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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for PAX1_PAX9

Z-value: 0.43

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.14 PAX1
PAX9
ENSG00000198807.13 PAX9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX1hg38_v1_chr20_+_21705651_21705673-0.116.1e-01Click!
PAX9hg38_v1_chr14_+_36657560_36657594-0.106.3e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_122826679 1.64 ENST00000264498.8
FGF2
fibroblast growth factor 2
chr4_+_122826824 1.59 ENST00000608478.1
ENST00000644866.2
FGF2
fibroblast growth factor 2
chr8_-_124372686 1.44 ENST00000297632.8
TMEM65
transmembrane protein 65
chr9_-_122228845 1.19 ENST00000394319.8
ENST00000340587.7
LHX6
LIM homeobox 6
chr6_+_34889228 0.95 ENST00000360359.5
ENST00000649117.1
ENST00000650178.1
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr2_+_68643579 0.65 ENST00000303786.5
PROKR1
prokineticin receptor 1
chr5_-_134411847 0.56 ENST00000458198.3
ENST00000395009.3
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr10_+_30434176 0.46 ENST00000263056.6
ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr4_-_162163955 0.44 ENST00000379164.8
FSTL5
follistatin like 5
chr10_+_30434021 0.43 ENST00000542547.5
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr17_+_78378633 0.43 ENST00000262764.11
ENST00000589689.5
ENST00000592043.5
ENST00000587356.1
PGS1
phosphatidylglycerophosphate synthase 1
chr4_-_162163989 0.43 ENST00000306100.10
ENST00000427802.2
FSTL5
follistatin like 5
chr13_+_20567131 0.33 ENST00000319980.10
ENST00000351808.10
ENST00000389373.3
IFT88
intraflagellar transport 88
chr6_+_132570322 0.32 ENST00000275198.1
TAAR6
trace amine associated receptor 6
chr17_-_41812586 0.31 ENST00000355468.7
ENST00000590496.1
P3H4
prolyl 3-hydroxylase family member 4 (inactive)
chr10_+_71319249 0.30 ENST00000373189.6
ENST00000479577.2
SLC29A3
solute carrier family 29 member 3
chr15_+_63277586 0.30 ENST00000261879.10
ENST00000380343.8
ENST00000560353.1
APH1B
aph-1 homolog B, gamma-secretase subunit
chr6_-_137173644 0.28 ENST00000296980.7
ENST00000349184.8
ENST00000339602.3
IL22RA2
interleukin 22 receptor subunit alpha 2
chr1_-_204196482 0.25 ENST00000367194.5
KISS1
KiSS-1 metastasis suppressor
chr2_-_162074394 0.25 ENST00000676810.1
DPP4
dipeptidyl peptidase 4
chr4_+_625555 0.22 ENST00000496514.6
ENST00000255622.10
PDE6B
phosphodiesterase 6B
chr2_-_162074182 0.22 ENST00000360534.8
DPP4
dipeptidyl peptidase 4
chr11_-_126268913 0.21 ENST00000532259.1
SRPRA
SRP receptor subunit alpha
chr2_-_206765274 0.21 ENST00000454776.6
ENST00000449792.5
ENST00000374412.8
MDH1B
malate dehydrogenase 1B
chr3_-_57079287 0.20 ENST00000338458.8
ENST00000468727.5
ARHGEF3
Rho guanine nucleotide exchange factor 3
chr3_+_195720974 0.19 ENST00000447234.7
ENST00000320736.10
MUC20
mucin 20, cell surface associated
chr19_-_51645545 0.18 ENST00000534261.3
SIGLEC5
sialic acid binding Ig like lectin 5
chr3_+_15206179 0.15 ENST00000253693.7
CAPN7
calpain 7
chr18_-_49491586 0.14 ENST00000584895.5
ENST00000580210.5
ENST00000579408.5
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr11_+_6926417 0.13 ENST00000610573.4
ENST00000278319.10
ZNF215
zinc finger protein 215
chr17_+_41812974 0.13 ENST00000321562.9
FKBP10
FKBP prolyl isomerase 10
chr17_-_3557798 0.13 ENST00000301365.8
ENST00000572519.1
ENST00000576742.6
TRPV3
transient receptor potential cation channel subfamily V member 3
chr14_+_24070837 0.12 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
CPNE6
copine 6
chrX_+_149781930 0.12 ENST00000243314.5
MAGEA9
MAGE family member A9
chr9_-_101487120 0.12 ENST00000374848.8
PGAP4
post-GPI attachment to proteins GalNAc transferase 4
chr2_-_162074050 0.11 ENST00000676768.1
DPP4
dipeptidyl peptidase 4
chr22_+_22895368 0.10 ENST00000390321.2
IGLC1
immunoglobulin lambda constant 1
chr3_+_195720867 0.10 ENST00000436408.6
MUC20
mucin 20, cell surface associated
chr11_+_61755372 0.10 ENST00000265460.9
MYRF
myelin regulatory factor
chr7_-_113118544 0.09 ENST00000397764.8
ENST00000441359.1
SMIM30
small integral membrane protein 30
chr11_+_6926490 0.08 ENST00000414517.6
ZNF215
zinc finger protein 215
chrX_-_149540900 0.08 ENST00000608355.1
ENST00000651111.1
LINC00893
ENSG00000241489.8
long intergenic non-protein coding RNA 893
novel protein
chr17_+_39200302 0.07 ENST00000579374.5
RPL19
ribosomal protein L19
chr1_-_1574824 0.07 ENST00000291386.4
SSU72
SSU72 homolog, RNA polymerase II CTD phosphatase
chrX_-_154479253 0.07 ENST00000357360.4
LAGE3
L antigen family member 3
chr17_+_39200275 0.06 ENST00000225430.9
RPL19
ribosomal protein L19
chr3_-_25783434 0.06 ENST00000396649.7
ENST00000280700.10
ENST00000428257.5
NGLY1
N-glycanase 1
chr8_-_120811988 0.06 ENST00000517992.2
SNTB1
syntrophin beta 1
chr3_-_25783381 0.06 ENST00000308710.9
ENST00000676225.1
NGLY1
N-glycanase 1
chr14_-_91417805 0.05 ENST00000389857.11
ENST00000553403.1
CCDC88C
coiled-coil domain containing 88C
chr17_+_39200334 0.05 ENST00000579260.5
ENST00000582193.5
RPL19
ribosomal protein L19
chr2_+_241809065 0.04 ENST00000415936.5
NEU4
neuraminidase 4
chr6_-_137044959 0.03 ENST00000468393.5
ENST00000367746.3
ENST00000316649.10
IL20RA
interleukin 20 receptor subunit alpha
chr2_+_27212320 0.03 ENST00000405489.7
ATRAID
all-trans retinoic acid induced differentiation factor
chr18_-_49492305 0.03 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
RPL17
RPL17-C18orf32
ribosomal protein L17
RPL17-C18orf32 readthrough
chr6_-_170584581 0.03 ENST00000392090.6
ENST00000542896.5
ENST00000453163.6
ENST00000537445.5
ENST00000541970.6
PDCD2
programmed cell death 2
chr17_+_39200507 0.03 ENST00000678573.1
RPL19
ribosomal protein L19
chr1_+_160151597 0.02 ENST00000368081.9
ATP1A4
ATPase Na+/K+ transporting subunit alpha 4
chr1_+_44674688 0.01 ENST00000418644.5
ENST00000458657.6
ENST00000535358.6
ENST00000441519.5
ENST00000445071.5
ARMH1
armadillo like helical domain containing 1
chr6_-_41734160 0.00 ENST00000424495.2
ENST00000420312.6
TFEB
transcription factor EB
chr14_+_64388296 0.00 ENST00000554739.5
ENST00000554768.6
ENST00000652179.1
ENST00000652337.1
ENST00000557370.3
MTHFD1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.9 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 1.2 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.2 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.1 0.6 GO:0036343 negative regulation of extracellular matrix disassembly(GO:0010716) psychomotor behavior(GO:0036343)
0.0 0.4 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.1 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.3 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.3 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.0 0.3 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.9 GO:0000186 activation of MAPKK activity(GO:0000186)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0046581 intercellular canaliculus(GO:0046581) invadopodium membrane(GO:0071438)
0.0 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 1.4 GO:0014704 intercalated disc(GO:0014704)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.1 3.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 0.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling