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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for PLAGL1
Z-value: 1.39
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg38_v1_chr6_-_144064511_144064608 | -0.26 | 2.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_680707 Show fit | 3.35 |
ENST00000592947.5
ENST00000588773.5 ENST00000591573.1 ENST00000605925.3 |
follistatin like 3 |
|
| chr21_-_44240840 Show fit | 2.91 |
ENST00000344330.8
ENST00000407780.7 ENST00000400379.7 ENST00000400377.3 |
inducible T cell costimulator ligand |
|
| chr9_-_93134234 Show fit | 2.12 |
ENST00000375446.5
|
ninjurin 1 |
|
| chr10_-_5977535 Show fit | 2.11 |
ENST00000379977.8
|
interleukin 15 receptor subunit alpha |
|
| chr21_+_43741420 Show fit | 1.96 |
ENST00000467908.1
|
pyridoxal kinase |
|
| chr6_-_4079100 Show fit | 1.94 |
ENST00000492651.5
ENST00000498677.5 ENST00000274673.8 |
family with sequence similarity 217 member A |
|
| chr16_-_11586941 Show fit | 1.92 |
ENST00000571976.1
ENST00000413364.6 |
lipopolysaccharide induced TNF factor |
|
| chr16_+_66604782 Show fit | 1.86 |
ENST00000565003.5
|
CKLF like MARVEL transmembrane domain containing 3 |
|
| chr19_+_676385 Show fit | 1.77 |
ENST00000166139.9
|
follistatin like 3 |
|
| chr17_-_3691887 Show fit | 1.75 |
ENST00000552050.5
|
purinergic receptor P2X 5 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.2 | 5.2 | GO:0006972 | hyperosmotic response(GO:0006972) |
| 0.2 | 4.4 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.3 | 3.6 | GO:0030578 | PML body organization(GO:0030578) |
| 1.0 | 3.1 | GO:2000752 | regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755) |
| 0.1 | 3.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 3.1 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.0 | 3.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.6 | 2.8 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
| 0.2 | 2.7 | GO:0042940 | D-amino acid transport(GO:0042940) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.7 | 6.0 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 4.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 4.5 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 3.5 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 3.3 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 3.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 3.1 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 2.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.6 | 2.6 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.7 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 5.9 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 5.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 4.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 3.9 | GO:0048185 | activin binding(GO:0048185) |
| 0.3 | 3.8 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.2 | 2.9 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 2.8 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 2.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 2.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 7.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 5.0 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 4.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.1 | 4.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 4.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 4.1 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 3.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 3.5 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 3.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 5.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 5.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 4.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 4.1 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 4.1 | REACTOME COSTIMULATION BY THE CD28 FAMILY | Genes involved in Costimulation by the CD28 family |
| 0.1 | 4.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 4.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 3.8 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 3.6 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |