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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for PAX4

Z-value: 0.77

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Transcription factors associated with PAX4

Gene Symbol Gene ID Gene Info
PAX4
ENSG00000106331.17 PAX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX4hg38_v1_chr7_-_127618137_1276181450.125.8e-01Click!

Activity profile of PAX4 motif

Sorted Z-values of PAX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_102355881 4.36 ENST00000409599.5
IL18R1
interleukin 18 receptor 1
chr2_+_102355750 4.36 ENST00000233957.7
IL18R1
interleukin 18 receptor 1
chr9_-_120926752 3.47 ENST00000373887.8
TRAF1
TNF receptor associated factor 1
chr9_-_120914549 2.97 ENST00000546084.5
TRAF1
TNF receptor associated factor 1
chr8_+_32548303 1.96 ENST00000650967.1
NRG1
neuregulin 1
chr3_+_112086335 1.86 ENST00000431717.6
ENST00000480282.5
C3orf52
chromosome 3 open reading frame 52
chr14_-_91244669 1.85 ENST00000650645.1
GPR68
G protein-coupled receptor 68
chr8_+_32548210 1.74 ENST00000523079.5
ENST00000650919.1
NRG1
neuregulin 1
chr3_-_123620496 1.70 ENST00000578202.1
MYLK
myosin light chain kinase
chr3_+_112086364 1.66 ENST00000264848.10
C3orf52
chromosome 3 open reading frame 52
chr3_-_79767987 1.66 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr3_-_123620571 1.65 ENST00000583087.5
MYLK
myosin light chain kinase
chr7_-_22220226 1.60 ENST00000420196.5
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr16_-_28610032 1.59 ENST00000567512.1
SULT1A1
sulfotransferase family 1A member 1
chr6_+_31586124 1.49 ENST00000418507.6
ENST00000376096.5
ENST00000376099.5
ENST00000376110.7
LST1
leukocyte specific transcript 1
chr6_-_32838727 1.46 ENST00000652259.1
ENST00000374897.4
ENST00000620123.4
ENST00000452392.2
TAP2
ENSG00000250264.1
transporter 2, ATP binding cassette subfamily B member
novel protein, TAP2-HLA-DOB readthrough
chr6_+_31586269 1.28 ENST00000438075.7
LST1
leukocyte specific transcript 1
chr12_+_78036248 1.11 ENST00000644176.1
NAV3
neuron navigator 3
chr10_+_6144883 0.98 ENST00000379789.8
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr16_+_50696999 0.98 ENST00000300589.6
NOD2
nucleotide binding oligomerization domain containing 2
chr6_+_31586680 0.97 ENST00000339530.8
LST1
leukocyte specific transcript 1
chr7_+_26152188 0.93 ENST00000056233.4
NFE2L3
nuclear factor, erythroid 2 like 3
chr4_-_112285892 0.91 ENST00000361717.4
TIFA
TRAF interacting protein with forkhead associated domain
chr7_-_16833411 0.90 ENST00000412973.1
AGR2
anterior gradient 2, protein disulphide isomerase family member
chr5_-_143403297 0.86 ENST00000415690.6
NR3C1
nuclear receptor subfamily 3 group C member 1
chr6_-_25042003 0.86 ENST00000510784.8
RIPOR2
RHO family interacting cell polarization regulator 2
chr3_-_71583713 0.85 ENST00000649528.3
ENST00000471386.3
ENST00000493089.7
FOXP1
forkhead box P1
chr21_+_42513834 0.82 ENST00000352133.3
SLC37A1
solute carrier family 37 member 1
chr1_-_204494752 0.81 ENST00000684373.1
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
chr2_+_202073282 0.81 ENST00000459709.5
KIAA2012
KIAA2012
chr2_+_202073249 0.80 ENST00000498697.3
KIAA2012
KIAA2012
chr8_+_32548267 0.80 ENST00000356819.7
NRG1
neuregulin 1
chr5_-_133968578 0.79 ENST00000231512.5
C5orf15
chromosome 5 open reading frame 15
chr6_+_31586859 0.75 ENST00000433492.5
LST1
leukocyte specific transcript 1
chr5_-_16916400 0.73 ENST00000513882.5
MYO10
myosin X
chr17_-_79009731 0.72 ENST00000392446.10
ENST00000590370.5
ENST00000591625.5
CANT1
calcium activated nucleotidase 1
chr5_-_143403611 0.71 ENST00000394464.7
ENST00000231509.7
NR3C1
nuclear receptor subfamily 3 group C member 1
chr11_-_18588699 0.70 ENST00000379387.8
ENST00000541984.5
ENST00000396197.8
ENST00000543987.5
UEVLD
UEV and lactate/malate dehyrogenase domains
chr6_+_31586835 0.70 ENST00000211921.11
LST1
leukocyte specific transcript 1
chr17_-_79009778 0.70 ENST00000591773.5
ENST00000588611.5
ENST00000586916.6
ENST00000592033.5
ENST00000588075.5
ENST00000302345.6
ENST00000591811.1
CANT1
calcium activated nucleotidase 1
chr18_-_5396265 0.70 ENST00000579951.2
EPB41L3
erythrocyte membrane protein band 4.1 like 3
chr5_-_59586393 0.68 ENST00000505453.1
ENST00000360047.9
PDE4D
phosphodiesterase 4D
chr8_-_673547 0.65 ENST00000522893.1
ERICH1
glutamate rich 1
chr1_+_152908538 0.64 ENST00000368764.4
IVL
involucrin
chr6_+_31547560 0.64 ENST00000376148.9
ENST00000376145.8
NFKBIL1
NFKB inhibitor like 1
chr2_-_24328113 0.63 ENST00000622089.4
ITSN2
intersectin 2
chr3_+_119579676 0.61 ENST00000357003.7
ADPRH
ADP-ribosylarginine hydrolase
chr5_+_144205250 0.60 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr14_-_68793055 0.60 ENST00000439696.3
ZFP36L1
ZFP36 ring finger protein like 1
chr17_+_1771688 0.60 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin family F member 1
chrX_+_110944285 0.59 ENST00000425146.5
ENST00000446737.5
PAK3
p21 (RAC1) activated kinase 3
chr5_-_147081428 0.59 ENST00000394413.7
PPP2R2B
protein phosphatase 2 regulatory subunit Bbeta
chr3_-_142448060 0.55 ENST00000264951.8
XRN1
5'-3' exoribonuclease 1
chr12_-_108827384 0.54 ENST00000326470.9
SSH1
slingshot protein phosphatase 1
chr1_-_228406761 0.54 ENST00000366699.3
ENST00000284551.11
TRIM11
tripartite motif containing 11
chr3_+_130850585 0.53 ENST00000505330.5
ENST00000504381.5
ENST00000507488.6
ATP2C1
ATPase secretory pathway Ca2+ transporting 1
chr1_+_15153698 0.53 ENST00000400796.7
ENST00000376008.3
ENST00000434578.6
TMEM51
transmembrane protein 51
chr16_-_28597042 0.52 ENST00000533150.5
ENST00000335715.9
SULT1A2
sulfotransferase family 1A member 2
chr9_+_89605004 0.52 ENST00000252506.11
ENST00000375769.1
GADD45G
growth arrest and DNA damage inducible gamma
chr16_-_28609976 0.52 ENST00000566189.5
SULT1A1
sulfotransferase family 1A member 1
chr10_+_112375196 0.51 ENST00000393081.6
ACSL5
acyl-CoA synthetase long chain family member 5
chr3_-_142448028 0.51 ENST00000392981.7
XRN1
5'-3' exoribonuclease 1
chr10_+_84452208 0.51 ENST00000480006.1
CCSER2
coiled-coil serine rich protein 2
chr15_-_40108861 0.50 ENST00000354670.9
ENST00000559701.5
ENST00000557870.1
ENST00000558774.5
BMF
Bcl2 modifying factor
chr1_-_247760556 0.50 ENST00000641256.1
OR1C1
olfactory receptor family 1 subfamily C member 1
chr7_-_138002017 0.49 ENST00000452463.5
ENST00000456390.5
ENST00000330387.11
CREB3L2
cAMP responsive element binding protein 3 like 2
chr12_+_121743623 0.49 ENST00000541467.1
TMEM120B
transmembrane protein 120B
chr12_-_13095664 0.49 ENST00000337630.10
ENST00000545699.1
GSG1
germ cell associated 1
chr8_-_133297092 0.48 ENST00000522890.5
ENST00000675983.1
ENST00000518176.5
ENST00000323851.13
ENST00000522476.5
ENST00000518066.5
ENST00000521544.5
ENST00000674605.1
ENST00000518480.5
ENST00000523892.5
NDRG1
N-myc downstream regulated 1
chr10_+_72893572 0.48 ENST00000622652.1
OIT3
oncoprotein induced transcript 3
chr11_+_72114840 0.47 ENST00000622388.4
FOLR3
folate receptor gamma
chr11_-_35419213 0.46 ENST00000642171.1
ENST00000644050.1
ENST00000643134.1
SLC1A2
solute carrier family 1 member 2
chr12_+_64497968 0.46 ENST00000676593.1
ENST00000677093.1
TBK1
ENSG00000288665.1
TANK binding kinase 1
novel transcript
chr6_+_29301701 0.46 ENST00000641895.1
OR14J1
olfactory receptor family 14 subfamily J member 1
chr19_+_14433284 0.43 ENST00000242783.11
PKN1
protein kinase N1
chr16_-_28609992 0.42 ENST00000314752.11
SULT1A1
sulfotransferase family 1A member 1
chr7_+_100884974 0.42 ENST00000448764.5
SRRT
serrate, RNA effector molecule
chr7_-_138001794 0.42 ENST00000616381.4
ENST00000620715.4
CREB3L2
cAMP responsive element binding protein 3 like 2
chrX_+_47145240 0.41 ENST00000628161.2
ENST00000345781.10
RBM10
RNA binding motif protein 10
chr11_+_62123991 0.41 ENST00000533896.5
ENST00000278849.4
ENST00000394818.8
INCENP
inner centromere protein
chr11_-_35420050 0.41 ENST00000395753.6
ENST00000395750.6
ENST00000645634.1
SLC1A2
solute carrier family 1 member 2
chr11_-_35420017 0.40 ENST00000643000.1
ENST00000646099.1
ENST00000647372.1
ENST00000642578.1
SLC1A2
solute carrier family 1 member 2
chr11_-_35419098 0.40 ENST00000606205.6
ENST00000645303.1
SLC1A2
solute carrier family 1 member 2
chr12_-_44875647 0.40 ENST00000395487.6
NELL2
neural EGFL like 2
chr15_+_63048436 0.39 ENST00000334895.10
ENST00000404484.9
ENST00000558910.3
ENST00000317516.12
TPM1
tropomyosin 1
chr8_+_17577179 0.39 ENST00000251630.11
PDGFRL
platelet derived growth factor receptor like
chr17_-_42964437 0.38 ENST00000427569.7
ENST00000430739.5
AARSD1
alanyl-tRNA synthetase domain containing 1
chrM_+_5824 0.37 ENST00000361624.2
MT-CO1
mitochondrially encoded cytochrome c oxidase I
chr10_-_68332878 0.37 ENST00000309049.8
PBLD
phenazine biosynthesis like protein domain containing
chr1_+_172420681 0.37 ENST00000367727.9
C1orf105
chromosome 1 open reading frame 105
chr18_-_3874270 0.37 ENST00000400149.7
ENST00000400155.5
ENST00000400150.7
DLGAP1
DLG associated protein 1
chrX_+_47145200 0.37 ENST00000377604.8
RBM10
RNA binding motif protein 10
chr22_-_17219424 0.36 ENST00000649540.1
ENST00000399837.8
ENST00000543038.1
ADA2
adenosine deaminase 2
chr19_-_10309783 0.36 ENST00000403352.1
ENST00000403903.7
ZGLP1
zinc finger GATA like protein 1
chr6_+_10694916 0.36 ENST00000379568.4
PAK1IP1
PAK1 interacting protein 1
chr8_+_142700465 0.34 ENST00000522591.1
LY6K
lymphocyte antigen 6 family member K
chr9_-_83267230 0.34 ENST00000328788.5
FRMD3
FERM domain containing 3
chr22_-_37109703 0.34 ENST00000406856.7
ENST00000676104.1
TMPRSS6
transmembrane serine protease 6
chr3_-_21751189 0.34 ENST00000281523.8
ZNF385D
zinc finger protein 385D
chr10_+_113126670 0.33 ENST00000369389.6
TCF7L2
transcription factor 7 like 2
chr11_-_114595777 0.33 ENST00000375478.4
NXPE4
neurexophilin and PC-esterase domain family member 4
chr5_+_168486462 0.33 ENST00000231572.8
ENST00000626454.1
RARS1
arginyl-tRNA synthetase 1
chr19_+_49119531 0.33 ENST00000334186.9
PPFIA3
PTPRF interacting protein alpha 3
chr4_-_175812746 0.33 ENST00000393658.6
GPM6A
glycoprotein M6A
chr13_+_36674013 0.33 ENST00000315190.4
SERTM1
serine rich and transmembrane domain containing 1
chr8_+_142700095 0.33 ENST00000292430.10
ENST00000518841.5
ENST00000519387.1
LY6K
lymphocyte antigen 6 family member K
chr18_-_3874247 0.32 ENST00000581699.5
DLGAP1
DLG associated protein 1
chr22_-_17219571 0.32 ENST00000610390.4
ADA2
adenosine deaminase 2
chr17_+_45221993 0.32 ENST00000328118.7
FMNL1
formin like 1
chr5_-_169980474 0.31 ENST00000377365.4
INSYN2B
inhibitory synaptic factor family member 2B
chr19_-_49451793 0.31 ENST00000262265.10
PIH1D1
PIH1 domain containing 1
chr15_+_80152772 0.30 ENST00000407106.5
ENST00000537726.5
ENST00000558767.6
ENST00000261755.9
FAH
fumarylacetoacetate hydrolase
chr11_-_114595750 0.30 ENST00000424261.6
NXPE4
neurexophilin and PC-esterase domain family member 4
chr6_+_55174508 0.29 ENST00000370862.4
HCRTR2
hypocretin receptor 2
chr4_-_170090153 0.29 ENST00000509167.5
ENST00000353187.6
ENST00000507375.5
ENST00000515480.5
AADAT
aminoadipate aminotransferase
chr17_-_17577440 0.29 ENST00000395782.5
PEMT
phosphatidylethanolamine N-methyltransferase
chr19_+_38289138 0.28 ENST00000590738.1
ENST00000587519.4
ENST00000591889.2
SPINT2
ENSG00000267748.4
serine peptidase inhibitor, Kunitz type 2
novel protein
chr20_-_53593829 0.28 ENST00000371471.7
ZNF217
zinc finger protein 217
chr9_-_5185628 0.28 ENST00000381641.4
ENST00000649639.1
INSL6
insulin like 6
chr12_-_13095798 0.27 ENST00000396302.7
GSG1
germ cell associated 1
chr6_+_110982028 0.27 ENST00000441448.7
RPF2
ribosome production factor 2 homolog
chr4_+_164754116 0.27 ENST00000507311.1
SMIM31
small integral membrane protein 31
chrX_-_75785205 0.27 ENST00000373359.4
MAGEE2
MAGE family member E2
chrX_-_103688090 0.26 ENST00000433176.6
MORF4L2
mortality factor 4 like 2
chr2_+_104854104 0.26 ENST00000361360.4
POU3F3
POU class 3 homeobox 3
chr2_-_216694794 0.26 ENST00000449583.1
IGFBP5
insulin like growth factor binding protein 5
chr7_+_73433761 0.25 ENST00000344575.5
FZD9
frizzled class receptor 9
chr8_-_38996466 0.25 ENST00000456845.6
ENST00000456397.7
ENST00000397070.6
ENST00000517872.1
TM2D2
TM2 domain containing 2
chr17_+_16381083 0.25 ENST00000535788.1
ENST00000302182.8
UBB
ubiquitin B
chr12_-_13095628 0.25 ENST00000457134.6
ENST00000537302.5
GSG1
germ cell associated 1
chr1_+_151060357 0.24 ENST00000368921.5
MLLT11
MLLT11 transcription factor 7 cofactor
chr3_-_142448004 0.24 ENST00000463916.5
XRN1
5'-3' exoribonuclease 1
chrX_-_103688033 0.24 ENST00000434230.5
ENST00000418819.5
ENST00000360458.5
MORF4L2
mortality factor 4 like 2
chr11_-_65606959 0.24 ENST00000532507.5
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr8_+_68330923 0.23 ENST00000518698.6
C8orf34
chromosome 8 open reading frame 34
chr10_+_113129285 0.23 ENST00000637574.1
TCF7L2
transcription factor 7 like 2
chr11_-_62601223 0.23 ENST00000527204.5
MTA2
metastasis associated 1 family member 2
chr2_+_104853259 0.22 ENST00000598623.1
ENST00000653688.1
ENST00000662784.1
ENST00000666977.1
ENST00000674056.1
ENSG00000269707.2
POU3F3
novel transcript, sense overlapping POU3F3
POU class 3 homeobox 3
chr16_-_3024230 0.22 ENST00000572355.5
ENST00000574980.5
ENST00000354679.3
ENST00000573842.1
HCFC1R1
host cell factor C1 regulator 1
chr15_+_80152978 0.22 ENST00000561421.6
ENST00000684363.1
FAH
fumarylacetoacetate hydrolase
chr12_-_113136224 0.21 ENST00000546530.5
ENST00000261729.9
RASAL1
RAS protein activator like 1
chr19_+_10013468 0.21 ENST00000591589.3
RDH8
retinol dehydrogenase 8
chr5_-_32444722 0.21 ENST00000265069.13
ZFR
zinc finger RNA binding protein
chr20_-_56005466 0.21 ENST00000064571.3
CBLN4
cerebellin 4 precursor
chr13_-_46897021 0.20 ENST00000542664.4
ENST00000543956.5
HTR2A
5-hydroxytryptamine receptor 2A
chr2_-_131093378 0.20 ENST00000409185.5
ENST00000389915.4
FAM168B
family with sequence similarity 168 member B
chr1_-_244862381 0.20 ENST00000640001.1
ENST00000639628.1
HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr11_-_35419899 0.19 ENST00000646847.1
ENST00000449068.2
ENST00000643401.1
ENST00000645966.1
ENST00000647104.1
SLC1A2
solute carrier family 1 member 2
chr2_+_203014842 0.19 ENST00000683969.1
ENST00000449802.5
NBEAL1
neurobeachin like 1
chr9_+_127803208 0.19 ENST00000373225.7
ENST00000431857.5
FPGS
folylpolyglutamate synthase
chr17_+_74274229 0.19 ENST00000311014.11
DNAI2
dynein axonemal intermediate chain 2
chr7_-_127252919 0.19 ENST00000339582.7
GRM8
glutamate metabotropic receptor 8
chr8_+_7495892 0.19 ENST00000355602.3
DEFB107B
defensin beta 107B
chr1_+_206440061 0.19 ENST00000604925.5
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr19_+_49388243 0.19 ENST00000447857.8
KASH5
KASH domain containing 5
chr12_-_121039204 0.19 ENST00000620239.5
OASL
2'-5'-oligoadenylate synthetase like
chr8_+_103880412 0.18 ENST00000436393.6
RIMS2
regulating synaptic membrane exocytosis 2
chr9_+_19049385 0.18 ENST00000380527.3
RRAGA
Ras related GTP binding A
chr19_-_6333603 0.18 ENST00000301452.5
ACER1
alkaline ceramidase 1
chr22_-_16825404 0.17 ENST00000684488.1
XKR3
XK related 3
chr21_-_32279012 0.17 ENST00000290130.4
MIS18A
MIS18 kinetochore protein A
chr12_-_2876986 0.17 ENST00000342628.6
ENST00000361953.7
FOXM1
forkhead box M1
chr16_-_84239750 0.17 ENST00000568181.1
KCNG4
potassium voltage-gated channel modifier subfamily G member 4
chr12_-_121039236 0.16 ENST00000257570.9
OASL
2'-5'-oligoadenylate synthetase like
chr6_-_116668751 0.16 ENST00000368576.8
ENST00000368573.5
ZUP1
zinc finger containing ubiquitin peptidase 1
chr3_-_9880250 0.16 ENST00000423850.5
ENST00000336832.7
ENST00000675828.1
ENST00000618572.4
ENST00000455015.6
CIDEC
cell death inducing DFFA like effector c
chr5_+_147878703 0.16 ENST00000296694.5
SCGB3A2
secretoglobin family 3A member 2
chr8_-_144428502 0.15 ENST00000531032.5
ENST00000530790.5
ENST00000292510.6
ENST00000533806.5
ENST00000377348.6
VPS28
VPS28 subunit of ESCRT-I
chr17_-_76053639 0.15 ENST00000602720.5
SRP68
signal recognition particle 68
chr11_-_111871530 0.15 ENST00000614444.4
ENST00000616540.5
ALG9
ALG9 alpha-1,2-mannosyltransferase
chr11_+_120236635 0.15 ENST00000260264.8
POU2F3
POU class 2 homeobox 3
chr19_-_50833187 0.14 ENST00000598673.1
KLK15
kallikrein related peptidase 15
chr10_-_24723185 0.14 ENST00000376410.7
ENST00000446003.5
ARHGAP21
Rho GTPase activating protein 21
chr6_+_31615215 0.14 ENST00000337917.11
ENST00000376059.8
AIF1
allograft inflammatory factor 1
chr2_-_169694367 0.14 ENST00000447353.6
CCDC173
coiled-coil domain containing 173
chr19_+_14941489 0.14 ENST00000248072.3
OR7C2
olfactory receptor family 7 subfamily C member 2
chr22_-_39244969 0.14 ENST00000331163.11
PDGFB
platelet derived growth factor subunit B
chr8_-_7815716 0.14 ENST00000335021.2
DEFB107A
defensin beta 107A
chr11_-_31369728 0.14 ENST00000684477.1
ENST00000452803.1
DCDC1
doublecortin domain containing 1
chr8_+_41490396 0.13 ENST00000518270.5
ENST00000520817.5
GOLGA7
golgin A7
chr17_+_45221854 0.13 ENST00000331495.8
FMNL1
formin like 1
chr22_-_31292445 0.13 ENST00000402249.7
ENST00000215912.10
ENST00000443175.1
ENST00000441972.5
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr2_+_86942118 0.13 ENST00000641458.2
RGPD1
RANBP2 like and GRIP domain containing 1
chr12_+_116559381 0.13 ENST00000556529.4
MAP1LC3B2
microtubule associated protein 1 light chain 3 beta 2
chr10_-_69573416 0.13 ENST00000242462.5
NEUROG3
neurogenin 3
chr1_-_151346806 0.13 ENST00000392746.7
RFX5
regulatory factor X5
chr12_-_121039156 0.13 ENST00000339275.10
OASL
2'-5'-oligoadenylate synthetase like
chr7_-_23470469 0.13 ENST00000258729.8
IGF2BP3
insulin like growth factor 2 mRNA binding protein 3
chr3_+_35641421 0.12 ENST00000449196.5
ARPP21
cAMP regulated phosphoprotein 21
chr1_-_109075944 0.12 ENST00000338366.6
TAF13
TATA-box binding protein associated factor 13
chr17_+_7281711 0.12 ENST00000317370.13
ENST00000571308.5
SLC2A4
solute carrier family 2 member 4
chr11_-_59212869 0.12 ENST00000361050.4
MPEG1
macrophage expressed 1
chrX_-_132489842 0.12 ENST00000436215.5
MBNL3
muscleblind like splicing regulator 3
chr7_+_66921217 0.12 ENST00000341567.8
ENST00000607045.5
TMEM248
transmembrane protein 248
chrX_+_66164340 0.11 ENST00000441993.7
ENST00000419594.6
ENST00000425114.2
HEPH
hephaestin
chrX_+_77447387 0.11 ENST00000439435.3
FGF16
fibroblast growth factor 16
chr1_+_26317950 0.11 ENST00000374213.3
CD52
CD52 molecule
chr1_+_162069768 0.11 ENST00000530878.5
NOS1AP
nitric oxide synthase 1 adaptor protein
chr12_+_123458092 0.11 ENST00000526639.3
SNRNP35
small nuclear ribonucleoprotein U11/U12 subunit 35
chr16_+_69924984 0.11 ENST00000568684.1
WWP2
WW domain containing E3 ubiquitin protein ligase 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 8.9 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.5 1.5 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) cytosol to ER transport(GO:0046967)
0.5 3.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.4 1.7 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) negative regulation of negative chemotaxis(GO:0050925)
0.3 4.5 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.3 1.3 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.2 1.0 GO:0032499 detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 1.8 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.2 0.6 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.2 1.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.2 0.9 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.2 0.5 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.2 0.9 GO:1903904 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.2 0.5 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.2 0.6 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 1.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.9 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 3.1 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.9 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.3 GO:1904204 skeletal muscle hypertrophy(GO:0014734) regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.3 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 0.3 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.1 0.6 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.1 0.7 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.1 0.5 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 0.5 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.3 GO:1904397 negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.4 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.6 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.3 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 0.7 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.2 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363)
0.1 0.3 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 6.4 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.1 0.2 GO:1905026 positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903762) positive regulation of ventricular cardiac muscle cell action potential(GO:1903947) positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905026) positive regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905033)
0.1 0.5 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.2 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.8 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.3 GO:0010840 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.0 0.5 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 0.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.5 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.2 GO:0010446 response to alkaline pH(GO:0010446)
0.0 0.2 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.6 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686) positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 3.9 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.4 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.0 0.5 GO:0015884 folic acid transport(GO:0015884)
0.0 0.3 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.5 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 1.0 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.4 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.4 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.6 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.5 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.6 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0051801 cytolysis in other organism involved in symbiotic interaction(GO:0051801) neutrophil mediated killing of gram-negative bacterium(GO:0070945) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.3 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:1904849 positive regulation of fat cell proliferation(GO:0070346) positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 1.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.0 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0051014 actin filament severing(GO:0051014)
0.0 0.7 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.2 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.0 0.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 1.1 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.0 0.2 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.2 GO:2000781 positive regulation of double-strand break repair(GO:2000781)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0042825 TAP complex(GO:0042825)
0.1 7.1 GO:0030673 axolemma(GO:0030673)
0.1 0.3 GO:1990742 microvesicle(GO:1990742)
0.1 0.9 GO:0060171 stereocilium membrane(GO:0060171)
0.1 0.4 GO:0000801 central element(GO:0000801)
0.0 0.6 GO:0043203 axon hillock(GO:0043203)
0.0 0.8 GO:0032059 bleb(GO:0032059)
0.0 4.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.3 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.7 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.4 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 2.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 1.0 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.5 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 1.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.6 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.5 3.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.5 1.4 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.4 3.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.4 6.4 GO:0031996 thioesterase binding(GO:0031996)
0.3 1.6 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 1.5 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.2 4.5 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 1.3 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.2 0.9 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.2 1.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 1.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 1.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.4 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.6 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.1 0.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.5 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.3 GO:0080101 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.1 0.8 GO:0001727 lipid kinase activity(GO:0001727)
0.1 0.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 1.0 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.7 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 1.0 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.3 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 1.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.7 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.7 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.5 GO:0005542 folic acid binding(GO:0005542)
0.0 0.2 GO:0005047 signal recognition particle binding(GO:0005047) endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.6 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.2 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.0 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176) platelet-derived growth factor binding(GO:0048407)
0.0 0.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.8 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 4.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 6.4 PID CD40 PATHWAY CD40/CD40L signaling
0.1 3.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.2 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 3.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.9 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 1.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 3.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.0 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 1.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.5 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.9 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins