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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for PGR
Z-value: 0.68
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Transcription factors associated with PGR
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PGR | hg38_v1_chr11_-_101129042_101129070, hg38_v1_chr11_-_101129706_101129735 | 0.41 | 4.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PGR
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_149333407 Show fit | 1.84 |
ENST00000470080.5
|
transmembrane 4 L six family member 18 |
|
| chr17_-_44199206 Show fit | 1.66 |
ENST00000589805.1
|
ataxin 7 like 3 |
|
| chr12_+_78864768 Show fit | 1.62 |
ENST00000261205.9
ENST00000457153.6 |
synaptotagmin 1 |
|
| chr9_-_104928139 Show fit | 1.45 |
ENST00000423487.6
ENST00000374733.1 ENST00000374736.8 ENST00000678995.1 |
ATP binding cassette subfamily A member 1 |
|
| chr1_+_148748774 Show fit | 1.34 |
ENST00000322209.5
|
nudix hydrolase 4B |
|
| chr6_-_75493629 Show fit | 1.30 |
ENST00000393004.6
|
filamin A interacting protein 1 |
|
| chr1_+_25616780 Show fit | 1.30 |
ENST00000374332.9
|
mannosidase alpha class 1C member 1 |
|
| chr4_-_185775271 Show fit | 1.29 |
ENST00000430503.5
ENST00000319454.10 ENST00000450341.5 |
sorbin and SH3 domain containing 2 |
|
| chr2_+_172821575 Show fit | 1.29 |
ENST00000397087.7
|
Rap guanine nucleotide exchange factor 4 |
|
| chr2_-_187448244 Show fit | 1.20 |
ENST00000392370.8
ENST00000410068.5 ENST00000447403.5 ENST00000410102.5 |
calcitonin receptor like receptor |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 2.6 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 1.6 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.5 | 1.5 | GO:0015917 | aminophospholipid transport(GO:0015917) |
| 0.3 | 1.3 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.1 | 1.2 | GO:0034285 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
| 0.1 | 1.1 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.0 | 1.1 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.2 | 1.0 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.2 | 1.0 | GO:0051621 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.6 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 2.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 1.7 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 1.6 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 1.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 1.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 1.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 1.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.2 | 0.8 | GO:0005595 | collagen type XII trimer(GO:0005595) |
| 0.0 | 0.8 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 2.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.4 | 1.5 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) |
| 0.1 | 1.3 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.3 | 1.2 | GO:0004948 | calcitonin receptor activity(GO:0004948) |
| 0.0 | 1.2 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.0 | 1.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.2 | 1.1 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 1.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 1.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.7 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 1.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.2 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.8 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.7 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 2.2 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.0 | 1.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 1.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 0.8 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.8 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 0.7 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |