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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for PATZ1_KLF4
Z-value: 2.54
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Transcription factors associated with PATZ1_KLF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PATZ1 | hg38_v1_chr22_-_31346143_31346232, hg38_v1_chr22_-_31346317_31346364 | -0.60 | 1.5e-03 | Click! |
| KLF4 | hg38_v1_chr9_-_107489754_107489776 | 0.25 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PATZ1_KLF4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 57.8 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 7.0 | 34.9 | GO:0007571 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 1.8 | 32.6 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 1.6 | 31.8 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.4 | 31.6 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 2.4 | 31.3 | GO:0036155 | acylglycerol acyl-chain remodeling(GO:0036155) |
| 0.1 | 29.3 | GO:0008380 | RNA splicing(GO:0008380) |
| 0.8 | 24.2 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 2.0 | 24.1 | GO:0030578 | PML body organization(GO:0030578) |
| 3.0 | 23.9 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 59.4 | GO:0009986 | cell surface(GO:0009986) |
| 0.1 | 53.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 51.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 47.4 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.2 | 37.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.4 | 36.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.3 | 35.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 29.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.5 | 27.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.4 | 27.1 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 103.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 85.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 46.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 45.1 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.3 | 42.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 36.8 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.5 | 35.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 3.6 | 35.6 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 1.2 | 31.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 1.4 | 29.8 | GO:0048185 | activin binding(GO:0048185) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 92.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.7 | 64.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.6 | 60.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.1 | 58.2 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.3 | 48.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 32.4 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.3 | 31.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.5 | 30.5 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 30.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.8 | 29.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 90.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.4 | 64.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.5 | 55.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.8 | 46.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 1.0 | 46.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.4 | 42.9 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.9 | 41.5 | REACTOME GRB2 EVENTS IN ERBB2 SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
| 0.2 | 40.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 39.3 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.4 | 29.0 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |