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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for PITX1
Z-value: 1.13
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Transcription factors associated with PITX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX1 | hg38_v1_chr5_-_135034212_135034294 | 0.05 | 8.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 2.0 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.2 | 1.5 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.0 | 1.3 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.2 | 1.1 | GO:0006154 | adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103) |
| 0.1 | 1.1 | GO:0014056 | acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) |
| 0.1 | 1.1 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.0 | 1.1 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.2 | 1.0 | GO:0097319 | fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539) |
| 0.0 | 1.0 | GO:0045576 | mast cell activation(GO:0045576) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 1.0 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 0.9 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.3 | 0.8 | GO:0005760 | gamma DNA polymerase complex(GO:0005760) |
| 0.0 | 0.8 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 0.7 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.7 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.7 | GO:0005861 | troponin complex(GO:0005861) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 1.5 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) |
| 0.3 | 1.3 | GO:0047685 | amine sulfotransferase activity(GO:0047685) |
| 0.0 | 1.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.1 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.1 | 1.1 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.0 | 1.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 1.0 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.2 | 1.0 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) |
| 0.1 | 1.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.9 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 0.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.3 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.3 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 2.9 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 1.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 1.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 1.1 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 1.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 0.9 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 0.9 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 0.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |