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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for PBX2

Z-value: 0.25

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.12 PBX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg38_v1_chr6_-_32190170_321902140.462.0e-02Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_12716893 0.81 ENST00000381465.2
ENST00000155926.9
TRIB2
tribbles pseudokinase 2
chr8_-_6563409 0.45 ENST00000325203.9
ANGPT2
angiopoietin 2
chr3_-_129440007 0.43 ENST00000503197.5
ENST00000249910.5
ENST00000507208.1
ENST00000393278.6
MBD4
methyl-CpG binding domain 4, DNA glycosylase
chr3_-_129439925 0.38 ENST00000429544.7
MBD4
methyl-CpG binding domain 4, DNA glycosylase
chr10_-_44978789 0.36 ENST00000448778.1
ENST00000298295.4
DEPP1
DEPP1 autophagy regulator
chr18_-_75208417 0.35 ENST00000581620.1
ENST00000582437.1
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr17_+_7855055 0.35 ENST00000574668.1
ENST00000301599.7
TMEM88
transmembrane protein 88
chr11_-_104898670 0.21 ENST00000422698.6
CASP12
caspase 12 (gene/pseudogene)
chr14_+_22516273 0.19 ENST00000390510.1
TRAJ27
T cell receptor alpha joining 27
chr3_+_129440082 0.18 ENST00000347300.6
ENST00000296266.7
IFT122
intraflagellar transport 122
chr2_+_33436304 0.17 ENST00000402538.7
RASGRP3
RAS guanyl releasing protein 3
chr2_+_20447065 0.17 ENST00000272233.6
RHOB
ras homolog family member B
chr7_-_33100886 0.16 ENST00000448915.1
RP9
RP9 pre-mRNA splicing factor
chr3_+_129440196 0.16 ENST00000507564.5
ENST00000348417.7
ENST00000504021.5
ENST00000349441.6
IFT122
intraflagellar transport 122
chr14_-_23155302 0.15 ENST00000529705.6
SLC7A8
solute carrier family 7 member 8
chr2_-_264024 0.12 ENST00000403712.6
ENST00000356150.10
ENST00000626873.2
ENST00000405430.5
SH3YL1
SH3 and SYLF domain containing 1
chr9_-_20382461 0.11 ENST00000380321.5
ENST00000629733.3
MLLT3
MLLT3 super elongation complex subunit
chr18_-_75209126 0.10 ENST00000322342.4
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr2_+_233693659 0.10 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase family 1 member A6
chr12_-_27971970 0.10 ENST00000395872.5
ENST00000201015.8
PTHLH
parathyroid hormone like hormone
chr6_+_26045374 0.09 ENST00000612966.3
H3C3
H3 clustered histone 3
chr10_+_122560639 0.08 ENST00000344338.7
ENST00000330163.8
ENST00000652446.2
ENST00000666315.1
ENST00000368955.7
ENST00000368909.7
ENST00000368956.6
ENST00000619379.1
DMBT1
deleted in malignant brain tumors 1
chr10_+_122560751 0.08 ENST00000338354.10
ENST00000664692.1
ENST00000653442.1
ENST00000664974.1
DMBT1
deleted in malignant brain tumors 1
chr10_+_122560679 0.07 ENST00000657942.1
DMBT1
deleted in malignant brain tumors 1
chr14_+_58298497 0.06 ENST00000348476.7
ENST00000355431.8
ENST00000395168.7
ARID4A
AT-rich interaction domain 4A
chr13_-_106568107 0.06 ENST00000400198.8
ARGLU1
arginine and glutamate rich 1
chr5_+_141392616 0.05 ENST00000398604.3
PCDHGA8
protocadherin gamma subfamily A, 8
chr7_-_32490361 0.05 ENST00000410044.5
ENST00000450169.7
ENST00000409987.5
ENST00000409782.5
LSM5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
chr16_+_1078781 0.05 ENST00000293897.5
SSTR5
somatostatin receptor 5
chr17_+_8288637 0.04 ENST00000407006.8
ENST00000226105.11
ENST00000580434.5
ENST00000439238.3
RANGRF
RAN guanine nucleotide release factor
chrX_+_120604199 0.04 ENST00000371315.3
MCTS1
MCTS1 re-initiation and release factor
chr1_+_206865620 0.04 ENST00000367098.6
IL20
interleukin 20
chr13_+_108269629 0.04 ENST00000430559.5
ENST00000375887.9
TNFSF13B
TNF superfamily member 13b
chr6_+_159790448 0.04 ENST00000367034.5
MRPL18
mitochondrial ribosomal protein L18
chr11_-_55936400 0.03 ENST00000301532.3
OR5I1
olfactory receptor family 5 subfamily I member 1
chrX_+_1615049 0.03 ENST00000381241.9
ASMT
acetylserotonin O-methyltransferase
chr3_+_189171948 0.02 ENST00000345063.8
TPRG1
tumor protein p63 regulated 1
chr4_-_117085541 0.02 ENST00000310754.5
TRAM1L1
translocation associated membrane protein 1 like 1
chr14_+_64388296 0.02 ENST00000554739.5
ENST00000554768.6
ENST00000652179.1
ENST00000652337.1
ENST00000557370.3
MTHFD1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
chr17_-_30824665 0.02 ENST00000324238.7
CRLF3
cytokine receptor like factor 3
chr3_+_120908072 0.02 ENST00000273666.10
ENST00000471454.6
ENST00000472879.5
ENST00000497029.5
ENST00000492541.5
STXBP5L
syntaxin binding protein 5 like
chr2_+_112275588 0.02 ENST00000409871.6
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr10_+_68109433 0.02 ENST00000613327.4
ENST00000358913.10
ENST00000373675.3
MYPN
myopalladin
chr3_-_52830664 0.02 ENST00000266041.9
ENST00000406595.5
ENST00000485816.5
ITIH4
inter-alpha-trypsin inhibitor heavy chain 4
chr3_+_160225409 0.01 ENST00000326474.5
C3orf80
chromosome 3 open reading frame 80
chrX_+_120604084 0.01 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chr7_-_151519891 0.00 ENST00000262187.10
RHEB
Ras homolog, mTORC1 binding
chr1_+_101237009 0.00 ENST00000305352.7
S1PR1
sphingosine-1-phosphate receptor 1
chrX_+_46837034 0.00 ENST00000218340.4
RP2
RP2 activator of ARL3 GTPase
chr2_+_203867943 0.00 ENST00000295854.10
ENST00000487393.1
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte associated protein 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.2 0.5 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.3 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.8 GO:0045008 depyrimidination(GO:0045008)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.0 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.0 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.0 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.0 GO:0002636 positive regulation of germinal center formation(GO:0002636)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0072557 IPAF inflammasome complex(GO:0072557) AIM2 inflammasome complex(GO:0097169)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0005785 signal recognition particle receptor complex(GO:0005785)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.1 0.2 GO:0035375 zymogen binding(GO:0035375)
0.1 0.5 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.8 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling