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Inflammatory response time course, HUVEC (Wada, 2009)
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Results for POU3F3_POU3F4
Z-value: 0.99
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Transcription factors associated with POU3F3_POU3F4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F4 | hg38_v1_chrX_+_83508284_83508309 | 0.65 | 4.5e-04 | Click! |
| POU3F3 | hg38_v1_chr2_+_104853259_104853490 | -0.05 | 8.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F3_POU3F4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_127577168 Show fit | 3.97 |
ENST00000329722.8
|
chromosome 6 open reading frame 58 |
|
| chr1_-_169734064 Show fit | 3.87 |
ENST00000333360.12
|
selectin E |
|
| chr5_+_126423122 Show fit | 2.74 |
ENST00000515200.5
|
GRAM domain containing 2B |
|
| chr5_+_126423176 Show fit | 2.72 |
ENST00000542322.5
ENST00000544396.5 |
GRAM domain containing 2B |
|
| chr5_+_126423363 Show fit | 2.71 |
ENST00000285689.8
|
GRAM domain containing 2B |
|
| chr3_-_127736329 Show fit | 2.69 |
ENST00000398101.7
|
monoglyceride lipase |
|
| chr3_-_108058361 Show fit | 2.60 |
ENST00000398258.7
|
CD47 molecule |
|
| chr10_-_48604952 Show fit | 2.38 |
ENST00000417912.6
|
Rho GTPase activating protein 22 |
|
| chr21_-_36542600 Show fit | 2.33 |
ENST00000399136.5
|
claudin 14 |
|
| chr2_-_219399981 Show fit | 2.24 |
ENST00000519905.1
ENST00000523282.5 ENST00000434339.5 ENST00000457935.5 |
aspartyl aminopeptidase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 3.9 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.1 | 2.9 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.3 | 2.7 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 2.6 | GO:0008228 | opsonization(GO:0008228) |
| 0.1 | 2.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 2.1 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.0 | 1.9 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.2 | 1.8 | GO:0060574 | intestinal epithelial cell maturation(GO:0060574) |
| 0.1 | 1.8 | GO:0070777 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 3.3 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 2.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 2.8 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 2.6 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 2.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.6 | 1.9 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.4 | 1.9 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.0 | 1.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 1.6 | GO:0000795 | synaptonemal complex(GO:0000795) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.3 | 3.9 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.1 | 3.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.3 | 2.9 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.1 | 2.7 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.3 | 2.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.4 | 1.9 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.3 | 1.8 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 1.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 1.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 4.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 3.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 1.9 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 1.1 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 1.0 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.2 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 2.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 2.6 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 2.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 2.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 2.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 2.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.9 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |