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Inflammatory response time course, HUVEC (Wada, 2009)

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Results for PITX2

Z-value: 0.52

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.17 PITX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg38_v1_chr4_-_110623051_110623085,
hg38_v1_chr4_-_110636963_110637042,
hg38_v1_chr4_-_110641920_110642123		-0.414.5e-02Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_+_2476118 2.07 ENST00000215631.9
ENST00000587345.1
GADD45B
growth arrest and DNA damage inducible beta
chr9_-_14300231 1.27 ENST00000636735.1
NFIB
nuclear factor I B
chr4_-_101347492 1.23 ENST00000394854.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr4_-_101347327 1.05 ENST00000394853.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr4_-_101347471 1.01 ENST00000323055.10
ENST00000512215.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr4_-_101346842 1.00 ENST00000507176.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr6_-_111483700 0.83 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr15_+_40929338 0.79 ENST00000249749.7
DLL4
delta like canonical Notch ligand 4
chr17_+_4740005 0.77 ENST00000269289.10
ZMYND15
zinc finger MYND-type containing 15
chr17_+_4740042 0.77 ENST00000592813.5
ZMYND15
zinc finger MYND-type containing 15
chr17_-_41518878 0.62 ENST00000254043.8
KRT15
keratin 15
chr11_-_119346655 0.61 ENST00000360167.4
MFRP
membrane frizzled-related protein
chr6_+_35342535 0.61 ENST00000360694.8
ENST00000418635.6
ENST00000448077.6
PPARD
peroxisome proliferator activated receptor delta
chr1_+_43300971 0.59 ENST00000372476.8
ENST00000538015.1
TIE1
tyrosine kinase with immunoglobulin like and EGF like domains 1
chr6_+_130018565 0.52 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr12_-_54981838 0.49 ENST00000316577.12
TESPA1
thymocyte expressed, positive selection associated 1
chr12_+_56521798 0.46 ENST00000262031.10
RBMS2
RNA binding motif single stranded interacting protein 2
chr14_+_75522427 0.40 ENST00000286639.8
BATF
basic leucine zipper ATF-like transcription factor
chr1_+_202010575 0.39 ENST00000367283.7
ENST00000367284.10
ELF3
E74 like ETS transcription factor 3
chr12_-_52796110 0.38 ENST00000417996.2
KRT3
keratin 3
chr22_-_17258235 0.36 ENST00000649310.1
ENST00000649746.1
ADA2
adenosine deaminase 2
chr7_+_74453790 0.35 ENST00000265755.7
ENST00000424337.7
ENST00000455841.6
GTF2IRD1
GTF2I repeat domain containing 1
chr12_-_89656093 0.31 ENST00000359142.7
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr11_-_119346695 0.30 ENST00000619721.6
MFRP
membrane frizzled-related protein
chr18_-_49491586 0.30 ENST00000584895.5
ENST00000580210.5
ENST00000579408.5
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr12_-_89656051 0.30 ENST00000261173.6
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr10_-_48274567 0.30 ENST00000636244.1
ENST00000374201.8
FRMPD2
FERM and PDZ domain containing 2
chr9_-_92404559 0.29 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr3_+_159069252 0.27 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr16_-_11976611 0.27 ENST00000538896.5
ENST00000673243.1
NPIPB2
nuclear pore complex interacting protein family member B2
chr12_+_6840800 0.25 ENST00000541978.5
ENST00000229264.8
ENST00000435982.6
GNB3
G protein subunit beta 3
chr14_+_75522531 0.23 ENST00000555504.1
BATF
basic leucine zipper ATF-like transcription factor
chr10_+_102226293 0.19 ENST00000370005.4
ELOVL3
ELOVL fatty acid elongase 3
chr6_+_35342614 0.19 ENST00000337400.6
ENST00000311565.4
PPARD
peroxisome proliferator activated receptor delta
chr22_-_29838227 0.17 ENST00000307790.8
ENST00000397771.6
ENST00000542393.5
ASCC2
activating signal cointegrator 1 complex subunit 2
chr11_+_61755372 0.16 ENST00000265460.9
MYRF
myelin regulatory factor
chr16_-_67980483 0.14 ENST00000268793.6
ENST00000672962.1
DPEP3
dipeptidase 3
chr7_-_123199960 0.11 ENST00000194130.7
SLC13A1
solute carrier family 13 member 1
chr15_+_41774539 0.11 ENST00000514566.5
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr17_-_4739866 0.10 ENST00000574412.6
ENST00000293778.12
CXCL16
C-X-C motif chemokine ligand 16
chr12_-_118359639 0.09 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr6_-_41705813 0.09 ENST00000419574.6
ENST00000445214.2
TFEB
transcription factor EB
chr22_-_38700655 0.09 ENST00000216039.9
JOSD1
Josephin domain containing 1
chr7_+_30284574 0.09 ENST00000323037.5
ZNRF2
zinc and ring finger 2
chr8_+_48008409 0.07 ENST00000523432.5
ENST00000521346.5
ENST00000523111.7
ENST00000517630.5
UBE2V2
ubiquitin conjugating enzyme E2 V2
chr6_+_46693835 0.07 ENST00000450697.1
TDRD6
tudor domain containing 6
chr13_-_35855758 0.07 ENST00000615680.4
DCLK1
doublecortin like kinase 1
chr7_-_128775793 0.06 ENST00000249389.3
OPN1SW
opsin 1, short wave sensitive
chr13_-_35855627 0.05 ENST00000379893.5
DCLK1
doublecortin like kinase 1
chr4_-_67754335 0.04 ENST00000420975.2
ENST00000226413.5
GNRHR
gonadotropin releasing hormone receptor
chr2_+_120013111 0.04 ENST00000331393.8
ENST00000443124.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr11_-_5227063 0.03 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
HBB
hemoglobin subunit beta
chr3_+_154121366 0.03 ENST00000465093.6
ENST00000496710.5
ENST00000465817.1
ARHGEF26
Rho guanine nucleotide exchange factor 26
chr9_-_128724088 0.03 ENST00000406904.2
ENST00000452105.5
ENST00000372667.9
ENST00000372663.9
ZDHHC12
zinc finger DHHC-type palmitoyltransferase 12
chr2_+_3575303 0.01 ENST00000646909.1
ENST00000647131.1
ENST00000462576.5
ENST00000403564.5
RPS7
ribosomal protein S7
chr22_-_30471986 0.01 ENST00000401751.5
ENST00000402286.5
ENST00000403066.5
ENST00000215812.9
SEC14L3
SEC14 like lipid binding 3
chr19_+_47821907 0.01 ENST00000539067.5
ENST00000221996.12
ENST00000613299.1
CRX
cone-rod homeobox
chr3_+_98497681 0.00 ENST00000427338.3
OR5K2
olfactory receptor family 5 subfamily K member 2
chr13_+_73058993 0.00 ENST00000377687.6
KLF5
Kruppel like factor 5
chrM_+_9207 0.00 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chrX_-_21658324 0.00 ENST00000379499.3
KLHL34
kelch like family member 34
chr8_-_132111159 0.00 ENST00000673615.1
ENST00000434736.6
HHLA1
HERV-H LTR-associating 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.1 0.8 GO:1903588 regulation of neural retina development(GO:0061074) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.5 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 1.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 2.1 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 0.6 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.1 0.4 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.8 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.1 0.4 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.6 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.4 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.8 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.2 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.1 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 0.0 GO:0030185 nitric oxide transport(GO:0030185)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.8 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 1.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.6 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 0.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.8 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 2.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.8 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 1.3 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation