39A
chr11_-_61161414 0.09 ENST00000301765.10
VPS37C subunit of ESCRT-I
chr2_-_96740034 0.09 ENST00000264963.9
ENST00000377079.8
lectin, mannose binding 2 like
chr3_+_158801926 0.08 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
major facilitator superfamily domain containing 1
chr1_-_151790475 0.08 ENST00000368825.7
ENST00000368823.5
ENST00000368824.8
ENST00000458431.6
ENST00000368827.10
ENST00000440583.6
tudor and KH domain containing
chr4_-_65670478 0.08 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPH receptor A5
chr19_+_42306937 0.08 ENST00000595750.2
proline rich 19
chr5_-_22853320 0.08 ENST00000504376.6
ENST00000382254.6
cadherin 12
chr17_-_4967790 0.08 ENST00000575142.5
ENST00000206020.8
sperm associated antigen 7
chr4_-_53365976 0.07 ENST00000401642.8
ENST00000388940.8
ENST00000503450.1
sec1 family domain containing 2
chr12_-_55296569 0.07 ENST00000358433.3
olfactory receptor family 6 subfamily C member 6
chr19_+_32406076 0.07 ENST00000342179.9
ENST00000586427.1
dpy-19 like C-mannosyltransferase 3
chr10_+_97446137 0.07 ENST00000370854.7
ENST00000393760.6
ENST00000414567.5
zinc finger DHHC-type palmitoyltransferase 16
chr1_+_15236509 0.07 ENST00000683790.1
forkhead associated phosphopeptide binding domain 1
chr1_-_23344259 0.07 ENST00000476451.2
ENST00000302271.11
ENST00000606561.5
ENST00000374616.7
heterogeneous nuclear ribonucleoprotein R
chr1_-_23344314 0.07 ENST00000374612.5
ENST00000675048.1
ENST00000478691.5
heterogeneous nuclear ribonucleoprotein R
chr10_+_97446194 0.07 ENST00000370846.8
ENST00000352634.8
ENST00000353979.7
ENST00000370842.6
ENST00000345745.9
zinc finger DHHC-type palmitoyltransferase 16
chr4_-_65670339 0.07 ENST00000273854.7
EPH receptor A5
chr7_+_120988683 0.07 ENST00000340646.9
ENST00000310396.10
cadherin like and PC-esterase domain containing 1
chr17_+_47209375 0.06 ENST00000572303.1
myosin light chain 4
chr10_+_119029711 0.06 ENST00000425699.3
nanos C2HC-type zinc finger 1
chr17_+_82519694 0.06 ENST00000335255.10
forkhead box K2
chr4_+_3074661 0.06 ENST00000355072.11
huntingtin
chr12_+_6852115 0.06 ENST00000389231.9
ENST00000229268.13
ENST00000542087.1
ubiquitin specific peptidase 5
chr10_-_54801179 0.06 ENST00000373955.5
protocadherin related 15
chr14_-_24242600 0.06 ENST00000646753.1
ENST00000558566.1
ENST00000267415.12
ENST00000559019.1
ENST00000399423.8
ENST00000626689.2
TERF1 interacting nuclear factor 2
chr5_+_64505981 0.05 ENST00000334025.3
regulator of G protein signaling 7 binding protein
chr7_-_6009072 0.05 ENST00000642456.1
ENST00000642292.1
ENST00000441476.6
PMS1 homolog 2, mismatch repair system component
chr6_-_31862809 0.05 ENST00000375631.5
neuraminidase 1
chr1_+_160400543 0.05 ENST00000368061.3
VANGL planar cell polarity protein 2
chr11_-_47176851 0.04 ENST00000629231.2
ENST00000526342.5
ENST00000528444.5
ENST00000530596.5
ENST00000525398.5
ENST00000524782.6
ENST00000527927.5
ENST00000525314.5
ADP ribosylation factor GTPase activating protein 2
chr19_+_9835292 0.04 ENST00000247970.9
ENST00000587625.5
ENST00000588695.5
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
chr19_+_32405789 0.04 ENST00000586987.5
dpy-19 like C-mannosyltransferase 3
chr3_+_23810436 0.04 ENST00000467766.5
ENST00000424381.5
ubiquitin conjugating enzyme E2 E1
chrX_+_19343893 0.04 ENST00000540249.5
ENST00000545074.5
ENST00000379806.9
ENST00000423505.5
ENST00000422285.7
ENST00000417819.5
ENST00000355808.9
ENST00000379805.3
pyruvate dehydrogenase E1 subunit alpha 1
chr17_+_59155726 0.04 ENST00000578777.5
ENST00000577457.1
ENST00000582995.5
ENST00000262293.9
ENST00000614081.1
proline rich 11
chrY_-_24813393 0.04 ENST00000382365.7
ENST00000315357.9
ENST00000446723.4
deleted in azoospermia 3
chr10_-_54801221 0.03 ENST00000644397.2
ENST00000395445.6
ENST00000613657.5
ENST00000320301.11
protocadherin related 15
chr14_+_94174284 0.03 ENST00000304338.8
protein phosphatase 4 regulatory subunit 4
chr19_+_35758143 0.03 ENST00000444637.6
ENST00000396908.8
ENST00000301165.9
proline and serine rich 3
chr7_-_6009019 0.03 ENST00000382321.5
ENST00000265849.12
PMS1 homolog 2, mismatch repair system component
chr10_-_54801262 0.03 ENST00000373965.6
ENST00000616114.4
ENST00000621708.4
ENST00000495484.5
ENST00000395440.5
ENST00000395442.5
ENST00000617271.4
ENST00000395446.5
ENST00000409834.5
ENST00000361849.7
ENST00000373957.7
ENST00000395430.5
ENST00000395433.5
ENST00000437009.5
protocadherin related 15
chrX_-_154097668 0.03 ENST00000407218.5
ENST00000303391.11
ENST00000453960.7
methyl-CpG binding protein 2
chr19_+_32405758 0.03 ENST00000392250.7
dpy-19 like C-mannosyltransferase 3
chr12_+_6904733 0.03 ENST00000007969.12
ENST00000622489.4
ENST00000443597.7
ENST00000323702.9
leucine rich repeat containing 23
chr1_+_174874434 0.03 ENST00000478442.5
ENST00000465412.5
RAB GTPase activating protein 1 like
chr10_+_1049476 0.03 ENST00000358220.5
WD repeat domain 37
chr21_+_33025927 0.03 ENST00000430860.1
ENST00000382357.4
ENST00000333337.3
oligodendrocyte transcription factor 2
chr19_-_6424802 0.03 ENST00000600480.2
KH-type splicing regulatory protein
chr7_+_71132123 0.03 ENST00000333538.10
polypeptide N-acetylgalactosaminyltransferase 17
chr11_-_59615673 0.03 ENST00000263847.6
oxysterol binding protein
chr19_+_56141317 0.02 ENST00000592949.5
zinc finger protein 444
chr6_-_82247697 0.02 ENST00000306270.12
ENST00000610980.4
inhibitor of Bruton tyrosine kinase
chr12_+_48105466 0.02 ENST00000549003.5
ENST00000550924.6
phosphofructokinase, muscle
chr6_-_166627244 0.02 ENST00000265678.9
ribosomal protein S6 kinase A2
chr1_+_240091866 0.02 ENST00000319653.14
formin 2
chr5_-_160119389 0.02 ENST00000523662.1
ENST00000456329.7
ENST00000307063.9
PWWP domain containing 2A
chr15_-_74906872 0.02 ENST00000562698.5
family with sequence similarity 219 member B
chr1_-_51331315 0.02 ENST00000262676.9
tetratricopeptide repeat domain 39A
chr20_-_41618362 0.02 ENST00000373222.3
ENST00000373233.8
chromodomain helicase DNA binding protein 6
chr19_-_6424772 0.01 ENST00000619396.4
ENST00000398148.7
KH-type splicing regulatory protein
chr22_-_38755458 0.01 ENST00000405510.5
ENST00000433561.5
Sad1 and UNC84 domain containing 2
chr10_-_124418912 0.01 ENST00000368845.6
ENST00000539214.5
ornithine aminotransferase
chrX_+_155216452 0.01 ENST00000286428.7
VHL binding protein 1
chrX_-_152830721 0.01 ENST00000370277.5
centrin 2
chr17_-_46579651 0.01 ENST00000573185.5
ENST00000570550.5
ENST00000445552.6
ENST00000329240.10
ENST00000622488.6
ENST00000336125.6
ADP ribosylation factor like GTPase 17A
chr3_+_186842687 0.01 ENST00000444204.2
ENST00000320741.7
adiponectin, C1Q and collagen domain containing
chr12_-_50396601 0.01 ENST00000327337.6
ENST00000543111.5
family with sequence similarity 186 member A
chr19_-_8005590 0.01 ENST00000407627.7
ENST00000593807.1
ELAV like RNA binding protein 1
chr14_+_22202561 0.00 ENST00000390460.1
T cell receptor alpha variable 26-2
chr9_+_121567057 0.00 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2 interacting protein

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0033384 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 0.3 GO:0050992 dimethylallyl diphosphate biosynthetic process(GO:0050992) dimethylallyl diphosphate metabolic process(GO:0050993)
0.1 0.2 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.3 GO:0021564 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 0.2 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.2 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.0 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.0 0.2 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.1 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 0.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.0 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.2 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 0.2 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.0 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:0071547 piP-body(GO:0071547)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 0.3 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.1 0.2 GO:0047012 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity(GO:0047012)
0.1 0.3 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.2 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)