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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for NR1I3

Z-value: 0.40

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Transcription factors associated with NR1I3

Gene Symbol Gene ID Gene Info
NR1I3
ENSG00000143257.12 NR1I3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1I3hg38_v1_chr1_-_161238085_161238111-0.067.9e-01Click!

Activity profile of NR1I3 motif

Sorted Z-values of NR1I3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_205321737 0.53 ENST00000367157.6
NUAK2
NUAK family kinase 2
chr17_+_34255274 0.51 ENST00000580907.5
ENST00000225831.4
CCL2
C-C motif chemokine ligand 2
chr19_+_676385 0.51 ENST00000166139.9
FSTL3
follistatin like 3
chr19_-_7497447 0.46 ENST00000593942.5
PEX11G
peroxisomal biogenesis factor 11 gamma
chr14_+_22508602 0.37 ENST00000390504.1
TRAJ33
T cell receptor alpha joining 33
chr11_+_64241600 0.37 ENST00000535135.7
ENST00000652094.1
FKBP2
FKBP prolyl isomerase 2
chr2_-_39120383 0.36 ENST00000395038.6
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1
chr17_-_8295342 0.35 ENST00000579192.5
ENST00000577745.2
SLC25A35
solute carrier family 25 member 35
chr4_+_70028452 0.34 ENST00000530128.5
ENST00000381057.3
ENST00000673563.1
HTN3
histatin 3
chr12_+_53423849 0.34 ENST00000257863.9
ENST00000550311.5
ENST00000379791.7
AMHR2
anti-Mullerian hormone receptor type 2
chr18_-_23586422 0.33 ENST00000269228.10
NPC1
NPC intracellular cholesterol transporter 1
chr11_-_82900406 0.33 ENST00000313010.8
ENST00000393399.6
ENST00000680437.1
PRCP
prolylcarboxypeptidase
chr16_+_2988256 0.32 ENST00000573315.2
LINC00514
long intergenic non-protein coding RNA 514
chr2_-_68952880 0.31 ENST00000481498.1
ENST00000328895.9
GKN2
gastrokine 2
chr3_-_116444983 0.29 ENST00000333617.8
LSAMP
limbic system associated membrane protein
chr11_+_197303 0.28 ENST00000342593.6
ODF3
outer dense fiber of sperm tails 3
chr19_-_45792755 0.28 ENST00000377735.7
ENST00000270223.7
DMWD
DM1 locus, WD repeat containing
chr16_+_30699155 0.27 ENST00000262518.9
SRCAP
Snf2 related CREBBP activator protein
chr7_+_143381907 0.26 ENST00000392910.6
ZYX
zyxin
chr2_-_68871382 0.26 ENST00000295379.2
BMP10
bone morphogenetic protein 10
chr17_-_29294141 0.25 ENST00000225388.9
NUFIP2
nuclear FMR1 interacting protein 2
chr15_+_84980440 0.25 ENST00000310298.8
ENST00000557957.5
PDE8A
phosphodiesterase 8A
chr7_+_143381561 0.24 ENST00000354434.8
ZYX
zyxin
chr6_+_108166015 0.24 ENST00000368986.9
NR2E1
nuclear receptor subfamily 2 group E member 1
chr6_-_43528867 0.22 ENST00000455285.2
XPO5
exportin 5
chr11_+_62789124 0.22 ENST00000526546.1
TMEM179B
transmembrane protein 179B
chr10_-_72088972 0.21 ENST00000317376.8
ENST00000412663.5
SPOCK2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chr14_+_21057822 0.21 ENST00000308227.2
RNASE8
ribonuclease A family member 8
chr2_-_227164194 0.20 ENST00000396625.5
COL4A4
collagen type IV alpha 4 chain
chr11_-_57322197 0.19 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1
chr7_-_56092932 0.19 ENST00000446428.5
ENST00000432123.5
ENST00000297373.7
PHKG1
phosphorylase kinase catalytic subunit gamma 1
chr7_+_101127095 0.18 ENST00000223095.5
SERPINE1
serpin family E member 1
chr7_-_56092974 0.18 ENST00000452681.6
ENST00000537360.5
PHKG1
phosphorylase kinase catalytic subunit gamma 1
chr19_-_43802438 0.18 ENST00000377950.8
LYPD5
LY6/PLAUR domain containing 5
chr16_+_67873036 0.17 ENST00000358933.10
EDC4
enhancer of mRNA decapping 4
chr20_+_36461303 0.16 ENST00000475894.5
DLGAP4
DLG associated protein 4
chr4_-_81215185 0.15 ENST00000264399.6
PRKG2
protein kinase cGMP-dependent 2
chr4_-_81214960 0.15 ENST00000395578.3
ENST00000628926.1
PRKG2
protein kinase cGMP-dependent 2
chr6_+_33454543 0.15 ENST00000621915.1
ENST00000395064.3
ZBTB9
zinc finger and BTB domain containing 9
chr9_+_34179005 0.14 ENST00000625521.2
ENST00000379186.8
ENST00000297661.9
ENST00000626262.2
UBAP1
ubiquitin associated protein 1
chrX_-_111412162 0.14 ENST00000637570.1
ENST00000356220.8
ENST00000636035.2
ENST00000637453.1
ENST00000635795.1
DCX
doublecortin
chr10_-_73808616 0.14 ENST00000299641.8
NDST2
N-deacetylase and N-sulfotransferase 2
chr12_-_108598036 0.14 ENST00000392806.4
ENST00000547567.1
TMEM119
transmembrane protein 119
chr13_-_21061492 0.14 ENST00000382592.5
LATS2
large tumor suppressor kinase 2
chr12_-_53335737 0.14 ENST00000303846.3
SP7
Sp7 transcription factor
chr11_-_47848539 0.13 ENST00000526870.1
NUP160
nucleoporin 160
chr5_-_136193143 0.13 ENST00000607574.2
SMIM32
small integral membrane protein 32
chr1_+_40817190 0.13 ENST00000443478.3
KCNQ4
potassium voltage-gated channel subfamily Q member 4
chr14_+_94026314 0.13 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr19_-_45782388 0.13 ENST00000458663.6
DMPK
DM1 protein kinase
chr10_+_18400562 0.12 ENST00000377315.5
ENST00000650685.1
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr8_-_51809414 0.12 ENST00000356297.5
PXDNL
peroxidasin like
chr14_-_77320813 0.11 ENST00000682467.1
POMT2
protein O-mannosyltransferase 2
chr14_-_102509713 0.10 ENST00000286918.9
ANKRD9
ankyrin repeat domain 9
chr14_-_77320855 0.10 ENST00000556394.2
ENST00000261534.9
POMT2
protein O-mannosyltransferase 2
chr8_-_108787563 0.10 ENST00000297459.4
TMEM74
transmembrane protein 74
chr20_+_6007245 0.10 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr7_-_99784175 0.10 ENST00000651514.1
ENST00000336411.7
ENST00000415003.1
ENST00000354593.6
CYP3A4
cytochrome P450 family 3 subfamily A member 4
chr3_-_116445458 0.10 ENST00000490035.7
LSAMP
limbic system associated membrane protein
chr10_+_102503956 0.10 ENST00000369902.8
SUFU
SUFU negative regulator of hedgehog signaling
chr19_-_15449920 0.10 ENST00000263381.12
ENST00000643092.1
ENST00000673675.1
WIZ
WIZ zinc finger
chr6_-_119149124 0.09 ENST00000368475.8
FAM184A
family with sequence similarity 184 member A
chr1_-_23559490 0.09 ENST00000374561.6
ID3
inhibitor of DNA binding 3, HLH protein
chr19_+_58408735 0.09 ENST00000599238.5
ENST00000322834.7
ZNF584
zinc finger protein 584
chr19_+_58408633 0.09 ENST00000306910.9
ENST00000598901.1
ENST00000593920.5
ENST00000596281.1
ZNF584
zinc finger protein 584
chr11_+_113908983 0.09 ENST00000537778.5
HTR3B
5-hydroxytryptamine receptor 3B
chr15_+_73684731 0.09 ENST00000560995.5
CD276
CD276 molecule
chr7_-_99784248 0.09 ENST00000652018.1
CYP3A4
cytochrome P450 family 3 subfamily A member 4
chr6_-_127459364 0.09 ENST00000487331.2
ENST00000483725.8
KIAA0408
KIAA0408
chr2_+_70087468 0.08 ENST00000303577.7
PCBP1
poly(rC) binding protein 1
chr9_-_95317671 0.08 ENST00000490972.7
ENST00000647778.1
ENST00000649611.1
ENST00000289081.8
FANCC
FA complementation group C
chr8_+_11494367 0.08 ENST00000259089.9
ENST00000529894.1
BLK
BLK proto-oncogene, Src family tyrosine kinase
chr17_-_35063648 0.07 ENST00000394597.7
RFFL
ring finger and FYVE like domain containing E3 ubiquitin protein ligase
chr1_-_151146611 0.07 ENST00000341697.7
ENST00000368914.8
SEMA6C
semaphorin 6C
chr10_-_88583304 0.07 ENST00000331772.9
RNLS
renalase, FAD dependent amine oxidase
chr14_+_22281097 0.07 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr11_-_47848313 0.06 ENST00000530326.5
ENST00000528071.5
NUP160
nucleoporin 160
chr19_-_50833187 0.06 ENST00000598673.1
KLK15
kallikrein related peptidase 15
chr9_-_114099275 0.06 ENST00000468460.2
ENST00000640217.2
KIF12
kinesin family member 12
chr6_-_31541937 0.06 ENST00000456662.5
ENST00000431908.5
ENST00000456976.5
ENST00000428450.5
ENST00000418897.5
ENST00000396172.6
ENST00000419020.1
ENST00000428098.5
DDX39B
DExD-box helicase 39B
chr1_+_56854764 0.06 ENST00000361249.4
C8A
complement C8 alpha chain
chr16_+_527698 0.06 ENST00000219611.7
ENST00000562370.5
ENST00000568988.5
CAPN15
calpain 15
chr19_+_54201122 0.06 ENST00000391753.6
ENST00000441429.1
RPS9
ribosomal protein S9
chr13_+_24309565 0.06 ENST00000332018.4
C1QTNF9
C1q and TNF related 9
chr1_-_151146643 0.06 ENST00000613223.1
SEMA6C
semaphorin 6C
chr17_+_64506953 0.06 ENST00000580188.1
ENST00000556440.7
ENST00000581056.5
CEP95
centrosomal protein 95
chr1_+_32465046 0.06 ENST00000609129.2
ZBTB8B
zinc finger and BTB domain containing 8B
chr17_+_28506320 0.06 ENST00000579795.6
FOXN1
forkhead box N1
chrX_+_70455093 0.06 ENST00000542398.1
DLG3
discs large MAGUK scaffold protein 3
chr18_-_26090584 0.06 ENST00000415083.7
SS18
SS18 subunit of BAF chromatin remodeling complex
chr13_-_94479671 0.05 ENST00000377028.10
ENST00000446125.1
DCT
dopachrome tautomerase
chr11_-_64996963 0.05 ENST00000301887.9
ENST00000534177.1
BATF2
basic leucine zipper ATF-like transcription factor 2
chr20_-_45378305 0.05 ENST00000372726.5
TP53TG5
TP53 target 5
chr17_-_35943707 0.05 ENST00000615905.5
LYZL6
lysozyme like 6
chr17_-_35943662 0.04 ENST00000618542.4
LYZL6
lysozyme like 6
chr16_-_66934144 0.04 ENST00000568572.5
CIAO2B
cytosolic iron-sulfur assembly component 2B
chr2_-_127884860 0.04 ENST00000393001.1
AMMECR1L
AMMECR1 like
chr14_-_102509798 0.04 ENST00000560748.5
ANKRD9
ankyrin repeat domain 9
chr14_-_77320741 0.04 ENST00000682795.1
ENST00000682247.1
POMT2
protein O-mannosyltransferase 2
chr5_-_39270623 0.04 ENST00000512138.1
ENST00000646045.2
FYB1
FYN binding protein 1
chr14_+_24130659 0.03 ENST00000267426.6
FITM1
fat storage inducing transmembrane protein 1
chr19_+_7497544 0.03 ENST00000361664.7
TEX45
testis expressed 45
chr11_-_47848467 0.03 ENST00000378460.6
NUP160
nucleoporin 160
chr11_-_89065969 0.03 ENST00000305447.5
GRM5
glutamate metabotropic receptor 5
chr15_+_43593054 0.03 ENST00000453782.5
ENST00000300283.10
ENST00000437924.5
CKMT1B
creatine kinase, mitochondrial 1B
chr12_-_75207998 0.03 ENST00000550433.5
ENST00000548513.5
KCNC2
potassium voltage-gated channel subfamily C member 2
chr18_-_26091175 0.02 ENST00000579061.5
ENST00000542420.6
SS18
SS18 subunit of BAF chromatin remodeling complex
chr6_+_96521796 0.02 ENST00000369278.5
UFL1
UFM1 specific ligase 1
chr1_+_43337803 0.02 ENST00000372470.9
ENST00000413998.7
MPL
MPL proto-oncogene, thrombopoietin receptor
chr1_+_153357846 0.02 ENST00000368738.4
S100A9
S100 calcium binding protein A9
chr1_+_43935807 0.02 ENST00000438616.3
ARTN
artemin
chr19_+_54200849 0.02 ENST00000626547.2
ENST00000302907.9
ENST00000391752.5
ENST00000402367.5
ENST00000391751.7
RPS9
ribosomal protein S9
chr1_-_19799872 0.02 ENST00000294543.11
TMCO4
transmembrane and coiled-coil domains 4
chr1_-_145918485 0.02 ENST00000537888.1
PEX11B
peroxisomal biogenesis factor 11 beta
chr19_-_48637338 0.02 ENST00000601104.1
ENST00000222122.10
DBP
D-box binding PAR bZIP transcription factor
chr6_-_34146080 0.01 ENST00000538487.7
ENST00000374181.8
GRM4
glutamate metabotropic receptor 4
chr16_-_66934362 0.01 ENST00000567511.1
ENST00000422424.7
CIAO2B
cytosolic iron-sulfur assembly component 2B
chr9_+_131125973 0.01 ENST00000651639.1
ENST00000451030.5
ENST00000531584.1
NUP214
nucleoporin 214
chr2_+_219597838 0.01 ENST00000456909.6
STK11IP
serine/threonine kinase 11 interacting protein
chr1_+_160127672 0.01 ENST00000447527.1
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
chr7_-_73738792 0.01 ENST00000222800.8
ENST00000458339.6
ABHD11
abhydrolase domain containing 11
chr1_-_145918685 0.01 ENST00000369306.8
PEX11B
peroxisomal biogenesis factor 11 beta
chr4_+_37244735 0.01 ENST00000309447.6
NWD2
NACHT and WD repeat domain containing 2
chr1_-_45542726 0.00 ENST00000676549.1
PRDX1
peroxiredoxin 1
chr1_+_27392612 0.00 ENST00000374024.4
GPR3
G protein-coupled receptor 3
chr9_+_121286586 0.00 ENST00000545652.6
GSN
gelsolin

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 0.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.3 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 0.2 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.1 0.4 GO:1904693 midbrain morphogenesis(GO:1904693)
0.1 0.3 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.1 0.2 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.5 GO:0044375 regulation of peroxisome size(GO:0044375)
0.0 0.1 GO:0001827 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.2 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.3 GO:0002254 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0 0.2 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.3 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.3 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.5 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.1 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) regulation of positive thymic T cell selection(GO:1902232)
0.0 0.1 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.1 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042565 RNA nuclear export complex(GO:0042565)
0.0 0.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.5 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.3 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.2 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.1 0.3 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.2 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.5 GO:0048185 activin binding(GO:0048185)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:1990932 5.8S rRNA binding(GO:1990932)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.4 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4