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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for NR4A1

Z-value: 0.41

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Transcription factors associated with NR4A1

Gene Symbol Gene ID Gene Info
ENSG00000123358.20 NR4A1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR4A1hg38_v1_chr12_+_52051402_520514590.164.4e-01Click!

Activity profile of NR4A1 motif

Sorted Z-values of NR4A1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_+_227813834 1.15 ENST00000358813.5
ENST00000409189.7
C-C motif chemokine ligand 20
chr20_+_33168148 0.50 ENST00000354932.6
BPI fold containing family A member 2
chr1_+_212565334 0.48 ENST00000366981.8
ENST00000366987.6
activating transcription factor 3
chr2_+_161160299 0.43 ENST00000440506.5
ENST00000429217.5
ENST00000406287.5
ENST00000402568.5
TRAF family member associated NFKB activator
chr12_-_108826161 0.43 ENST00000546697.1
slingshot protein phosphatase 1
chr2_+_26346086 0.36 ENST00000613142.4
ENST00000260585.12
ENST00000447170.1
selenoprotein I
chr6_+_108295037 0.35 ENST00000368977.9
ENST00000421954.5
AFG1 like ATPase
chr12_+_18242955 0.33 ENST00000676171.1
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr1_-_161132659 0.33 ENST00000368006.8
ENST00000490843.6
ENST00000545495.5
death effector domain containing
chr1_-_161132577 0.32 ENST00000464113.1
death effector domain containing
chr1_-_111200633 0.30 ENST00000357640.9
DENN domain containing 2D
chr8_+_122781621 0.29 ENST00000314393.6
zinc fingers and homeoboxes 2
chr11_-_113706330 0.23 ENST00000540540.5
ENST00000538955.5
ENST00000545579.6
transmembrane serine protease 5
chr2_+_161160420 0.23 ENST00000392749.7
ENST00000405852.5
TRAF family member associated NFKB activator
chr4_-_158159657 0.21 ENST00000590648.5
golgi associated kinase 1B
chr19_+_49210734 0.20 ENST00000597316.1
transient receptor potential cation channel subfamily M member 4
chr3_+_66998297 0.20 ENST00000484414.5
ENST00000460576.5
ENST00000417314.2
kelch repeat and BTB domain containing 8
chr12_-_16606102 0.20 ENST00000537304.6
LIM domain only 3
chr12_-_16605939 0.20 ENST00000541295.5
ENST00000535535.5
LIM domain only 3
chr10_-_73591330 0.19 ENST00000451492.5
ENST00000681793.1
ENST00000680396.1
ENST00000413442.5
ubiquitin specific peptidase 54
chr19_+_4153616 0.19 ENST00000078445.7
ENST00000595923.5
ENST00000602257.5
ENST00000602147.1
cAMP responsive element binding protein 3 like 3
chr12_-_76878985 0.19 ENST00000547435.1
ENST00000552330.5
ENST00000311083.10
ENST00000546966.5
cysteine and glycine rich protein 2
chr11_-_113706292 0.19 ENST00000544634.5
ENST00000539732.5
ENST00000538770.1
ENST00000536856.5
ENST00000299882.11
ENST00000544476.1
transmembrane serine protease 5
chr2_+_233307806 0.17 ENST00000447536.5
ENST00000409110.6
S-antigen visual arrestin
chr20_-_44187093 0.16 ENST00000342272.3
junctophilin 2
chr14_-_24242320 0.16 ENST00000557921.2
TERF1 interacting nuclear factor 2
chr4_+_99574812 0.16 ENST00000422897.6
ENST00000265517.10
microsomal triglyceride transfer protein
chr1_+_50103903 0.16 ENST00000371827.5
ELAV like RNA binding protein 4
chr5_-_27038576 0.15 ENST00000511822.1
ENST00000231021.9
cadherin 9
chr1_+_117001744 0.15 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101 molecule
chr7_-_100177336 0.15 ENST00000292377.4
glypican 2
chr6_+_63636481 0.15 ENST00000509330.5
PHD finger protein 3
chr3_+_113747022 0.15 ENST00000273398.8
ENST00000496747.5
ENST00000475322.1
ATPase H+ transporting V1 subunit A
chr6_-_43627302 0.14 ENST00000307114.11
GTP binding protein 2
chrX_-_54798253 0.14 ENST00000218436.7
inter-alpha-trypsin inhibitor heavy chain family member 6
chr3_+_63652663 0.13 ENST00000343837.8
ENST00000469440.5
sentan, cilia apical structure protein
chr4_-_64409444 0.13 ENST00000381210.8
ENST00000507440.5
trans-2,3-enoyl-CoA reductase like
chr7_-_107803215 0.13 ENST00000340010.10
ENST00000453332.1
solute carrier family 26 member 3
chr6_+_31927486 0.13 ENST00000442278.6
complement C2
chr19_-_16496156 0.12 ENST00000269881.8
calreticulin 3
chr2_-_25252072 0.12 ENST00000683760.1
DNA methyltransferase 3 alpha
chr18_+_58196736 0.11 ENST00000675221.1
NEDD4 like E3 ubiquitin protein ligase
chrX_-_129523436 0.11 ENST00000371123.5
ENST00000371121.5
ENST00000371122.8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr16_-_30029429 0.11 ENST00000564806.1
TLC domain containing 3B
chr3_-_113746059 0.11 ENST00000477813.5
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr16_+_31355165 0.10 ENST00000562918.5
ENST00000268296.9
integrin subunit alpha X
chr10_+_35195843 0.09 ENST00000488741.5
ENST00000474931.5
ENST00000468236.5
ENST00000344351.5
ENST00000490511.1
cAMP responsive element modulator
chr12_-_16606795 0.09 ENST00000447609.5
LIM domain only 3
chr19_+_11435619 0.09 ENST00000589126.5
ENST00000588269.1
ENST00000587509.5
ENST00000591462.6
ENST00000592741.5
ENST00000677123.1
ENST00000593101.5
ENST00000587327.5
protein kinase C substrate 80K-H
chr7_-_81770122 0.08 ENST00000423064.7
hepatocyte growth factor
chr11_+_87037820 0.08 ENST00000340353.11
transmembrane protein 135
chr8_+_98944403 0.08 ENST00000457907.3
ENST00000523368.5
ENST00000297565.8
ENST00000435298.6
odd-skipped related transciption factor 2
chr4_-_88823165 0.08 ENST00000508369.5
family with sequence similarity 13 member A
chr8_+_144095054 0.08 ENST00000318911.5
cytochrome c1
chr4_+_176065827 0.08 ENST00000508596.6
WD repeat domain 17
chr19_+_11436044 0.08 ENST00000589838.5
protein kinase C substrate 80K-H
chr4_-_40630588 0.08 ENST00000514014.1
RNA binding motif protein 47
chr6_+_44158807 0.07 ENST00000532171.5
ENST00000398776.2
calpain 11
chr20_+_58891981 0.07 ENST00000488652.6
ENST00000476935.6
ENST00000492907.6
ENST00000603546.2
GNAS complex locus
chr6_-_33803980 0.07 ENST00000507738.1
ENST00000266003.9
ENST00000430124.7
motilin
chr10_+_99782628 0.07 ENST00000648689.1
ENST00000647814.1
ATP binding cassette subfamily C member 2
chr14_-_95157270 0.07 ENST00000674628.1
ENST00000529720.1
ENST00000393063.6
ENST00000532939.3
dicer 1, ribonuclease III
chr6_+_118548289 0.07 ENST00000357525.6
phospholamban
chr17_+_75633420 0.07 ENST00000375215.3
small integral membrane protein 5
chr12_+_93569814 0.06 ENST00000340600.6
suppressor of cytokine signaling 2
chr17_+_1742836 0.06 ENST00000324015.7
ENST00000450523.6
ENST00000453723.5
ENST00000453066.6
ENST00000382061.5
serpin family F member 2
chr20_+_38962299 0.06 ENST00000373325.6
ENST00000373323.8
ENST00000252011.8
ENST00000615559.1
DEAH-box helicase 35
novel transcript, sense intronic to DHX35
chr11_+_87037915 0.06 ENST00000526733.5
ENST00000305494.6
ENST00000532959.5
transmembrane protein 135
chr15_+_43692886 0.06 ENST00000434505.5
ENST00000411750.5
creatine kinase, mitochondrial 1A
chr3_-_30894661 0.06 ENST00000282538.10
ENST00000454381.3
glutamate decarboxylase like 1
chr7_+_6009222 0.06 ENST00000400479.6
ENST00000223029.8
ENST00000395236.2
aminoacyl tRNA synthetase complex interacting multifunctional protein 2
chr17_+_4951758 0.06 ENST00000518175.1
enolase 3
chr6_+_31927683 0.06 ENST00000456570.5
novel complement component 2 (C2) and complement factor B (CFB) protein
chr11_+_278398 0.06 ENST00000534750.6
NLR family pyrin domain containing 6
chr5_-_74866779 0.05 ENST00000510496.5
family with sequence similarity 169 member A
chr7_-_105876477 0.05 ENST00000478915.1
ataxin 7 like 1
chr2_-_27380715 0.05 ENST00000323703.11
ENST00000436006.1
zinc finger protein 513
chr17_+_7219857 0.05 ENST00000583312.5
ENST00000350303.9
ENST00000584103.5
ENST00000356839.10
ENST00000579886.2
acyl-CoA dehydrogenase very long chain
chr18_-_27143024 0.05 ENST00000581714.5
carbohydrate sulfotransferase 9
chr18_-_5197241 0.05 ENST00000434239.4
A-kinase anchor inhibitor 1
chr2_-_177392673 0.05 ENST00000447413.1
ENST00000397057.6
ENST00000456746.5
ENST00000464747.5
novel transcript
nuclear factor, erythroid 2 like 2
chr18_+_46174055 0.05 ENST00000615553.1
chromosome 18 open reading frame 25
chr10_-_72954790 0.05 ENST00000373032.4
phospholipase A2 group XIIB
chr11_+_121101243 0.05 ENST00000392793.6
ENST00000642222.1
tectorin alpha
chr14_+_35122537 0.04 ENST00000604948.5
ENST00000321130.14
ENST00000534898.9
ENST00000605201.1
ENST00000250377.11
protein only RNase P catalytic subunit
chr18_-_55302613 0.04 ENST00000561831.7
transcription factor 4
chr3_-_139044892 0.04 ENST00000413199.1
proline rich 23C
chr13_-_32538732 0.04 ENST00000674437.1
NEDD4 binding protein 2 like 2
chr9_-_72953047 0.04 ENST00000297785.8
ENST00000376939.5
aldehyde dehydrogenase 1 family member A1
chr16_+_55655960 0.04 ENST00000568943.6
solute carrier family 6 member 2
chr3_+_46497970 0.04 ENST00000296142.4
receptor transporter protein 3
chr2_-_24972032 0.04 ENST00000534855.5
DnaJ heat shock protein family (Hsp40) member C27
chr3_-_113746218 0.04 ENST00000497255.1
ENST00000240922.8
ENST00000478020.1
ENST00000493900.5
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr11_+_3855629 0.04 ENST00000526596.2
ENST00000300737.8
ENST00000616714.4
stromal interaction molecule 1
chr8_-_119673368 0.04 ENST00000427067.6
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr3_+_138621207 0.04 ENST00000464668.5
Fas apoptotic inhibitory molecule
chr3_-_157503574 0.03 ENST00000494677.5
ENST00000468233.5
ventricular zone expressed PH domain containing 1
chr12_+_21372899 0.03 ENST00000240652.8
ENST00000542023.1
ENST00000537593.1
islet amyloid polypeptide
chr7_-_126533850 0.03 ENST00000444921.3
glutamate metabotropic receptor 8
chr7_-_37448845 0.03 ENST00000310758.9
engulfment and cell motility 1
chr4_-_110641920 0.03 ENST00000354925.6
ENST00000511990.1
ENST00000613094.4
ENST00000614423.4
ENST00000616641.4
ENST00000511837.5
paired like homeodomain 2
chr1_+_228208024 0.03 ENST00000570156.7
ENST00000680850.1
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr19_+_13023958 0.03 ENST00000587760.5
ENST00000585575.5
nuclear factor I X
chr15_-_40828699 0.03 ENST00000299174.10
ENST00000427255.2
protein phosphatase 1 regulatory inhibitor subunit 14D
chr7_-_6009072 0.03 ENST00000642456.1
ENST00000642292.1
ENST00000441476.6
PMS1 homolog 2, mismatch repair system component
chr20_+_17699942 0.03 ENST00000427254.1
ENST00000377805.7
BANF family member 2
chr6_-_116060859 0.03 ENST00000606080.2
fyn related Src family tyrosine kinase
chr9_+_12693327 0.03 ENST00000388918.10
tyrosinase related protein 1
chr16_-_31150058 0.03 ENST00000569305.1
ENST00000268281.9
ENST00000418068.6
serine protease 36
chr9_-_136245802 0.03 ENST00000358701.10
quiescin sulfhydryl oxidase 2
chr6_+_69232406 0.02 ENST00000238918.12
adhesion G protein-coupled receptor B3
chr17_+_4951080 0.02 ENST00000521811.5
ENST00000323997.10
ENST00000522249.5
ENST00000519584.5
ENST00000519602.6
enolase 3
chr5_-_127073467 0.02 ENST00000607731.5
ENST00000509733.7
ENST00000296662.10
ENST00000535381.6
chromosome 5 open reading frame 63
chr19_-_5622768 0.02 ENST00000252542.9
scaffold attachment factor B2
chr3_-_113746185 0.02 ENST00000616174.1
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr11_+_73950985 0.02 ENST00000339764.6
DnaJ heat shock protein family (Hsp40) member B13
chr20_+_17699960 0.02 ENST00000246090.6
BANF family member 2
chr1_+_40247926 0.02 ENST00000372766.4
transmembrane and coiled-coil domains 2
chr16_+_81238682 0.02 ENST00000258168.7
ENST00000564552.1
beta-carotene oxygenase 1
chr3_-_185821092 0.02 ENST00000421047.3
insulin like growth factor 2 mRNA binding protein 2
chr13_-_32538762 0.02 ENST00000267068.5
ENST00000674428.1
ENST00000674297.1
ENST00000674180.1
ENST00000674421.1
ENST00000674484.1
ENST00000674377.1
NEDD4 binding protein 2 like 2
chr3_+_51707059 0.02 ENST00000395052.8
glutamate metabotropic receptor 2
chr10_-_17129786 0.02 ENST00000377833.10
cubilin
chr7_-_81770039 0.02 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
hepatocyte growth factor
chr19_-_4066892 0.01 ENST00000322357.9
zinc finger and BTB domain containing 7A
chr2_-_206159509 0.01 ENST00000423725.5
NADH:ubiquinone oxidoreductase core subunit S1
chr14_+_21918161 0.01 ENST00000390439.2
T cell receptor alpha variable 13-2
chr7_-_6009019 0.01 ENST00000382321.5
ENST00000265849.12
PMS1 homolog 2, mismatch repair system component
chr2_+_206159580 0.01 ENST00000236957.9
ENST00000392221.5
ENST00000445505.5
eukaryotic translation elongation factor 1 beta 2
chr6_+_31927703 0.01 ENST00000418949.6
ENST00000299367.10
ENST00000383177.7
ENST00000477310.1
complement C2
novel complement component 2 (C2) and complement factor B (CFB) protein
chrX_+_136536099 0.01 ENST00000440515.5
ENST00000456412.1
vestigial like family member 1
chr2_-_24971900 0.01 ENST00000264711.7
DnaJ heat shock protein family (Hsp40) member C27
chr3_+_138621225 0.01 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr2_+_206159884 0.01 ENST00000392222.7
eukaryotic translation elongation factor 1 beta 2
chr16_+_9091593 0.01 ENST00000327827.12
chromosome 16 open reading frame 72
chr12_+_21526287 0.00 ENST00000256969.7
spexin hormone
chr22_+_24495242 0.00 ENST00000382760.2
ENST00000326010.10
beta-ureidopropionase 1
chr1_+_160205411 0.00 ENST00000368076.1
proliferation and apoptosis adaptor protein 15
chr7_+_12570712 0.00 ENST00000417018.1
ENST00000297029.10
scinderin

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 0.5 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 0.4 GO:1904719 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.1 0.7 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.2 GO:1903949 positive regulation of atrial cardiac muscle cell action potential(GO:1903949)
0.1 0.2 GO:0071962 mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.0 0.3 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.2 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.0 0.1 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.0 0.1 GO:1901877 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.0 0.1 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.1 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.4 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.0 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.1 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.0 0.2 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.0 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.0 0.1 GO:0036022 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.2 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.4 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.1 0.2 GO:0052858 peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858)
0.0 0.2 GO:0002046 opsin binding(GO:0002046)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.1 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.0 GO:0005334 norepinephrine:sodium symporter activity(GO:0005334)
0.0 0.1 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle