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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for NKX2-1

Z-value: 0.79

Motif logo

Transcription factors associated with NKX2-1

Gene Symbol Gene ID Gene Info
ENSG00000136352.19 NKX2-1

Activity-expression correlation:

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_-_224401994 3.58 ENST00000389874.3
family with sequence similarity 124 member B
chr2_-_224402097 3.56 ENST00000409685.4
family with sequence similarity 124 member B
chr4_-_185956652 3.41 ENST00000355634.9
sorbin and SH3 domain containing 2
chr18_+_44680875 2.62 ENST00000649279.2
ENST00000677699.1
SET binding protein 1
chr9_-_14313642 2.10 ENST00000637742.1
nuclear factor I B
chr19_+_39406831 1.97 ENST00000597629.3
ENST00000594442.2
ENST00000594045.2
ZFP36 ring finger protein
chr20_+_43916142 1.95 ENST00000423191.6
ENST00000372999.5
TOX high mobility group box family member 2
chr6_+_136038195 1.72 ENST00000615259.4
phosphodiesterase 7B
chr12_-_85836372 1.71 ENST00000361228.5
Ras association domain family member 9
chr4_+_54657918 1.50 ENST00000412167.6
ENST00000288135.6
KIT proto-oncogene, receptor tyrosine kinase
chr2_-_156332694 1.39 ENST00000424077.1
ENST00000426264.5
ENST00000421709.1
ENST00000339562.9
nuclear receptor subfamily 4 group A member 2
chrX_-_136767322 1.39 ENST00000370620.5
Rac/Cdc42 guanine nucleotide exchange factor 6
chr22_+_50705495 1.36 ENST00000664402.1
SH3 and multiple ankyrin repeat domains 3
chrX_-_120559889 1.20 ENST00000371323.3
cullin 4B
chr6_-_134052594 1.14 ENST00000275230.6
solute carrier family 2 member 12
chrX_+_87517784 1.10 ENST00000373119.9
ENST00000373114.4
kelch like family member 4
chr8_-_17002327 1.09 ENST00000180166.6
fibroblast growth factor 20
chr4_+_143433491 1.07 ENST00000512843.1
GRB2 associated binding protein 1
chr7_-_120857124 1.05 ENST00000441017.5
ENST00000424710.5
ENST00000433758.5
tetraspanin 12
chr10_+_35195843 1.04 ENST00000488741.5
ENST00000474931.5
ENST00000468236.5
ENST00000344351.5
ENST00000490511.1
cAMP responsive element modulator
chr1_+_66533575 1.01 ENST00000684751.1
ENST00000683291.1
ENST00000682054.1
ENST00000435165.3
ENST00000684539.1
ENST00000681971.1
ENST00000682476.1
ENST00000684168.1
ENST00000371039.5
SH3GL interacting endocytic adaptor 1
chr14_-_89417148 0.93 ENST00000557258.6
forkhead box N3
chr6_+_32153441 0.89 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
palmitoyl-protein thioesterase 2
chr7_-_27185223 0.88 ENST00000517402.1
ENST00000006015.4
homeobox A11
chr14_-_75660816 0.86 ENST00000256319.7
ergosterol biosynthesis 28 homolog
chr1_+_65309517 0.81 ENST00000371069.5
DnaJ heat shock protein family (Hsp40) member C6
chr6_+_32154010 0.81 ENST00000375137.6
palmitoyl-protein thioesterase 2
chr14_+_93927259 0.79 ENST00000556222.1
ENST00000554404.1
family with sequence similarity 181 member A
chr15_+_76995118 0.79 ENST00000558012.6
ENST00000379595.7
proline-serine-threonine phosphatase interacting protein 1
chr15_+_57219411 0.73 ENST00000543579.5
ENST00000537840.5
ENST00000343827.7
transcription factor 12
chr2_-_151261839 0.73 ENST00000331426.6
RNA binding motif protein 43
chr21_-_33643926 0.72 ENST00000438788.1
crystallin zeta like 1
chr11_-_106077401 0.72 ENST00000526793.5
kelch repeat and BTB domain containing 3
chr14_-_77616630 0.72 ENST00000216484.7
serine palmitoyltransferase long chain base subunit 2
chr5_-_123036664 0.72 ENST00000306442.5
peptidylprolyl isomerase C
chrX_-_71254106 0.71 ENST00000373984.7
ENST00000314425.9
ENST00000373982.5
zinc finger MYM-type containing 3
chr3_+_58008350 0.71 ENST00000490882.5
ENST00000358537.7
ENST00000429972.6
ENST00000682871.1
ENST00000295956.9
filamin B
chr17_-_59964714 0.68 ENST00000589113.1
ENST00000305783.13
ring finger protein, transmembrane 1
chr9_-_94593810 0.66 ENST00000375337.4
fructose-bisphosphatase 2
chr7_+_30852273 0.65 ENST00000509504.2
novel protein, MINDY4 and AQP1 readthrough
chr14_+_63204436 0.64 ENST00000316754.8
ras homolog family member J
chr13_-_44436801 0.63 ENST00000261489.6
TSC22 domain family member 1
chr2_+_135531460 0.63 ENST00000683871.1
ENST00000409478.5
ENST00000264160.8
ENST00000438014.5
R3H domain containing 1
chr20_-_38165261 0.63 ENST00000361475.7
transglutaminase 2
chr3_+_100492548 0.61 ENST00000323523.8
ENST00000403410.5
ENST00000449609.1
transmembrane protein 45A
chrX_-_32155462 0.60 ENST00000359836.5
ENST00000378707.7
ENST00000541735.5
ENST00000684130.1
ENST00000682238.1
ENST00000620040.5
ENST00000474231.5
dystrophin
chr12_+_25052512 0.59 ENST00000557489.5
ENST00000354454.7
ENST00000536173.5
inositol 1,4,5-triphosphate receptor associated 2
chr6_+_31706866 0.58 ENST00000375832.5
ENST00000503322.1
lymphocyte antigen 6 family member G6F
LY6G6F-LY6G6D readthrough
chr8_-_28889958 0.57 ENST00000521022.6
integrator complex subunit 9
chr17_-_42017410 0.54 ENST00000316603.12
ENST00000674175.1
ENST00000674233.1
ENST00000457167.9
ENST00000674306.1
DnaJ heat shock protein family (Hsp40) member C7
chr16_-_28211476 0.53 ENST00000569951.1
ENST00000565698.5
exportin 6
chrX_-_135344101 0.53 ENST00000370766.8
zinc finger protein 75D
chr12_+_93378625 0.52 ENST00000546925.1
nudix hydrolase 4
chr12_+_93378550 0.51 ENST00000550056.5
ENST00000549992.5
ENST00000548662.5
ENST00000547014.5
nudix hydrolase 4
chr8_-_28889909 0.49 ENST00000523436.5
ENST00000521777.5
ENST00000520184.1
integrator complex subunit 9
chr8_-_38468601 0.49 ENST00000341462.9
ENST00000683765.1
ENST00000356207.9
ENST00000326324.10
ENST00000335922.9
ENST00000532791.5
fibroblast growth factor receptor 1
chr8_+_69492793 0.48 ENST00000616868.1
ENST00000419716.7
ENST00000402687.9
sulfatase 1
chr17_+_4710622 0.47 ENST00000574954.5
ENST00000269260.7
ENST00000346341.6
ENST00000572457.5
ENST00000381488.10
ENST00000412477.7
ENST00000571428.5
ENST00000575877.5
arrestin beta 2
chr14_+_63204859 0.47 ENST00000555125.1
ras homolog family member J
chr1_-_61725121 0.46 ENST00000371177.2
ENST00000606498.5
TM2 domain containing 1
chr1_-_153626948 0.46 ENST00000392622.3
S100 calcium binding protein A13
chr20_-_57710539 0.46 ENST00000395816.7
ENST00000347215.8
prostate transmembrane protein, androgen induced 1
chr19_+_48469202 0.46 ENST00000427476.4
cytohesin 2
chr16_+_58500135 0.45 ENST00000563978.5
ENST00000569923.5
ENST00000356752.8
ENST00000563799.5
ENST00000562999.5
ENST00000570248.5
ENST00000562731.5
ENST00000568424.1
NDRG family member 4
chrX_+_153411472 0.44 ENST00000338647.7
ZFP92 zinc finger protein
chr10_+_110207587 0.44 ENST00000332674.9
ENST00000453116.5
MAX interactor 1, dimerization protein
chr15_+_69160620 0.43 ENST00000261858.7
glucuronic acid epimerase
chr7_-_95434951 0.42 ENST00000478801.5
ENST00000469926.5
ENST00000493290.5
ENST00000222572.8
ENST00000633531.1
ENST00000490778.5
ENST00000433091.6
paraoxonase 2
chr17_-_61928005 0.42 ENST00000444766.7
integrator complex subunit 2
chr16_+_58500047 0.41 ENST00000566192.5
ENST00000565088.5
ENST00000568640.5
NDRG family member 4
chr17_-_61927968 0.41 ENST00000646954.1
ENST00000251334.7
ENST00000647009.1
integrator complex subunit 2
chr7_-_105691637 0.41 ENST00000472195.1
ataxin 7 like 1
chr7_-_92134417 0.40 ENST00000003100.13
cytochrome P450 family 51 subfamily A member 1
chr22_-_19178402 0.40 ENST00000451283.5
solute carrier family 25 member 1
chr11_-_106077313 0.39 ENST00000531837.2
ENST00000534815.1
kelch repeat and BTB domain containing 3
chr16_+_28637654 0.39 ENST00000529716.5
nuclear pore complex interacting protein family member B8
chr12_-_120581361 0.39 ENST00000341039.6
ENST00000357500.5
POP5 homolog, ribonuclease P/MRP subunit
chr16_-_29745951 0.38 ENST00000329410.4
chromosome 16 open reading frame 54
chr11_+_6863057 0.38 ENST00000641461.1
olfactory receptor family 10 subfamily A member 2
chr19_-_38899529 0.37 ENST00000249396.12
ENST00000437828.5
sirtuin 2
chrX_-_71254527 0.36 ENST00000373978.1
ENST00000373981.5
zinc finger MYM-type containing 3
chr2_-_85668172 0.36 ENST00000428225.5
ENST00000519937.7
surfactant protein B
chr2_-_191847068 0.35 ENST00000304141.5
caveolae associated protein 2
chr6_-_49463173 0.34 ENST00000274813.4
methylmalonyl-CoA mutase
chr9_+_35341830 0.33 ENST00000636694.1
unc-13 homolog B
chr6_+_42915989 0.31 ENST00000441198.4
ENST00000446507.5
ENST00000616441.2
pre T cell antigen receptor alpha
chr17_+_47971105 0.31 ENST00000338399.9
ENST00000578018.5
ENST00000579175.5
CDK5 regulatory subunit associated protein 3
chr11_-_1753870 0.31 ENST00000636579.1
novel protein
chr17_-_65561640 0.30 ENST00000618960.4
ENST00000307078.10
axin 2
chr6_+_42916046 0.30 ENST00000304672.6
pre T cell antigen receptor alpha
chr11_+_106077638 0.28 ENST00000278618.9
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr3_-_115071333 0.28 ENST00000462705.5
zinc finger and BTB domain containing 20
chrX_-_108091520 0.28 ENST00000340200.5
ENST00000217958.8
ENST00000372296.5
ENST00000372295.5
ENST00000361815.9
proteasome 26S subunit, non-ATPase 10
chrX_+_119072960 0.27 ENST00000620151.3
novel cancer/testis antigen family protein
chr12_-_70920612 0.27 ENST00000283228.7
protein tyrosine phosphatase receptor type R
chr13_-_75482114 0.27 ENST00000377625.6
ENST00000431480.6
TBC1 domain family member 4
chr19_+_51127030 0.27 ENST00000599948.1
sialic acid binding Ig like lectin 9
chr9_-_7799752 0.27 ENST00000358227.5
distal membrane arm assembly complex 1
chr1_+_211259932 0.27 ENST00000367005.8
REST corepressor 3
chr6_-_149484965 0.26 ENST00000409806.8
zinc finger CCCH-type containing 12D
chr3_+_49007062 0.26 ENST00000395474.7
ENST00000610967.4
ENST00000429900.6
WD repeat domain 6
chr12_-_21657792 0.26 ENST00000396076.5
lactate dehydrogenase B
chr12_-_21657831 0.26 ENST00000450584.5
ENST00000350669.5
ENST00000673047.2
lactate dehydrogenase B
chr12_-_10826358 0.25 ENST00000240619.2
taste 2 receptor member 10
chr15_-_33067884 0.25 ENST00000334528.13
formin 1
chr7_-_142885737 0.25 ENST00000359396.9
ENST00000436401.1
transient receptor potential cation channel subfamily V member 6
chrX_+_136497079 0.24 ENST00000535601.5
ENST00000448450.5
ENST00000425695.5
HIV-1 Tat specific factor 1
chr17_+_42458844 0.24 ENST00000393829.6
ENST00000537728.5
ENST00000343619.9
ENST00000264649.10
ENST00000585525.5
ENST00000544137.5
ENST00000589727.5
ENST00000587824.5
ATPase H+ transporting V0 subunit a1
chr17_+_68525795 0.24 ENST00000592800.5
protein kinase cAMP-dependent type I regulatory subunit alpha
chr13_-_75482151 0.23 ENST00000377636.8
TBC1 domain family member 4
chr1_-_17011891 0.23 ENST00000341676.9
ENST00000326735.13
ENST00000452699.5
ATPase cation transporting 13A2
chr19_+_48469354 0.23 ENST00000452733.7
ENST00000641098.1
cytohesin 2
chr19_-_49361475 0.23 ENST00000598810.5
TEA domain transcription factor 2
chr2_+_128091166 0.22 ENST00000259253.11
UDP-glucose glycoprotein glucosyltransferase 1
chr2_+_118942188 0.22 ENST00000327097.5
macrophage receptor with collagenous structure
chr6_-_26056460 0.22 ENST00000343677.4
H1.2 linker histone, cluster member
chr12_-_102197827 0.22 ENST00000329406.5
pro-melanin concentrating hormone
chr9_-_4299547 0.21 ENST00000682749.1
GLIS family zinc finger 3
chr17_-_3595831 0.21 ENST00000399759.7
transient receptor potential cation channel subfamily V member 1
chr3_-_195442853 0.21 ENST00000635383.1
ENST00000439666.1
ENST00000618471.4
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr11_-_66317037 0.20 ENST00000311330.4
CD248 molecule
chr1_+_213989691 0.20 ENST00000607425.1
prospero homeobox 1
chr8_+_22161655 0.20 ENST00000318561.7
surfactant protein C
chr12_-_54300974 0.20 ENST00000435572.7
ENST00000553070.5
nuclear factor, erythroid 2
chr15_-_44663644 0.19 ENST00000559511.6
ENST00000427534.6
ENST00000559193.5
ENST00000261866.12
ENST00000535302.6
ENST00000684235.1
ENST00000682065.1
ENST00000682669.1
ENST00000558319.5
SPG11 vesicle trafficking associated, spatacsin
chr2_-_240561029 0.19 ENST00000405002.5
ENST00000441168.5
ENST00000403283.5
ankyrin repeat and MYND domain containing 1
chr12_+_25052634 0.19 ENST00000548766.5
inositol 1,4,5-triphosphate receptor associated 2
chr12_-_610407 0.18 ENST00000397265.7
ninjurin 2
chr1_-_109042093 0.18 ENST00000369962.8
ENST00000357672.7
ENST00000531337.1
ENST00000529074.1
ENST00000369965.8
WD repeat domain 47
chrX_-_16869840 0.18 ENST00000380084.8
RB binding protein 7, chromatin remodeling factor
chr8_-_140800535 0.17 ENST00000521986.5
ENST00000523539.5
protein tyrosine kinase 2
chr1_+_207104226 0.17 ENST00000367070.8
complement component 4 binding protein alpha
chr1_+_14945775 0.17 ENST00000400797.3
kazrin, periplakin interacting protein
chr6_-_39431313 0.16 ENST00000229913.9
ENST00000394362.5
kinesin family member 6
chrX_-_84188148 0.16 ENST00000262752.5
ribosomal protein S6 kinase A6
chr22_+_24495242 0.16 ENST00000382760.2
ENST00000326010.10
beta-ureidopropionase 1
chrX_+_71254781 0.16 ENST00000677446.1
non-POU domain containing octamer binding
chr1_-_1390943 0.16 ENST00000408952.8
cyclin L2
chrX_+_153904714 0.15 ENST00000646375.1
arginine vasopressin receptor 2
chr9_-_4300049 0.14 ENST00000381971.8
GLIS family zinc finger 3
chr12_+_59664677 0.14 ENST00000548610.5
solute carrier family 16 member 7
chr8_+_22161788 0.14 ENST00000521315.5
ENST00000437090.6
ENST00000679463.1
ENST00000520605.5
ENST00000522109.5
ENST00000524255.5
ENST00000523296.1
surfactant protein C
chrX_+_154398367 0.13 ENST00000436473.5
ENST00000344746.8
ENST00000369817.7
ENST00000458500.5
ribosomal protein L10
chr3_-_42702778 0.13 ENST00000457462.5
ENST00000441594.6
hedgehog acyltransferase like
chr1_-_9943314 0.12 ENST00000377223.6
ENST00000377213.1
leucine zipper and CTNNBIP1 domain containing
chr6_-_41705813 0.12 ENST00000419574.6
ENST00000445214.2
transcription factor EB
chrX_-_109733181 0.12 ENST00000673016.1
acyl-CoA synthetase long chain family member 4
chr1_+_151540299 0.12 ENST00000392712.7
ENST00000368848.6
ENST00000368849.8
ENST00000353024.4
tuftelin 1
chr10_+_102503956 0.12 ENST00000369902.8
SUFU negative regulator of hedgehog signaling
chr4_-_65670478 0.11 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPH receptor A5
chr17_+_36544896 0.11 ENST00000611219.1
ENST00000613102.5
gametogenetin binding protein 2
chr1_-_37931712 0.11 ENST00000373027.5
inositol polyphosphate-5-phosphatase B
chr16_+_51553436 0.11 ENST00000565308.2
heterogeneous nuclear ribonucleoprotein A1 pseudogene 48
chr16_-_4242068 0.11 ENST00000399609.7
sarcalumenin
chrX_+_153905001 0.10 ENST00000430697.1
ENST00000337474.5
ENST00000370049.1
arginine vasopressin receptor 2
chr22_-_30529163 0.10 ENST00000437871.1
SEC14 like lipid binding 6
chr3_+_121593363 0.10 ENST00000338040.6
F-box protein 40
chr7_+_99558632 0.09 ENST00000252713.9
ENST00000449244.5
zinc finger protein 655
chr19_-_50833187 0.08 ENST00000598673.1
kallikrein related peptidase 15
chr20_+_64164446 0.08 ENST00000328439.6
myelin transcription factor 1
chr8_+_76683779 0.07 ENST00000523885.2
zinc finger homeobox 4
chr4_+_37244735 0.07 ENST00000309447.6
NACHT and WD repeat domain containing 2
chr2_-_186849164 0.06 ENST00000295131.3
zinc finger SWIM-type containing 2
chr3_+_188212931 0.06 ENST00000618621.4
ENST00000640853.1
LIM domain containing preferred translocation partner in lipoma
chr17_+_47896150 0.06 ENST00000642065.1
ENST00000613139.1
ENST00000637314.1
ENST00000637943.1
ENST00000376741.5
ENST00000635868.1
Sp2 transcription factor
chr2_+_219627394 0.06 ENST00000373760.6
solute carrier family 4 member 3
chr19_-_54189670 0.06 ENST00000391754.5
membrane bound O-acyltransferase domain containing 7
chr1_-_236281951 0.06 ENST00000354619.10
endoplasmic reticulum oxidoreductase 1 beta
chr18_-_46098275 0.06 ENST00000589252.5
ENST00000398752.11
ENST00000590665.5
ENST00000593152.6
ATP synthase F1 subunit alpha
chr19_-_35740535 0.06 ENST00000591748.1
IGF like family receptor 1
chr11_-_89063631 0.05 ENST00000455756.6
glutamate metabotropic receptor 5
chr8_-_61689768 0.05 ENST00000517847.6
ENST00000389204.8
ENST00000517661.5
ENST00000517903.5
ENST00000522603.5
ENST00000541428.5
ENST00000522349.5
ENST00000522835.5
ENST00000518306.5
aspartate beta-hydroxylase
chr9_-_120580125 0.05 ENST00000360190.8
ENST00000349780.9
ENST00000360822.7
CDK5 regulatory subunit associated protein 2
chr1_+_150293830 0.04 ENST00000614145.5
ENST00000581066.2
mitochondrial ribosomal protein S21
chr17_+_28319149 0.03 ENST00000226230.8
ENST00000583381.5
ENST00000582113.1
ENST00000582384.1
transmembrane protein 97
chr8_-_93740718 0.03 ENST00000519109.6
RNA binding motif protein 12B
chr16_+_57092570 0.03 ENST00000290776.13
ENST00000535318.6
copine 2
chr10_-_79560386 0.03 ENST00000372327.9
ENST00000417041.1
ENST00000640627.1
ENST00000372325.7
surfactant protein A2
chr22_+_24603147 0.03 ENST00000412658.5
ENST00000445029.5
ENST00000400382.6
ENST00000419133.5
ENST00000438643.6
ENST00000452551.5
ENST00000412898.5
ENST00000400380.5
ENST00000455483.5
ENST00000430289.5
gamma-glutamyltransferase 1
chrX_-_16870325 0.03 ENST00000468092.1
ENST00000404022.5
ENST00000380087.7
RB binding protein 7, chromatin remodeling factor
chrX_-_130385656 0.02 ENST00000276218.4
ENST00000682440.1
G protein-coupled receptor 119
chrX_-_109733220 0.02 ENST00000672282.1
ENST00000340800.7
acyl-CoA synthetase long chain family member 4
chr11_+_60455839 0.02 ENST00000532491.5
ENST00000532073.5
ENST00000345732.9
ENST00000534668.6
ENST00000528313.1
ENST00000533306.6
ENST00000674194.1
membrane spanning 4-domains A1
chrX_-_30308333 0.02 ENST00000378963.1
nuclear receptor subfamily 0 group B member 1
chr20_-_62220267 0.02 ENST00000317393.10
ENST00000611492.1
ENST00000340177.10
histamine receptor H3
chr5_+_134758770 0.01 ENST00000628477.2
ENST00000452510.7
ENST00000354283.8
DEAD-box helicase 46
chr7_+_130266847 0.01 ENST00000222481.9
carboxypeptidase A2
chr2_+_11539833 0.01 ENST00000263834.9
growth regulating estrogen receptor binding 1
chr10_+_62049211 0.01 ENST00000309334.5
AT-rich interaction domain 5B
chr5_+_141051374 0.00 ENST00000306549.6
protocadherin beta 1
chr3_+_155870623 0.00 ENST00000295920.7
ENST00000496455.7
guanine monophosphate synthase
chr9_+_33290493 0.00 ENST00000379540.8
ENST00000318524.6
nuclear transcription factor, X-box binding 1
chr12_+_18261511 0.00 ENST00000538779.6
ENST00000433979.6
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chrX_-_109733249 0.00 ENST00000469796.7
ENST00000672401.1
ENST00000671846.1
acyl-CoA synthetase long chain family member 4
chr5_+_34929572 0.00 ENST00000382021.2
DnaJ heat shock protein family (Hsp40) member C21

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.5 1.5 GO:0070662 erythropoietin-mediated signaling pathway(GO:0038162) mast cell proliferation(GO:0070662)
0.5 1.4 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2 0.7 GO:0006667 sphinganine metabolic process(GO:0006667)
0.2 1.4 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.2 2.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 1.0 GO:1901907 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 0.7 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.2 0.5 GO:1903465 vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.2 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 0.6 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 1.7 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 0.4 GO:0035674 tricarboxylic acid transmembrane transport(GO:0035674)
0.1 0.4 GO:2000777 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.1 0.5 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1 0.3 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 1.1 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.3 GO:0009085 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 3.4 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 1.0 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.8 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 1.9 GO:0016180 snRNA processing(GO:0016180)
0.1 0.2 GO:0043049 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 1.2 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 0.2 GO:0019483 beta-alanine biosynthetic process(GO:0019483)
0.1 0.2 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.1 0.3 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.9 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 0.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 0.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.3 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.1 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.0 0.4 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.3 GO:0035811 regulation of systemic arterial blood pressure by vasopressin(GO:0001992) negative regulation of urine volume(GO:0035811)
0.0 0.2 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.5 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 1.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.7 GO:0003334 keratinocyte development(GO:0003334)
0.0 1.1 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.4 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.2 GO:1905123 regulation of glucosylceramidase activity(GO:1905123)
0.0 0.2 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.5 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 1.1 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.5 GO:0006089 lactate metabolic process(GO:0006089)
0.0 1.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.2 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.2 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.0 0.2 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 0.1 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.0 0.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.2 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.2 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.1 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.4 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.4 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.2 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.7 GO:1901661 quinone metabolic process(GO:1901661)
0.0 0.4 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.2 GO:0060033 anatomical structure regression(GO:0060033)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0051964 negative regulation of synapse assembly(GO:0051964)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0032039 integrator complex(GO:0032039)
0.1 2.0 GO:0070578 RISC-loading complex(GO:0070578)
0.1 1.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 1.7 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.7 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.2 GO:1905103 integral component of lysosomal membrane(GO:1905103)
0.1 1.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 0.7 GO:0097486 multivesicular body lumen(GO:0097486)
0.1 2.0 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0044305 calyx of Held(GO:0044305)
0.0 0.6 GO:0016013 syntrophin complex(GO:0016013)
0.0 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.4 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.8 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0031588 cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.2 0.7 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.2 1.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.7 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 1.7 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 2.0 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.4 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 0.5 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 3.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.4 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.7 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.1 1.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 1.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 0.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.4 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1 1.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.7 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 0.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:1903135 cupric ion binding(GO:1903135)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.7 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 2.7 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.1 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.7 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.3 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.4 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166) nitric-oxide synthase binding(GO:0050998)
0.0 0.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 1.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.7 PID ARF 3PATHWAY Arf1 pathway
0.0 2.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 1.6 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 1.5 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 2.1 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.5 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 1.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle