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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1
Z-value: 0.67
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Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000214513.4 | NOTO | |
| ENSG00000119614.3 | VSX2 | |
| ENSG00000115844.11 | DLX2 | |
| ENSG00000006377.11 | DLX6 | |
| ENSG00000163623.10 | NKX6-1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DLX6 | hg38_v1_chr7_+_97005538_97005562 | 0.26 | 2.0e-01 | Click! |
| DLX2 | hg38_v1_chr2_-_172102893_172102909 | -0.24 | 2.5e-01 | Click! |
| NKX6-1 | hg38_v1_chr4_-_84499281_84499298 | 0.06 | 7.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_158461574 Show fit | 1.60 |
ENST00000641432.1
ENST00000641460.1 ENST00000641535.1 ENST00000641971.1 |
olfactory receptor family 10 subfamily K member 1 |
|
| chr1_+_74235377 Show fit | 1.51 |
ENST00000326637.8
|
TNNI3 interacting kinase |
|
| chr4_-_137532452 Show fit | 1.30 |
ENST00000412923.6
ENST00000511115.5 ENST00000344876.9 ENST00000507846.5 ENST00000510305.5 ENST00000611581.1 |
protocadherin 18 |
|
| chr12_-_16608183 Show fit | 1.23 |
ENST00000354662.5
ENST00000538051.5 |
LIM domain only 3 |
|
| chr12_-_16608073 Show fit | 1.16 |
ENST00000441439.6
|
LIM domain only 3 |
|
| chr17_-_40994159 Show fit | 0.86 |
ENST00000391586.3
|
keratin associated protein 3-3 |
|
| chr17_-_42185452 Show fit | 0.75 |
ENST00000293330.1
|
hypocretin neuropeptide precursor |
|
| chr7_-_13989658 Show fit | 0.75 |
ENST00000430479.6
ENST00000433547.1 ENST00000405192.6 |
ETS variant transcription factor 1 |
|
| chr6_+_136038195 Show fit | 0.72 |
ENST00000615259.4
|
phosphodiesterase 7B |
|
| chr21_-_30166782 Show fit | 0.71 |
ENST00000286808.5
|
claudin 17 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 2.8 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.1 | 1.7 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 1.5 | GO:0086069 | bundle of His cell to Purkinje myocyte communication(GO:0086069) |
| 0.0 | 1.1 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 1.1 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.2 | 0.8 | GO:2000690 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.1 | 0.8 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.0 | 0.7 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.0 | 0.7 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 1.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.6 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.1 | 0.4 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.0 | 0.4 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.0 | 0.4 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.4 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.0 | 0.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.4 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 2.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 1.5 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 1.1 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 1.1 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.7 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.1 | 0.5 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.1 | 0.5 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 0.0 | 0.5 | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity(GO:0015321) |
| 0.0 | 0.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.8 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.6 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 0.4 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.4 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.4 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 0.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.3 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 0.2 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |