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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for NRF1
Z-value: 1.87
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg38_v1_chr7_+_129611680_129611760 | -0.31 | 1.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_36951701 Show fit | 3.79 |
ENST00000646673.2
|
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
|
| chr19_-_49929525 Show fit | 3.69 |
ENST00000596437.5
ENST00000341114.7 ENST00000595948.5 |
nucleoporin 62 interleukin 4 induced 1 |
|
| chr20_-_36951837 Show fit | 3.12 |
ENST00000262878.5
|
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
|
| chr6_-_41072529 Show fit | 2.79 |
ENST00000373154.6
ENST00000464633.5 ENST00000628419.2 ENST00000479950.5 ENST00000482515.5 |
O-acyl-ADP-ribose deacylase 1 |
|
| chrX_+_7147819 Show fit | 2.72 |
ENST00000660000.2
|
steroid sulfatase |
|
| chr6_-_41072456 Show fit | 2.66 |
ENST00000463088.5
ENST00000469104.5 ENST00000486443.5 |
O-acyl-ADP-ribose deacylase 1 |
|
| chr8_-_141000937 Show fit | 2.64 |
ENST00000520892.5
|
protein tyrosine kinase 2 |
|
| chr10_+_58269132 Show fit | 2.44 |
ENST00000333926.6
|
CDGSH iron sulfur domain 1 |
|
| chr1_-_197201262 Show fit | 2.22 |
ENST00000367405.5
|
zinc finger and BTB domain containing 41 |
|
| chr20_-_36951665 Show fit | 2.20 |
ENST00000643918.1
|
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 11.3 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.0 | 4.2 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.5 | 3.8 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.3 | 3.8 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.9 | 3.6 | GO:1903438 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 0.3 | 3.1 | GO:0007068 | negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070) |
| 0.6 | 2.9 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.4 | 2.8 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.4 | 2.7 | GO:0060356 | leucine import(GO:0060356) |
| 0.1 | 2.6 | GO:0009226 | nucleotide-sugar biosynthetic process(GO:0009226) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.4 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 5.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 4.3 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 4.2 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 3.3 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.2 | 3.2 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 3.1 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 2.8 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 2.6 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 2.6 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.0 | GO:0032560 | dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793) guanyl deoxyribonucleotide binding(GO:0032560) dGTP binding(GO:0032567) |
| 0.1 | 5.4 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.0 | 4.7 | GO:0061659 | ubiquitin-like protein ligase activity(GO:0061659) |
| 1.3 | 4.0 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.1 | 3.6 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.1 | 3.4 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 3.3 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 3.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 3.2 | GO:0001163 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.2 | 2.9 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 3.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.4 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.1 | 3.4 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 3.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 3.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.5 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 4.6 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 4.4 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.1 | 3.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 2.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 2.4 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.1 | 2.3 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 2.3 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 2.1 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 2.0 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |