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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for NKX2-6

Z-value: 0.88

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.8 NKX2-6

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_5978022 3.30 ENST00000525219.6
IL15RA
interleukin 15 receptor subunit alpha
chr10_-_5977589 3.25 ENST00000620345.4
ENST00000397251.7
ENST00000397248.6
ENST00000622442.4
ENST00000620865.4
IL15RA
interleukin 15 receptor subunit alpha
chr10_-_5977535 3.24 ENST00000379977.8
IL15RA
interleukin 15 receptor subunit alpha
chr3_-_123620496 2.96 ENST00000578202.1
MYLK
myosin light chain kinase
chr3_-_123620571 2.89 ENST00000583087.5
MYLK
myosin light chain kinase
chr10_-_5977492 2.31 ENST00000530685.5
ENST00000397255.7
ENST00000379971.5
ENST00000528354.5
ENST00000397250.6
ENST00000429135.2
IL15RA
interleukin 15 receptor subunit alpha
chr12_+_55681711 2.26 ENST00000394252.4
METTL7B
methyltransferase like 7B
chr12_+_55681647 2.22 ENST00000614691.1
METTL7B
methyltransferase like 7B
chr2_+_102311502 2.20 ENST00000404917.6
ENST00000410040.5
IL1RL1
IL18R1
interleukin 1 receptor like 1
interleukin 18 receptor 1
chr1_+_205256189 2.05 ENST00000329800.7
TMCC2
transmembrane and coiled-coil domain family 2
chr15_+_67067780 2.01 ENST00000679624.1
SMAD3
SMAD family member 3
chr1_-_120051714 1.80 ENST00000579475.7
NOTCH2
notch receptor 2
chr2_-_100104530 1.67 ENST00000432037.5
ENST00000673232.1
ENST00000423966.6
ENST00000409236.6
AFF3
AF4/FMR2 family member 3
chr9_+_94084458 1.46 ENST00000620992.5
ENST00000288976.3
PTPDC1
protein tyrosine phosphatase domain containing 1
chr3_-_121660892 1.38 ENST00000428394.6
ENST00000314583.8
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr8_+_27771942 1.30 ENST00000523566.5
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr12_-_89526011 1.16 ENST00000313546.8
POC1B
POC1 centriolar protein B
chr12_-_89526164 1.10 ENST00000548729.5
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr15_-_55270874 1.09 ENST00000567380.5
ENST00000565972.5
ENST00000569493.5
RAB27A
RAB27A, member RAS oncogene family
chr12_-_89526253 1.07 ENST00000547474.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr19_-_43670153 1.04 ENST00000601723.5
ENST00000339082.7
ENST00000340093.8
PLAUR
plasminogen activator, urokinase receptor
chr12_-_70788914 1.04 ENST00000342084.8
PTPRR
protein tyrosine phosphatase receptor type R
chr16_+_78022538 0.99 ENST00000651443.1
ENST00000299642.10
CLEC3A
C-type lectin domain family 3 member A
chr5_+_52787899 0.90 ENST00000274311.3
ENST00000282588.7
PELO
ITGA1
pelota mRNA surveillance and ribosome rescue factor
integrin subunit alpha 1
chr9_-_83063159 0.90 ENST00000340717.4
RASEF
RAS and EF-hand domain containing
chr3_+_171843337 0.87 ENST00000334567.9
ENST00000619900.4
ENST00000450693.1
TMEM212
transmembrane protein 212
chr2_+_69915100 0.86 ENST00000264444.7
MXD1
MAX dimerization protein 1
chr3_+_100709424 0.84 ENST00000675246.1
ENST00000675692.1
ENST00000675890.1
ENST00000675586.1
ENST00000674645.1
ENST00000675958.1
ENST00000479672.6
ENST00000675420.1
ENST00000674615.1
ENST00000676431.1
ENST00000674758.1
TFG
trafficking from ER to golgi regulator
chr3_+_100709382 0.80 ENST00000620299.5
TFG
trafficking from ER to golgi regulator
chr7_+_75915148 0.76 ENST00000461988.6
ENST00000421059.1
ENST00000394893.5
ENST00000412521.5
ENST00000414186.5
POR
cytochrome p450 oxidoreductase
chr3_+_100709344 0.76 ENST00000418917.7
ENST00000675553.1
TFG
trafficking from ER to golgi regulator
chr1_+_19251786 0.75 ENST00000330263.5
MRTO4
MRT4 homolog, ribosome maturation factor
chr2_+_69915041 0.75 ENST00000540449.5
MXD1
MAX dimerization protein 1
chr3_+_100709473 0.75 ENST00000240851.9
ENST00000675243.1
ENST00000676111.1
ENST00000476228.5
ENST00000463568.6
ENST00000676395.1
TFG
trafficking from ER to golgi regulator
chr8_+_49911801 0.74 ENST00000643809.1
SNTG1
syntrophin gamma 1
chr14_+_23185316 0.73 ENST00000399910.5
ENST00000492621.5
RNF212B
ring finger protein 212B
chr14_-_106875069 0.72 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr4_-_78939352 0.70 ENST00000512733.5
PAQR3
progestin and adipoQ receptor family member 3
chr1_+_156369202 0.70 ENST00000537040.6
RHBG
Rh family B glycoprotein
chr3_+_100709290 0.69 ENST00000675047.1
ENST00000490574.6
ENST00000675543.1
ENST00000676308.1
ENST00000675499.1
TFG
trafficking from ER to golgi regulator
chrY_-_23694579 0.65 ENST00000343584.10
PRYP3
PTPN13 like Y-linked pseudogene 3
chr10_+_119892692 0.64 ENST00000369075.8
SEC23IP
SEC23 interacting protein
chr12_-_55842927 0.63 ENST00000322569.9
ENST00000409200.7
MMP19
matrix metallopeptidase 19
chr19_+_51573171 0.62 ENST00000436511.2
ZNF175
zinc finger protein 175
chr13_+_43879895 0.62 ENST00000325686.7
LACC1
laccase domain containing 1
chr14_+_64715677 0.61 ENST00000634379.2
PLEKHG3
pleckstrin homology and RhoGEF domain containing G3
chr11_+_111255982 0.58 ENST00000637637.1
C11orf53
chromosome 11 open reading frame 53
chr7_+_123601815 0.58 ENST00000451215.6
ASB15
ankyrin repeat and SOCS box containing 15
chr9_+_72114595 0.57 ENST00000545168.5
GDA
guanine deaminase
chr7_+_123601836 0.56 ENST00000434204.5
ASB15
ankyrin repeat and SOCS box containing 15
chr6_+_125781108 0.55 ENST00000368357.7
NCOA7
nuclear receptor coactivator 7
chr7_+_142791635 0.55 ENST00000633705.1
TRBC1
T cell receptor beta constant 1
chr19_-_50476725 0.55 ENST00000595790.5
FAM71E1
family with sequence similarity 71 member E1
chr6_+_63563448 0.53 ENST00000673199.1
PTP4A1
protein tyrosine phosphatase 4A1
chr19_-_50476838 0.50 ENST00000600100.6
FAM71E1
family with sequence similarity 71 member E1
chr3_-_48089203 0.50 ENST00000468075.2
ENST00000360240.10
MAP4
microtubule associated protein 4
chr4_+_69280472 0.50 ENST00000335568.10
ENST00000511240.1
UGT2B28
UDP glucuronosyltransferase family 2 member B28
chr4_-_48080172 0.49 ENST00000507351.1
TXK
TXK tyrosine kinase
chrX_-_133097095 0.48 ENST00000511190.5
USP26
ubiquitin specific peptidase 26
chr15_-_40828699 0.45 ENST00000299174.10
ENST00000427255.2
PPP1R14D
protein phosphatase 1 regulatory inhibitor subunit 14D
chr11_-_64759967 0.44 ENST00000377432.7
ENST00000164139.4
PYGM
glycogen phosphorylase, muscle associated
chrX_+_30243715 0.44 ENST00000378981.8
ENST00000397550.6
MAGEB1
MAGE family member B1
chr22_-_23754376 0.44 ENST00000398465.3
ENST00000248948.4
VPREB3
V-set pre-B cell surrogate light chain 3
chr18_+_58362467 0.44 ENST00000675101.1
NEDD4L
NEDD4 like E3 ubiquitin protein ligase
chr11_+_65860394 0.44 ENST00000308110.9
MUS81
MUS81 structure-specific endonuclease subunit
chr12_-_110583305 0.43 ENST00000354300.5
PPTC7
protein phosphatase targeting COQ7
chr2_-_178702479 0.43 ENST00000414766.5
TTN
titin
chr17_+_35587478 0.43 ENST00000618940.4
AP2B1
adaptor related protein complex 2 subunit beta 1
chr1_+_16440700 0.43 ENST00000504551.6
ENST00000457722.6
ENST00000337132.10
ENST00000443980.6
NECAP2
NECAP endocytosis associated 2
chr2_-_162243375 0.42 ENST00000188790.9
ENST00000443424.5
FAP
fibroblast activation protein alpha
chr1_+_158289916 0.40 ENST00000368170.8
CD1C
CD1c molecule
chr4_-_170003738 0.39 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibril associated protein 3 like
chr3_+_122077776 0.38 ENST00000264468.9
CD86
CD86 molecule
chr4_-_155953851 0.38 ENST00000679136.1
ENST00000433477.4
ENST00000679996.1
ENST00000680741.1
ENST00000680553.1
ENST00000679942.1
CTSO
cathepsin O
chr11_-_66593031 0.38 ENST00000333861.5
CCDC87
coiled-coil domain containing 87
chr1_+_171512032 0.38 ENST00000426496.6
PRRC2C
proline rich coiled-coil 2C
chr12_-_49900250 0.38 ENST00000552669.5
FAIM2
Fas apoptotic inhibitory molecule 2
chr19_+_496454 0.37 ENST00000346144.8
ENST00000215637.8
ENST00000382683.8
MADCAM1
mucosal vascular addressin cell adhesion molecule 1
chr17_-_36534841 0.37 ENST00000614623.5
ENST00000621344.4
MYO19
myosin XIX
chr19_-_51108365 0.36 ENST00000421832.3
CTU1
cytosolic thiouridylase subunit 1
chr1_+_202462730 0.36 ENST00000290419.9
ENST00000491336.5
PPP1R12B
protein phosphatase 1 regulatory subunit 12B
chr2_-_174598206 0.36 ENST00000392546.6
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family member 1
chr22_-_50085331 0.35 ENST00000395876.6
MLC1
modulator of VRAC current 1
chr17_+_4932248 0.35 ENST00000329125.6
GP1BA
glycoprotein Ib platelet subunit alpha
chr7_+_141764097 0.35 ENST00000247879.2
TAS2R3
taste 2 receptor member 3
chr17_-_42964437 0.35 ENST00000427569.7
ENST00000430739.5
AARSD1
alanyl-tRNA synthetase domain containing 1
chr22_+_29205877 0.34 ENST00000334018.11
ENST00000429226.5
ENST00000404755.7
ENST00000404820.7
ENST00000430127.1
EMID1
EMI domain containing 1
chr17_+_4932285 0.33 ENST00000611961.1
GP1BA
glycoprotein Ib platelet subunit alpha
chr6_-_89315291 0.33 ENST00000402938.4
GABRR2
gamma-aminobutyric acid type A receptor subunit rho2
chr11_-_61920267 0.33 ENST00000531922.2
ENST00000301773.9
RAB3IL1
RAB3A interacting protein like 1
chr3_+_122055355 0.32 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86
CD86 molecule
chr7_+_111091006 0.32 ENST00000451085.5
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3
chr2_-_68952880 0.32 ENST00000481498.1
ENST00000328895.9
GKN2
gastrokine 2
chr1_-_173824322 0.31 ENST00000356198.6
CENPL
centromere protein L
chr5_-_140557414 0.31 ENST00000336283.9
SRA1
steroid receptor RNA activator 1
chr22_-_50085414 0.31 ENST00000311597.10
MLC1
modulator of VRAC current 1
chr7_+_111091119 0.31 ENST00000308478.10
LRRN3
leucine rich repeat neuronal 3
chr3_+_186996444 0.31 ENST00000676633.1
ST6GAL1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr4_+_168497044 0.30 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr4_+_165378998 0.30 ENST00000402744.9
CPE
carboxypeptidase E
chr11_+_65040895 0.29 ENST00000531072.1
ENST00000398846.6
SAC3D1
SAC3 domain containing 1
chr20_-_1393045 0.29 ENST00000400137.9
ENST00000381715.4
FKBP1A
FKBP prolyl isomerase 1A
chr7_+_142800957 0.29 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr6_+_29396555 0.29 ENST00000623183.1
OR12D2
olfactory receptor family 12 subfamily D member 2
chr10_+_18340821 0.29 ENST00000612743.1
ENST00000612134.4
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr11_+_63369779 0.28 ENST00000279178.4
SLC22A9
solute carrier family 22 member 9
chr11_-_106022209 0.28 ENST00000301919.9
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr4_+_168497066 0.28 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr12_+_119593758 0.27 ENST00000426426.3
TMEM233
transmembrane protein 233
chr12_+_69825221 0.27 ENST00000552032.7
MYRFL
myelin regulatory factor like
chr5_+_140691427 0.27 ENST00000643996.1
ENST00000509299.6
ENST00000645065.1
ENST00000642752.1
ENST00000503873.6
ENST00000642970.1
ENST00000230771.9
ENST00000646468.1
ENST00000645749.1
HARS2
histidyl-tRNA synthetase 2, mitochondrial
chr12_+_69825273 0.26 ENST00000547771.6
MYRFL
myelin regulatory factor like
chr7_+_31687208 0.26 ENST00000409146.3
ENST00000342032.8
PPP1R17
protein phosphatase 1 regulatory subunit 17
chrX_+_47193796 0.26 ENST00000442035.5
ENST00000335972.11
ENST00000457753.5
UBA1
ubiquitin like modifier activating enzyme 1
chr19_+_55600277 0.26 ENST00000301073.4
ZNF524
zinc finger protein 524
chr2_-_178651500 0.26 ENST00000446966.1
ENST00000426232.5
TTN
titin
chr4_+_119027335 0.26 ENST00000627783.2
SYNPO2
synaptopodin 2
chr8_+_49911604 0.26 ENST00000642164.1
ENST00000644093.1
ENST00000643999.1
ENST00000647073.1
ENST00000646880.1
SNTG1
syntrophin gamma 1
chr7_+_121873152 0.25 ENST00000650826.1
ENST00000650728.1
ENST00000393386.7
ENST00000651390.1
ENST00000651842.1
ENST00000650681.1
PTPRZ1
protein tyrosine phosphatase receptor type Z1
chr19_+_51571249 0.25 ENST00000262259.7
ENST00000545217.5
ENST00000596504.1
ZNF175
zinc finger protein 175
chr15_+_75347431 0.25 ENST00000567657.5
NEIL1
nei like DNA glycosylase 1
chr1_-_173824107 0.25 ENST00000345664.10
ENST00000367710.7
CENPL
centromere protein L
chr1_-_28058087 0.24 ENST00000373864.5
EYA3
EYA transcriptional coactivator and phosphatase 3
chr7_-_91880672 0.24 ENST00000456229.1
ENST00000442961.1
ENST00000406735.6
ENST00000419292.1
ENST00000351870.8
MTERF1
mitochondrial transcription termination factor 1
chr1_+_158254414 0.24 ENST00000289429.6
CD1A
CD1a molecule
chr3_+_122077850 0.24 ENST00000482356.5
ENST00000393627.6
CD86
CD86 molecule
chr6_+_31571957 0.24 ENST00000454783.5
LTA
lymphotoxin alpha
chr6_+_32439866 0.24 ENST00000374982.5
ENST00000395388.7
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr1_-_247536440 0.23 ENST00000366487.4
ENST00000641802.1
OR2C3
olfactory receptor family 2 subfamily C member 3
chr3_+_114294020 0.23 ENST00000383671.8
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr10_+_32446102 0.23 ENST00000277657.12
ENST00000362006.11
CCDC7
coiled-coil domain containing 7
chr22_-_43143339 0.23 ENST00000327555.5
ENST00000290429.11
MCAT
malonyl-CoA-acyl carrier protein transacylase
chr1_+_171248471 0.23 ENST00000402921.6
ENST00000617670.6
ENST00000367750.7
FMO1
flavin containing dimethylaniline monoxygenase 1
chr17_-_76053639 0.23 ENST00000602720.5
SRP68
signal recognition particle 68
chr17_-_36534883 0.22 ENST00000620640.4
MYO19
myosin XIX
chr1_-_200669708 0.22 ENST00000436897.1
ENST00000447706.6
ENST00000331314.11
DDX59
DEAD-box helicase 59
chr1_-_173824856 0.22 ENST00000682279.1
CENPL
centromere protein L
chr7_+_150801695 0.22 ENST00000475536.5
ENST00000468689.2
TMEM176A
transmembrane protein 176A
chr12_-_49897056 0.22 ENST00000552863.5
FAIM2
Fas apoptotic inhibitory molecule 2
chr6_+_10528326 0.22 ENST00000379597.7
GCNT2
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr9_+_122371036 0.22 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr3_-_39192584 0.22 ENST00000340369.4
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin binding repeat containing 1
chr6_-_166587594 0.22 ENST00000444122.2
RAMACL
RNA guanine-7 methyltransferase activating subunit like (pseudogene)
chr12_-_56645955 0.21 ENST00000552959.5
ENST00000551020.5
ENST00000553007.2
ENST00000262030.8
ATP5F1B
ATP synthase F1 subunit beta
chr17_-_36534927 0.21 ENST00000610930.4
MYO19
myosin XIX
chr12_+_4720395 0.21 ENST00000252318.7
GALNT8
polypeptide N-acetylgalactosaminyltransferase 8
chr5_+_140691591 0.20 ENST00000508522.5
ENST00000448069.2
HARS2
histidyl-tRNA synthetase 2, mitochondrial
chr4_+_90127555 0.20 ENST00000509176.5
CCSER1
coiled-coil serine rich protein 1
chr11_-_65856944 0.20 ENST00000524553.5
CFL1
cofilin 1
chr2_-_174597728 0.19 ENST00000409891.5
ENST00000410117.5
WIPF1
WAS/WASL interacting protein family member 1
chr3_-_39154558 0.19 ENST00000514182.1
CSRNP1
cysteine and serine rich nuclear protein 1
chr1_-_77979054 0.19 ENST00000370768.7
ENST00000370767.5
ENST00000421641.1
FUBP1
far upstream element binding protein 1
chr11_-_65857007 0.19 ENST00000527344.5
CFL1
cofilin 1
chr8_+_55102012 0.18 ENST00000327381.7
XKR4
XK related 4
chr7_+_121873089 0.18 ENST00000651065.1
PTPRZ1
protein tyrosine phosphatase receptor type Z1
chr6_-_34696733 0.18 ENST00000374023.8
ILRUN
inflammation and lipid regulator with UBA-like and NBR1-like domains
chr17_-_28576882 0.18 ENST00000395319.7
ENST00000581807.5
ENST00000226253.9
ENST00000584086.5
ENST00000395321.6
ALDOC
aldolase, fructose-bisphosphate C
chr6_-_34696839 0.17 ENST00000374026.7
ILRUN
inflammation and lipid regulator with UBA-like and NBR1-like domains
chr1_+_109620578 0.17 ENST00000531203.6
ENST00000256578.8
AMPD2
adenosine monophosphate deaminase 2
chr2_+_17541157 0.17 ENST00000406397.1
VSNL1
visinin like 1
chr2_+_70978380 0.17 ENST00000272421.10
ENST00000441349.5
ENST00000457410.5
ANKRD53
ankyrin repeat domain 53
chr14_-_63318933 0.17 ENST00000621500.2
GPHB5
glycoprotein hormone subunit beta 5
chr16_+_715092 0.16 ENST00000568223.7
METRN
meteorin, glial cell differentiation regulator
chr20_-_1393074 0.16 ENST00000614856.2
ENST00000678408.1
ENST00000618612.5
ENST00000439640.5
ENST00000381719.8
ENST00000677533.1
FKBP1A
FKBP prolyl isomerase 1A
chr19_-_42242526 0.16 ENST00000222330.8
ENST00000676537.1
GSK3A
glycogen synthase kinase 3 alpha
chr1_-_107688492 0.15 ENST00000415432.6
VAV3
vav guanine nucleotide exchange factor 3
chr1_-_153312919 0.15 ENST00000683862.1
PGLYRP3
peptidoglycan recognition protein 3
chr1_+_169367934 0.15 ENST00000367807.7
ENST00000329281.6
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr7_+_23680130 0.15 ENST00000409192.7
ENST00000409653.5
ENST00000409994.3
ENST00000344962.9
FAM221A
family with sequence similarity 221 member A
chr12_-_262828 0.15 ENST00000343164.9
ENST00000436453.1
ENST00000445055.6
ENST00000546319.5
SLC6A13
solute carrier family 6 member 13
chr15_+_81182579 0.14 ENST00000302987.9
IL16
interleukin 16
chr2_+_112911159 0.14 ENST00000263326.8
IL37
interleukin 37
chr7_+_16661182 0.14 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
BZW2
basic leucine zipper and W2 domains 2
chr11_-_111379268 0.13 ENST00000393067.8
POU2AF1
POU class 2 homeobox associating factor 1
chr6_-_39322540 0.13 ENST00000425054.6
ENST00000373227.8
ENST00000373229.9
KCNK16
potassium two pore domain channel subfamily K member 16
chr7_+_100602344 0.13 ENST00000223061.6
PCOLCE
procollagen C-endopeptidase enhancer
chr12_+_54280842 0.13 ENST00000678077.1
ENST00000548688.5
HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
chr17_+_62423891 0.13 ENST00000616852.1
ENST00000311506.10
METTL2A
methyltransferase like 2A
chr15_-_28099293 0.13 ENST00000431101.1
ENST00000445578.5
ENST00000353809.9
ENST00000354638.8
OCA2
OCA2 melanosomal transmembrane protein
chr2_-_174597795 0.12 ENST00000679041.1
WIPF1
WAS/WASL interacting protein family member 1
chr19_+_10452891 0.12 ENST00000344979.7
PDE4A
phosphodiesterase 4A
chr11_+_1870252 0.12 ENST00000612798.4
LSP1
lymphocyte specific protein 1
chr10_-_27240505 0.12 ENST00000375888.5
ENST00000676732.1
ACBD5
acyl-CoA binding domain containing 5
chr11_-_28108109 0.12 ENST00000263181.7
KIF18A
kinesin family member 18A
chr7_+_128476748 0.11 ENST00000262432.13
ENST00000480046.5
METTL2B
methyltransferase like 2B
chr1_+_173824626 0.11 ENST00000648960.1
ENST00000648807.1
ENST00000649067.1
ENST00000649689.2
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr4_-_46124046 0.11 ENST00000295452.5
GABRG1
gamma-aminobutyric acid type A receptor subunit gamma1
chr1_+_203128279 0.11 ENST00000367235.1
ENST00000618295.1
ADORA1
adenosine A1 receptor
chr3_-_46208304 0.11 ENST00000296140.4
CCR1
C-C motif chemokine receptor 1
chr8_-_100950549 0.11 ENST00000395951.7
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr9_-_101738640 0.10 ENST00000361820.6
GRIN3A
glutamate ionotropic receptor NMDA type subunit 3A
chr9_+_4839761 0.10 ENST00000448872.6
ENST00000441844.2
RCL1
RNA terminal phosphate cyclase like 1
chr1_+_20186076 0.10 ENST00000375099.4
UBXN10
UBX domain protein 10
chr5_-_140691312 0.10 ENST00000438307.6
ENST00000415192.6
ENST00000509087.2
ENST00000675698.1
ENST00000504156.7
ENST00000457527.6
ENST00000307633.7
ENST00000676327.1
ENST00000675851.1
ENST00000675366.1
ENST00000675204.1
ENST00000507746.7
ENST00000431330.7
HARS1
histidyl-tRNA synthetase 1
chr22_+_41621977 0.09 ENST00000405506.2
XRCC6
X-ray repair cross complementing 6
chr1_+_173824694 0.09 ENST00000647645.1
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr6_+_28267107 0.09 ENST00000621053.1
ENST00000617168.4
ENST00000421553.7
ENST00000611552.2
ENST00000623276.3
ENSG00000276302.1
ZSCAN26
novel protein
zinc finger and SCAN domain containing 26
chr4_+_94489030 0.09 ENST00000510099.5
PDLIM5
PDZ and LIM domain 5
chr3_-_48595267 0.09 ENST00000328333.12
ENST00000681320.1
COL7A1
collagen type VII alpha 1 chain
chr22_+_22395005 0.09 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 1.0 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.3 2.0 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.3 0.9 GO:0002665 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.3 2.0 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.3 1.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.3 0.8 GO:0090031 regulation of growth plate cartilage chondrocyte proliferation(GO:0003420) positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.2 0.7 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.2 0.6 GO:0006147 guanine catabolic process(GO:0006147)
0.2 1.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 0.9 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.2 1.0 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.4 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.1 0.7 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.4 GO:0097325 melanocyte proliferation(GO:0097325)
0.1 1.8 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.1 1.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.5 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.5 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 0.2 GO:0006393 termination of mitochondrial transcription(GO:0006393)
0.1 0.2 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
0.1 0.2 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 0.4 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 0.2 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.6 GO:0001554 luteolysis(GO:0001554)
0.1 0.4 GO:0034227 tRNA thio-modification(GO:0034227)
0.1 0.6 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.3 GO:0030070 insulin processing(GO:0030070)
0.1 0.2 GO:0032826 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.0 0.1 GO:0070256 negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.0 4.6 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.1 GO:0006726 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.7 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.2 GO:2000077 UDP-glucose catabolic process(GO:0006258) negative regulation of type B pancreatic cell development(GO:2000077)
0.0 0.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:2000784 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.4 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.2 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.7 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.4 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.4 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.6 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 1.6 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 0.3 GO:0032264 IMP salvage(GO:0032264)
0.0 0.3 GO:0015747 urate transport(GO:0015747)
0.0 1.8 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 1.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.8 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.2 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.8 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.0 0.2 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 0.2 GO:0002155 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 0.7 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.1 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.1 GO:0097680 cellular hyperosmotic salinity response(GO:0071475) double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 1.2 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 0.1 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.0 0.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.2 2.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 3.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.5 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.4 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 0.4 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.4 GO:0072534 perineuronal net(GO:0072534)
0.1 1.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 1.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.0 GO:0016013 syntrophin complex(GO:0016013)
0.1 5.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.8 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 9.3 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.9 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.7 5.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 2.0 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 1.8 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.2 0.6 GO:0008892 guanine deaminase activity(GO:0008892)
0.2 1.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 0.8 GO:0008941 nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708)
0.1 0.4 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1 0.9 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.1 0.4 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 0.7 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 0.8 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.2 GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420)
0.1 0.6 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 11.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.4 GO:0048256 flap endonuclease activity(GO:0048256)
0.0 0.7 GO:0031433 telethonin binding(GO:0031433)
0.0 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.2 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.0 0.2 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 1.1 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 1.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0030942 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.4 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.6 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.1 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.0 0.5 GO:0005522 profilin binding(GO:0005522)
0.0 2.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.9 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 4.4 GO:0008168 methyltransferase activity(GO:0008168)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.9 PID AURORA B PATHWAY Aurora B signaling
0.1 3.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 1.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.4 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.8 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.9 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 1.1 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage