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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for PBX3
Z-value: 1.61
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Transcription factors associated with PBX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX3 | hg38_v1_chr9_+_125748175_125748199 | 0.66 | 3.0e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_99646025 Show fit | 8.50 |
ENST00000263174.9
ENST00000605497.5 ENST00000615664.1 |
palmdelphin |
|
| chr16_-_30021288 Show fit | 7.83 |
ENST00000574405.5
|
double C2 domain alpha |
|
| chr4_+_6269869 Show fit | 5.74 |
ENST00000506362.2
|
wolframin ER transmembrane glycoprotein |
|
| chr4_-_148442342 Show fit | 5.42 |
ENST00000358102.8
|
nuclear receptor subfamily 3 group C member 2 |
|
| chr4_-_148442508 Show fit | 5.33 |
ENST00000625323.2
|
nuclear receptor subfamily 3 group C member 2 |
|
| chr1_+_164559173 Show fit | 5.10 |
ENST00000420696.7
|
PBX homeobox 1 |
|
| chr3_+_194136138 Show fit | 4.96 |
ENST00000232424.4
|
hes family bHLH transcription factor 1 |
|
| chr21_+_44573724 Show fit | 4.78 |
ENST00000622352.3
ENST00000400374.4 ENST00000616689.2 |
keratin associated protein 10-4 |
|
| chr3_-_149086488 Show fit | 4.60 |
ENST00000392912.6
ENST00000465259.5 ENST00000310053.10 ENST00000494055.5 |
helicase like transcription factor |
|
| chr21_+_44600597 Show fit | 4.46 |
ENST00000609664.2
|
keratin associated protein 10-7 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.7 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 10.3 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 3.3 | 10.0 | GO:1903892 | negative regulation of ATF6-mediated unfolded protein response(GO:1903892) |
| 0.1 | 7.8 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.3 | 7.7 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.1 | 7.6 | GO:0000305 | response to oxygen radical(GO:0000305) |
| 1.2 | 6.1 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691) |
| 0.6 | 5.8 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.0 | 5.4 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.6 | 5.1 | GO:1903027 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 11.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 9.5 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.1 | 6.7 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.2 | 5.8 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.4 | 4.5 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 4.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 4.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.3 | 4.1 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.7 | 3.4 | GO:0097513 | myosin II filament(GO:0097513) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 10.4 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 9.8 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.5 | 7.8 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.1 | 7.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 6.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 6.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 6.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 5.9 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 1.9 | 5.8 | GO:0005128 | erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.0 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.4 | 5.8 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 5.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 3.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 3.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 3.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 2.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 9.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 7.7 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.4 | 6.0 | REACTOME SIGNALING BY NOTCH3 | Genes involved in Signaling by NOTCH3 |
| 0.1 | 6.0 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.2 | 4.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 3.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 3.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 2.4 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 2.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |