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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for NR1D1

Z-value: 0.64

Motif logo

Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
ENSG00000126368.6 NR1D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1D1hg38_v1_chr17_-_40100569_401005970.029.1e-01Click!

Activity profile of NR1D1 motif

Sorted Z-values of NR1D1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr3_+_58237773 1.65 ENST00000478253.6
abhydrolase domain containing 6, acylglycerol lipase
chr17_+_41237998 1.59 ENST00000254072.7
keratin associated protein 9-8
chr7_+_114922346 1.23 ENST00000393486.5
MyoD family inhibitor domain containing
chr5_-_111976925 1.14 ENST00000395634.7
neuronal regeneration related protein
chrX_+_54920796 1.13 ENST00000442098.5
ENST00000430420.5
ENST00000453081.5
ENST00000319167.12
ENST00000622017.4
ENST00000375022.8
ENST00000399736.5
ENST00000440072.5
ENST00000173898.12
ENST00000431115.5
ENST00000440759.5
ENST00000375041.6
trophinin
chr19_-_18884219 1.07 ENST00000596048.1
ceramide synthase 1
chr11_+_7513966 1.00 ENST00000299492.9
PPFIA binding protein 2
chr22_-_37484505 0.88 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr8_-_109648825 0.74 ENST00000533895.5
ENST00000446070.6
ENST00000528331.5
ENST00000526302.5
ENST00000408908.6
ENST00000433638.1
ENST00000524720.5
syntabulin
chr1_-_11805949 0.73 ENST00000376590.9
methylenetetrahydrofolate reductase
chr19_+_21020675 0.69 ENST00000595401.1
zinc finger protein 430
chr19_-_42423100 0.68 ENST00000597001.1
lipase E, hormone sensitive type
chr7_+_94509793 0.65 ENST00000297273.9
CAS1 domain containing 1
chr13_+_100089015 0.64 ENST00000376286.8
ENST00000376279.7
ENST00000376285.6
propionyl-CoA carboxylase subunit alpha
chr22_+_26621952 0.63 ENST00000354760.4
crystallin beta A4
chr5_-_43313473 0.59 ENST00000433297.2
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr17_+_45844875 0.58 ENST00000329196.7
signal peptide peptidase like 2C
chr6_+_13574227 0.56 ENST00000680432.1
ENST00000681012.1
ENST00000397350.7
sirtuin 5
chr1_-_11805294 0.56 ENST00000413656.5
ENST00000376592.6
ENST00000376585.6
methylenetetrahydrofolate reductase
chr5_-_43313403 0.55 ENST00000325110.11
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr17_+_6070361 0.53 ENST00000317744.10
WSC domain containing 1
chr1_-_147773341 0.50 ENST00000430508.1
ENST00000621517.1
gap junction protein alpha 5
chr6_-_41747390 0.48 ENST00000356667.8
ENST00000373025.7
ENST00000425343.6
progastricsin
chr3_-_45915698 0.48 ENST00000539217.5
leucine zipper transcription factor like 1
chr3_-_185821092 0.47 ENST00000421047.3
insulin like growth factor 2 mRNA binding protein 2
chr19_-_22422335 0.47 ENST00000357774.9
ENST00000601553.1
ENST00000593657.5
zinc finger protein 98
chr19_+_21142058 0.45 ENST00000598331.1
zinc finger protein 431
chr19_-_14518383 0.44 ENST00000254322.3
ENST00000595139.2
DnaJ heat shock protein family (Hsp40) member B1
chr10_+_133453936 0.44 ENST00000640237.1
scavenger receptor family member expressed on T cells 1
chr14_+_24070837 0.44 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
copine 6
chr6_-_27473058 0.43 ENST00000683788.1
ENST00000211936.10
zinc finger protein 184
chr18_-_21704763 0.42 ENST00000580981.5
ENST00000289119.7
abhydrolase domain containing 3, phospholipase
chr19_-_21767498 0.42 ENST00000608416.5
ENST00000598026.1
zinc finger protein 100
chr11_+_111976902 0.41 ENST00000614104.4
DIX domain containing 1
chr2_+_74513441 0.41 ENST00000621092.1
T cell leukemia homeobox 2
chr4_+_87608529 0.37 ENST00000651931.1
dentin sialophosphoprotein
chr15_+_65611336 0.35 ENST00000537259.5
solute carrier family 24 member 1
chr1_-_11805977 0.33 ENST00000376486.3
methylenetetrahydrofolate reductase
chr1_+_159826860 0.33 ENST00000289707.10
SLAM family member 8
chr15_-_65611236 0.31 ENST00000420799.7
ENST00000313182.6
ENST00000431261.6
ENST00000652388.1
ENST00000442903.3
integrator complex subunit 14
chr3_+_170037982 0.31 ENST00000355897.10
G protein-coupled receptor 160
chr13_+_112968496 0.31 ENST00000397030.5
MCF.2 cell line derived transforming sequence like
chr1_-_25906457 0.29 ENST00000426559.6
stathmin 1
chr12_-_7018465 0.29 ENST00000261407.9
lysophosphatidylcholine acyltransferase 3
chr17_-_18644418 0.28 ENST00000575220.5
ENST00000405044.6
ENST00000573652.1
TBC1 domain family member 28
chr1_+_168280872 0.28 ENST00000367821.8
T-box transcription factor 19
chr1_+_20589044 0.28 ENST00000375071.4
cytidine deaminase
chr19_+_21082190 0.27 ENST00000618422.1
ENST00000618008.4
ENST00000425625.5
ENST00000456283.7
zinc finger protein 714
chr17_-_78132407 0.27 ENST00000322914.7
transmembrane channel like 6
chr19_+_21142024 0.26 ENST00000600692.5
ENST00000599296.5
ENST00000594425.5
ENST00000311048.11
zinc finger protein 431
chr13_+_112969179 0.26 ENST00000535094.7
MCF.2 cell line derived transforming sequence like
chr22_-_17258235 0.26 ENST00000649310.1
ENST00000649746.1
adenosine deaminase 2
chr11_-_18046262 0.25 ENST00000682019.1
tryptophan hydroxylase 1
chr10_-_102120246 0.24 ENST00000425280.2
LIM domain binding 1
chr19_-_43198079 0.24 ENST00000597374.5
ENST00000599371.1
pregnancy specific beta-1-glycoprotein 4
chr1_+_109712227 0.24 ENST00000256593.8
glutathione S-transferase mu 5
chr16_+_71358713 0.24 ENST00000349553.9
ENST00000302628.9
ENST00000562305.5
calbindin 2
chr1_+_203795614 0.23 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr3_-_52826834 0.23 ENST00000441637.2
inter-alpha-trypsin inhibitor heavy chain 4
chr19_+_21082224 0.23 ENST00000620627.1
zinc finger protein 714
chr10_-_77140757 0.23 ENST00000637862.2
potassium calcium-activated channel subfamily M alpha 1
chr1_-_11805924 0.22 ENST00000418034.1
methylenetetrahydrofolate reductase
chr1_-_6497096 0.22 ENST00000537245.6
pleckstrin homology and RhoGEF domain containing G5
chr3_-_182985926 0.21 ENST00000487822.5
ENST00000460412.6
ENST00000469954.5
defective in cullin neddylation 1 domain containing 1
chr12_-_123271089 0.21 ENST00000535979.5
cyclin dependent kinase 2 associated protein 1
chr17_-_39918589 0.21 ENST00000309481.11
gasdermin B
chr12_-_110445540 0.21 ENST00000547365.1
actin related protein 2/3 complex subunit 3
chr7_+_114922561 0.21 ENST00000448022.1
MyoD family inhibitor domain containing
chr10_-_102120318 0.20 ENST00000673968.1
LIM domain binding 1
chr16_+_77191173 0.19 ENST00000248248.8
ENST00000439557.6
ENST00000545553.1
MON1 homolog B, secretory trafficking associated
chr1_-_31938302 0.19 ENST00000647444.2
protein tyrosine phosphatase 4A2
chr1_-_226186673 0.19 ENST00000366812.6
acyl-CoA binding domain containing 3
chr8_+_104223344 0.18 ENST00000523362.5
regulating synaptic membrane exocytosis 2
chr5_-_63962438 0.18 ENST00000323865.5
ENST00000506598.1
5-hydroxytryptamine receptor 1A
chr17_-_39918606 0.18 ENST00000418519.6
ENST00000520542.5
gasdermin B
chr11_+_66857056 0.18 ENST00000309602.5
ENST00000393952.3
leucine rich repeat and fibronectin type III domain containing 4
chr22_+_22922594 0.16 ENST00000390331.3
immunoglobulin lambda constant 7
chr1_-_25906931 0.16 ENST00000357865.6
stathmin 1
chr14_-_23301474 0.15 ENST00000561437.1
ENST00000559942.5
ENST00000560913.1
ENST00000559314.5
ENST00000558058.5
protein phosphatase 1 regulatory subunit 3E
chr15_-_65611110 0.15 ENST00000567744.5
ENST00000568573.1
ENST00000562830.1
ENST00000569491.5
ENST00000561769.1
integrator complex subunit 14
chr9_-_33167296 0.13 ENST00000379731.5
ENST00000535206.5
beta-1,4-galactosyltransferase 1
chr8_+_100150621 0.12 ENST00000522439.1
ENST00000353107.8
RNA polymerase II, I and III subunit K
chr6_+_75749231 0.12 ENST00000664209.1
ENST00000369975.6
ENST00000627432.3
ENST00000369985.9
ENST00000369977.8
ENST00000664640.1
ENST00000662603.1
myosin VI
chr1_+_197413827 0.11 ENST00000367397.1
ENST00000681519.1
crumbs cell polarity complex component 1
chr2_-_102736819 0.11 ENST00000258436.10
major facilitator superfamily domain containing 9
chr9_+_136327424 0.11 ENST00000616132.4
G protein signaling modulator 1
chrX_+_16946862 0.11 ENST00000303843.7
RALBP1 associated Eps domain containing 2
chr22_+_37019735 0.11 ENST00000429360.6
ENST00000341116.7
ENST00000404393.5
mercaptopyruvate sulfurtransferase
chrX_-_49233309 0.10 ENST00000376251.5
ENST00000323022.10
ENST00000376265.2
calcium voltage-gated channel subunit alpha1 F
chr1_-_10947870 0.10 ENST00000468348.1
chromosome 1 open reading frame 127
chr11_-_119381629 0.09 ENST00000260187.7
ENST00000455332.6
ubiquitin specific peptidase 2
chr1_+_165543992 0.09 ENST00000294818.2
leucine rich repeat containing 52
chr9_-_133376085 0.09 ENST00000485435.6
surfeit 4
chr19_-_49361475 0.09 ENST00000598810.5
TEA domain transcription factor 2
chr6_+_75749192 0.08 ENST00000369981.7
myosin VI
chr14_+_100323332 0.08 ENST00000361529.5
ENST00000557052.1
solute carrier family 25 member 47
chr19_-_38315919 0.08 ENST00000591755.5
ENST00000337679.12
ENST00000339413.11
Yip1 interacting factor homolog B, membrane trafficking protein
chr17_-_2025289 0.08 ENST00000331238.7
reticulon 4 receptor like 1
chr17_-_61863327 0.08 ENST00000584322.2
ENST00000682369.1
ENST00000683039.1
ENST00000683381.1
BRCA1 interacting protein C-terminal helicase 1
chr10_+_88586762 0.08 ENST00000371939.7
lipase family member J
chr17_-_58280928 0.07 ENST00000225275.4
myeloperoxidase
chr1_+_43933277 0.07 ENST00000414809.7
artemin
chr2_+_207711534 0.06 ENST00000392209.7
cyclin Y like 1
chr6_+_167111789 0.06 ENST00000400926.5
C-C motif chemokine receptor 6
chr3_-_48685835 0.05 ENST00000439518.5
ENST00000416649.6
ENST00000294129.7
NCK interacting protein with SH3 domain
chr12_-_6606642 0.05 ENST00000545584.2
ENST00000545942.6
chromodomain helicase DNA binding protein 4
chr19_-_38315749 0.05 ENST00000589247.1
ENST00000329420.12
ENST00000591784.5
Yip1 interacting factor homolog B, membrane trafficking protein
chr4_+_168921555 0.04 ENST00000503290.1
palladin, cytoskeletal associated protein
chr9_+_35490103 0.04 ENST00000361226.8
RUN and SH3 domain containing 2
chr19_-_38315900 0.04 ENST00000592694.5
Yip1 interacting factor homolog B, membrane trafficking protein
chr2_+_63588953 0.03 ENST00000409908.5
ENST00000442225.5
ENST00000233114.13
ENST00000539945.7
ENST00000409476.5
ENST00000436321.5
malate dehydrogenase 1
chr17_+_42854078 0.02 ENST00000591562.1
ENST00000588033.1
amine oxidase copper containing 3
chr19_-_4455292 0.02 ENST00000394765.7
ENST00000592515.1
UBX domain protein 6
chr20_+_48921775 0.01 ENST00000681021.1
ENST00000679436.1
ADP ribosylation factor guanine nucleotide exchange factor 2
chr10_+_22928010 0.01 ENST00000376528.8
armadillo repeat containing 3
chr19_-_43204223 0.01 ENST00000599746.5
pregnancy specific beta-1-glycoprotein 4
chr10_+_22928030 0.01 ENST00000409983.7
ENST00000298032.10
ENST00000409049.7
armadillo repeat containing 3
chr19_-_23395418 0.00 ENST00000595533.1
ENST00000397082.2
ENST00000599743.5
ENST00000300619.12
zinc finger protein 91
chr3_+_170038129 0.00 ENST00000492492.5
G protein-coupled receptor 160

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0072720 response to dithiothreitol(GO:0072720)
0.3 1.9 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.2 0.6 GO:0036046 protein demalonylation(GO:0036046) peptidyl-lysine demalonylation(GO:0036047) protein desuccinylation(GO:0036048) peptidyl-lysine desuccinylation(GO:0036049) protein deglutarylation(GO:0061698) peptidyl-lysine deglutarylation(GO:0061699)
0.2 1.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 0.5 GO:0035922 pulmonary valve formation(GO:0003193) foramen ovale closure(GO:0035922) regulation of bundle of His cell action potential(GO:0098905)
0.2 0.5 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.4 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 0.6 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.1 0.7 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.3 GO:0019858 cytosine metabolic process(GO:0019858)
0.1 0.5 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.1 1.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.3 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.1 0.9 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.1 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.0 0.3 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.0 0.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.2 GO:0019086 late viral transcription(GO:0019086)
0.0 0.3 GO:1905098 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.1 GO:0009439 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.0 0.4 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.4 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 1.4 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.4 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.1 GO:1990918 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 0.4 GO:0009642 response to light intensity(GO:0009642)
0.0 0.2 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
0.0 0.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 1.0 GO:0007566 embryo implantation(GO:0007566)
0.0 0.4 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.7 GO:0021762 substantia nigra development(GO:0021762)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.7 GO:0097433 dense body(GO:0097433)
0.0 1.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 1.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0005921 gap junction(GO:0005921)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.3 1.9 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.2 0.7 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 0.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 0.6 GO:0036055 protein-malonyllysine demalonylase activity(GO:0036054) protein-succinyllysine desuccinylase activity(GO:0036055) protein-glutaryllysine deglutarylase activity(GO:0061697)
0.1 0.4 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.1 0.5 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.1 0.3 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1 1.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 1.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.4 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.2 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.1 0.4 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.6 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.3 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.1 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.3 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.2 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.2 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.0 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones