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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for NKX2-2

Z-value: 0.87

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Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
ENSG00000125820.6 NKX2-2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-2hg38_v1_chr20_-_21514046_215140700.038.9e-01Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_69141878 2.41 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr1_+_84164370 2.15 ENST00000446538.5
ENST00000610703.4
ENST00000370682.7
ENST00000394838.6
ENST00000432111.5
protein kinase cAMP-activated catalytic subunit beta
chr4_-_98657635 1.76 ENST00000515287.5
ENST00000511651.5
ENST00000505184.5
tetraspanin 5
chr8_+_96584920 1.73 ENST00000521590.5
syndecan 2
chr2_+_172860038 1.65 ENST00000538974.5
ENST00000540783.5
Rap guanine nucleotide exchange factor 4
chr10_+_35167516 1.40 ENST00000361599.8
cAMP responsive element modulator
chrX_+_136205982 1.36 ENST00000628568.1
four and a half LIM domains 1
chr6_+_143677935 1.27 ENST00000440869.6
ENST00000367582.7
ENST00000451827.6
phosphatase and actin regulator 2
chr13_+_102656933 1.04 ENST00000650757.1
tripeptidyl peptidase 2
chr4_+_87006988 0.97 ENST00000307808.10
AF4/FMR2 family member 1
chr18_+_44700796 0.95 ENST00000677130.1
SET binding protein 1
chr7_-_22194709 0.95 ENST00000458533.5
Rap guanine nucleotide exchange factor 5
chr5_+_141421064 0.91 ENST00000518882.2
protocadherin gamma subfamily A, 11
chr14_+_22495890 0.89 ENST00000390494.1
T cell receptor alpha joining 43
chr3_+_41200080 0.87 ENST00000644524.1
catenin beta 1
chr5_-_11588842 0.87 ENST00000503622.5
catenin delta 2
chr9_+_2159672 0.86 ENST00000634343.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr14_-_100375333 0.85 ENST00000557297.5
ENST00000555813.5
ENST00000392882.7
ENST00000557135.5
ENST00000556698.5
ENST00000554509.5
ENST00000555410.5
tryptophanyl-tRNA synthetase 1
chr7_+_116222804 0.84 ENST00000393481.6
testin LIM domain protein
chr2_+_201129826 0.83 ENST00000457277.5
CASP8 and FADD like apoptosis regulator
chr1_+_84164684 0.81 ENST00000370680.5
protein kinase cAMP-activated catalytic subunit beta
chr3_+_41200104 0.78 ENST00000643297.1
ENST00000450969.6
catenin beta 1
chr18_-_55321640 0.76 ENST00000637169.2
transcription factor 4
chr4_+_143381939 0.73 ENST00000505913.5
GRB2 associated binding protein 1
chr6_+_28281555 0.71 ENST00000259883.3
ENST00000682144.1
piggyBac transposable element derived 1
chr1_-_243843226 0.69 ENST00000336199.9
AKT serine/threonine kinase 3
chrX_-_71255060 0.69 ENST00000373988.5
ENST00000373998.5
zinc finger MYM-type containing 3
chr13_-_44474296 0.68 ENST00000611198.4
TSC22 domain family member 1
chr14_-_100375602 0.68 ENST00000553395.5
ENST00000553545.5
ENST00000344102.9
ENST00000556338.5
ENST00000553934.1
tryptophanyl-tRNA synthetase 1
chr15_-_52652031 0.67 ENST00000546305.6
family with sequence similarity 214 member A
chr7_-_120858066 0.67 ENST00000222747.8
tetraspanin 12
chr12_-_102197827 0.67 ENST00000329406.5
pro-melanin concentrating hormone
chr13_-_19782923 0.66 ENST00000338910.9
paraspeckle component 1
chr5_-_78985288 0.64 ENST00000264914.10
arylsulfatase B
chr13_-_19782970 0.63 ENST00000427943.1
ENST00000619300.4
paraspeckle component 1
chr17_-_3592877 0.61 ENST00000399756.8
transient receptor potential cation channel subfamily V member 1
chr4_+_94455245 0.60 ENST00000508216.5
ENST00000514743.5
PDZ and LIM domain 5
chr7_-_120857124 0.59 ENST00000441017.5
ENST00000424710.5
ENST00000433758.5
tetraspanin 12
chrX_+_11759678 0.58 ENST00000649797.1
ENST00000648614.1
MSL complex subunit 3
chr12_-_9869345 0.58 ENST00000228438.3
C-type lectin domain family 2 member B
chr2_-_182522703 0.58 ENST00000410103.1
phosphodiesterase 1A
chr5_-_11589019 0.58 ENST00000511377.5
catenin delta 2
chr7_-_22193824 0.57 ENST00000401957.6
Rap guanine nucleotide exchange factor 5
chr18_-_55321986 0.54 ENST00000570287.6
transcription factor 4
chrX_+_105822531 0.53 ENST00000243300.14
ENST00000536164.5
Nik related kinase
chr11_-_125111708 0.53 ENST00000531909.5
ENST00000529530.1
transmembrane protein 218
chr17_+_68525795 0.51 ENST00000592800.5
protein kinase cAMP-dependent type I regulatory subunit alpha
chr3_+_159273235 0.50 ENST00000638749.1
IQCJ-SCHIP1 readthrough
chr2_+_161231078 0.50 ENST00000439442.1
TRAF family member associated NFKB activator
chr14_+_23185316 0.49 ENST00000399910.5
ENST00000492621.5
ring finger protein 212B
chrX_-_154805386 0.49 ENST00000393531.5
ENST00000369534.8
ENST00000453245.5
ENST00000428488.1
ENST00000369531.1
membrane palmitoylated protein 1
chr13_+_57631735 0.49 ENST00000377918.8
protocadherin 17
chr12_-_8650529 0.48 ENST00000543467.5
microfibril associated protein 5
chrX_+_71254781 0.48 ENST00000677446.1
non-POU domain containing octamer binding
chr8_-_100950549 0.48 ENST00000395951.7
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr15_+_65550819 0.47 ENST00000569894.5
3-hydroxyacyl-CoA dehydratase 3
chr7_+_80135694 0.46 ENST00000457358.7
G protein subunit alpha i1
chr13_-_98978022 0.46 ENST00000682017.1
ENST00000442173.5
ENST00000627024.2
dedicator of cytokinesis 9
chr16_+_22490337 0.45 ENST00000415833.6
nuclear pore complex interacting protein family member B5
chr22_-_35824373 0.45 ENST00000473487.6
RNA binding fox-1 homolog 2
chr1_-_246507237 0.45 ENST00000490107.6
SET and MYND domain containing 3
chr8_-_140800535 0.44 ENST00000521986.5
ENST00000523539.5
protein tyrosine kinase 2
chr9_+_96928310 0.44 ENST00000354649.7
NUT family member 2G
chr9_+_113501359 0.44 ENST00000343817.9
ENST00000394646.7
regulator of G protein signaling 3
chr5_+_151025343 0.44 ENST00000521632.1
glutathione peroxidase 3
chr9_+_121207774 0.44 ENST00000373823.7
gelsolin
chr8_+_11808417 0.43 ENST00000525954.5
farnesyl-diphosphate farnesyltransferase 1
chr1_-_243843164 0.43 ENST00000491219.6
ENST00000680056.1
ENST00000492957.2
AKT serine/threonine kinase 3
chr2_-_219571241 0.42 ENST00000373876.5
ENST00000603926.5
ENST00000373873.8
ENST00000289656.3
obscurin like cytoskeletal adaptor 1
chr5_+_141223332 0.42 ENST00000239449.7
ENST00000624896.1
ENST00000624396.1
protocadherin beta 14
novel protein
chr8_+_11802667 0.42 ENST00000443614.6
ENST00000220584.9
ENST00000525900.5
farnesyl-diphosphate farnesyltransferase 1
chr3_-_15798184 0.42 ENST00000624145.3
ankyrin repeat domain 28
chr6_+_32969345 0.42 ENST00000678250.1
bromodomain containing 2
chr8_+_11802611 0.41 ENST00000623368.3
farnesyl-diphosphate farnesyltransferase 1
chr8_+_11803012 0.41 ENST00000528812.5
ENST00000622850.2
farnesyl-diphosphate farnesyltransferase 1
chr1_-_154502402 0.41 ENST00000304760.3
Src homology 2 domain containing E
chr19_-_2427538 0.41 ENST00000591871.1
ENST00000215570.8
translocase of inner mitochondrial membrane 13
chr10_-_70376779 0.40 ENST00000395011.5
leucine rich repeat containing 20
chr9_-_94593810 0.40 ENST00000375337.4
fructose-bisphosphatase 2
chr6_+_32153441 0.39 ENST00000414204.5
ENST00000361568.6
ENST00000395523.5
palmitoyl-protein thioesterase 2
chr8_+_11809135 0.39 ENST00000528643.5
ENST00000525777.5
farnesyl-diphosphate farnesyltransferase 1
chr12_+_80099535 0.38 ENST00000646859.1
ENST00000547103.7
otogelin like
chr6_+_32969165 0.38 ENST00000496118.2
ENST00000449085.4
bromodomain containing 2
chr3_+_98763331 0.38 ENST00000485391.5
ENST00000492254.5
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr13_-_77919390 0.38 ENST00000475537.2
ENST00000646605.1
endothelin receptor type B
chr2_+_188292771 0.38 ENST00000359135.7
GULP PTB domain containing engulfment adaptor 1
chrX_+_123961696 0.36 ENST00000371145.8
ENST00000371157.7
ENST00000371144.7
stromal antigen 2
chrX_+_47232866 0.36 ENST00000218348.7
ENST00000377107.7
ubiquitin specific peptidase 11
chr6_-_109690500 0.36 ENST00000448084.6
adenylate kinase 9
chr6_+_32968557 0.36 ENST00000374825.9
bromodomain containing 2
chr7_+_150368189 0.36 ENST00000519397.1
ENST00000479668.5
replication initiator 1
chr11_+_34632464 0.34 ENST00000531794.5
ETS homologous factor
chr14_-_81533800 0.34 ENST00000555824.5
ENST00000557372.1
ENST00000336735.9
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
chr6_-_109690515 0.33 ENST00000532976.1
adenylate kinase 9
chr10_+_5094405 0.33 ENST00000380554.5
aldo-keto reductase family 1 member C3
chrX_+_101488044 0.33 ENST00000423738.4
armadillo repeat containing X-linked 4
chr4_-_155866277 0.33 ENST00000537611.3
acid sensing ion channel subunit family member 5
chr20_-_61998132 0.33 ENST00000474089.5
TATA-box binding protein associated factor 4
chr11_-_119196769 0.33 ENST00000415318.2
coiled-coil domain containing 153
chrX_+_108439866 0.32 ENST00000361603.7
collagen type IV alpha 5 chain
chr1_-_44788168 0.32 ENST00000372207.4
bestrophin 4
chr5_+_160229499 0.32 ENST00000402432.4
fatty acid binding protein 6
chr1_+_174700413 0.32 ENST00000529145.6
ENST00000325589.9
RAB GTPase activating protein 1 like
chr19_-_39391029 0.32 ENST00000221265.8
PAF1 homolog, Paf1/RNA polymerase II complex component
chr20_+_58651785 0.31 ENST00000358029.8
syntaxin 16
chr19_-_17255448 0.31 ENST00000594059.1
novel protein
chr14_-_89412025 0.31 ENST00000553840.5
ENST00000556916.5
forkhead box N3
chr1_-_216805367 0.30 ENST00000360012.7
estrogen related receptor gamma
chr1_+_241532121 0.30 ENST00000366558.7
kynurenine 3-monooxygenase
chr12_-_57846686 0.30 ENST00000548823.1
ENST00000398073.7
CTD small phosphatase 2
chr8_-_140764386 0.30 ENST00000520151.5
ENST00000519024.5
ENST00000519465.5
protein tyrosine kinase 2
chr19_+_57682019 0.29 ENST00000596085.1
ENST00000594684.1
zinc finger protein 551
novel protein
chr2_-_73233206 0.29 ENST00000258083.3
protease associated domain containing 1
chr20_+_11890785 0.29 ENST00000399006.6
ENST00000405977.5
BTB domain containing 3
chr3_+_184053047 0.29 ENST00000318351.2
5-hydroxytryptamine receptor 3C
chr1_-_74733253 0.29 ENST00000417775.5
crystallin zeta
chr22_-_50085331 0.29 ENST00000395876.6
modulator of VRAC current 1
chr2_-_27335403 0.28 ENST00000454704.5
general transcription factor IIIC subunit 2
chr13_+_101489940 0.28 ENST00000376162.7
integrin subunit beta like 1
chr15_-_42548763 0.28 ENST00000563454.5
ENST00000397130.8
ENST00000570160.1
ENST00000323443.6
leucine rich repeat containing 57
chr9_+_128685062 0.28 ENST00000409104.7
SET nuclear proto-oncogene
chr2_-_32039776 0.28 ENST00000342166.10
ENST00000295066.3
dpy-30 histone methyltransferase complex regulatory subunit
chr1_-_53940100 0.27 ENST00000371376.1
heat shock protein family B (small) member 11
chr7_+_32979445 0.27 ENST00000418354.5
ENST00000490776.3
FKBP prolyl isomerase 9
chr5_+_141412979 0.27 ENST00000612503.1
ENST00000398610.3
protocadherin gamma subfamily A, 10
chrX_-_71254106 0.27 ENST00000373984.7
ENST00000314425.9
ENST00000373982.5
zinc finger MYM-type containing 3
chr10_+_13161543 0.27 ENST00000378714.8
ENST00000479669.5
ENST00000484800.6
minichromosome maintenance 10 replication initiation factor
chr4_+_122339221 0.27 ENST00000442707.1
KIAA1109
chr2_+_201129483 0.26 ENST00000440180.5
CASP8 and FADD like apoptosis regulator
chr5_+_141172637 0.26 ENST00000231137.6
protocadherin beta 7
chr9_+_89311187 0.26 ENST00000314355.7
CDC28 protein kinase regulatory subunit 2
chrX_+_34942790 0.26 ENST00000329357.6
family with sequence similarity 47 member B
chr8_-_123737378 0.25 ENST00000419625.6
ENST00000262219.10
annexin A13
chr9_-_20622479 0.25 ENST00000380338.9
MLLT3 super elongation complex subunit
chr20_+_58651228 0.25 ENST00000361830.7
ENST00000458280.5
ENST00000355957.9
ENST00000312283.12
ENST00000412911.5
ENST00000359617.8
ENST00000371141.8
syntaxin 16
chr6_+_32154010 0.25 ENST00000375137.6
palmitoyl-protein thioesterase 2
chr12_+_10505602 0.25 ENST00000322446.3
eukaryotic translation initiation factor 2 subunit gamma B
chr2_+_188292814 0.25 ENST00000409580.5
ENST00000409637.7
GULP PTB domain containing engulfment adaptor 1
chr5_+_141421020 0.25 ENST00000622044.1
ENST00000398587.7
protocadherin gamma subfamily A, 11
chr9_-_92404559 0.24 ENST00000262551.8
ENST00000375561.10
osteoglycin
chr6_+_158536398 0.24 ENST00000367090.4
transmembrane protein 181
chr15_+_67067780 0.24 ENST00000679624.1
SMAD family member 3
chrX_+_11759604 0.23 ENST00000649602.1
ENST00000650215.1
ENST00000649685.1
ENST00000649649.1
ENST00000380693.8
ENST00000380692.7
ENST00000650628.1
ENST00000649851.1
ENST00000421368.3
MSL complex subunit 3
chr8_-_132760548 0.23 ENST00000519187.5
ENST00000523829.5
ENST00000677595.1
ENST00000356838.7
ENST00000377901.8
ENST00000519304.1
transmembrane protein 71
chrM_+_12329 0.23 ENST00000361567.2
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr9_+_37667997 0.23 ENST00000539465.5
FERM and PDZ domain containing 1
chr11_-_11353241 0.23 ENST00000528848.3
casein kinase 2 alpha 3
chr7_+_92057602 0.23 ENST00000491695.2
A-kinase anchoring protein 9
chr8_-_120445092 0.23 ENST00000518918.1
mitochondrial ribosomal protein L13
chr1_-_226739271 0.22 ENST00000429204.6
ENST00000366784.1
inositol-trisphosphate 3-kinase B
chr15_+_58410543 0.22 ENST00000356113.10
ENST00000414170.7
lipase C, hepatic type
chr10_+_79841358 0.22 ENST00000602967.5
NUT family member 2E
chr12_+_56152579 0.22 ENST00000551834.5
ENST00000552568.5
myosin light chain 6B
chr5_-_78985951 0.22 ENST00000396151.7
arylsulfatase B
chr5_+_126423363 0.22 ENST00000285689.8
GRAM domain containing 2B
chr20_+_58888779 0.21 ENST00000488546.6
ENST00000667293.2
ENST00000481039.6
ENST00000467321.6
GNAS complex locus
chr6_-_73225465 0.21 ENST00000370388.4
KH domain containing 1 like
chrX_+_11760087 0.21 ENST00000649271.1
MSL complex subunit 3
chr1_+_119507203 0.21 ENST00000369413.8
ENST00000528909.1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr5_+_126423122 0.21 ENST00000515200.5
GRAM domain containing 2B
chr19_-_3971051 0.21 ENST00000545797.7
ENST00000596311.5
death associated protein kinase 3
chr5_+_126423176 0.20 ENST00000542322.5
ENST00000544396.5
GRAM domain containing 2B
chr13_-_77919459 0.20 ENST00000643890.1
endothelin receptor type B
chr3_+_152299392 0.20 ENST00000498502.5
ENST00000545754.5
ENST00000357472.7
ENST00000324196.9
muscleblind like splicing regulator 1
chr2_-_219571529 0.20 ENST00000404537.6
obscurin like cytoskeletal adaptor 1
chrX_+_11760035 0.19 ENST00000482871.6
ENST00000648013.1
MSL complex subunit 3
chrX_-_19799751 0.18 ENST00000379698.8
SH3 domain containing kinase binding protein 1
chr2_-_144517663 0.18 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
zinc finger E-box binding homeobox 2
chr11_-_129024157 0.18 ENST00000392657.7
Rho GTPase activating protein 32
chr9_-_15510289 0.18 ENST00000397519.6
PC4 and SFRS1 interacting protein 1
chr13_+_101452569 0.18 ENST00000618057.4
integrin subunit beta like 1
chr2_+_10368645 0.18 ENST00000613496.4
hippocalcin like 1
chr12_+_56152439 0.18 ENST00000550443.5
myosin light chain 6B
chr14_+_56117702 0.18 ENST00000559044.5
pellino E3 ubiquitin protein ligase family member 2
chr6_-_27472681 0.18 ENST00000377419.1
zinc finger protein 184
chr1_-_109613070 0.17 ENST00000351050.8
G protein subunit alpha transducin 2
chr7_-_130441136 0.17 ENST00000675596.1
ENST00000676312.1
centrosomal protein 41
chr11_-_124673708 0.17 ENST00000263593.8
sialic acid acetylesterase
chr5_+_136059151 0.17 ENST00000503087.1
transforming growth factor beta induced
chr12_-_71157872 0.17 ENST00000546561.2
tetraspanin 8
chrM_+_4467 0.17 ENST00000361453.3
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
chr5_+_119476530 0.16 ENST00000645099.1
ENST00000513628.5
hydroxysteroid 17-beta dehydrogenase 4
chr10_+_72893734 0.16 ENST00000334011.10
oncoprotein induced transcript 3
chr12_-_10826358 0.16 ENST00000240619.2
taste 2 receptor member 10
chr17_+_50746534 0.16 ENST00000511974.5
LUC7 like 3 pre-mRNA splicing factor
chr2_+_10368764 0.16 ENST00000620771.4
hippocalcin like 1
chr9_-_39239174 0.16 ENST00000358144.6
contactin associated protein family member 3
chr2_+_151410090 0.16 ENST00000430328.6
replication timing regulatory factor 1
chr1_-_202967229 0.16 ENST00000367249.9
cytochrome b5 reductase 1
chr16_+_71808439 0.15 ENST00000683775.1
ataxin 1 like
chr13_-_106568107 0.15 ENST00000400198.8
arginine and glutamate rich 1
chr1_+_180632001 0.15 ENST00000367590.9
ENST00000367589.3
xenotropic and polytropic retrovirus receptor 1
chr1_+_241532370 0.15 ENST00000366559.9
ENST00000366557.8
kynurenine 3-monooxygenase
chr11_+_22668101 0.15 ENST00000630668.2
ENST00000278187.7
growth arrest specific 2
chr1_+_53014926 0.15 ENST00000430330.6
ENST00000408941.7
ENST00000478274.6
ENST00000484100.5
ENST00000435345.6
ENST00000488965.1
sterol carrier protein 2
chr13_-_75366973 0.15 ENST00000648194.1
TBC1 domain family member 4
chr8_-_120445140 0.15 ENST00000306185.8
mitochondrial ribosomal protein L13
chr4_-_87529092 0.14 ENST00000503414.5
SPARC like 1
chrX_-_135764444 0.14 ENST00000597510.6
cancer/testis antigen family 45 member A3
chr2_+_69013379 0.14 ENST00000409349.7
ANTXR cell adhesion molecule 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 GO:0097338 response to clozapine(GO:0097338)
0.3 2.1 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.3 1.7 GO:0008218 bioluminescence(GO:0008218)
0.3 1.6 GO:1904499 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.3 0.8 GO:0061580 colon epithelial cell migration(GO:0061580)
0.2 0.7 GO:0061569 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.2 0.5 GO:0060720 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.2 0.6 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.1 0.6 GO:0035645 enteric smooth muscle cell differentiation(GO:0035645)
0.1 0.3 GO:0016107 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.4 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 1.1 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 0.5 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.4 GO:0009405 pathogenesis(GO:0009405)
0.1 0.4 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.1 0.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.4 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 1.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.5 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.1 0.2 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.1 0.6 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.5 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.3 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.7 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.2 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.0 0.1 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.0 1.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.8 GO:0031033 myosin filament organization(GO:0031033)
0.0 0.5 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.3 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0042640 anagen(GO:0042640)
0.0 0.1 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 0.5 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.6 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 0.2 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
0.0 0.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.3 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 1.3 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0 0.5 GO:2000480 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.2 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 0.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.0 1.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.1 GO:0036215 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.7 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 1.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.2 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.1 GO:0000964 mitochondrial RNA 5'-end processing(GO:0000964)
0.0 0.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:1904253 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 2.1 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.4 GO:0019321 pentose metabolic process(GO:0019321)
0.0 0.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.5 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 0.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.3 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.0 1.5 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.6 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.0 0.3 GO:0071397 cellular response to cholesterol(GO:0071397)
0.0 0.2 GO:0046549 response to light intensity(GO:0009642) retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 1.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.0 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.0 0.5 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.0 0.2 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.5 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.2 1.8 GO:0042382 paraspeckles(GO:0042382)
0.2 3.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.2 GO:0072487 MSL complex(GO:0072487)
0.1 0.6 GO:1990393 3M complex(GO:1990393)
0.1 0.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.2 GO:0044307 dendritic branch(GO:0044307)
0.0 1.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 1.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.2 GO:0001940 female pronucleus(GO:0001939) male pronucleus(GO:0001940)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.1 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.4 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.3 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.2 1.0 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.2 0.8 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.2 3.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.4 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.1 0.3 GO:0047787 geranylgeranyl reductase activity(GO:0045550) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.1 1.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.6 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.4 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 1.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.6 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.1 0.6 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.6 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.3 GO:0070404 NADH binding(GO:0070404)
0.1 0.5 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 0.3 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.2 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.1 0.7 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.1 0.6 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.2 GO:0070538 oleic acid binding(GO:0070538)
0.0 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.3 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 1.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 1.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.7 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.4 GO:0045159 myosin II binding(GO:0045159)
0.0 0.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 1.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.1 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.3 GO:0032052 bile acid binding(GO:0032052)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 2.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.1 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.0 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.2 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.2 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.0 GO:0052596 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 PID IL3 PATHWAY IL3-mediated signaling events
0.1 2.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.6 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 1.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.6 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.7 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 2.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.7 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.8 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.7 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport